Researchers have identified a specific cellular mechanism that may help overcome endocrine therapy-resistance in patients with estrogen-positive breast cancers. A novel molecular 'crosstalk' point between estrogen and HER2 signaling pathways has been found to drive tamoxifen resistance, according to new findings.
Researchers at University of Cincinnati develop a paper-thin plastic screen that can be folded or rolled up repeatedly, eliminating pixel borders. This breakthrough technology uses ambient light to reduce power consumption and enables magazine-quality color displays in foldable e-devices.
A University of Cincinnati study found that adolescent males are at a higher risk of reporting long-term use of over-the-counter drugs compared to their female peers. The study, which analyzed data from over 54,000 students, highlights the growing concern of over-the-counter drug abuse among young people.
A new study from the University of Cincinnati found a common bond between school bullies and their victims: alcohol abuse. The research analyzed data from over 54,000 students and discovered that bullying was associated with increased odds of recent alcohol use and heavy drinking among males and females.
Researchers have developed a new microfluidic device that can separate rare cells and blood components with high accuracy and speed. The device uses inertial microfluidics to sort blood into different streams, allowing for rapid diagnosis of conditions such as anemia, malaria, or leukemia.
A study published in Current Biology demonstrates that male genital shape affects fertilization success in a species of seed beetle. Males with longer genital spines produced substantially more offspring than those with shorter spines, highlighting the importance of competition among males in driving evolutionary changes.
Research by UC's Susan Prince suggests that ancient Cynics, like Antisthenes, advocated for a rigorous path toward virtue and happiness, requiring drastic attitude changes and emphasizing ethical literature. This approach led to more leisure time, which could be spent living an ethically fulfilling life.
The University of Cincinnati will conduct a clinical trial studying the immunosuppressant tacrolimus against two generic manufacturers in liver and kidney transplant patients. The study aims to address concerns over the quality, pharmacokinetics, and therapeutic efficacy of generic drugs compared to brand-name products.
A University of Cincinnati pilot study found that nodding wild onion and goldmoss sedum can survive and thrive on green roofs in the Southwest Ohio region. The research tested four Ohio native plants and one sedum under two conditions, with all plants receiving regular watering surviving.
A study found that holidays like Christmas and Thanksgiving may reduce suicide attempts by poisoning, while New Year's Day sees a spike. The researchers suggest increased family or social support structures around holidays may play a role in this phenomenon.
A study by University of Cincinnati Marketing Professor James Kellaris found that inadequate signage can lead to loss of business and tax revenue. Women experience signage communication failure more than men, with about half the population surveyed in 2011 having driven past businesses due to signage issues.
Researchers at the University of Cincinnati have identified a genetic mutation responsible for deafness and hearing loss associated with Usher syndrome type 1. The discovery of the CIB2 protein provides new insights into the mechanism of mechano-electrical transduction, which converts mechanical energy into sound.
Researchers found that both biological organisms and electronic devices use similar approaches to change reflective colors, but biology outperforms electronics in efficiency, scalability, and sophistication. Human-made technology excels in speed and color range, but lags behind nature's complex adaptations.
University of Cincinnati doctoral student Dippy Aggarwal presents early results on leveraging power analytics and linked data for enterprise computing at the Grace Hopper Celebration of Women in Computing Conference. Her project aims to capture an organization's ecological footprint through real-time power consumption tracking.
The new LandEx tool uses the National Land Cover Dataset 2006 to enable example-based queries for localities with similar patterns of land cover. The tool allows researchers and educators to explore its capabilities online, providing a total search for a sense of place.
University of Cincinnati researchers have created an adaptive, active algorithm to counter sudden road noises, such as those from potholes or bumps. The algorithm aims to reduce road-impact noise perceived by drivers by three to five decibels, significantly minimizing the resulting sound.
Researchers at the University of Cincinnati are working to reduce noise in sophisticated military aircraft and quieter car rides. They have developed mathematical models for quick-response noise cancellation and clusters of harmonic responses to minimize sudden road noises.
Researchers at the University of Cincinnati's Gas Dynamics and Propulsion Laboratory have made progress in reducing supersonic jet noise using chevrons and fluidic injection. The goal is to reduce noise by up to 10 decibels while maintaining or improving engine performance.
Researchers found that consumers perceive greater risk when prices involve non-monetary costs, such as time or information privacy. Businesses must strike a risk balance when combining different pricing structures.
A study by the University of Cincinnati found that exposure to Aspergillus ochraceus, Aspergillus unguis and Penicillium variabile during infancy increases the risk of developing asthma in childhood. The research used a DNA-based mold level analysis tool to determine this link.
Researchers at the University of Cincinnati have identified a new genetic target, pendrin, for diuretic therapy. The study suggests that targeting pendrin could lead to a targeted treatment option for patients with severe fluid overload who may not respond well to current diuretics.
Researchers at the University of Cincinnati have shown that pulsed-dye laser treatment improves burn scar appearance, texture, and elasticity. The study found significant improvements in redness, scar thickness, and biomechanical properties, with potential implications for further refining treatment options.
Researchers at the University of Cincinnati discovered a massive ancient dam built by the Maya, stretching over 260 feet and holding 20 million gallons of water. The dam, constructed from cut stone and earth, was part of a sophisticated water management system that allowed the city to thrive despite periodic droughts.
Researchers at the University of Cincinnati have successfully treated a severe form of autism spectrum disorder called creatine transporter deficiency (CTD) using a creatine analogue called CincY. The treatment reversed mental retardation-like symptoms in mice and improved cognitive abilities, including recognition and spatial learning.
Researchers at the University of Cincinnati discovered a new gene target for leukemia therapy by inhibiting the protein Vav3, which controls cell signaling. This finding could lead to cellular targets for patients with BCR-ABL lymphoid leukemia, a type of leukemia with poor treatment outcomes.
A University of Cincinnati study found strong correlations between Mycobacterium and visible mold, as well as between Stenotrophomonas and environmental relative moldiness index. These bacteria strains are linked to indoor bacterial contamination in water-damaged homes, posing health risks to occupants.
A new study found that gay and lesbian couples are more likely to engage in mutual health behaviors, while straight couples rely on one partner as the 'health expert.' The research also suggests that societal conditions can shape health behavior dynamics in intimate partnerships.
A 1998 medical journal publication sparked concerns about an alleged link between the MMR vaccine and autism, leading to a decline in vaccination rates. The controversy persisted even after epidemiological studies refuted the claim. Research found that higher-educated mothers were less likely to vaccinate their children.
Researchers have identified a genetic variant in a cardiac protein that increases the risk of heart rhythm dysfunction and sudden death in patients with dilated cardiomyopathy. The variant, known as Ser96Ala, affects calcium regulation in heart cells, leading to arrhythmias and increased mortality.
Research on lemur extinctions over 2,000 years reveals that remaining species go into 'ecological retreat,' increasing extinction risk. Surviving lemurs rely on denser habitats due to vacant environmental niches, which may be a result of human disturbance.
Researchers found that T cell imbalance increases risk for gastrointestinal infection recurrence, particularly in C. difficile cases. Patients with recurrent infections had higher levels of regulatory and TH17 cells, which could lead to targeted molecular therapies.
Researchers at the University of Cincinnati have identified apolipoprotein A-IV (apoA-IV) as a promising target for a new diabetes treatment. The study found that apoA-IV improves insulin secretion and reduces blood sugar levels in mice with impaired glucose tolerance.
Researchers found that surface layer proteins of C. difficile produce a different cytokine response in patients with recurrent infection compared to those with initial onset. This suggests a more chronic inflammatory process, potentially leading to continuous or re-infection.
Researchers created a website called Twipolitico that analyzes tweets to track the presidential race. The site utilizes machine learning algorithms and natural language processing techniques to analyze sentiment and topic trends in real-time, providing valuable insights for candidates and strategists alike.
A new study examined what influences children's snack choices and found that intentions, attitude, social connections and behavioral control play a significant role. The researchers discovered that girls and African-American children tend to make healthier snack choices, while Hispanic and Asian children consume more fruits and vegetab...
Scientists trim fruit fly males' spines using precision laser surgery and monitor mating success, finding spines aid reproduction before sex. The study sheds light on the evolution of male genital traits, suggesting a similar process to secondary sexual traits.
An amateur paleontologist has discovered a massive, roughly elliptical shape with multiple lobes, totaling almost seven feet in length, which is believed to be a biological organism. The team plans to reconstruct the timeline of the fossil's life and burial events to better understand its origins.
Researchers are investigating the factors predicting senior executive turnover in federal workplaces, which can result in costly losses for organizations. The study focuses on the U.S. Department of Veteran Affairs' Senior Executive Service, finding that turnover is highest among new or low-tenure executives.
Global gene expression analysis reveals distinct molecular differences between perivascular and subcutaneous fat tissues. Perivascular fat tissue is highly inflamed in humans with coronary artery diseases, suggesting it as a key player in disease formation.
Researchers at the University of Cincinnati have found a cellular pathway linked to obesity-related disorders such as diabetes, heart disease, and fatty liver disease. Deleting the enzyme histone deacetylase 9 (HDAC9) completely protected mice against high-fat feeding's negative health consequences.
Researchers will investigate four cellular processes using Neurospora fungi to develop general principles of coupled network dynamics. The goal is to improve care for patients with abdominal trauma or gut pathogens exposure. The project aims to elucidate potential methods for enhanced disease treatment and trauma care.
Researchers identify two distinct autophagy-regulated pathways downstream from the von Hippel-Lindau tumor suppressor gene in kidney cancer. This discovery could lead to more effective treatment approaches for metastatic disease by targeting specific pro-oncogenic pathways.
Researchers have found evidence of cereal-based agriculture and domesticated animals at Vashtëmi, a site in southeastern Albania that dates back to 6,500 BC. This discovery suggests that early farmers in the region preferred resource-rich settings, such as wetland edges, to establish pioneer farming villages.
Researchers found that older and male dogs are more successful hunters in small-scale societies, with higher success rates than younger females. The study also revealed that early European farmers cast a wide net for food resources, diversifying their diet beyond crops and domesticated animals.
The study explores the relationship between distress tolerance, excessive worry, and anxiety symptoms in college students. Researchers found that distress tolerance plays a unique role in excessive worry, suggesting it could be a useful intervention in therapy.
Researchers aim to create targeted compounds that selectively attack cancerous cells by zeroing-in on pollutants produced by tumors' characteristic metabolism. This approach seeks to minimize side effects associated with conventional chemotherapy.
University of Cincinnati researchers have developed predictive software to analyze two years' worth of operating data from a commercial wind turbine, identifying key components with high failure rates and average downtime. The study aims to establish real-world performance metrics for turbines, enabling optimal scheduling of maintenanc...
A new study from the University of Cincinnati found that children exposed to high levels of secondhand smoke who also had allergic sensitizations during early childhood are at greater risk for decreased lung function. Lung function among girls was six times worse than in boys who were exposed to similar levels of both secondhand smoke ...
Paramedics can reduce medical contact to balloon time by calling ahead to activate helicopter emergency medical services (HEMS), speeding up patient care. This study found that HEMS activation in the field or at a smaller hospital can save up to 48 minutes of treatment time
Researchers at the University of Cincinnati found evidence that BPA can alter the structure of the uterus, leading to increased susceptibility to pyometra, a potentially deadly infection. In animal models, exposure to BPA induced immune cell numbers in the uteri, which were five-fold higher than control animals.