The Barbara Ann Karmanos Cancer Institute, in partnership with Wayne State University School of Medicine, is one of the lead centers participating in the National Cancer Institute's MATCH Trial. The trial seeks to determine whether targeted therapies for people with tumors having specific gene mutations will be effective.
A $4.8 million NIH study will provide essential information to clinicians on the proper intravenous dosing of polymyxin B in critically ill patients. The study aims to minimize unnecessary toxic side effects and preserve the drug's efficacy against superbug-resistant Gram-negative bacteria.
Patrick Hines, a Wayne State University School of Medicine professor, was selected for the Aspen Institute's inaugural class of Health Innovators Fellows. He founded Functional Fluidics, which provides diagnostic platforms to predict bleeding and clotting disorders.
Peter Lichtenberg's Institute of Gerontology at Wayne State University has developed the Lichtenberg Financial Decision-Making Screening and Rating Scales, a tool to profile an older adult's vulnerability to exploitation. The scales have shown initial studies confirm their reliability in identifying those at risk of financial abuse.
Wayne State University has secured a $1.9 million NIH grant to study the role of chemokine receptor CXCR2 in regulating new blood vessel formation and enhancing endothelial progenitor cells (EPCs)-based cell therapy for vascular diseases.
Researchers at Wayne State University are conducting a three-year study to investigate the effects of tocotrienol supplements on end-stage renal disease patients. The study aims to improve dyslipidemia, inflammation, and oxidative stress markers in patients undergoing hemodialysis.
Researchers developed a diagnostic test for sperm RNA based on next-generation sequencing, which may help determine the best infertility treatment for couples having difficulty conceiving. The test can identify those who benefit from assisted reproductive technologies and those who may be successful with minimal intervention.
A $1.25 million NIH grant will fund research into the effectiveness of rosiglitazone, a diabetic medication, in stimulating placental function and halting severe preeclampsia. The condition is responsible for 76,000 maternal deaths and 500,000 infant deaths annually worldwide.
A new study aims to understand MS pathology by activating metabolic stress in oligodendrocytes, a type of cell that produces myelin. The research seeks to determine if this nonimmune-mediated animal model can recapitulate MS pathology and find evidence for behavioral changes and cognitive decline.
A new national study will develop guidelines for patients released from the emergency room after treatment for suspected acute heart failure symptoms. The Wayne State University School of Medicine and Detroit Receiving Hospital will serve as a site for the three-year project, funded by the Patient-Centered Outcomes Research Institute.
Researchers at Wayne State University aim to determine contaminant prevalence in urban agriculture soil, identify risk factors and develop guidance for safe and sustainable gardening. The project will provide urgently needed information on physical, chemical and biological contamination in urban agricultural environments.
A decade-long investigation by Wayne State University and Children's Hospital of Michigan researchers identified a key gene mutation that can trigger acute lymphoblastic leukemia. The mutation affects ETV6, a gene that regulates growth rates in bone marrow, leading to an increased risk of blood cancer.
A Wayne State research team has developed a new anesthesia monitoring technology that uses real-time data analysis to predict patient responses to anesthesia. This system provides individualized and dynamic prediction of anesthesia depth and vital signs, allowing anesthesiologists to make more accurate decisions during surgery.
Dr. Eranda Nikolla receives $750,000 grant to develop efficient catalysts for oxygen evolution in energy generation and storage
A randomized clinical trial found that cognitive-behavioral coping skills training had positive effects on pain and mood in rheumatoid arthritis patients for at least one year. Written emotional disclosure was less effective, with no long-term benefits on joint functioning or pain reduction.
A recent study published in the New England Journal of Medicine found that cooling children after cardiac arrest does not provide any significant survival-with-quality-of-life benefits. The study, which included nearly 300 participants, compared two groups: one cooled to a lower body temperature and the other maintained normal temperat...
Researchers at Wayne State University are seeking to understand the genomic information of herpes simplex virus 1 and its interactions with host cells to develop new anti-herpes treatments. The study aims to uncover the functions of infected cell protein 0, which plays a key role in disrupting host defenses.
Researchers at Wayne State University have developed a new nanoengineering method that uses essential oil nanoemulsions to reduce bacteria in fresh produce. The study found that oregano oil was effective against common foodborne bacteria such as E. coli, Salmonella, and Listeria.
A new grant-funded project aims to create effective exercise programs for people with dysferlinopathies, or dysferlin-linked muscular dystrophies. The researchers will investigate the impact of mechanical loading on muscle damage and inflammation in dysferlin-deficient mice.
RetroSense Therapeutics, a Wayne State University start-up, has received the prestigious Luis Villalobos Award for its innovative optogenetic gene therapy approach. The technology has the potential to treat all forms of blindness due to degenerated photoreceptors.
Researchers at Wayne State University are working on a new approach to diagnose Alzheimer's disease in its earliest stages. The goal is to develop affordable and portable tests that can be easily administered in senior centers or church basements, reducing barriers for African Americans who are disproportionately affected by the disease.
A new Wayne State University study demonstrates altered communication between brain centers in children with obsessive-compulsive disorder (OCD). The research found that the dorsal anterior cingulate cortex exerts exaggerated brain network effects in OCD, suggesting a putative scientific framework for understanding the disorder.
A higher intake of lycopene among postmenopausal women may lower the risk of renal cell carcinoma by 39%. The study analyzed data from 96,196 women and found a significant association between lycopene intake and reduced kidney cancer risk. Lycopene is a natural antioxidant found in foods like tomatoes and watermelon.
A Wayne State University assistant professor has received a $520,000 NSF CAREER Award to investigate the causes of seismic anisotropy. The research aims to improve our understanding of Earth materials and their impact on seismic waves.
Biophysicist Takeshi Sakamoto received a $692,000 NSF grant to investigate how molecular motors transport large vesicles in cells. He aims to understand the mechanisms of chemical energy conversion to mechanical force.
A new study of over 40,000 cases of brain trauma in children reveals that falling from bikes or scooters is the leading cause of injury in kids under 12. The findings emphasize the importance of safety helmets and seatbelts to reduce severity.
An interdisciplinary research team at Wayne State University found that older, more mature motorists are worse at texting and driving than their younger counterparts. The study suggests that age may be a factor in the negative impact of texting on driving performance.
A team of researchers, led by Wayne State University's Steven M. Firestine, has been awarded a $3.2 million NIH grant to assess the effectiveness of a new treatment for C. difficile infection. The study aims to prevent the spore germination of the bacterium, which is responsible for the majority of hospital-acquired cases.
A study published in AIDS reveals that anti-HIV medications may cause significant long-term heart problems in non-HIV-infected children. The research found persistently impaired heart muscle development and reduced heart performance in these children, highlighting the need for further investigation into the long-term impact of HIV medi...
The Kresge Foundation has awarded Wayne State University a $100,000 grant to support CitizenDetroit, a community outreach program that educates and mobilizes residents on political discourse. The program aims to create informed civic activists by challenging myths and educating voters about current issues.
Michigan AHEC will use the funds to develop its infrastructure, promote health career preparation initiatives, and provide clinical experiences for underrepresented minorities. The goal is to address primary care shortages in underserved communities across Michigan.
Researchers at Wayne State University are working on a grant-funded project to design molecular vaccines for Type 1 diabetes and other autoimmune diseases. They aim to use a novel approach called 'hitchhiking' to deliver therapeutics to specific sites in the lymph nodes.
A consortium of Detroit colleges aims to increase diversity in biomedical research by recruiting and mentoring underrepresented students. The REBUILD Detroit project will provide research opportunities, mentorship, and pipeline programs to support the goal of producing more undergraduate students with biomedical degrees.
Researchers have found that vascular endothelial growth factor (VEGF) can stimulate soluble sFlt1 production in the placenta, contributing to the development of preeclampsia. Elevated VEGF levels during early pregnancy can cause severe placental damage and embryonic lethality.
A Wayne State research team is developing new, more efficient catalytic materials to reduce energy consumption in chemical conversion systems. The project aims to create multicomponent catalysts that can improve reaction efficiency and reduce unwanted byproducts.
A study by Wayne State University researchers found that cognitive-behavioral coping skills training significantly improved RA patients' pain and mood for at least a year. In contrast, written emotional disclosure had only short-term benefits on joints and functioning. The combination of both therapies showed no unique benefits.
Researchers at PRB, WSU, and DMC identify preterm labor as a syndrome caused by multiple disease states, including silent infections and maternal anti-fetal rejection. Studies show that administering vaginal progesterone can reduce preterm birth rates by 45%, highlighting potential therapeutic interventions.
A Wayne State University professor has received a $330,000 NSF grant to explore a novel method for manufacturing nanoscale devices using solution-based processes and inexpensive raw materials. The research aims to overcome the current bottleneck in scaling up nanotechnology by connecting different functional materials into one device.
The research aims to improve the accuracy of failure and reliability prediction in ultra-high strength steel autobody manufacturing systems. By incorporating material microstructure and micro-damage information, the study may lead to solutions for manufacturers in reducing tool failures and improving product quality.
Eranda Nikolla's research aims to improve energy efficiency and lessen environmental pollutants by developing robust solid-state electrochemical systems. Her project will utilize a combination of experimental and theoretical techniques to design efficient electrocatalysts for CO2 conversion, producing syngas.
A recent study published in Annals of Internal Medicine found that current standard medical guidelines for childhood cancer survivors can be reduced, saving large cost-savings and little reduction in overall quality of patient care. The study suggests that screenings can be safely done cost-effectively and improve the quantity of patie...
Research participants showed greater positive attitudes toward answering questions when interacting with intergroup couples versus same-race couple interactions. Interacting in an intergroup context with a romantic partner can alleviate threats and improve conversations, leading to improved attitudes towards other groups.
Wayne State University has received a $2.4 million NIH grant to develop a cleaner, healthier environment in Detroit through its Center for Urban Responses to Environmental Stressors (CURES) program. The program will explore the impact of environmental exposures on human health, particularly in vulnerable populations such as children an...
A recent clinical trial published in the Journal of the American Medical Association found that lorazepam and diazepam are equally effective in treating seizures in children. The study, led by Dr. Prashant V. Mahajan, compared outcomes in 273 seizure patients and found no significant differences between the two medications.
A Wayne State University study reveals that children genetically at risk for schizophrenia and bipolar disorder experience communication breakdowns in brain networks supporting attention. This dysfunction may amplify risk for psychiatric illnesses, highlighting potential premeditative intervention strategies.
African Americans have higher preterm delivery rates than non-Hispanic whites, partly due to disparities in residential environments. Researchers are investigating the links between subjective and objective measures of neighborhood exposures and preterm delivery among African American women.
Researchers at Wayne State University have developed high-strength low-alloy steels and cast irons with improved energy efficiency, reduced emissions, and increased safety. The university has licensed its patented technology to Detroit Materials, Inc., a new start-up company focused on commercializing ultra-high performance materials.
A new study published in the Journal of the American College of Cardiology shows that nearly one-fourth of children diagnosed with idiopathic dilated cardiomyopathy (DCM) can recover normal size and function of their hearts within two years. Dr. Steven Lipshultz's team found that appropriate medical treatment and management can lead to...
Researchers at Wayne State University are investigating grape skin extract as a potential treatment for type 2 diabetes. The study aims to understand the novel inhibitory activity of GSE on postprandial hyperglycemia, with hopes of developing a safe and targeted nutritional intervention.
A new NIH-funded study provides evidence that treating children with vesicoureteral reflux (VUR) with long-term low-dose antibiotics reduces the risk of frequent urinary tract infections (UTIs). Children with VUR who received antibiotics were 50% less likely to develop recurrent UTIs.