Researchers have improved consistency assessment in meta-analysis by considering statistical power. This new measure can alter the interpretation of meta-analyses. Studies with high statistical power should have stronger effects on results.
A new study by researchers at the University of Eastern Finland provides novel insight into the previously unknown effects of factors regulating blood vessel formation. Bone morphogenetic factor 6, BMP6, is shown to regulate blood vessel formation via vascular endothelial growth factor receptor 2 (VEGFR2) and Hippo signalling pathway.
A study by the University of Eastern Finland found that online horse race bettors tend to stay away from betting for a longer time after a losing day. The study analyzed data from over 9,000 individuals in Finland and found no significant differences in behavior between men and women.
A new study from the University of Eastern Finland found that over 40% of women experience constipation during pregnancy and right after childbirth. Daily exercise, balanced diet, and hydration can help prevent constipation. Lifestyle changes may not be enough to alleviate symptoms, with laxatives needed in some cases.
A study found that tundra vegetation regenerated rapidly after a major landslide event, but took decades to recover. High-resolution satellite data revealed small changes in land cover and permafrost thawing.
A new study found that the PLCG2-P522R genetic variant protects against Alzheimer's disease by enhancing immune cell functions, including phagocytic activity and immune response. The results highlight the importance of targeting this pathway for future therapy development.
A new study from the University of Eastern Finland finds that sustainable nature tourism can effectively mediate conflicts between nature conservation and tourism. The approach was successfully implemented in Koli National Park, where it helped balance economic development with environmental protection.
Unverricht-Lundborg disease is more prevalent in Finland due to a genetic mutation that affects the Finnish population. Patients with EPM1 have a higher risk of premature death than the general population, but individual outcomes vary widely.
A study using iPSC technology reveals astrocytes' role in PD pathology, including altered alpha-synuclein production and disrupted calcium homeostasis. The findings suggest LRRK2 and GBA mutant astrocytes contribute to PD progression.
A study of 2,500 Finnish children aged 2-6 years found that negative experiences of early childhood education and care were mainly related to interaction with peers, play, rules, and restrictions. Children's positive experiences were associated with their own activities, such as play and excursions.
Researchers found that women's reproductive secretions have a stronger effect on sperm performance in HLA dissimilar male-female combinations, indicating post-mating sexual selection. The study suggests that fertilization capability is dependent on immunogenetic compatibility between partners.
A recent study found that social distancing measures significantly decreased paediatric emergency room visits and hospital referrals due to viral respiratory tract infections, including bronchitis and pneumonia. The incidence of lower respiratory tract infections decreased by around one-fifth.
The study found that oat and rye bran fibres support beneficial gut microbiota growth, improving cholesterol metabolism, gut barrier function, and reducing liver inflammation. Diets enriched with either bran type attenuated weight gain associated with a high-fat diet.
Researchers have developed a blood test that can accurately diagnose frontotemporal lobar degeneration (FTLD) and predict disease severity. The test measures neurofilament light chain levels in the blood, which are associated with FTLD progression, clinical phenotype, and prognosis.
Researchers found that beaver-induced floods create a network of interconnected habitats in southern Finland, increasing environmental heterogeneity. The study suggests beavers can help restore wetland ecosystems and conserve biodiversity.
A good vitamin D status is associated with a lower cancer risk, particularly in colon and blood cancers. Vitamin D responsiveness varies between individuals, affecting their need for supplementation.
A Finnish study used machine learning to analyze the economic burden of alcohol use disorders, finding that patients with multiple chronic conditions faced significantly higher care costs. The study highlights the importance of rehabilitation services and non-alcohol related treatment for individuals with alcohol use disorders.
New modern school spaces need active negotiations between all stakeholders, including teachers and students, to be transformed into learning environments. This process involves cyclic processes of interaction and meaning-making, which can lead to the development of authentic and functional learning environments.
A new study from the University of Eastern Finland found that antiepileptic drug use is associated with a significantly higher risk of death among people with Alzheimer's disease. The increased mortality risk was observed even after controlling for comorbidities and other factors.
A 2-year lifestyle intervention reduced LDL cholesterol levels in Finnish children, with high-fat vegetable oil-based spreads and decreased butter consumption having the greatest impact. The study suggests a family-based approach to prevent atherosclerosis in adulthood.
A new LAT1 inhibitor has been developed that can induce apoptosis in cancer cells without affecting brain amino acid homeostasis. The inhibitor was tested in vitro and found to be hemocompatible, making it a promising treatment option for various cancers.
Researchers found no clinically significant changes in metabolite levels after transcranial direct current stimulation (tDCS) treatment. The study's results support the understanding of tDCS as a safe treatment option, even when considering metabolic effects.
Researchers at the University of Eastern Finland developed a hybrid material combining mesoporous silicon microparticles and carbon nanotubes to improve silicon's performance in Li-ion batteries. The material was produced from barley husk ash, reducing its carbon footprint.
Researchers found that novel polysomnography parameters describing oxygen desaturation severity are significantly associated with impaired daytime alertness in people with sleep apnea. Conventional parameters do not show the same correlation.
New study reveals B2B customers' behavior varies by stage of customer relationship, with new customers seeking solutions and long-term customers maintaining relationships
Researchers predict that northern peatlands will remain carbon sinks until the end of this century, but their sink capacity will be substantially reduced after 2050. The modeling study aimed to address these concerns and highlighted the importance of peatlands in the global carbon cycle.
A new study found that coercive measures like seclusion and mechanical restraint are commonly used in Finnish psychiatric care, with an average duration of nearly three days for seclusion. The use of coercive measures is more common than previously thought, highlighting the need for accurate data collection.
A new study from the University of Eastern Finland reveals that cross-border regions often struggle to achieve concrete outcomes in cooperation. Despite local decision-makers' support for integration, innovation cooperation remains sparse in many regions, including Cascadia and European border areas.
A 10-year longitudinal study found that young people given a religious upbringing at home by both parents have the strongest faith in God. In contrast, those with only one parent or no parental influence experience wavering faith.
A new study reveals that warmer winters and shorter ice-free periods in northern lakes significantly increase methane emissions. In Finland, this could lead to a 26-59% increase in methane emissions by the end of the century.
A recent study from the University of Eastern Finland analyzed data from 1.4 million births and found that quitting smoking during the first trimester reduces low birth weight risk but doesn't fully prevent smaller brain size and body length issues. The study highlights the importance of quitting smoking before pregnancy to minimize lo...
A new study from the University of Eastern Finland found that reduced stress is associated with changes in the plasma lipid profile, including lower levels of certain lysophosphatidylcholines and higher levels of plasmalogens. This suggests a potential molecular mechanism linking psychological well-being to metabolic health.
A new study found that both parental examples and encouragement play a significant role in teaching children to eat vegetables. The researchers suggest serving cooked vegetables as a main course or side dish can promote healthy eating habits, while dinner is the most important meal for teaching kids to eat greens.
A new gene mutation, A143T variant of GLA gene, is associated with an increased risk of Fabry cardiomyopathy. Patients carrying the mutation should initiate treatment to prevent disease progression.
Researchers developed an algorithm using deep convolutional neural networks to analyze myoclonus severity from video footage. The method successfully quantified myoclonic jerks in EPM1 patients, correlating well with clinical evaluations and detecting small-amplitude and high-frequency jerks.
A new deep learning model can identify sleep stages with high accuracy, opening up new avenues for diagnostics and treatment of sleep disorders like obstructive sleep apnea. The model's accuracies are equivalent to those of experienced physicians, but it has the benefit of being systematic and faster.
A recent study published in Seizure found that over 40% of status epilepticus patients suffer from adverse outcomes, including a 9% risk of death. The researchers developed two prognostic scores, STESS and EMSE, which can accurately predict mortality risk in the emergency room.
A recent study found that community-dwellers with Alzheimer's disease who used antipsychotics had a 29% higher risk of head injuries and a 22% higher risk of traumatic brain injuries. The risk was highest when antipsychotics were first introduced.
Researchers found that melanoma cells secrete extracellular vesicles via the hedgehog signalling pathway, intensifying malignant properties in target cells. This discovery can help develop better treatment and diagnostics for melanoma.
A history of falls in postmenopausal women can predict a higher risk of subsequent fractures. Slip falls were associated with a greater risk of fracture than other types of falls.
Good aerobic fitness is not linked to lower risk of insulin resistance in obese children. Instead, more physical activity and less sedentary time were associated with reduced insulin resistance regardless of body fat percentage. The study suggests that more physical activity plays a key role in preventing type 2 diabetes in childhood.
Researchers at the University of Eastern Finland have developed two new cell models that can mimic the blood-retinal barrier, a key regulator of drug delivery to the eye. The models, continuously growing retinal pigment epithelial cells, can be re-pigmented with melanin and studied for drug accumulation in greater detail.
A Finnish study uses GIS data to compare the costs of warfarin and direct oral anticoagulant therapies, finding that DOACs are more cost-effective for patients living far from INR sample collection points or requiring frequent monitoring. The researchers developed a geospatial model to determine market areas and costs for each therapy.
The tourism industry is facing significant challenges due to food waste, with globally estimated 1.3 billion tons of food lost or wasted each year. Food waste in tourist households has been neglected despite growing numbers of tourists and diverse travel experiences.
A new electrode set enables easy at-home assessment of sleep bruxism, a condition affecting 8-15% of the population. The set's diagnostic accuracy is similar to conventional polysomnography, allowing for reliable and cost-effective management.
Increased inflammatory activity found in FTD patients, associated with parkinsonism symptoms and rapid disease progression. The study also revealed a low prevalence of cancer among FTD patients, suggesting an overactive immune system may contribute to the disease.
Researchers found that serum neurofilament levels are significantly higher in patients with frontotemporal dementia than those with psychiatric disorders. This biomarker shows promise for differential diagnosis and prognostication of the disease.
A new Finnish study published in Nature Metabolism challenges the long-held mitochondrial theory of aging by proposing that compromised nuclear DNA maintenance is responsible for accelerated aging. The study found that Mitutor mice, which harbor a defective polymerase-gamma enzyme, present with pronounced mtDNA mutagenesis and accelera...
A new study from the University of Eastern Finland found that people with Alzheimer's disease who used antipsychotic drugs accumulated more hospital days over a two-year period. The study, based on the MEDALZ cohort, found that antipsychotic initiators had approximately eleven more hospital days per person-year compared to non-initiators.
A recent Finnish study found that more active and fit children have better cardiac regulation than less active peers. Higher sedentary time and lower levels of aerobic fitness were associated with poorer heart function in both boys and girls.