Articles tagged with Systems Biology
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A team of WVU chemists has created a new molecular research tool that simplifies experiments in mass spectrometry, enabling non-invasive analysis of biological systems. The instrument, developed by Assistant Professor Peng Li, uses a vibrating sharp-edge spray ionization device to collect and ionize samples on the spot.
The Harvard Pilgrim Health Care Institute will lead the FDA Sentinel System, a national program monitoring drug safety using electronic health data. The institute's 10-year experience in developing and operating the system will be expanded with the addition of a new Sentinel Innovation Center.
Patients who use online patient portals are 50 percent more likely to get a flu shot and twice as likely to have their blood pressure checked compared to those who do not interact with these portals.
MIT researchers are developing a multicellular integrated chip platform to model the complexity of Alzheimer's disease. They will integrate blood vessels and key cell types, including neurons, immune cells, and oligodendrocytes, to provide a powerful testbed for personalized research.
A new study from the University of Michigan suggests that an opt-out organ donation policy could alleviate some of the burden on US waiting lists, but its impact would be marginal. The researchers found that such a policy could potentially translate to large gains in life years for thousands of patients awaiting organ transplantation.
A new study by St. Michael's Hospital found female surgeons performed fewer high-paying procedures and earned 24% less per hour, challenging the notion that a fee-for-service system closes the earnings gap between men and women.
Researchers at NIH and Siemens developed a low-magnetic-field MRI system that improves image quality of lungs and other internal structures, making medical imaging more affordable and accessible. The new system also reduces the risk of heating and allows for safer procedures for patients with pacemakers or defibrillators.
A new AI system can accurately identify key findings in chest X-rays of pneumonia patients in just 10 seconds, significantly outperforming current clinical practice. This ultra-quick detection enables physicians to confirm a pneumonia diagnosis faster, allowing for timely treatment and reducing delays for severely ill patients.
Scientists at Cincinnati Children's developed the world's first three-organoid system, growing a connected set of mini human organs including liver, pancreas, and biliary ducts. The breakthrough allows for studying organ function in concert, reducing animal-based medication studies and accelerating precision medicine.
A study of nine emergency department residents found significant discrepancies between the electronic medical record and physicians' behaviors during patient encounters. The review of systems and physical examinations documented by physicians were often inaccurately recorded, with limitations including a small sample size and potential...
Research by Oregon State University found that stricter arsenic standards have led to a significant decrease in public water system violations, dropping from 1.3% in 2008 to 0.55% in 2017. This translates to nearly 1 million fewer people exposed to out-of-arsenic-compliance water.
Researchers at UW-Madison have developed tiny customizable nanocapsules to deliver gene-editing payloads, reducing the risk of unintended genetic edits. The nanocapsules are expected to improve the efficiency and safety of gene therapies, potentially treating inherited diseases and stubborn viral infections.
A sepsis care quality improvement program at Loyola Medicine has been shown to lower in-hospital death rates by 30% and reduce discharge time by 25%. The program also resulted in significant cost savings of $272,645 among patients with suspected infections.
A Regenstrief Institute researcher suggests redesigning EHR platforms to clearly access relevant data, reducing distractions and information overload. His 13 principles aim to combat inefficiencies and improve EHR functionality for better clinician-patient care.
A new study by MIT linguist Shigeru Miyagawa and Esther Clarke reveals that Old World monkeys can combine two items in language sequences, but this ability stops at two. Unlike humans, who can recombine terms to create an infinite variety of sequences, the monkeys' language lacks the capacity for greater complexity.
Researchers tested AuroLase Therapy, a treatment using gold-silica nanoshells, in 16 men with low- to intermediate-grade prostate cancer. The treatment was successful in 87.5 percent of lesions treated at one year of follow-up, preserving quality of life.
A new CRISPR gene editing system, encapsulated in a nanolipogel, effectively targets and knocks out the Lcn2 oncogene, curbing tumor growth in mice, providing a potential genetic treatment for triple-negative breast cancer.
Researchers created an all-aqueous, water-in-water construct that achieves compartmentalization in a synthetic biologic system. The system uses electrical charge to separate functions and materials, mimicking the behavior of living cells.
A study published in Cell found that intermittent fasting reduces the release of pro-inflammatory cells called monocytes, which can cause serious tissue damage. Fasting also leads to these cells going into a less inflammatory state.
Researchers used virtual patients and in silico clinical studies to evaluate the effectiveness of blue light therapy for psoriasis. They found that this approach can accurately capture patient variability and improve treatment response.
Researchers found that more than half of surgical errors were caused by human performance deficiencies, including cognitive biases and lack of attention. The study suggests that training medical staff to recognize cognitive pitfalls is crucial to preventing adverse outcomes.
A new AI-powered tool, scGen, accurately models cellular response to perturbations, enabling reliable predictions for different systems. This breakthrough has the potential to revolutionize the understanding and treatment of common human diseases.
Researchers at the University of Louisville have developed a new method to keep human heart slices alive for up to 6 days, enabling more extensive preclinical testing of heart drugs and therapies. This innovation will facilitate improved testing of efficacy and toxicity, saving time and costs in clinical trials.
Researchers have created a new concept for self-assembling micromachines using dielectrophoresis, which enables components to find each other in an electric field. This technique has the potential to construct medical microrobots and laboratory devices on microchips.
A study by Vanderbilt University Medical Center found that 49% of independent physicians reported using electronic health records, compared to 70% of those in group practices and hospitals. Independent physicians may face higher costs and less authority over technology adoption, contributing to the disparity.
The University of Maryland School of Medicine has been awarded a $750,000 grant to establish a rural residency program in Maryland's Eastern shore communities. The program aims to develop a sustainable pipeline for primary care physicians in rural areas, addressing the growing shortage of providers in the region.
The All of Us Research Program aims to advance individualized prevention, treatment and care by enrolling more than 1 million participants from diverse backgrounds. Participants will share health information, participate in clinical trials and contribute to the development of precision medicine.
A study published in BMJ found that reduced training hours for medical residents did not compromise the quality of care delivered by new physicians. The analysis of 485,685 hospitalizations showed no significant differences in patient outcomes, including mortality and readmissions.
A biomedical scientist is studying how the body's cannabis-like molecules affect feeding behavior and contribute to obesity. The research aims to identify novel therapeutic strategies for safely treating obesity and related metabolic disorders, which are currently lacking reliable options.
Researchers at Temple University Health System discovered that VPS35 clears the brain of a potentially harmful protein called tau, which accumulates in neurodegenerative disorders. The study found that altering VPS35 levels in individual neurons can directly control tau accumulation, implicating VPS35 in tauopathy.
A new nanotheranostic system uses silica-coated bismuth-ferrite harmonic nanoparticles to combine diagnostic imaging with targeted drug delivery, overcoming limitations of previous approaches. The system allows for medically safe release of therapeutics upon near-infrared light activation.
A biochemical oxygen sensor conserved across biological kingdoms allows both plant and animal cells to sense changes in oxygen levels. The newly identified enzymatic oxygen sensor is functionally identical in plants and animals, with potential implications for addressing cellular hypoxia in human diseases like cancer.
Physicists at Saarland University have developed a mathematical model that describes how biological systems can measure and regulate their length. The model explains how neurons can determine their own length and can be generalized to other biological systems, including trees, humans, and cells.
A comprehensive review by Mount Sinai experts aims to help clinicians understand medical issues relevant to transgender people, addressing the biggest barrier to care - lack of knowledgeable providers. Recommendations include determining transgender identity, prescribing hormone therapy, and updating electronic medical records.
Researchers have developed effective activators for the bitter taste receptor TAS2R14, which could have significant health effects. The receptors play a role in the human immune system and are found on lung and testicle cells.
A Penn Medicine pilot study finds that shorter intensive care unit rotations can significantly reduce burnout rates by as much as 41% while increasing job fulfillment. The study suggests that organizations can implement strategies like truncated staffing rotations to mitigate burnout and improve physician well-being.
A team of scientists is using single-cell sequencing to map the diversity of cells in the human heart, aiming to understand how different cell types contribute to its function. The research, part of the Human Cell Atlas initiative, aims to provide a reference for future studies on heart diseases.
A human-on-a-chip model developed by Hesperos, Inc. realistically replicates the responses of cancer treatments, enabling more accurate and efficient preclinical testing. The model demonstrated efficacy and toxicity of anticancer drugs on various cell lines, informing treatment decisions for individual patients.
The Finnish healthcare system has seen increased use of e-services, including electronic appointment bookings and data viewing, improving citizen experience. Healthcare professionals also benefit from enhanced clinical decision support systems, but face challenges with information management tools.
A VA study examined over 600,000 veterans with diabetes and found that health outcomes were similar regardless of whether primary providers were physicians, nurse practitioners, or physician assistants. The results suggest using these providers in primary care may improve healthcare efficiency.
A genome-wide association study found that individuals who attempt suicide carry an increased genetic liability for depression, regardless of their underlying psychiatric disorder. The study analyzed the genomes of over 6,500 suicide attempters and 17,000 non-attempters with major depressive disorder, bipolar disorder, or schizophrenia.
Researchers develop method to mimic human decision-making, enabling computers to render multiple acceptable decisions. This allows for variability in computer systems, similar to human experts, and can lead to better performance.
Researchers identified four simple rules to contain Candida auris infection: double personal protective equipment (PPE), work buddy system, disinfection, and biomonitoring. These procedures can effectively limit exposure in hospitals and nursing homes.
Researchers at Pitt and CMU aim to develop AI-powered robotic suits that can treat and stabilize soldiers in the field, extending the 'golden hour' for medical evacuations. The project uses real-world data and medical algorithms to guide critical care interventions.
Bats use echolocation by emitting ultrasonic signals and analyzing echoes to detect objects, but their navigational system relies on a surprisingly small amount of spatial information. This allows them to navigate effectively despite receiving an 'extremely fuzzy picture' of their environment.
The statement emphasizes that high-quality CCL care should not be limited by fiscal concerns, and provides recommendations for balancing revenue and expenses. It also highlights the importance of aligning leadership, strategy, organization, processes, personnel, and culture to optimize outcomes and efficiency.
A new smartphone-based platform can quickly detect possible ear infections in children by analyzing reflected acoustic signals. The system uses a commercial phone's speakers and microphones to send sound into the ear canal, detecting middle ear fluid with high accuracy.
The DGIST-ETH Micro Robot Research Center won 6 awards, including 3 golds and a special award from the Taiwan Invention Association, at The 47th International Exhibition of Inventions Geneva. The center's inventions featured innovative technologies such as magnetic control and video systems for surgical applications.
A large-scale assessment of over 20,000 patients found that reading office visit notes offers considerable benefits, particularly for those from underserved populations. Patients reported increased control and understanding of their care, as well as improved adherence to treatment plans and medications.
The upgraded picture archiving and communication system (PACS) significantly reduces the time radiologists spend searching for prior studies, with average search times decreasing from 6.1 to 4.6 seconds. The new system also reduces total study reading time, with a decrease of 137 to 113 seconds per study.
The Pennsylvania Pediatric Medical Device Consortium has awarded four companies with $50,000 each to develop innovative medical devices for children. Devices include a rapid platelet monitoring system and tracheostomy tube dislodgement alarm, which aim to improve care for newborns and pediatric patients.
A study using family-based genetic analysis has identified the DENND1A gene as playing a major role in PCOS, enabling personalized medicine approaches and better disease prediction. The findings suggest that rare genetic variants in this gene contribute to the disorder's distinctive hormonal profile.
The Hospital Readmissions Reduction Program saw a 4 percentage point reduction in penalties across all hospitals and a 14 percentage point reduction in penalties for safety net hospitals. Researchers found the greatest impact on nonteaching, physician-owned hospitals in rural regions.
Researchers at UBC Okanagan have created an automated encapsulation device that encases cells in microgels, protecting them from physical damage and the immune system. The device enables over 85% of cells to survive and can be scaled up for rapid production of cell-encapsulated microgels.
A team of UC students used a novel approach called Network Assisted Genomic Association (NAGA) to identify schizophrenia genes from terabytes of data. The technique outperformed previously published methods and ran the analysis in under five minutes.
A SHEA white paper outlines how IT can improve antimicrobial use, track outcomes, and reduce provider burden. The role of EHR and 'add-on' clinical decision support systems is explored to enhance stewardship programs.
A Mount Sinai study shows that preschool intervention can improve healthy lifestyle habits in young children, with 12% increase in knowledge and attitudes towards a healthy lifestyle. The intervention group also showed improved behaviors in physical activity, diet, and emotional management.
Researchers at Florida Atlantic University developed an algorithm and sensor-based system to detect Parkinson's medication ON and OFF states with high accuracy. The system uses wearable motion sensors and can continuously monitor patients' responses during daily activities, providing objective measures for clinicians.
The University of Texas at San Antonio (UTSA) researchers have each been awarded a National Science Foundation (NSF) Faculty Early Career Development (CAREER) Award, totaling $2 million. The awards will support various projects, including energy planning and management for smart cities and biomedical engineering research.
A new RAND Corporation study finds that primary care services account for only 2.12% to 4.88% of total medical and prescription spending among Medicare beneficiaries. This estimate is lower than previous studies, and highlights the importance of investing in primary care for better outcomes and lower costs.