The two-year program will help recruit, teach, and graduate the next generation of water pipeline managers. The GLWA faces significant employee recruitment, training, and retention challenges due to technological advances in the water sector.
A Wayne State University team, led by Dr. Arash Javanbakht, will study augmented reality-enhanced exposure therapy for post-traumatic stress disorder (PTSD). The technology aims to provide immersive real-life environments for patients to practice comfort and interaction with diverse characters.
A recent study by Wayne State University researchers has demonstrated a connection between exposure to per- and polyfluorinated alkyl substances (PFAS) in males and health problems in their offspring. The study found that PFAS mixtures can alter sperm methylation and affect the long-term reprogramming of offspring liver and fat tissues.
A new NIH grant will investigate biological processes that contribute to defects in immune response in the eyes of those with diabetes. Researchers aim to understand why diabetic patients are more susceptible to corneal infections and identify methods to reverse these effects.
Alexander Gow is studying the disease's effects on oligodendrocytes to provide new insight into the development and origins of MS. He aims to develop improved treatments by identifying a protein called Trb3 that may be a good drug target for the disease.
A Wayne State University researcher is working to transform code review tools and workflows to address participants' challenges in understanding and communicating code changes. The goal is to produce high-quality feedback using empirical methods, machine learning, and natural language techniques.
The project aims to overcome limitations of conventional semen analyses by examining mitochondrial DNA levels in sperm as a novel biomarker of sperm fitness. Researchers will evaluate relationships between mtDNA biomarkers and male reproductive health using large study samples.
A groundbreaking study reveals that targeting cholesterol metabolism can mitigate Zika virus-induced ocular pathology, offering promising therapeutic strategies. Researchers identified ABCG1 and SREBP-2 as key players in the pathway, and treatments with LXR agonists or SREBP-2 inhibitors showed promise in animal models.
A research project led by Lobelia Samavati has developed a tool to rapidly and inexpensively diagnose sarcoidosis using a simple blood test. The tool can accurately identify the disease in patients and may reduce the need for invasive diagnostic tests.
A team of researchers from Wayne State University and the Barbara Ann Karmanos Cancer Institute have received a five-year, $9.6 million grant to improve the identification and clinical management of hereditary and multiple primary cancers in African Americans. The study aims to overcome barriers to genetic testing in this population.
A team of researchers from Wayne State University received a $1.4 million grant to investigate the role of cytochrome c in prostate cancer aggressiveness and the Warburg effect. The study aims to establish novel therapeutic targets to overcome treatment resistance.
A Wayne State University study reports progress in a therapeutic approach that can restore immune surveillance and provide long-term protection against ovarian cancer tumors. The therapy, CARG-2020, has shown promise in animal models and may prove more effective than existing immunotherapies.
Researchers at Wayne State University aim to extend the lifespan of infusion pumps and injection ports to minimize tissue damage and maintain site integrity. The project seeks to reduce inflammation and fibrosis caused by insulin phenolic preservatives, leading to improved diabetes management practices.
A $2.9 million NIH award supports the study of sepiapterin reductase deficiency and cerebral palsy, with goals to develop new therapies for these disorders. Researchers will investigate changes in cellular pathways and explore potential treatments.
A review article confirms neurofilament light (NfL) blood levels can predict the severity and rate of neurodegeneration in Alzheimer's disease. High NfL levels are correlated with brain damage, cognitive decline, and increased risk of developing the disease.
A new study led by Wayne State University aims to discover gene-heavy metal interactions in human livers that contribute to nonalcoholic fatty liver disease (NAFLD). The research, funded by the National Institute of Environmental Health Sciences, will investigate how naturally accumulated metals interact with the liver genome.
A $3 million NIH award will support an intervention aimed at improving health outcomes in Black youth with type 1 diabetes. The project aims to optimize family interactions related to diabetes care through mobile health technology, potentially reducing disparities in health outcomes for this vulnerable population.
Rodlescia Sneed aims to scale up the Chronic Disease Self-Management Program for older adults in state prisons, analyzing factors that influence effectiveness. She seeks to maximize program use in prisons and determine maximum effectiveness through user manual creation and future R01 grant testing.
A Wayne State University researcher has received a $1.95 million grant to study the regulation of inositol synthesis and its effects on essential cellular functions in human cells. The study aims to identify mechanisms that regulate inositol synthesis and determine its impact on cell signaling and metabolism.
Researchers at Wayne State University have developed a novel non-sputum-based technology to differentiate between active TB and latent TB infection. The technology uses IgG antibodies against transketolase, an essential enzyme required for the intracellular growth of TB bacteria.
Researchers have improved Brillouin microscopy to acquire mechanical images of cells and tissues at speeds 50-100 times faster than existing methods. This innovation enables the investigation of cell behaviors in real-time, with potential applications in cancer diagnosis and embryonic tissue development.
A Wayne State University researcher has received a $1.7 million, five-year award from the National Institute on Deafness and Other Communication Disorders to understand cisplatin-induced ototoxicity. The goal is to identify novel therapeutic approaches to prevent this condition in cancer survivors.
Researchers will use household dust samples to develop a receptor bioactivity component model to predict adipogenic health outcomes. The goal is to improve chemical risk assessment models to account for everyday exposures to hundreds of different chemicals.
The Center for Leadership in Environmental Awareness and Research (CLEAR) will investigate toxic mechanisms, exposure pathways, biomarkers, and strategies to prevent exposures. It aims to reduce toxic exposures and improve health outcomes through innovative methods such as phytoscreening and Internet of Things technology.
A new framework developed by researchers at Wayne State University aims to help state and local water authorities prioritize funding for infrastructure improvements on drinking water lead service line replacement programs. The study incorporates drinking water quality characteristics with community and environmental quality attributes,...
A three-year project will focus on developing the Waterworks Park Pilot Plant facility for applied research, testing and evaluation of new technologies. The project aims to address critical shortages of technicians and engineers for water utilities nationwide.
A new study finds that progesterone does not prevent preterm birth in women who have had a previous preterm birth. The research calls for revised guidelines on the use of vaginal progesterone in these patients.
Researchers at Wayne State University developed a novel technique to measure the age of male sperm, finding a link between sperm epigenetic aging and pregnancy outcomes. The study suggests that older sperm can be associated with lower pregnancy success rates and shorter gestation periods.
A Wayne State study reveals that communication between two key brain regions determines how we remember experiences. As these regions mature, their precise interactions improve our ability to form lasting memories. The research also found that age-related differences in fast and slow theta oscillations impact memory development.
Researchers at Wayne State University have found that SARS-CoV-2 can induce fetal immune responses in pregnant women, even if they don't display symptoms. This increase in inflammatory markers poses a risk for preterm birth, stillbirth, and other complications.
A new mobile management intervention program aims to improve asthma control in young Black American adults. The project, led by Karen MacDonell, will assess the effectiveness of technological components in traditional asthma education among Black Americans aged 18-30.
A multidisciplinary team at Wayne State University has been awarded a grant to develop alternative sources of rare earth elements critical to advanced military and consumer technologies. The project aims to create a sustainable US rare earth element supply chain and mitigate potential supply disruptions.
A study by researchers at Wayne State University found a dose-response relationship between SARS-CoV-2 severity and the risk of preterm birth, with severely infected mothers more likely to experience early birth. The study also linked severe COVID-19 infection to an increased risk of preeclampsia.
The ACHIEVE GREATER Center aims to reduce cardiometabolic health disparities by implementing a proactive approach using community health workers and pharmacists. The center will use collaborative care, PAL2, to address multiple domains of influence contributing to disparate health outcomes in the Black population.
The project aims to enhance U.S. surveillance of laboratory-confirmed SARS-CoV-2, influenza, and other respiratory viruses through a network of emergency departments across 21 states and 100 hospitals. Data will be obtained from electronic medical records, providing insights into viral infection trends and patient outcomes.
A recent systematic review and meta-analysis found that COVID-19 infection during pregnancy significantly increases the risk of developing preeclampsia. Women with SARS-CoV-2 infection had a 62% higher odds of developing preeclampsia than those without the infection.
A new NIH-funded study aims to identify the psychosocial factors that contribute to high cardiovascular disease risk among urban African American adults. The research, led by Wayne State University, will explore how stressors like racial discrimination and social isolation impact health behaviors and disease progression.
Wayne State University researcher Yaoxian Huang received $332,689 for a three-year research study to improve understanding of reactive nitrogen from snowpack and transportation. The project aims to provide scientific support for air quality management and promote air quality education for future generations.
A Wayne State University researcher is applying topological data analysis to functional magnetic resonance imaging (fMRI) data to discover hidden brain structures. This collaboration aims to provide medical researchers with new tools for analyzing complex fMRI data.
A Wayne State University researcher has been awarded a $1.93 million NIH grant to investigate the impact of maternal immunoglobulin D on infant immune protection against food allergies. The study aims to elucidate the mechanisms of placental IgD transfer and its potential as a prophylactic fetal immune education cue.
The Wayne State LEAP-HTN project aims to improve access and delivery of care for Black adults with high blood pressure living in under-resourced neighborhoods in Detroit. The program deploys mobile health units and community health workers to provide personalized coaching and direct healthcare.
A Wayne State University School of Medicine researcher has been awarded a $2.3 million grant to explore the mechanism by which circadian stress regulates RNA modification associated with non-alcoholic fatty liver disease and hyperlipidemia. The study aims to shed light on developing therapeutics for lipid-associated metabolic disease.
Repela Tech LLC, a Detroit-based sustainability tech startup, is developing a novel non-toxic antifoulant coating to protect ships and boats from biofouling. The coating aims to reduce drag, fuel consumption, and CO2 emissions, benefiting the global shipping industry.
Researchers at Wayne State University are developing new strategies to assess appropriate treatments of peripheral nerve diseases using MRI biomarkers. The study focuses on nerve MRI methods that can directly image pathology within nerves, offering valuable information on disease progression and improving treatment evaluation.
Wayne State University has been awarded a $1.29 million NIH grant to purchase a new mass spectrometer for biomedical research, enhancing protein analysis and disease understanding. The instrument will also aid in training students and promoting local product development.
The research team will investigate how viruses interact with and transmit through the mucus layer, a crucial defense mechanism in the respiratory tract. The project aims to improve understanding of viral transmission and develop engineered nanoparticles for efficient drug or gene delivery.
A three-year study found significant changes in brain connectivity in older adults with subjective cognitive decline, which may predict dementia. The study suggests that brain alterations underlie the experience of decline and could emerge before cognitive assessments detect a deficit.
The university will support approximately 20 undergraduate students annually in a structured academic community with career development activities and individualized mentoring to prepare them for Ph.D. and M.D./Ph.D. programs in the biomedical sciences.
The university will provide 10 graduate students per year with structured academic support, career development activities, and individualized mentoring to cultivate highly sought-after skills in the biomedical sciences.
Chun Shen, a Wayne State University physics professor, has been awarded a $750,000 grant from the Department of Energy to study Quark-Gluon Plasma properties. His research aims to develop a new open-source framework to decode hot nuclear matter properties.