Researchers at the University of Eastern Finland have developed two new cell models that can mimic the blood-retinal barrier, a key regulator of drug delivery to the eye. The models, continuously growing retinal pigment epithelial cells, can be re-pigmented with melanin and studied for drug accumulation in greater detail.
A Finnish study uses GIS data to compare the costs of warfarin and direct oral anticoagulant therapies, finding that DOACs are more cost-effective for patients living far from INR sample collection points or requiring frequent monitoring. The researchers developed a geospatial model to determine market areas and costs for each therapy.
The tourism industry is facing significant challenges due to food waste, with globally estimated 1.3 billion tons of food lost or wasted each year. Food waste in tourist households has been neglected despite growing numbers of tourists and diverse travel experiences.
A new electrode set enables easy at-home assessment of sleep bruxism, a condition affecting 8-15% of the population. The set's diagnostic accuracy is similar to conventional polysomnography, allowing for reliable and cost-effective management.
Increased inflammatory activity found in FTD patients, associated with parkinsonism symptoms and rapid disease progression. The study also revealed a low prevalence of cancer among FTD patients, suggesting an overactive immune system may contribute to the disease.
Researchers found that serum neurofilament levels are significantly higher in patients with frontotemporal dementia than those with psychiatric disorders. This biomarker shows promise for differential diagnosis and prognostication of the disease.
A new Finnish study published in Nature Metabolism challenges the long-held mitochondrial theory of aging by proposing that compromised nuclear DNA maintenance is responsible for accelerated aging. The study found that Mitutor mice, which harbor a defective polymerase-gamma enzyme, present with pronounced mtDNA mutagenesis and accelera...
A new study from the University of Eastern Finland found that people with Alzheimer's disease who used antipsychotic drugs accumulated more hospital days over a two-year period. The study, based on the MEDALZ cohort, found that antipsychotic initiators had approximately eleven more hospital days per person-year compared to non-initiators.
A recent Finnish study found that more active and fit children have better cardiac regulation than less active peers. Higher sedentary time and lower levels of aerobic fitness were associated with poorer heart function in both boys and girls.
Researchers at University of Eastern Finland developed a new approach to improve brain drug delivery by utilizing LAT1. The study showed that prodrugs can be converted into active drugs that utilize LAT1 for cell entry, achieving higher concentrations in target cells.
A new study reveals that APOE4, the strongest genetic risk factor for Alzheimer's disease, impairs the function of human brain immune cells, microglia. This impairment increases inflammation and reduces their ability to remove toxic amyloid from the brain.
A new study found that schizophrenia's neurobiological mechanisms vary between males and females, with many genes related to the illness expressed differently in each. This suggests that sex-specific treatments may be necessary to address the different underlying causes of schizophrenia in males and females.
A new study reveals that psychopathic violent offenders exhibit abnormal expression of genes and immune-response-related molecular pathways, which have also been linked to autism. The findings suggest that targeting the opioid system could be a feasible treatment approach for psychopathy.
Researchers developed a simplified computational model to predict locations susceptible to post-traumatic osteoarthritis in patients with ligament ruptures. The model identified areas prone to degeneration, suggesting potential pathways for patient-specific clinical evaluation and rehabilitation protocols.
A recent study at University of Eastern Finland discovered a novel T-cell subset, peripheral helper T cells, associated with the onset of type 1 diabetes. These cells were found to be more frequent in children who later developed the disease and those with autoantibodies indicating genetic risk.
A new study from the University of Eastern Finland found that gamification through online trivia quizzes enhances student motivation and collaboration in histology education. Students reported better understanding and performance when working in groups after participating in Kahoot-based quizzes.
A new study from the University of Eastern Finland shows that health-related quality of life in people with knee osteoarthritis varies significantly among different patient groups. The study found that females, those with higher body mass index, smokers, and lower-income individuals experience rapid worsening of their quality of life, ...
A new study found that dietary phosphatidylcholine intake was associated with a 28% lower risk of dementia in men. The study also showed enhanced cognitive performance in those with the highest intake of choline.
A new study from the University of Eastern Finland reveals that rye's bioactive compounds are processed by both gut microbiomes and lactic acid bacteria, leading to improved insulin metabolism and reduced cardiovascular disease risk. The study used metabolomics to analyze compounds found in rye and its effects on human health.
Scientists have discovered that microRNAs play a crucial role in regulating genes in cell nuclei, not just cytoplasm. MicroRNAs targeting the nucleus can increase gene expression, offering a novel approach to gene therapy.
Postural sway is a significant independent risk factor for bone fractures in postmenopausal women, doubling their fracture risk compared to those with the lowest postural sway. A combination of high postural sway and low bone mineral density increases overall and osteoporotic fracture risks five- and eleven-fold respectively.
A recent study found that adequate protein intake is associated with a reduced risk of frailty and prefrailty in older women. Protein sources such as animal-based foods may also play a role in preventing frailty. The recommended daily protein intake for older adults is around 77g, equivalent to about 1.1-1.3g per kg body weight.
Researchers at the University of Eastern Finland developed a machine learning-based application to detect Twitter bots across languages. The tool achieved high accuracy, classifying 15,000 tweets from Finnish, Swedish, and English, and can quickly process vast amounts of data.
A new Finnish study published in the American Journal of Clinical Nutrition found that dietary cholesterol and moderate egg consumption are not associated with an increased risk of stroke. The study, which followed 1,950 men for 21 years, also found no association between these factors and stroke risk in carriers of the APOE4 phenotype.
A recent study found that consuming whole grain rye led to lower plasma serotonin levels compared to low-fibre wheat bread, suggesting a link between whole grains and improved health. The study also identified changes in metabolite profiles and increased levels of certain phytochemicals in the bloodstream.
Researchers discovered a new gene mutation that reduces fear and anxiety and increases social interaction in mice, according to a study published in Neuropharmacology. The P4h-tm knockout mice showed striking courage and a lack of learned helplessness compared to control mice.
Long-term thiazide use significantly reduces the risk of low-energy fractures in people with Alzheimer's disease. The association was strongest for hip fractures, which saw a 30% decrease in risk.
A diet high in animal protein and meat is associated with a greater risk of death, according to a 20-year follow-up study. Men who primarily consumed animal-based proteins had a 23% higher risk of mortality compared to those with a balanced ratio of animal and plant-based proteins.
A recent study published in Global Change Biology reveals that climate change primarily affects peatland CO2 gas exchange through changes in moisture conditions, rather than temperature. The research found that drying conditions led to increased photosynthesis and respiration, while warming had a minimal impact on CO2 exchange.
A recent study from University of Eastern Finland reveals that persons with Alzheimer's disease have approximately 30% higher risk of head injuries. Falls are the most common cause of these injuries, which can lead to shortened life expectancy and loss of daily activities.
A new study found that Arctic permafrost peatlands can add to atmospheric CO2 burden post-thaw, strengthening the permafrost-carbon feedback. However, these ecosystems also have a strong methane sink capacity, potentially compensating for part of the permafrost CO2 losses over longer timescales.
Scientists discovered over 1,000 buried wetland sites worldwide, revealing a record of wetland presence and peat burial. These findings suggest that peat burial can slow down the transfer of carbon from the atmosphere to land, potentially offsetting climate warming.
A nationwide study published in ESC Heart Failure has identified four major mutations causing hypertrophic cardiomyopathy in Finland. The study found that 40% of patients carried a specific or likely mutation, while 20% were carriers of a rare gene mutation with unknown role.
A new study from the University of Eastern Finland explores the effects of ice cover on river channels and sediment transport. The research found that ice cover influences flow structures and increases sediment deposition in 'whirlpools' with low flow velocity. This discovery highlights the importance of considering seasonal changes in...
A new study from the University of Eastern Finland found that hotel loyalty programs cater to different traveler types, with frequent business travelers prioritizing convenience and good customer reviews over room level. Leisure travelers, on the other hand, seek instant rewards through these programs.
A new study from the University of Eastern Finland explores how norms related to touch are reproduced through embodied emotions, influenced by Finland's historical trauma and childcare ideals. The researchers analysed a unique set of data, namely touch biographies, which narrate individuals' lives through their touching experiences.
A new study from the University of Eastern Finland examines consumers' intentions to consume foods of insect origin among vegans, non-vegan vegetarians, and omnivores. Vegans held the most rigid negative attitude toward consuming foods of insect origin, while non-vegan vegetarians showed the most positive attitude towards eating insects.
A new study found that people with Alzheimer's disease who used antiepileptic drugs had more accumulated hospital days compared to those without. The study, published in the Journal of American Medical Directors Association, suggests a potential risk-benefit ratio for antiepileptic drug use in older adults with Alzheimer's disease.
A new study from the University of Eastern Finland reveals that linoleic acid's impact on human inflammatory response is influenced by genetic variations. The study, which analyzed over 1,300 middle-aged men, found that different FADS1 gene variants resulted in varying effects on fasting glucose levels and inflammation.
A new study found that eating one egg per day is associated with a blood metabolite profile linked to a lower risk of type 2 diabetes. Researchers identified several biochemical compounds in blood that predicted a higher risk of developing the disease, including tyrosine.
Researchers identified associations between functional changes in certain brain cell types with Alzheimer's-related accumulation of phosphorylated tau protein. The study also showed that machine learning can be used to classify patients into different stages of disease pathogenesis based on gene expression patterns.
A new study reveals major challenges in incorporating traditional knowledge into Atlantic salmon governance in Norway and Finland. The authors argue that unrealistic international expectations and local legitimacy issues hinder the successful integration of Sámi knowledge with science.
Maintaining high negative pressures (-10 Pa in hospital rooms, -5 Pa in renovation sites) effectively limits airborne contaminant dispersion. Local airflow patterns are more important than air change rates for efficient removal of infectious agents.
Researchers found that boys with better motor skills had higher cognitive scores over a two-year follow-up period. In contrast, aerobic fitness was not associated with cognitive function in either boys or girls.
A new study from Finland highlights the importance of post-mining land use planning to mitigate environmental impacts and retain local activities. The research shows that old mines can have far-reaching effects on landscape values, natural products, and community land use.
Medication administration errors are a significant concern, with omissions being the most common cause, particularly among elderly patients. The study highlights the need for vigilant attention to safe dosing practices, especially in older adults.
A Finnish-Chinese study found that global warming increases frost damage on trees in Central Europe, with some areas experiencing substantial increases in spring frosts. This is due to earlier flowering and leafing out of plants, which can lead to more frequent and severe frost events.
A Finnish study of 68,800 patients found that hip fracture surgery is associated with a significant risk of surgical complications. Patients with osteoarthritis, Parkinson's disease, and rheumatic diseases are particularly at risk, with 4.6% experiencing complications within three months of surgery.
A new study from the University of Eastern Finland highlights the need to revise fish stocking obligations in hydropower operations. The research emphasizes that compensating harm to fisheries with fish farming is unsustainable, and natural reproductive cycles must be prioritized.
A new study from the University of Eastern Finland found that strong opioids increase the risk of hip fractures in people with Alzheimer's disease. The risk was highest in the first two months of opioid use, and was significantly higher for moderate to strong opioids.