Articles tagged with Systems Biology
A novel therapeutic agent, MS21, has been developed to disrupt a biological pathway that helps cancer survive. The therapy shows high effectiveness in vitro by causing the degradation of AKT, an enzyme overly active in many cancers.
A study published in Frontiers in Human Neuroscience found that brain activity associated with aesthetically appealing natural landscapes is not limited to the reward system, but also involves early visual areas. This suggests an early form of beauty perception that can be triggered by surprise and unexpected stimuli
A team of researchers from HKU has developed a transferrable and integrative type I CRISPR-based platform that can efficiently edit Pseudomonas aeruginosa, a superbug capable of infecting various tissues and organs. The technique enables rapid identification of resistance determinants and development of novel anti-resistance strategies.
Researchers at USC have developed a new simulator that accurately predicts the forces acting on a knife as it cuts through soft materials, enabling applications in safer food processing and surgical robotics. The system uses 'differentiable' simulation to automatically tune parameters from real-world measurements.
Researchers have developed a new scoring system to evaluate wound healing in mice, using parameters such as re-epithelization and granulation tissue thickness. The system was validated in four different skin wound models, providing a more accurate and reproducible assessment of wound dynamics.
A new Dartmouth-led study found that white patients receive higher annual doses of prescription pain medicine than Black patients, even when treated by the same health system and team of clinicians. The researchers suggest that systematic racial bias is a major contributor to these disparities.
Elite runners exhibit 'stiffer' spring-mass systems with steeper impact angles, spending more time in the air and less on the ground. This may allow for better energy recycling and improved performance.
A new machine learning algorithm, BITFAM, helps identify transcription factor activity in individual cells, providing insights into gene regulation. This system can aid researchers in understanding biological functions and developing new treatments for diseases.
A research group discovered that β-catenin signaling is used for axial patterning in sea anemones and sea urchins, a mechanism that also exists in vertebrates. This suggests that this system was present in the common ancestor of Cnidaria and Bilateria around 650 million years ago.
Researchers have identified an olfactory receptor that selectively recognizes pyrazines, a type of volatile substance found in food and contributing to animal communication. This discovery could lead to the development of biobased artificial noses for monitoring sensory quality and authenticity of food.
A robot system with a digital twin uses intra-operative ultrasound to guide cardiac surgeons, improving their view of the patient without radiation exposure. The platform can assist less experienced operators and aid in pre-planning and real-time control.
A Henry Ford Health System study reveals that e-scooter-related head and neck injuries account for nearly 28% of reported riding mishaps. The study's findings highlight the importance of wearing helmets and following safety tips to reduce the risk of injury while using e-scooters.
Researchers at Skoltech have designed a labeling system for individual cells using polymer multilayer microcapsules that can be easily reproducible and non-toxic. The system allows for the tracking of single-cell behavior and migration with extreme precision, facilitating studies on cell movement and communication in populations.
Researchers created a neighborhood-level COVID-19 inequity index to analyze disparities in New York City neighborhoods. The index showed that areas with higher inequity indices had higher subway ridership, implying lower social distancing capacity.
Researchers developed a non-contact laser imaging system that can detect telltale signs of major blinding diseases in retinal blood and tissue, allowing for earlier diagnosis and management. The technology, known as photoacoustic remote sensing, improves patient comfort and test accuracy.
The American Medical Association has awarded Penn State College of Medicine $1.8 million to develop residency education programs that prepare physicians for the complexities of modern healthcare. The project aims to equip residents with health systems science knowledge and skills to deliver high-quality patient care.
A new study using a computational model found that cutting food waste would provide enough protein and energy to feed the growing population but fall short in terms of micronutrients like calcium, iron, and vitamin E. Researchers emphasize the need for attention to essential vitamins and minerals to address global nutritional needs.
Researchers propose techniques to decode fungal electrical activity, enabling efficient information transmission and complex processing. Fungal networks can monitor large data flows, providing insights into ecosystem dynamics and promoting sustainable development.
Researchers at EPFL's Integrated Systems Laboratory have developed a system that can measure propofol concentration in patients as they're being operated on, adjusting doses accordingly. The device uses machine learning to provide accurate measurements, overcoming the challenge of propofol sticking to needles
Researchers developed an AI system to guide oncologists in treating head and neck cancer patients, considering treatment efficacy and potential future decisions. The system analyzes real patient data to provide personalized recommendations and maximize survival outcomes while minimizing chemotherapy and radiation side effects.
Researchers found that excess pericardial fat increases the risk of heart failure, even after adjusting for established risk factors. High pericardial fat volume was associated with a double increase in risk for women and a 50% increase for men, according to the study published in the Journal of the American College of Cardiology.
A Perspective counters the DOJ's claim that forensic analysis of visual patterns is not metrology by highlighting biological sensory systems' ability to quantify patterns. This clarifies processes underlying human sensation and perception, potentially improving forensic accuracy.
During the winter wave of COVID-19, anaesthetic and critical care staff in the UK faced immense pressure due to a surge in newly admitted infected patients. Surgery rates plummeted by one quarter compared to previous years, with many hospitals expanding ICUs to accommodate the influx.
University of Maryland faculty members Shelby Bensi, Gregg Duncan, Katrina Groth, and Katharina Maisel have received CAREER grants for their innovative research in hazard assessment, gene therapy, risk assessment, and immunotherapy. Their work aims to advance the fields of civil engineering, bioengineering, and mechanical engineering.
Evinacumab reduces triglyceride levels by up to 82 percent in patients with severe hypertriglyceridemia and a history of hospitalizations for acute pancreatitis. The therapy also lowers the risk of recurrent acute pancreatitis, quality of life, and cardiovascular events.
A new study found that artificial food colorants like Red 40 and Yellow 6 can cause disease in mice with dysregulated immune systems, specifically colitis. Researchers are now investigating the potential impact on humans, given that similar cytokine IL-23 dysregulation is a factor in human inflammatory bowel disease.
Researchers created a tiny, wireless chip that uses ultrasound to monitor body processes, enabling the development of miniaturized implantable medical devices. The team achieved volumetric efficiency with their design, paving the way for chips that can be injected into the body and communicate wirelessly.
A study in mice reveals genes and metabolic processes that could aid or hinder recovery after a heart attack, with potential targets for treatments. The research used systems biology approaches to analyze gene activity across multiple tissues, identifying common and tissue-specific responses.
Researchers have developed soft sensors that comprehensively monitor pregnant women without wires, providing more precise data on vital signs, physical movements, and laboring positions. The devices offer improved comfort and freedom of movement, while also increasing the reliability of data collected during labor.
Chemists create supramolecular cage using Pd6(TPT)4 cages that can transport and release pharmaceutically active molecules like ibuprofen and progesterone. The system uses ultrasonification to break the bonds, releasing the drugs at the desired location.
Researchers at NTU Singapore have developed a device that seals tears and holes in blood vessels using an electrically-activated glue patch applied via a minimally invasive balloon catheter. The Voltaglue system has the potential to replace open or keyhole surgery for patching up internal blood vessel defects.
The Harmony transcatheter pulmonary valve system is a less invasive treatment option for patients with CHD and RVOT abnormalities. The one-year results show no mortality, endocarditis, or need for surgical intervention, with over 90% of patients reporting little to no pulmonary regurgitation.
A new study reveals a significant increase in heart attack survival rates for patients treated with a standardized protocol for cardiogenic shock. The National Cardiogenic Shock Initiative, led by Henry Ford Hospital, demonstrated a 71% survival rate in patients whose hearts were unable to pump enough blood during a heart attack.
Researchers from Tohoku University developed a novel imaging method to visualize respiratory activity of 3D tissue models. The method uses potential step-based electrochemiluminescence (ECL) imaging to track oxygen consumption and produce luminescent signals.
Researchers develop Nanotraps that capture SARS-CoV-2 viruses within the body, utilizing the body's own immune system to destroy them. The therapy has shown promising results in early stages of testing and could potentially be administered via a nasal spray as a treatment for COVID-19.
A new study by Henry Ford Health System has found that a non-opioid approach to managing pain after knee surgery is just as effective as traditional opioid-based methods. The novel multimodal pain management protocol, developed at Henry Ford, brings immediate pain relief without the use of powerful opioids.
Postponing cardiovascular surgeries during the pandemic sparked anxiety and fear among patients, illustrating the profound impact of medical decisions on their emotional well-being. Many patients preferred to wait for surgery due to uncertainty about COVID-19's impact on their health.
Researchers have developed a novel method to detect and manipulate the terahertz optoacoustic signal of water, enabling sensitive detection of solutes like ions with an order of magnitude greater sensitivity than traditional spectroscopy. This breakthrough allows for nondestructive analysis of aqueous solutions and tissues, opening up ...
Genetic ancestry data provides specific insights into disease risk and management, allowing for targeted interventions. The study found that 25% of BioMe participants had links to populations predisposed to certain genetic diseases.
A study by Kaunas University of Technology reveals the benefits of telehealth, including accessibility, convenience, and cost-saving. However, organizational and individual barriers, such as lack of digital training and reimbursement issues, hinder its widespread adoption.
Researchers use CRISPR-Cas9 to introduce thousands of mutations into C. elegans worms, then analyze the effects on physical traits and functions. They discover a surprise finding that mutations in specific microRNA binding sites can affect gene expression.
Beth Israel Deaconess Medical Center shares five key lessons on health equity from its COVID-19 vaccination campaign, including obtaining reliable patient data and addressing structural inequalities. The health system's approach aims to reach marginalized communities with trust-building strategies.
The new approach provides a powerful tool for recording cell lineage in diverse cellular systems. Researchers use intMEMOIR to reconstruct lineage histories and link cell fate, spatial structure, and tissue organization in mouse embryonic stem cells and fruit fly brain.
A retrospective study published in the Journal of Occupational and Environmental Medicine found that manual labor jobs contribute to higher rates of carpal tunnel syndrome. Researchers estimate the overall cost of carpal tunnel syndrome cases to be between $47,000 and $119,000, including healthcare costs and lost productivity.
A University of Washington-led team has developed a system that uses machine learning to capture subtle changes in facial light reflection to estimate pulse and respiration rates from smartphone videos. The system outperforms previous versions on diverse datasets, including those with darker skin tones.
A study published in Critical Care Medicine found that racial differences in COVID-19 ICU outcomes do not exist. Patients of color had a lower 28-day mortality rate compared to white patients, while overall hospital mortality and length of stay were unaffected by race.
Researchers at Mount Sinai Hospital have identified genetic and cellular mechanisms underlying Crohn's disease, providing new insights for tailored treatments. By blocking the gp130 protein, they found that some patients may benefit from alternative therapies, complementing standard anti-TNF treatments.
Researchers at UFSCar in Brazil have developed a novel luciferin-luciferase system that produces far red light at 650 nanometers, three times brighter than natural luciferin and luciferase. This system has better thermal stability, cell membrane penetrability, and more lasting continuous bioluminescence.
An international research team of otolaryngologists and dental specialists has reached consensus on diagnosing and managing odontogenic sinusitis (ODS), a condition that can spread from teeth to sinuses, brain, or rest of the body. The initiative aims to improve collaboration between ENT surgeons and dental providers to diagnose ODS mo...
A team of researchers led by Professor Alexander Meyer has created an early warning system for intensive care units (ICUs) using big data and artificial intelligence. The system predicts postoperative bleeding and acute kidney injury with high accuracy, allowing timely interventions to save lives.
The Systems Biology of Early Atopy study aims to integrate biological, environmental, and genetic data to better understand the origins of allergic diseases in children. The 2,500-family study will examine prenatal and early childhood markers of high risk for food allergy and eczema.
A recent study developed an AI-based system to predict optimal medication dosages for patients with kidney disease undergoing hemodialysis. The system achieved high prediction accuracy rates, providing clinically appropriate classifications at even higher rates.
UofL and Medtronic will develop a closed-loop system to monitor and adjust stimulator settings for multiple functions, including locomotion and bladder control. The project aims to improve the lives of people with spinal cord injury by reducing manual interaction and increasing positive outcomes.
A computational guide to lead cells down desired differentiation paths uses a novel computer-guided design tool to predict effective combinations of transcription factors. The approach significantly increases the efficiency of cell conversions, generating higher numbers of immune cells and skin cells than other methods.
A joint effort by Pitt bioengineer and orthopaedic surgeon aims to improve surgical outcomes for capsular injuries, potentially leading to a more effective treatment. The study uses quantitative techniques to measure injury magnitude and location, with the goal of reducing failure rates and improving patient recovery.
Researchers developed a tissue-section analysis system that integrates morphological, molecular, and histological data for diagnosing breast cancer. The system provides heatmaps to explain the AI decision-making process, enabling doctors to assess results plausibility.
Frailty is characterized by three or more of five key clinical signs and symptoms, including weakness, slow walking speed, and fatigue. Researchers developed a system for diagnosing frailty and found that it's a distinct state caused by disharmony among physiological and biological systems.
Penn Medicine's collaborative care program, Penn Integrated Care (PIC), integrates mental health professionals into primary care settings. A new study suggests that this approach is effective and efficient in meeting the needs of patients with various mental health conditions.
A new method developed by Salk researchers enables scientists to improve microscope image quality using artificial intelligence and artificially degraded images. The 'crappifier' tool can help democratize microscopy, making it accessible to those without powerful microscopes.
A national survey and cohort study found that patients are accepting and satisfied with robotic system evaluations, with 92.5% reporting satisfaction. Robotic systems are deemed useful for acquiring vital signs, conducting testing, and supporting placement of intravenous catheters.