Articles tagged with Systems Biology
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A new computer modelling study suggests that simple interactions between nerve cells contribute to the development of complex brain circuits, making a precise genetic blueprint unnecessary. The findings help answer how the brain wires itself during development and may inform new ways to treat conditions that disrupt brain circuits.
Historical racial & ethnic health inequities significantly contribute to the disproportionate COVID-19 impact, particularly among African American, Latinx, and Navajo Nation communities. Baseline inequalities in healthcare are exacerbated by the pandemic.
Researchers at Henry Ford Health System used UV-C light to effectively kill COVID-19 on N95 respirators, with two models showing optimal results. The process worked best when paired with fit testing, but may require additional steps like ethanol wipes for maximum safety.
A new study provides a framework for guideline developers to offer specific guidance on right-sizing care, including when to start and stop treatments or screening. The recommendations are tailored for adult primary care and aim to reduce unnecessary testing and treatment, improving patient outcomes and quality of life.
Researchers isolated molecules from a blue light-emitting fungus gnat found in the Appalachians, which could lead to novel biotech applications and elucidate human diseases. The study revealed an almost unknown bioluminescent system composed of luciferin and luciferase.
Researchers found higher TMPRSS2 expression in Blacks compared to Asians, Latinos, and Whites, which may contribute to COVID-19 risk disparities. The study emphasizes the importance of diverse participants in clinical trials and addressing social determinants of health.
The new study found that both Ellipsys and WavelinQ systems enabled patients to start dialysis sooner compared to surgery, offering significant quality-of-life benefits. The Ellipsys System demonstrated higher technical success rate and more durable access, with 82% of Ellipsys fistulas still functional at 12 months.
Biological condensates, previously known as membrane-less organelles, have been found to play a crucial role in DNA repair and aging. Researchers used the Frontera supercomputer to study their behavior and recruitment of molecules.
Researchers discovered a new link between arginine metabolism and plant shape formation, using the moss Physcomitrium patens as a model organism. The study identified a core pathway involving transcriptional co-activators ANGUSTIFOLIA3/GRF-INTERACTING FACTOR1 (AN3/GIF1) family signaling.
A study found that clinicians affiliated with health systems achieved mean performance scores of 79 versus 60 for unaffiliated clinicians, receiving fewer payment penalties and more exceptional performance bonus payments. The study suggests that system-affiliation is associated with better performance under value-based payment programs.
Researchers developed a new class of medical instruments equipped with advanced soft electronics, enabling simultaneous in vivo measurements and real-time feedback control. The new system conforms better to the body's soft tissue, reducing the length of invasive ablation procedures and exposure to X-ray radiation.
A large-scale study on frogs and their tadpoles found that larval and adult body sizes are significantly and positively related. The association is not completely random, with some families exhibiting strong constraints.
A recent study published in JAMA Network Open found that only 54% of Medicare patients referred to home health care services following a hospitalization received home health care visits. Disparities were observed in Black and Hispanic beneficiaries, as well as those living in disadvantaged neighborhoods.
Research reveals that circadian rhythms play a crucial role in guiding waste removal from the brain through the glymphatic system. The study found that individuals who rely on daytime sleep are at higher risk for developing neurological disorders, including Alzheimer's and dementia.
A new study published in the Aesthetic Surgery Journal found that UT Southwestern's expanded telehealth services increased patient care in specialties like plastic surgery. The study reported significant benefits for patients, including reduced stress, missed work, and hospital visits, as well as improved access to care.
The UC Davis-led AI Institute for Next Generation Food Systems aims to optimize crop yields, minimize resource consumption, and improve food safety through AI technologies. The institute will foster collaborations across academia, industry, and government to develop open-source solutions and promote education, outreach, and diversity.
Researchers have developed a synthetic gut lining that can target the small intestine, delivering drugs and influencing nutrient absorption. The system has shown potential in treating lactose intolerance, diabetes, obesity, and tropical diseases like schistosomiasis.
Researchers at IKBFU have discovered that heather is a rich source of biologically active compounds with various medicinal properties. The study found that the budding stage of heather plants contains the highest amount of flavonoids, which are of great medicinal value.
The U.S. Department of Energy has awarded Berkeley Lab $1.6 million over three years to develop a superconducting magnet system for cancer treatment, while another project aims to advance rapid-fire laser technology for particle colliders and tabletop accelerators.
A Mount Sinai study found that COVID patients were most commonly readmitted to the hospital for respiratory distress, with chronic obstructive pulmonary disease and hypertension being key comorbidities. The study also showed that these patients had shorter hospital stays and lower rates of anticoagulation treatment.
A recent study published in JAMA Network Open found that trauma-exposed adolescents with moderately elevated acyl-ghrelin hormone levels are almost eight times more likely to develop post-traumatic stress disorder (PTSD). The study also suggests that lower acyl-ghrelin levels may reduce the risk and severity of subsequent PTSD.
Researchers have identified master regulator genes that causally regulate key biological processes underlying asthma. These genes provide a novel path forward for uncovering mechanisms and developing novel therapies for asthma. The study also identified nasal gene signatures for mild, moderate, and severe persistent asthma.
Researchers have designed a new X-ray classification system for adult idiopathic scoliosis, providing a more universal and standard assessment of the condition. The three-component method maintains existing curve types while introducing assessments of global alignment and lumbosacral curve, improving treatment options for older patients.
Houston Methodist reports a significant increase in Hispanic COVID-19 patients from 26% to 43%, with a demographic shift toward a younger patient population, according to a peer-reviewed study published in JAMA.
A team of scientists has developed a novel 2D MFOR-PAM system utilizing a 2D microlens array and an acoustic ergodic relay to detect PA signals in parallel. This system can shorten scanning time by at least 400 times compared to conventional OR-PAM systems, while maintaining a simple and economic setup.
A study by the Leibniz-Institute for Food Systems Biology found that modern wheat varieties contain slightly less protein than older varieties, while maintaining a consistent gluten content. The researchers also discovered that environmental conditions, such as precipitation, played a significant role in shaping protein composition.
The NIH has funded a project to develop an AI-based system, PHK, that analyzes patients' clinical and genomic data to find new connections between biochemical pathways. This system could help doctors treat cancer and complex diseases more effectively by providing personalized treatment recommendations.
The University of California, Riverside is part of a new NSF Engineering Research Center aimed at preserving biological systems through breakthrough bioengineering technology. The center, ATP-Bio, will develop and deploy technologies to preserve cells, tissues, organs, and whole organisms.
A recent study found that larger, more integrated health systems do not generally deliver better quality of care. The research highlights the importance of enforcing antitrust guidelines and providing financial support for smaller healthcare organizations threatened by consolidation.
Countries in US, Europe struggle with funding, workforce shortages, and technology limitations to address growing demand for Alzheimer's disease treatment. Despite these challenges, initiatives like telehealth models and memory clinics are being implemented to improve access to care.
Scientists are developing a model to track mRNA movement through plant systems, aiming to predict and deliver targeted information. The goal is to engineer a method for using mRNA to alter plant responses to environmental stresses.
The Einstein-Mount Sinai Diabetes Research Center has received a $9.5 million grant from the NIH to support research in type 1 and type 2 diabetes, obesity, and metabolic disorders. The center will utilize a new shared Immuno-Technology Core (ITC) to pursue innovative projects, including immunotherapeutics and intermittent fasting diets.
Researchers found that roflumilast cream significantly improved psoriasis signs and symptoms in as early as two weeks, with clear skin, itch reduction, and burden of disease improvement. The treatment showed promise for patients with plaque psoriasis lacking suitable options.
The new micro-CT imaging technology has the potential to transform the landscape of imaging by lowering radiation doses and improving image resolution. The system detects how X-rays bend and measure absorption and phase changes for high contrast visibility.
A new study by Yale University researchers found that a nurse-delivered strategy to prevent falls among older adults reduced the rate of first adjudicated serious fall injury by nearly 10%. The approach also produced significant reductions in self-reported injuries, highlighting its potential in reducing fall-related harm.
A new study highlights the importance of access to nature in addressing community health needs, citing benefits to physical, mental, and social health. Researchers recommend incorporating assessments of nature access into patient encounters and refer patients to community groups increasing green areas.
A bioartificial system can act as 'dialysis' for the liver in pigs with acute liver failure. The system, developed by Wei-Jian Li and colleagues, effectively detoxifies blood and prevents further liver damage.
Researchers found a new formula that better matches canine-human life stages, with an 8-week-old dog equivalent to a 9-month-old baby. The study also identified developmental genes that drive aging and created an age-measuring clock for different species.
A new study has dissected the unique phenomenon of fertility-sterility transition at molecular level using systems biology approach in a single environment-sensitive genic male sterile (EGMS) line of pigeonpea. The research identified key transcription factor REVEILLE1 regulating auxin levels to explain fertility transition.
Researchers found that only 65% of excess deaths were attributed to COVID-19, with over a third linked to other causes. Deaths from heart disease, diabetes, and stroke spiked in states hardest hit by the virus.
A Johns Hopkins Medicine team recommends equitable care during pandemic resource allocation by requiring bias training and assessing system inequalities. Hospitals should prioritize resource distribution based on individual patient needs rather than solely on health factors like heart failure or diabetes.
Researchers discovered a new mechanism linking osmotic stress to the activation of autophagosomes and lysosomes, which play central roles in cellular recycling and degradation. The study provides insights into how environmental influences impact cellular processes and offers potential therapeutic avenues for neurodegenerative diseases.
A recent expert review published in the Health Physics journal concludes that exposure to 5G wireless networks within current limits poses little or no risk of adverse health effects. The Committee on Man and Radiation (COMAR) estimates the likelihood of unknown health hazards at these levels to be very low, if they exist at all.
Researchers identified reproductive and metabolic subtypes of PCOS associated with novel gene regions, promising to transform understanding of the disorder. The study used clustering of clinical, metabolic, and hormonal data from women with PCOS, revealing two distinct subtypes with different genetic architectures.
A study published in Cell reveals that viruses can produce previously undetected proteins by stitching together host and viral sequences, altering the course of viral infection. These new proteins could be exploited for vaccine purposes and may hold key to understanding viral virulence.
Researchers at Massachusetts General Hospital developed an algorithm to track patients' medical records over time in EHRs to predict disease likelihood. The strategy connects information on medications and diagnoses, revealing accurate disease markers that can be interpreted by clinicians.
The region's successful response was attributed to six key factors: early communication and coordination, regional coordination and situational awareness, rapid testing development, proactive management of long-term care facilities, effective physical distancing in the community, and partnership with local organizations. This coordinat...
Scientists have identified the ancient origin of key hormones essential for human reproduction, metabolism, and immune function in simple creatures like sea cucumbers. This breakthrough study suggests that these hormone systems predates the evolution of the spinal cord in animals.
Scientists at CNIC discover a system providing cells with positional information about their location in developing organs. The study shows that malfunctioning of this system causes congenital malformations and may explain the effects of thalidomide, a drug inducing limb defects.
A group of American College of Physicians (ACP) leaders suggest using the organization's 'New Vision' policy paper to guide U.S. health care reform during and after the COVID-19 pandemic. The paper aims to improve access to care, reduce per capita health care costs, and simplify the healthcare system.
A SISSA study shows that passive visual experience plays a key role in maturing the brain's 'complex' neurons involved in vision. This discovery has important implications for understanding cerebral development and could lead to new clinical and technological applications.
A Mount Sinai research team has identified the scaffolding protein histone deacetylase 3 (HDAC3) as essential for proper skin development and barrier formation. Mice lacking HDAC3 in the epidermis fail to develop a functional skin barrier, leading to dehydration and death shortly after birth.
A new pediatric-specific scoring system, pMeNTS, is presented to help surgeons prioritize non-emergency operations during the pandemic. The tool evaluates medical necessity, time-sensitivity, and COVID-19 factors to determine a higher priority for procedures.
Researchers developed a novel clinical decision support system to predict individual trauma patient outcome based on historical data and real-world evidence. The system uses an evidential reasoning rule to process clinical signs and symptoms, identifying patients at risk of adverse events such as ICU admission or in-hospital death.
Scientists discovered biological markers in teeth of children who later developed ALS, shedding light on the disease's early stages and potential preventive strategies. The study found abnormal metal uptake patterns, suggesting a link between environmental factors and disease onset.
The HEROS study will examine the rate of SARS-CoV-2 infection and COVID-19 symptom development among children with allergic conditions versus those without. The study aims to fill knowledge gaps on how the novel coronavirus affects young populations.
Researchers developed an AI model using CT scans and clinical data to diagnose COVID-19, achieving higher sensitivity than radiologists. The algorithm can rapidly detect the virus, isolate patients, and prevent its spread during pandemics.
Researchers used chest X-rays to identify patients at higher risk of severe illness from COVID-19. A unique scoring system evaluated lung patterns, predicting outcomes and guiding treatment for high-risk patients.
A compact sensor system using modified carbon nanotubes detects high concentrations of nitrogen dioxide in exhaled air, indicating chronic obstructive pulmonary disease (COPD) or other respiratory issues. The device's sensitivity is shown to detect biomarkers for specific diseases, including lung cancer and asthma.
Researchers at Texas A&M University developed a minimally invasive biosensor system to monitor urate levels, which can help patients with gout manage their symptoms better. The technology uses benzoporphyrins and is designed for personal management of gout, potentially reducing healthcare costs and improving patient outcomes.