A study has found that genetic loss of Ron receptor and its growth factor HGFL leads to aggressive inflammation and damage to the colon in models with IBD. The research suggests these genes may reduce their function due to SNPs, leading to chronic intestinal inflammation.
Researchers at the University of Cincinnati have solved a century-long puzzle by proving that Merkel cells are the initial sites for sensing touch. Their study published in Cell journal shows that gentle touch triggers action potentials in Merkel cells, mediated by the Piezo2 receptor/ion channel.
A clinical trial by UC researchers found that consuming chips with olestra reduces serum polychlorinated biphenyls (PCBs) levels in people exposed to PCBs. Olestra's effect on PCB removal is attributed to solubilizing fat-soluble compounds in the intestine, reducing absorption of these compounds into the body.
Researchers tracked drought dynamics in the US using a new Event-based Spatial-Temporal Data Model (ESTDM), which analyzed four years of European Space Agency's soil moisture and ocean salinity data. The study aims to predict future drought events by identifying patterns of spreading drought.
Researchers analyzed over 10 years of medical helicopter transports in Maryland, finding that 31% of trauma cases could have been transported by ambulance within the golden hour, saving thousands of dollars. GIS technology provides accurate estimates of transport times to trauma centers.
The iPad application is used to streamline behavior mapping, a research technique that records children's interactions in natural settings to assess their science skills and interests. The app allows for flexible data collection and upload, ensuring the safety of participant data.
Researchers have identified a genetic association with facial asymmetry in an ancient cavefish, which may help solve mysteries surrounding cleft palate and hemifacial microsomia. The study used high-tech imaging techniques to compare the craniofacial features of cavefish with those of surface-dwelling fish.
Researchers at the University of Cincinnati have discovered that gastric bypass surgery leads to excessive post-meal insulin response in a subset of patients, characterized by altered islet cell function and reduced insulin clearance. This study sheds light on mechanisms of glucose metabolism alterations following gastric bypass surgery.
Researchers found that vertical sleeve gastrectomy alters bile acids binding to nuclear receptor FXR, leading to weight loss and improved diabetes outcomes. Gut bacteria also change, with certain groups linked to Type 2 diabetes risk.
Researchers aim to investigate the impact of stored blood 'microparticles' on inflammation and injury. Studies have shown that transfusion with aged red blood cells can worsen patient outcomes, including increased risk of organ failure.
Researchers are using a unique approach to climate change vulnerability, involving community stakeholders and scenario-building techniques. The study focuses on two geographic case studies, Big Hole Valley in Montana and Grand County in Colorado, exploring how communities can prepare for future ecological hazards.
Researchers use years of data to understand how glaciers changed over time as climate has changed, providing insights into future glacier melting. The study's findings have significant implications for understanding global environmental change and planning protection efforts.
Researchers found that playscapes promote scientific inquiry, math education and environmental awareness, while reducing depression and attention deficit disorders. These specially designed outdoor spaces foster curiosity, nature exploration and sustainable practices.
Researchers have found a potential new treatment for patients with advanced melanoma and kidney cancer. The study used an antibody that targets the tumor-enhancing protein TGFβ, which is involved in cell growth and spread of tumors.
Researchers use computational fluid dynamics to study respiratory disorders and provide surgeons with more accurate treatment approaches. The method leads to better surgical outcomes, reduced surgeries, and improved patient recovery.
Researchers at the University of Cincinnati have developed a new method of light-matter interaction analysis, which appears to be a good way of helping make better semiconductor nanowires. The technique uses Rayleigh scattering to probe band structures and electron-hole dynamics in single indium phosphide nanowires.
Researchers at the University of Cincinnati have identified a zero-dimensional quantum dot structure that can confine electronic excitations within semiconductor nanowires. This discovery has significant implications for harnessing solar energy, creating stronger lasers, and developing more sensitive medical diagnostic devices.
University of Cincinnati researchers discovered that high-frequency electrical stimulus increased blood vessel network growth by up to 50%, leading to enhanced wound closure. The team developed a specialized antenna for localized application and filed a provisional patent for their design.
Researchers found higher levels of BPA in prostate cancer patients than non-prostate cancer patients, with low-dose exposure linked to centrosome amplification and cell transformation. The study suggests a previously unknown relationship between BPA exposure and prostate cancer development.
University of Cincinnati researchers are working on a new technology that manipulates light to create super-lenses with seven times the strength of a standard microscope, allowing for better viewing of tiny objects. The team also explores hiding objects in plain sight by cloaking them with metamaterial films.
A University of Cincinnati-led team studied four distinct magnetized nanoparticle systems to determine which one works best in delivering heat directly to cancer cells. The research found that uncoated iron-oxide nanoparticles and those coated with polyacrylic acid heated quickly to temperatures sufficient to kill breast cancer cells.
University of Cincinnati researchers have made a breakthrough in boosting the efficiency of polymer solar cells by adding graphene nanoflakes, increasing performance threefold. The new method aims to make solar-powered panels lighter, less expensive and more flexible.
Researchers have developed a cancer vaccine that utilizes the immune system to target and destroy tumor cells producing a specific protein. The vaccine, which involves genetically modified tumor cells producing IL-15 and its receptor, shows promise in slowing tumor growth and increasing survival rates in animal models.
Recent advances in data analysis technology have given federal controllers new weapons in the fight against Medicare and Medicaid fraud. Researchers found that for every dollar spent on fraud control, $7 was returned, with significant recoveries made in fiscal years 2011 and 2012.
A recent survey found that 64% of small businesses experience employee theft, but only 16% report it to the police. The most common items stolen were cash and products sold by the business. Employees most likely to steal are general or first-line employees, often due to lack of trust and opportunities for easy theft.
University of Cincinnati researchers are developing validation metrics that could help predict the success or failure of hypersonic aircraft. The metrics involve principal component analysis (PCA) decomposition of simulation and test data to measure uncertainty, which will ultimately determine the success in building such a plane.
The University of Cincinnati has received over $1 million from the US Air Force to fund seven research projects studying the effects of air medical evacuation. Researchers will investigate how altitude affects medical equipment, resuscitation methods, and caregiver performance during flights.
Researchers at the University of Cincinnati are developing unique approaches to drone autopilot systems, enabling them to track missing persons, navigate through smoke during wildfires, and deliver packages. The technology has the potential to save lives and provide significant time- and cost-efficiencies for first responders.
Researchers at the University of Cincinnati identified serine/threonine protein kinase-29 (STK-29) as a key component linking circadian rhythms and cell division cycles. The study, led by Christian Hong, provided insights that could lead to improved disease treatments and drug delivery.
Researchers found that targeting molecular profiles of non-small-cell lung cancer with mutated cancer-causing protein KRas is the most effective treatment strategy. The study suggests that combination therapy using approved inhibitors might improve outcomes for patients with wild-type KRas tumors.
A doctoral candidate used historical proxies, including coins, to create an interactive map of ancient Antioch's boundaries. She found the city's influence extended farther than previously theorized and was particularly abundant along a known trade route.
Archaeologists at the University of Cincinnati have uncovered a more complex picture of life in ancient Pompeii, finding that the poor did not scrounge for scraps but instead enjoyed a range of affordable food options. The research, led by Steven Ellis, reveals exotic spices and meats were part of non-elite diets.
UC researcher Emily Catherine Egan found evidence that ancient palace floors were designed to replicate a hybrid of cloth and stone, serving both aesthetic and instructional purposes. She also discovered the first use of artist's grids on floor paintings, solving a longstanding riddle.
Researchers have identified a clearance system that recognizes and breaks down the oncogenic KRas protein, leading to its degradation. This discovery provides a new avenue for developing targeted therapies for cancer types with KRas mutations.
Researchers at University of Cincinnati Cancer Institute found the retinoblastoma (Rb) protein plays a critical role in suppressing cell migration and metastasis in basal-like breast carcinomas. The study suggests that Rb suppression stimulates collective cell-based invasion, leading to lymphovascular invasion and metastasis.
Researchers from the University of Cincinnati found that people with migraines who also have allergies or hay fever experience more severe headaches than those without these conditions. Those with mixed rhinitis, experiencing both allergic and non-allergic triggers, were 45% more likely to endure disabling headaches.
A study by University of Cincinnati researcher Stephanie Sadre-Orafai compares the casting methods of New York City fashion scouts to the NYPD's stop-and-frisk program, revealing similarities between the two.
Researchers found that 71% of university students engaged in at least one cyberdeviance activity as teens, with most common activities including password guessing and unauthorized network access. Despite initial concerns, the authors suggest these behaviors may be beneficial for teaching IT security skills.
Research by University of Cincinnati's Matthew Logan suggests that inmates with military backgrounds are not more likely to misbehave, but rather fare better in prison. They were 20% less likely to be sent to solitary confinement and 36% less likely to use drugs or alcohol.
A new multilevel study examines the relationship between minimum wage increases and crime rates, concluding that higher wages do not lower violent or property crime. The researchers analyzed data from 18 states that raised their minimum wage above federal standards and found no significant change in crime rates.
Researchers from University of Cincinnati develop a brain-computer interface to detect brain signals and interpret intent, paving the way for thought-controlled smart tech and robotic personal assistants. The university also announces its development of an interdisciplinary curriculum for human-centered robotics.
Researchers at the University of Cincinnati are working on an exoskeleton that could help geriatric patients regain independence in movement. The device is designed to supplement the user's natural movement, rather than forcing a predetermined motion, and has the potential to benefit patients affected by stroke and paraplegia.
Researchers will examine conversion to generic tacrolimus in transplant patients to assess its safety and efficacy. The studies aim to address concerns about the use of generic tacrolimus formulations in transplant recipients and provide objective data for clinicians.
A study published by UC researchers found that patients with acute kidney injury (AKI) before starting dialysis are 1.5 times more likely to die in their first year compared to those without AKI. This discovery may help improve dialysis outcomes and quality of life for millions of patients.
SmartLight, a new technology developed by UC researchers, uses electrofluidic cells to channel sunlight into buildings, reducing energy consumption and emissions. The system can be controlled wirelessly via a mobile app, adjusting brightness according to user preferences.
A University of Cincinnati study found that web-based programs for mothers can improve children's fruit and vegetable intake and reduce screen time. The program, called EMPOWER, also increased physical activity and reduced sugary beverage consumption among participating families.
A study by Laura Nabors at the University of Cincinnati found that chronically ill children use imaginative play to work through fears and express a full recovery. Play also helps siblings cope with their child's illness, highlighting the importance of parental support.
University of Cincinnati researchers developed a new method for mapping landscape types using machine vision technology, discovering 15 distinctive landscape types in northern Georgia. The technique can be applied to socio-economic data, such as U.S. Census data, allowing for more efficient geographic research and land management.
Researchers have developed a novel nanostructure that can carry multiple components for simultaneous detection, diagnosis, and targeted drug delivery to cancer cells. This Janus nanostructure has the potential to provide earlier diagnosis and more accurate targeting of cancer cells, reducing drug side effects.
A new classification system is being proposed to identify regional identity and sustainability benefits of green roofs. The system, developed by University of Cincinnati researcher Virginia Russell, aims to stimulate research and development of uniquely North American green roofs.