Researchers at Wayne State University are investigating how genetic factors impact the benefits of exercise, using a fruit fly model to identify novel targets for therapeutic pharmaceuticals. The study aims to understand how exercise adaptations can be induced in patients who cannot perform regular physical activity.
The university is developing a technology-based parent-training program with a goal of addressing young children's challenging behaviors. The project aims to create a system that can be accessed in healthcare settings and online, facilitating the creation and evaluation of a wider-reaching training program.
Researchers at Wayne State University are working on a novel therapy for corneal bacterial infections, including those caused by antibiotic-resistant bacteria. The team is testing the role of microRNAs in regulating the innate immune response to Pseudomonas aeruginosa-induced keratitis.
Researchers at Wayne State University and Barbara Ann Karmanos Cancer Institute aim to improve cancer immunotherapy by using PET imaging to detect dendritic cells in tumors. This non-invasive method may help predict treatment outcome and guide patient care.
A Wayne State University research team will conduct a five-year trial to test an intervention on tablet computers that helps parents engage in effective parenting to assist their diabetic adolescents complete daily care. The study aims to improve health outcomes and metabolic control among African American youth with Type 1 diabetes.
The Michigan Health Endowment Fund awarded Wayne State University $460,305 for three research projects focused on reducing health disparities among children and seniors in Michigan. The projects aim to improve public transportation access, inspire future public health professionals, and support families at skilled nursing facilities.
A team of researchers at Wayne State University has received a $500,000 grant from the National Science Foundation to develop an open-source Monte Carlo simulation engine that can efficiently simulate complex systems. This project aims to improve computational efficiency and accelerate the development of new materials.
The Center for Urban Responses to Environmental Stressors (CURES) at Wayne State University has received a $7.5 million NIH renewal for five years. The center aims to understand the integrated health impacts of environmental exposures in Detroit's urban landscape and develop strategies to mitigate environmental health concerns.
A new study by Wayne State University researchers suggests that brain networks at rest are potentiated for action. Using fMRI data, the team found increased network interactions from the SMA to the dACC during rest periods.
Treatment with vaginal progesterone significantly reduced preterm birth, neonatal complications, and death in pregnant women with twins and a short cervix. The study, which included data from six studies involving 303 women, found that vaginal progesterone use was associated with a 31% lower risk of preterm delivery before 33 weeks.
The Detroit Research on Cancer Survivors (Detroit ROCS) study aims to better understand the major factors affecting cancer progression, recurrence, mortality and quality of life in African American cancer survivors. The five-year, $9 million study will include 5,560 cancer survivors to identify key risk factors and develop intervention...
Researchers at Wayne State University have developed a novel diagnostic tool to identify tinnitus in animals, providing a significant breakthrough in understanding the underlying mechanisms of this condition. The new method, which uses a conditioned licking suppression behavioral test, enables researchers to assess tinnitus onset, seve...
A team of researchers led by David Cinabro found that Type Ia Supernovas can be used to measure the pace at which the universe expands. The study challenges recent headlines suggesting these explosions cannot be relied upon for this purpose.
Researchers at Wayne State University have made a groundbreaking discovery about B lymphocytes and their role in preventing preterm birth. The study found that these cells produce molecules to suppress uterine inflammation and premature birth, potentially leading to new therapeutic approaches.
A clinical trial conducted by Wayne State University and Henry Ford Hospital found that a family psychoeducation consultation reduced 30-day all-cause hospital readmissions from 32% to 18%. The intervention improved patient health outcomes and reinforced the need for Integrative Behavioral Care.
The WSU study reveals a non-invasive testing method, Trophoblast Retrieval and Isolation from the Cervix (TRIC), that offers accuracy similar to invasive tests like amniocentesis. TRIC can be performed five to 10 weeks earlier than current testing modalities and has the potential to identify pregnancies at risk for complications.
Researchers at Wayne State University School of Medicine have shown that interactions between genetic variants and environmental exposures significantly impact human traits and diseases. The study highlights the importance of precision medicine initiatives for communities with different ancestries, including urban areas.
Researchers led by Mark Greenwald will explore whether buprenorphine can decrease stress responses in recovering addicts, potentially helping avoid relapse. The four-year study aims to identify new therapeutic features of the medication and its impact on stress reactivity.
Researchers at Wayne State University will use a new $3.2 million NIH grant to investigate impaired learning and memory in schizophrenia from the perspective of brain plasticity, function and network dynamics. The study aims to explore interventions that may normalize abnormal markers of the illness.
Researchers at Wayne State University are developing a new material formulation to resist foreign body reactions in implantable devices, such as insulin infusion pumps. This project aims to improve the long-term use of these devices by reducing the need for replacements.
A team of researchers led by Wayne State University will use naturalistic observations and next-generation genetic sequencing techniques to identify everyday family behaviors that impact youth asthma. The study aims to develop novel, developmentally sensitive interventions to reduce asthma morbidity and inform family-based interventions.
Five Wayne State University research teams received MTRAC funding for their biomedical innovations, accelerating commercialization of medical devices and materials. The program supports projects from $50,000 to $100,000, promoting entrepreneurship and economic growth.
A team of researchers from Wayne State University will test a technology-based intervention to improve medication adherence among African American emerging adults with moderate to severe persistent asthma. The goal is to enhance illness management and health outcomes at a low cost.
The project aims to develop a web-based Resistance Spot Welding (RSW) weldability prediction tool, which will improve design and engineering efficiency. The tool is expected to enhance product quality through the utilization of advanced materials and reduce physical testing required for new material candidates.
Researchers will investigate how memory systems develop in the human brain using unique neuroimaging methodologies. The project aims to identify spatial and temporal dynamics of memory networks in children with medically uncontrolled epilepsy, with potential clinical applications to improve their quality of life.
The MI-LEND program aims to improve the health of infants, children and adolescents with disabilities by training individuals from diverse disciplines. The program will address the complex needs of those with autism and other disabilities by increasing graduate students prepared to address their needs.
A Wayne State University researcher aims to improve upconversion nanocrystals' composition and atomic structure to expand the library of bright and multicolor emitters. The project is expected to lead to better diagnosing and treatment plans for numerous health issues by enhancing imaging and chemical sensing of disease biomarkers.
A Wayne State University Ph.D. student has been awarded a prestigious NIH fellowship to investigate the effects of stress on cigarette smokers. The research aims to understand how stress impairs brain function and increase the likelihood of relapse, with the goal of developing better treatments for patients.
Researchers at Wayne State University are developing novel aminoglycoside antibiotics with reduced toxicity and decreased resistance, aiming to combat multidrug-resistant diseases. The project, led by David Crich, will evaluate synthetic compounds in vitro and animal models for efficacy and antibacterial activity.
Gloria Heppner's 1984 article "Tumor Heterogeneity" has stood the test of time, cited more than any other article in Cancer Research history. The article's longevity is attributed to its clarity and interpretation of data, making it a landmark in cancer research.
Researchers at Wayne State University have discovered that dendritic cells play a crucial role in guiding sensory nerve regeneration after wounding, but their interactions are disrupted in diabetic corneas. The study found that applying exogenous CNTF and its soluble receptor CNTFR-alpha can partially reverse the adverse effects of dia...
A new national study by Children's Hospital of Michigan and Wayne State University School of Medicine researchers shows that chronic heart disease caused by cardiomyopathy is a family disease. The study suggests including the entire family in the treatment plan may be more effective for many pediatric heart disease survivors.
RetroSense Therapeutics has successfully completed the first dose of its lead compound RST-001 in a phase I/II clinical trial for patients with retinitis pigmentosa. The study aims to assess the safety and potential efficacy of optogenetics in restoring vision.
The WSU-IMSD program aims to facilitate the entry, persistence, and success of underrepresented minority students into science majors, guiding them to pursue careers in academics and scientific research. The program has shown significant impact, with IMSD student graduation rates at 87% and 64% pursuing further degrees.
Dr. Chung-Tse Michael Wu, an assistant professor of electrical and computer engineering at Wayne State University, has received a $500,000 NSF CAREER grant to develop antennas made of novel transmission-line-based metamaterials for a high-speed, microwave panoramic camera.
The university is leading an independent study on the association between changes in Flint's water system and public health issues, including a recent Legionnaires' disease outbreak. Researchers will conduct enhanced surveillance and engage with the community to investigate potential connections.
Researchers found that APOBEC3 enzymes target the lagging-strand template during DNA copying, causing C-to-T mutations. This discovery sheds light on a major source of mutations driving tumor growth and explains microbial evolution.
Jennifer Stockdill, a Wayne State University assistant professor of chemistry, has received a $650,000 NSF Faculty Early Career Development Award to investigate the reactivity of neutral aminyl radicals. The award also supports outreach programs aimed at promoting diversity in STEM fields among middle school girls and graduate students.
The grant will explore various dosing regimens of daptomycin, a lipopeptide antibiotic, to treat vancomycin-resistant Enterococcus faecium (VREfm) bacteria. The research aims to prevent resistance development and improve treatment outcomes for patients with life-threatening infections.
Researchers from Wayne State University and Michigan State University will receive funding to develop a mindfulness-based intervention for parents and teachers of toddlers. The project aims to strengthen skills in responding to children's cues, promoting social-emotional development and school readiness.
Researchers are studying how online dating technologies affect romantic connections, self-concepts, and decision-making processes. The project explores the social implications of updated online dating systems and their design features.
Wayne State University is preparing a new program to train elementary and middle school mathematics teachers in Detroit with a $1.4 million NSF grant. The project aims to improve student scores in mathematics by providing scholarships, stipends, and mentorship.
Wayne State University has received a $3 million NSF grant to transform its STEM teaching approaches, incorporating evidence-based instructional practices. The goal is to enhance student engagement, retention, and graduation rates, particularly for underrepresented minorities.
A Wayne State University research team, led by Zhengping Yi, aims to discover the abnormality in protein phosphatase 1 contributing to insulin resistance and type 2 diabetes. The $2.58 million NIH grant will support clinical studies, in vitro cell studies, and proteomics research.
Researchers led by Assia Shisheva found a novel interaction partner of the ArPIKfyve-Sac3 complex in the brain, which binds Synphilin-1 and prevents its aggregation. This discovery may lead to new therapeutic approaches for reducing cytoplasmic aggregates in Parkinson's disease.
The World Congress of the International Federation of Gynecology and Obstetrics has adopted recommendations from the Perinatology Research Branch at Wayne State University to prevent preterm birth. These guidelines include daily vaginal progesterone treatment for women with short cervices, which can reduce the risk by nearly half.
A recent study published in Scientific Reports found that maternal lead exposure during pregnancy can cause specific changes in DNA methylation, which can be detected in grandchildren's blood. The study suggests that this epigenetic effect can be transmitted to the next generation.
The university will train 100 students annually in Screening, Brief Intervention, and Referral to Treatment (SBIRT) for substance abuse behaviors. SBIRT is an integrated public health approach to delivering early intervention and treatment services.
A new, rapid testing method could help diagnose febrile infants with accuracy and speed. The innovative approach aims to reduce invasive procedures like lumbar punctures and antibiotic overuse, saving lives and improving treatment outcomes for thousands of young patients worldwide.
Exposure to high-concentration airborne particulate matter PM2.5 has been shown to directly affect the liver, triggering liver fibrosis in animal models. The study highlights air pollution as an independent risk factor for liver fibrosis, with implications for medical care and health policy-making.