Articles tagged with Systems Biology
Researchers analyzed data from over 80,000 primary care physicians and found no clear connection between MIPS scores and clinical performance. Doctors with low MIPS scores performed worse on some process measures but better on others, suggesting that the system may prioritize paperwork over patient outcomes.
Research on Fanconi anemia reveals its link to aggressive head-and-neck tumors due to gene-copy chaos, increasing the need for new treatments. The study also highlights a connection between smoking and drinking and elevated cancer risk.
A new bioreactor system developed by KAUST scientists delivers gases to maintain physiological environments, reducing unpredictable shifts in cell growth. The system allows for more accurate and reproducible experiments in biomedical research.
Research reveals that octopuses have a massively expanded repertoire of microRNAs in their neural tissue, similar to vertebrates. This finding suggests that miRNAs play a fundamental role in the development of complex brains.
Scientists at Ural Federal University have developed a sensor device that determines cholesterol levels without using enzymes. The system uses copper chloride, making the process cheaper, easier, and faster than traditional methods.
A new metric estimates cumulative exposure to PFAS chemicals, enabling comparisons across studies and applications. The calculator takes into account patterns of exposure to multiple chemicals, providing a robust tool for biomonitoring and disease assessment.
Research found a hospital code response team arrives at least one minute quicker and leads to better patient outcomes with smartphone emergency code notification systems. The study used a secure texting system that connected with electronic medical records, reducing conventional methods' average delay of 78 seconds.
Researchers found a longer PR interval and prolonged QT duration in genetically modified pig hearts after transplantation into humans, indicating signs of electrical disease. The study provides a foundation for future research to better understand xenotransplantation's effects on the heart's electrical system.
The $2.4 million grant will provide direct training for new community health workers in Lubbock and throughout the state through registered apprenticeship programs and job placements. The program aims to increase access to healthcare and address public health needs for underserved communities.
Researchers created predictable, novel expression patterns of fluorescent proteins using engineered gene circuits. They also redesigned root architecture by tuning the number of root branches using similar gene circuits.
A Princeton team invented a way to observe bacteria in 3D environments, finding that colonies consistently form intricate, branching shapes resembling broccoli. They discovered two factors causing these shapes: nutrient and oxygen availability, and the colony's internal structure.
Researchers at Mount Sinai's Tisch Cancer Institute have discovered a new gene, PDZK1IP1, essential to colon cancer growth. The study found that surrounding inflammation activates the super enhancer, promoting tumor cell survival and growth.
Researchers propose an optical imaging system for real-time hypoxia imaging in cancer treatment. The technique utilizes protoporphyrin IX to enhance contrast between tumors and healthy tissues, allowing for more effective surgical removal.
Researchers at Leibniz-Institut für Lebensmittel-Systembiologie an der TU München discovered that casein digestion produces peptides with a satiating effect, stimulating gastric acid secretion via bitter receptors. This mechanism may help regulate food intake and maintain a healthy body weight.
Researchers from Rutgers Cancer Institute have identified specific microorganisms associated with inflammation and poor survival in pancreatic tumors. These microbial signatures can be used as new targets for earlier diagnosis or treatment of the fourth leading cause of cancer death.
Researchers developed a low-cost, simple imaging system using tumor-targeting fluorescent molecules to determine tumor depth. The portable system provides quantitative information about the depth of tumor cells in the body, helping surgeons remove healthy tissue around tumors for better outcomes.
Researchers discovered a cellular decision-making mechanism in dormant bacterial spores that operates even in physiologically inactive cells. The spores can sense harsh environmental conditions and release dormancy when conditions become favorable, triggered by an electrochemical-state switching mechanism similar to neurons.
A recent study led by Veronika Somoza found that egg powder is a valuable source of essential nutrients, including vitamins and indispensable amino acids. The researchers discovered that the drying process did not lead to contamination with heavy metals and that egg powder can provide up to 61% of a child's daily requirement for selenium.
Researchers at UVA will study organelles in cancer cells to identify new pathways for understanding and fighting cancer. By focusing on the interactions between genes, proteins, and organelles within cells, they hope to develop fresh clues about therapies.
Valentin Fuster, MD, PhD, is honored with the TCT Career Achievement Award for his transformative work in interventional cardiology and patient care. He has made significant global contributions to cardiovascular medicine.
The University of Ottawa-led team aims to bridge the gap between heart and brain health by developing new diagnostic tools and treatments. They will focus on improving patient outcomes for disorders linked to both organs.
Researchers found that mTOR inhibition is crucial for p53-mediated tumor suppression, delaying cancer and increasing lifespan. In the absence of mTOR inhibition, cancer-promoting senescent cells drive tumor growth.
Scientists have developed a soft, bioresorbable device that cools peripheral nerves to reduce pain. The device was tested in rat models and found to be effective, reversible, and non-addictive, with potential applications for treating neuropathic pain after surgery.
Machine learning helps researchers discover how bacterial populations adapt to environmental diversity by analyzing growth curves. The analysis reveals distinct decision-making components for lag, growth, and saturation phases, protecting the population from extinction.
Researchers at Cornell University have discovered a new CRISPR system called Craspase, which has the potential to develop promising antiviral and tissue engineering tools in animals and plants. The study uses cryo-electron microscopy snapshots to explain how Craspase identifies RNA targets and activates proteases.
Researchers have developed a systematic strategy for creating phage-resistant E. coli strains, solving a major problem in industrial fermentation. The approach integrates a defense system and mutations to restrict phage life cycle, maintaining bacterial functionality and productivity.
A new study from Harvard Medical School reveals that patients who recover well after cardiovascular surgery exhibit precise paths for white blood cell and platelet counts. These trajectories can be used to monitor recovery in a personalized way, enabling clinicians to intervene earlier when necessary.
Researchers developed a label-free Raman spectroscopy approach with enhanced sensitivity and speed, allowing for non-invasive imaging of biological samples. The new CARS microscopy system can acquire microscopic images and identify biomolecules with unprecedented resolution and speed.
Researchers at Vienna University of Technology have successfully stimulated the auricular vagus nerve to reduce inflammation in severe COVID-19 cases, using a novel closed-loop control system. The therapy, dubbed an 'electric pill', has shown promising results in reducing inflammation and promoting healing.
A new breath-driven hand prosthesis offers a lightweight, low-maintenance option for children and those in low-resource settings. The device is powered by the user's breathing and provides simultaneous control and actuation, with minimal maintenance required.
Researchers at Max Delbrück Center for Molecular Medicine found that zebrafish can regenerate heart tissue after injury due to activated fibroblasts. The fibroblasts, which temporarily enter an activated state, read a series of genes responsible for forming proteins, enabling the regeneration process.
A team of scientists discovered a mathematical principle explaining how cells connect to form tissues and organs, shedding light on embryonic development and organ formation. The study found that epithelial cells can adopt complex three-dimensional shapes like scutoids, which determine cellular connectivity and tissue properties.
A new Mount Sinai study reveals that young Black adults are twice as likely to have atherosclerosis as their Hispanic counterparts. Researchers used comprehensive questionnaires and 3D vascular ultrasounds to determine cardiovascular risk scores, finding significant discrepancies between the groups.
A comprehensive study found that prenatal exposure to endocrine-disrupting chemicals is associated with non-alcoholic fatty liver disease in children. The researchers measured 45 chemicals in pregnant women and found elevated levels of biomarkers indicating risk for liver disease in children who were more highly exposed.
Researchers developed a new method using magneto-active polymers to study cellular behavior and replicate complex biological processes. The system allows for real-time control of mechanical forces on cells, enabling the analysis of mechanisms behind traumatic injuries and tissue damage.
Researchers at Leibniz-HKI found that lactic acid bacteria nourish intestinal cells, promoting bacterial growth and adapting Candida's metabolism to make it less infectious. This balance restores a healthy state and prevents fungal infections.
Researchers have developed a unique 3D printed system to harvest mesenchymal stem cells from bioreactors, which can be used for various treatments. The system combines microfluidics and 3D printing to process adult stem cells, potentially making stem cell therapies more widely available.
A collaborative initiative aims to establish common protocols for assessing and comparing diffuse optics systems used in medical diagnosis. The study presents the results of a multi-laboratory comparison of 12 institutions and 28 systems, proposing simple numeric values for easy comparison across instruments.
A new EU project, DeLIVERY, aims to develop a microscopy system for liver cells to test tolerability of drug interactions. The system will enable researchers to observe how liver cells react to different medications, dosages, and combinations, potentially leading to improved patient safety.
Researchers at Harvard Medical School used a new technique to analyze SARS-CoV-2 samples from university screening programs and found that omicron accounted for over 90% of infections just nine days after arrival. The study suggests universities can serve as monitoring hubs for early detection of infectious disease outbreaks.
The new technique, 3D optical coherence refraction tomography (3D OCRT), produces highly detailed images revealing features difficult to observe with traditional OCT. It has the potential for biomedical research and eventually more accurate medical diagnostic imaging.
Cornell researchers develop smaller gene-editing tool, IscB-ωRNA, to solve size problem of delivering CRISPR-Cas9 into every cell. The tool works similarly to CRISPR-Cas9 but with a smaller RNA component, offering new starting point for more powerful and accessible gene editing tools.
Researchers at the Lew lab have created a novel hardware and algorithm that enables visualization of cell membranes and molecular motions in six dimensions. This breakthrough allows for the observation of 3D structures with additional information on molecular orientation, providing new insights into biological systems.
A study led by Flinders University reveals that Australia's Letter-winged kite may not have enhanced vision for nighttime hunting as previously thought. The research found similar eye dimensions to its daytime-hunting relatives, contradicting decades of speculation about the kite's visual system.
A community-focused approach led by Boston Medical Center significantly improved COVID-19 vaccination uptake in historically disinvested Black and Latino communities. The initiative administered over 100,000 first doses, with a focus on mobile vaccination events and community-based clinics.
Researchers at Rice University have developed a theoretical framework to explain how cancers caused by multiple genetic mutations can be identified and potentially stopped. By analyzing energy landscapes of cellular transformation pathways, they found that the most dominant pathways are favored by chance.
A study published in Med found that the human microbiome's variation explains different patient responses to statins. The researchers discovered a Bacteroides enriched microbiome with lower diversity was associated with stronger LDL-lowering effects but greater disruption of blood glucose levels.
A new study by Ramin Hakami aims to improve detection of bacterial pathogens in food samples using an immunodetection method. The goal is to create rapid and accurate identification methods, which will be essential for food safety monitoring.
Researchers at Arizona State University have developed a new technique called evanescent scattering microscopy (ESM), which allows for the visualization of proteins and other vital biomolecules with unparalleled clarity. This label-free imaging method reduces light-induced heating and requires no fluorescent dye or gold coating, making...
Researchers analyzed 451 bacterial strains of C. difficile, identifying 9,924 distinct gene clusters and categorizing them into 176 genetically distinct groups. The study provides new insights into the genetic diversity and evolution of this pathogen, shedding light on its virulence factors and antimicrobial resistance determinants.
Researchers at Mount Sinai have discovered a previously unknown mechanism by which not-yet-malignant breast cancer cells can travel to other organs and 'turn on' to become metastatic. The study identified potential diagnostic biomarkers, including the transcription factor NR2F1, that could help predict relapse.
A new study found that native species in southwestern Washington floodplains adapt to bullfrogs and sunfish by changing their feeding strategies. The researchers analyzed carbon and nitrogen stable isotopes in predators and prey to understand food webs, finding that some species shifted towards more abundant food sources.
A new robotic system allows surgeons to remotely treat patients experiencing a stroke or aneurysm, providing teleoperated endovascular treatment during the critical golden hour. With just one hour of training, neurosurgeons can successfully operate the system to guide a wire through complex vessels and reach difficult-to-reach areas.
Researchers found a significant decline in in-hospital mortality and secondary endpoints for STEMI patients with COVID-19 in 2021 compared to 2020. Vaccination status showed zero hospital deaths among vaccinated patients, while unvaccinated patients experienced high death rates.
A new study found that customized digital alerts via an electronic health record system significantly increased the number of guideline-directed medications prescribed for heart failure patients. The alerts improved medication use by over a quarter of patients, translating to one medication addition per every 14 alerts received.
Researchers developed a novel genetic barcode system to mark cancer cells with different gene modifications and image their characteristics. The Perturb-map platform identified specific genes controlling lung tumor growth, immune composition, and response to immunotherapy, offering new approaches for targeting anti-cancer drugs.
Researchers discovered that plant volatile signals can warn neighboring plants of herbivore attacks, activating defense genes and increasing resistance. The team found epigenetic mechanisms, including histone acetylation, play a key role in this process.
UNIGE researchers developed a new approach combining genetics and cell biology experiments with physical modelling to simulate protein gradients. Their innovative model can explain complex mechanisms and be adapted to other biology systems.
The new laboratory will use microfluidics, AI, and machine learning to conduct thousands of parallel experiments on single-cell eukaryotic yeast and other microbes. This will simplify the study of biology and provide a pathbreaking 'robot scientist' for fundamental research.
A research team has discovered how the Covid virus reproduces itself by taking over the cell's protein factory. The team identified a specific structure in viral mRNA that allows the virus to access the ribosome and produce its own proteins, while blocking cellular production. This discovery opens up new avenues for antiviral treatments.