Researchers developed a CSIC vaccine that fully protects against SARS-CoV-2 infection in the brain and prevents associated brain damage. The MVA-CoV2-S vaccine candidate demonstrates sterilizing immunity and was effective even after reinfection with the virus.
The discovery pushes back the timeline of pre-Neanderthal hominins in Europe by 200,000 years, with the site yielding over 300 well-preserved footprints. The findings have significant implications for our understanding of human evolution and dispersal in the Middle Pleistocene.
Researchers describe how oxygen levels in the blood are detected using specialized mitochondria in glomus cells. A study on genetically modified mice reveals that a functional electron transport chain is crucial for this process, which has implications for respiratory depression and diseases.
Researchers at the University of Seville have discovered a method to attack cancer cells using an origin-of-life molecule. The study found that inhibiting RNA production boosts the utility of radiation therapy in cancer cells, offering a promising approach to treating various types of cancer.
Researchers have made a detailed study of the oldest map of the Coatzacoalcos river, showing its feasibility as a corridor between Atlantic and Pacific oceans. The Isthmus of Tehuantepec was used to shorten the journey by two-thirds along the river and one-third overland.
Developing a new technology for preventing catheter obstructions in patients with hydrocephaly has been successfully demonstrated in a European project. Concentrating ultrasound waves can detach materials from the inside of shunts implanted in the brains of patients, enabling preventive cleaning without affecting other areas.
A team from the Department of Energy Engineering at the University of Seville has developed a novel biomimetic design for PEM fuel cells, achieving up to 6.0% higher peak power compared to a reference design. The new design improves water management in high humidity conditions.
A team of scientists discovered a mathematical principle explaining how cells connect to form tissues and organs, shedding light on embryonic development and organ formation. The study found that epithelial cells can adopt complex three-dimensional shapes like scutoids, which determine cellular connectivity and tissue properties.
A recent study published in Molecular Therapy Nucleic Acids found that the molecule urocortin-2 may regulate recovery processes after a heart attack by modulating miR-29a. Treatment with urocortin-2 could favor patient recovery by regulating apoptosis and fibrosis.
Researchers found that urbanization increases hydrogen cyanide production in white clover as a defense mechanism against herbivores. The study, published in Science, reveals adaptive evolution due to urbanization is driving global-scale changes in plant species.
Researchers from the University of Seville have conducted a groundbreaking experiment demonstrating quantum contextuality without loopholes. The study uses atomic ions to show that certain probabilities have a limit, contradicting previous findings.
Fosfomycin, a long-dormant antibiotic, has been revived as a potential treatment for multidrug-resistant E. coli infections. The study involved 143 patients with invasive urinary tract infections and found effective results, offering an alternative to last-resort antibiotics.
Researchers at the University of Seville conducted a study on deficit irrigation for Sunchocola tomatoes, finding no significant changes in commercial quality but increased carotenoids and phenolic compounds. The results have significant nutritional importance and potential for global irrigation water savings.
Researchers at IBiS have developed a new treatment that completely eliminated glioblastoma tumors in animal models, offering a new therapeutic option against this aggressive disease. The therapy combines the use of ADI-PEG20 with focal brain radiotherapy and has shown promising results without side effects.
Developed by University of Seville researchers, the new methodology has a sensitivity of 100% and specificity of 87.5%. It can detect SARS-CoV-2 in saliva and synthetic viruses with minimal equipment and training.
A study of 1,000 patients found that some recoverees from hepatitis C still face liver cancer risks after treatment. Researchers propose a 2-step strategy combining FIB-4 and transient elastography/ultrasound to predict high-risk cases.
A recent study published in Experimental Neurology suggests that the accumulation of a fragment of the synaptic protein neurexin in the adult brain causes specific losses of memory. The researchers observed that this accumulation triggers defects in associative memory and presynaptic plasticity, particularly affecting the amygdala.
A study by University of Seville researchers reveals that messenger RNA modifying factors play a crucial role in the repair of DNA breaks. The discovery could lead to better understanding of rare diseases and cancer. Messenger RNA editing facilitates the removal of trapped RNA molecules, allowing for proper DNA repair.
Plants form cytoplasmic complexes called stress granules as a defense mechanism to promote cell survival. A recent study identified TSN protein as a crucial scaffolding protein that recruits plant-specific components, including SnRK1 kinase, to stress granules.
A recent study discovered high levels of mercury exposure in human bones from Copper Age Iberia, dating back 5000 years. Cinnabar powder used for pigments and rituals led to severe health effects, including intoxication.
Researchers have made significant breakthroughs in understanding Parkinson's disease, revealing that affected neurons don't die but lose properties. This knowledge opens the door to new therapeutic treatments targeting the cell body, rather than just axons.
Researchers used a yeast model to understand the dynamics of early-stage ribosomal subunit assembly, discovering snR190 functions as an RNA chaperone. The study also identified Dbp7 as the enzyme responsible for dissociating snR190 from ribosomal RNA precursors.
A study by José María Martín-Olalla suggests that cancelling daylight saving time could result in increased early morning activity in winter, negatively impacting human health. This is due to the UK's alignment with sunrise during winter mornings, which has helped regulate daily activity.
Researchers from the University of Seville discovered that a single amino acid mutation in Salmonella enzymes enables them to modify more proteins in infected cells, leading to increased virulence. This finding has significant implications for developing inhibitors as alternative antibacterial treatments.
Cancer cells exhibit increased genetic instability due to replication stress and DNA-RNA hybrids. Researchers have identified specific factors that prevent hybrid formation during different stages of the cell cycle.
A study by Elisa Cordero and colleagues identified key clinical indicators to detect COVID-19 in solid organ transplant recipients. These indicators enable personalized therapeutic measures to reduce mortality rates, particularly among older patients with respiratory failure or severe immunosuppression.
Extramitochondrial cytochrome C interacts with histone chaperone ANP32B to activate PP2A and facilitate DNA repair. In severe cases of DNA damage, cytochrome C triggers programmed cell death.
Alzheimer's disease disorganises blood vessels around amyloid plaques, causing loss of vessels and worsening pathology. This mechanism aggravates the disease by reducing the brain's ability to clean toxic substances, leading to increased strain on oxygen and nutrient supply.
A study published in Nature Aging suggests that low oxygen levels in senile plaques reduce immune system's defensive capacity against Alzheimer's disease. Reduced oxygen supply also compromises microglial activity, leading to increased pathology associated with the disease.
A University of Seville group discovered the mechanism by which BRG1 inactivation leads to genetic instability and tumour formation. The study reveals that the SWI/SNF complex plays a crucial role in resolving chromosomal conflicts, and its mutation can cause DNA replication defects and chromosomal breaks.
The study reveals that DNA's twisted structure actively regulates genes, particularly those responding to stress and stimuli. Topoisomerase TOP2A eliminates negative supercoiling at gene promoters, allowing for quick activation of these genes.
A new index, MEPI, quantifies environmental pollution in marinas by combining chemical and biological parameters. The study's innovative approach provides a simple and complete ecological analysis method to determine a port's quality, enabling authorities to establish minimum ecological quality levels.
The study reveals the involvement of SARAF and Orai1 proteins in VEGF-mediated activation of endothelial cells, affecting blood vessel development. This discovery could lead to therapeutic strategies controlling angiogenesis in pathological conditions.
Studies found that patients treated with antipsychotics had a lower risk of becoming infected or suffering a milder form of the disease. The protective effect was attributed to the reduction of inflammatory and immunological pathways associated with COVID-19 severity.
Researchers at the University of Seville are studying the Type VI Secretion System (T6SS) in bacteria like Pseudomonas putida to develop biocontrol agents for sustainable agriculture. The T6SS is a molecular weapon that allows bacteria to quickly eliminate competitors and protect plants from diseases.
A study on rehabilitating an old mine waste rock pile found that a new technique can successfully restore vegetation and reduce toxicity risks. The technique involves classifying and managing excavation waste based on its geochemical properties to prevent acid drainage and contamination.
A study analyzing over 7,000 tweets from four European public broadcasters found that sports information on social media is dominated by men's football, leaving out women's sports and minority disciplines. The study also highlights a lack of diversity in terms of gender and disability representation.
The study reveals opportunities for improved green space monitoring and increased access to nature for citizens. However, advances in robotics and automation could generate new sources of waste and pollution, threatening urban nature.
Researchers found that fear, isolation, and lack of training impacted nursing care during the first wave of COVID-19. The study revealed that these factors exacerbated negative emotions and reduced nurse well-being.
Researchers developed more sensitive and efficient biosensors to detect specific sequences corresponding to P. jirovecii using nanotechnology and capture probes. These sensors can detect the fungus in real time without prior amplification steps, enabling a reliable diagnosis of infectious diseases.
Researchers at the University of Seville have solved a long-standing enigma in basic biology by discovering how lipids distribute proteins within cells. Using a new microscopy technology, they found that membrane lipids select and direct specific proteins to correct exit doors.
The study found that having indoor plants had a positive influence on emotional well-being during the first COVID-19 lockdown, with 74% of respondents agreeing. The majority of participants reported spending more time on plant care at home and expressed desire to have more plants once normality was restored.
Researchers identify DNA-RNA hybrids as a key factor in ALS progression, leading to increased genomic damage and genetic instability. This breakthrough opens new avenues for understanding the disease's molecular basis and developing therapies to slow its evolution.
Patients with COVID-19 often suffer from severe pneumonia despite low arterial blood oxygen levels, contradicting typical symptoms of hypoxemia. Researchers suggest that SARS-CoV-2 infection in the carotid body may alter its ability to detect oxygen levels, leading to silent hypoxemia.
A preclinical study by researchers from the Institute of Biomedicine of Seville found that a combination of imipenem and meropenem may be effective in treating infections caused by carbapenemase-producing A. baumannii. The study showed promise for treating severe infections, including pneumonia and bacteremias.
Researchers identified VRK1 as a key player in tumour growth and proliferation. Inhibiting this protein may be a new strategy for treating aggressive neuroblastoma, a childhood cancer with poor survival rates.
Researchers have identified six biochemical biomarkers linked to COVID-19 infection using a blood test. The test can detect infected patients with high accuracy, allowing for rapid diagnosis and treatment prioritization.
An interdisciplinary team analyzed over 600 fossils from 82 archaeological sites in the Iberian Peninsula, revealing common presence at major sites and changes throughout prehistory. The study confirms the need for an interdisciplinary approach to analyze zooarchaeological records and sheds new light on fossil collection practices.
A study by the University of Seville found that an acebuchin oil-enriched diet significantly reduces blood pressure and ocular oxidative stress associated with hypertension. The diet also prevents changes in the retina's morphology, a common outcome of hypertension.
Brain metastases cause acute cerebrovascular dysfunction due to astrocyte activation, leading to decreased brain perfusion and irreversible damage. Treatment inhibition of this activation restores blood flow, limiting neurological deterioration and potentially improving patient outcomes.