Articles tagged with Systems Biology
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers analyzed firearm-injured patients arriving at Philadelphia-area hospitals within 15 minutes of each other, revealing 54 cluster events over 11 years. These clusters were more likely to occur at night and be female, with lower mortality rates than traditional mass shootings.
Researchers developed a virtual reality training system to aid people with Parkinson's disease in improving their balance and avoiding obstacles. The six-week program showed significant improvements in obstacle negotiation, balance, and range of motion.
A team of scientists has identified the Epsom salt receptor TAS2R7, which plays a crucial role in detecting bitter salts and affecting physiological responses. The discovery may lead to the development of new therapeutics for heart disease and other conditions.
A Virginia Tech professor and his team have developed a method to integrate electronic sensors into personalized 3D-printed prosthetics, gathering information on pressure and comfort. This technology aims to improve the functionality of wearable systems and create more affordable electric-powered prosthetics.
Scientists have improved their understanding of a new form of cell-cell communication based on extracellular RNA. Researchers analyzed human exRNAs from 19 studies and developed computational tools to deconvolute complex data, revealing six major types of exRNA cargo and carriers that can be detected in bodily fluids.
Artificial intelligence can amplify human capabilities, reducing systemic glitches and errors in medical decision-making. Machine learning models can analyze vast amounts of data to identify patterns predictive of outcomes and help diagnose diseases.
A new study analyzed nearly 43,000 patients on a kidney transplant wait-list after implementation of the new system in 2014. The research found racial disparities in patient status on the list and sensitivity levels, which can affect transplantation likelihood.
A new study assesses how large-scale patterns of brain activity relate to different cognitive systems, revealing variations between individuals. The research uses computational modeling to simulate brain activity and identify repeatable patterns in some cognitive systems.
Using graphics processing chips and web browsers, researchers can now model complex electrical waves causing heart arrhythmias on less powerful computers. This technology has the potential to diagnose and treat abnormal heart rhythms and study new drugs.
A new automated drug delivery system can detect impending low blood sugar and deliver glucagon to prevent severe hypoglycemia in patients with post-bariatric hypoglycemia. The study found the system was effective in improving blood glucose levels after meals and reducing severe hypoglycemia.
A University of Warwick study reveals that patients use online consultations in the same way they would book a traditional appointment, with highest usage during busy weekdays and weekends. The study highlights opportunities to tailor platforms to patient needs, improving their experience.
A recent study found that nearly one-fifth of first-time users of a new hybrid closed loop insulin pump stopped using the device due to difficulties meeting technical demands. Patients required calibration between their continuous blood glucose monitor and fingerstick blood tests, leading to frustration.
The article highlights the importance of trusted relationships among physicians for patient care safety and quality. The authors propose three initial principles to bolster physician-to-physician relationships: recognizing consequential relationships, valuing differences in perspective, and noticing quality in each moment.
Researchers predict widespread adoption of magnetoresistive sensors in biomedicine for genetic disease detection and treatment, as well as in flexible electronics and human-computer interaction systems. By 2030, these sensors may enable wearable devices, smart homes, and autonomous vehicles with high accuracy and low power consumption.
An international research team has developed an open-source solution for multiparametric optical mapping of the heart's electrical activity. The technique tracks both electrical excitation and intracellular calcium dynamics, enabling a deeper understanding of cardiac arrhythmias.
A new ICU model, called LOTUS, has been developed by Rutgers and RWJBarnabas Health System to improve patient care. The model prioritizes patient-centered care, empowering social workers to address underlying issues that lead to health emergencies.
The study found that telehealth users saved several hours of time and preferred access over continuity with their primary care physician. However, researchers also noted a lack of coordination between telehealth platforms and traditional healthcare systems, which could lead to fragmented care.
A supplement to OTA International journal summarizes current status and future needs of national trauma systems in lower- and higher-income countries. The report highlights the importance of well-developed trauma systems in improving patient outcomes and reducing trauma-related mortality.
Complete surgical removal of the thyroid gland improved symptoms in patients with Hashimoto thyroiditis, including profound fatigue, poor sleep quality, and muscle tenderness. Thyroidectomy also normalized serum antithyroid peroxidase (anti-TPO) antibodies, providing a more effective treatment option for these patients.
A study from a Japanese university consortium shows that university programs to promote rural healthcare increase the number of physicians practicing in rural areas. The programs led to an average 24% increase in graduates working in non-metropolitan areas compared to those without these programs.
A study led by Mount Sinai researchers found that aspiration is equally effective as traditional stent retriever approach for clot removal, with significant cost savings. The study showed comparable clinical results between the two approaches, including similar functional outcomes and revascularization rates.
MIT researchers have developed a new optical imaging system called DOLPHIN that can detect tiny tumors deep within living tissue. The system uses near-infrared light and hyperspectral imaging to pinpoint fluorescent probes, allowing for earlier cancer diagnosis and potentially more effective treatment.
Researchers analyzed data from a statewide clinical registry to examine the association of race on weight-loss surgery outcomes. The study found significant racial disparities in results, highlighting the need for tailored approaches to address health inequities.
Researchers developed an AI platform to detect neurodegenerative diseases, including Alzheimer's and chronic traumatic encephalopathy. The Precise Informatics Platform uses deep learning to accurately identify neurofibrillary tangles in digitized images.
A study published in Science Advances found that deeper sleep is crucial for the brain's waste removal system, known as the glymphatic system. The researchers observed that mice administered a combination of anesthetics exhibited slow and steady brain activity similar to deep non-REM sleep, which is optimal for glymphatic function.
Researchers debunked a common misconception that millions of people have an antibiotic allergy. Studies show that only 10% of reported allergies are true, and many lose their allergy over time.
A team of researchers found that as the temperature increases, the ergodization time-scale becomes huge, but the time-scales necessary for chaoticity remain practically unchanged. This phenomenon is known as dynamical glass, which emerges from the fragmentation of frozen and seemingly inert regions.
The Mount Sinai Health System, in collaboration with UC San Diego Health, has released a national framework report that identifies regulatory, financial, and technological obstacles to improving local and state EMS systems. The report provides recommendations to create a more dynamic system responsive to society's needs.
A study published in the Proceedings of the National Academy of Sciences reveals that UCHL1, a brain protein, plays a critical role in nerve cell repair after stroke damage. The research found that preventing the inhibition of UCHL1 can decrease injury to axons and preserve neuron function.
Researchers have developed micromachines that can mechanically stimulate cells and microtissues, potentially preventing diseases. These gummy-like robots use cell-sized artificial muscles powered by laser beams to carry out complex tasks.
A study published in the American Journal of Public Health found that medical problems contributed to 66.5% of all bankruptcies, with 530,000 families affected annually. The study suggests that health insurance offers little protection to middle-class Americans and that private health insurance is a defective product.
The study found that using Research Resource Identifiers (RRIDs) in scientific papers can lower incidences of problematic cell-line use. This could lead to better reporting and future reproducibility efforts, ultimately aiding research data validity.
Scientists from JNCASR and inStem successfully created a synthetic mimic of cytoskeletal networks with structural and temporal programming. The system was developed through reaction-driven controlled growth, enabling precise control over one-dimensional growth and self-repairing features.
Researchers in Canada identified seven core principles to improve substance use treatment systems, emphasizing the need for collaboration between sectors and a population-level approach. These principles aim to identify strengths, gaps, and required enhancements in system design.
A new analysis found that a classification system for hip preservation surgery relies heavily on age and radiographic tests, raising concerns about its accuracy. The system's limitations may lead to incorrect clinical decisions for patients with complex hip conditions.
Engineering researchers at the University of Toronto have developed a new platform called Biowire II that uses a rigorous training regimen to grow small amounts of cardiac tissue. The device measures how strongly it beats, allowing for testing of potential drug molecules and advancing personalized medicine.
Racial disparities in breast cancer survival in the US Military Health System are linked to delayed surgeries, but these delays do not explain overall survival gaps between black and white women. Researchers found that black women had greater estimated times to surgery compared to their white counterparts.
Russian scientists developed advanced implants for the Ilizarov orthopedic system, which form part of the system's variation applied for lengthening and correcting deformities in children. The new implants reduced treatment terms by two times, accelerating bone regeneration and improving tissue density.
A study found that automated text messaging systems can improve clinical outcomes after total knee or hip replacement surgery, including faster recovery times and higher patient satisfaction. The system sent personalized messages to patients, increasing their adherence to home exercises and reducing opioid use.
Biomedical engineers at Duke University developed a framework to predict mutually beneficial biological systems using machine learning. They created a simplified metric to determine collective benefit using variables like temperature, pH, and genetics.
A single national electronic health record will simplify information exchange among primary care sites, improving patient care and hospital coordination. Canada Health Infoway should select and adapt the system with physician and patient input.
Researchers found that herpes viruses use human satellite II RNA (HSATII RNA) to manipulate their environment and grow, similar to cancer cells. This discovery could lead to new diagnostic tools and drug targets for diseases like colitis and neurodegenerative disorders.
The DNA10K initiative will engage over 10,000 patients with genomics testing, providing personalized risk factors for hereditary conditions. Patients will have access to genetic counselors and clinical pharmacists to interpret test results and develop individualized care plans.
Researchers at the University of Chicago Medicine designed a study to improve patients' sleep by using electronic health record nudges and educating nurses. The results showed significant reductions in nighttime disruptions, including fewer room entries and improved medication administration.
A study of 1,736 trauma patients found that female gender and low education levels were associated with worse long-term recovery. Patient sociodemographic factors outweighed injury severity in predicting long-term outcomes.
Researchers at UC San Francisco discovered a second visual system in the mouse cerebral cortex, challenging 75-year-old dogma of mammalian vision. The post-rhinal cortex (POR) obtains visual data directly from the superior colliculus, an evolutionarily ancient sensory processing center.
Researchers have developed a novel way to streamline genetic analysis by utilizing the blacklist computing concept. This method has shown promise as a key to faster therapeutic innovation, enabling clinicians and researchers to focus on true disease-causing mutations., By removing non-pathogenic genetic variants from consideration, thi...
A Massachusetts General Hospital team developed an AI system to diagnose and classify brain hemorrhages using CT scan images. The system can provide the basis for its decisions by highlighting key features of each subtype.
A large-scale study identified 14 gene variants associated with PCOS, including new variants linked to metabolic and reproductive features of the disorder. The findings also suggest links between PCOS and other conditions like obesity, depression, and male pattern baldness.
A new study published in BMJ found that primary care doctors need to work six more hours a day to provide recommended preventive care, including colonoscopy and lung cancer screening. The simulation model also reveals that this would lead to 17 out of every 100 doctors taking early retirement each year.
A survey of psychiatrists found that a substantial proportion believe their electronic prescribing systems provide incorrect warnings, potentially leading to inadequate treatment. The study highlights the need for more research on the accuracy and usefulness of automated alerts.
The UrFU-developed system utilizes neuro-electrostimulation and AI to treat various brain disorders, including strokes, Alzheimer's, Parkinson's, and more. It has shown remarkable results in clinical trials, bringing patients out of vegetative states and restoring mental and emotional activity.
Patients value routine symptom reporting and expect their doctor's review, but perceive barriers in the current healthcare system. The study emphasizes the need for efficient clinical strategies and reimbursement to address symptoms like pain, depression, and anxiety.
The website tracks flu cases in Houston's eight-hospital system, offering real-time data on influenza A, B, RSV, and other pathogens. This tool helps physicians make informed decisions by providing timely information, often just hours or days before CDC data becomes available.
A team at the University of Delaware has pioneered methods to grow a self-assembling, functional network of blood vessels. The system works across centimeter scales, necessary for functional tissue replacement, and could someday be utilized for tissue and organ transplantation into humans.
A new template for referral communication has been developed to improve communication among clinicians, increasing satisfaction, workload, and efficiency. The template addresses issues such as incomplete medical histories, delayed appointments, and phone tag between professionals.
A study found that just 45 minutes of patient education can significantly improve patients' attitudes and abilities in self-managing their chronic care. Patients reported increased confidence and reduced emotional distress after the brief instruction.
BioJupies accelerates RNA sequencing data analysis, enabling researchers to share results in minutes. The cloud-based platform provides interactive reports and reduces costs to under one cent per sample.
The new robotic system uses a thin probe inserted into the brain through a small hole drilled in the skull to deliver high-intensity ultrasound energy lethal to tumors while minimizing damage to surrounding brain tissue. Real-time MRI-based thermal imaging provides feedback on dose delivery, ensuring precise control and safety.
The SWOG Cancer Research Network and The Hope Foundation for Cancer Research provide grant support to U.S. Department of Veterans Affairs medical centers to enroll veterans in cancer clinical trials. This program aims to create a sustainable national network of sites offering new treatment options through clinical trials.