Articles tagged with Systems Biology
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Despite Congress's adjournment, the Sustainable Growth Rate (SGR) Repeal and Medicare Provider Payment Modernization Act of 2014 remains a crucial issue in healthcare finance. Experts, including Dr. Eli Adashi, advocate for bipartisan efforts to address the SGR law and promote reforms to move Medicare towards quality-based compensation.
The Edge Radiosurgery Suite provides sub-millimeter accuracy with extreme precision in targeting cancer tumors. The study demonstrates its high accuracy, outperforming robot- or frame-based radiosurgery systems, making it a highly effective treatment option for patients.
A mandatory employee vaccination policy at Henry Ford Health System resulted in a significant increase in flu vaccination rates, reaching 99% among health care workers. The system's success can be attributed to effective communication, education, and sufficient vaccine availability.
According to a study by American College of Emergency Physicians, discharged patients often return to the emergency department because they're anxious about their symptoms. The main reasons cited are fear or uncertainty about their medical condition, distrust in the healthcare system, and difficulties accessing care due to lack of insu...
The Microphysiological Systems Program is developing human-on-a-chip models to study cell-cell, drug-cell, and organ-drug interactions. These models have the potential to revolutionize experimental biology and medicine by increasing efficiency and human relevance in pharmaceutical development and testing.
Researchers at UC San Diego have sequenced the complete genome of the EDL933 E. coli strain, a common cause of food poisoning outbreaks in the US. The full genome sequence provides precise locations of jumping genes, potentially aiding in tracking and treating future outbreaks.
Researchers design a network-like cell system that reproduces dynamic behavior of protein synthesis, allowing for control over genetic content and protein production. The system enables the study of gene network design and emerging protein dynamics, potentially paving the way for controlling protein synthesis for various applications.
Researchers at Mount Sinai Hospital discovered a biomarker linked to PTSD development, centered around the glucocorticoid receptor. This receptor is found in stressed animals with PTSD and may be targeted for new treatments.
Researchers at Mount Sinai School of Medicine developed an effective treatment for the rare disorder, which causes continuous feelings of swaying or rocking. The treatment re-adapts the vestibulo-ocular reflex, a mechanism in the inner ear that maintains balance, and achieves significant recovery rates in patients.
The study highlights the potential of increased adoption of complex care management to reduce healthcare costs and improve patient outcomes. However, several barriers, including fee-for-service payment systems and lack of resources in small practices, must be addressed.
A recent study published in Critical Care Medicine found that heavier patients are more likely to survive sepsis, a life-threatening infection. This obesity paradox challenges conventional wisdom and may improve care for all patients with sepsis and other critical illnesses.
Researchers identify mechanism explaining Zipf's law, a pattern found in complex systems. The study uses neural data from blowflies to demonstrate how the law arises when units respond to a hidden variable.
Researchers confirm a mathematical theory first proposed by Alan Turing in 1952 can explain the formation of fingers, revealing how signaling molecules act as the Turing system. The study uses systems biology and computational modeling to validate the theory, with be confirming results observed in limb bud tissue experiments.
A new study finds that consolidating recommendations and clear language are key to converting pediatric preventive care guidelines into computerized prompts. The guidelines currently lack organization to easily translate into electronic prompts, leading to missed or delayed visits.
Researchers have developed a single-pixel optical system that can overcome light scattering in tissue, enabling transmission of images through scattering media. The technique uses compressive sensing to compress large data files as they are measured, allowing it to reconstruct the image and penetrate deeper into tissue.
Researchers at Johns Hopkins Bayview Medical Center introduced guidelines and changes to the computerized provider order entry system to reduce redundant biomarker testing. This led to a 66% decrease in tests ordered and saved an estimated $1.25 million in laboratory charges.
Scientists at the University of Illinois have developed a new class of walking 'bio-bots' powered by muscle cells, controlled with electrical pulses. The breakthrough allows for unprecedented control over their function, opening up possibilities for environmental and medical applications.
A team of CAS researchers developed biomimetic nanochannels to harness the power of confined water in biological systems. Inspired by nature's intelligent design, they created a strategy for designing smart nanochannels with applications in energy conversion systems.
Researchers analyzed data from 6.2 million Danes over 14.9 years to identify patterns and correlations between diseases such as diabetes and cardiovascular disease. The study provides insights into the complex interactions between genes, proteins, and diseases, paving the way for tailored treatment approaches.
Research at Umeå University reveals that low cortisol levels increase the risk of depression in people with bipolar disorder. The study found that both high and low cortisol levels impaired mental health, with those having low cortisol levels experiencing a chronic state of the disorder.
A new special section in Optical Engineering highlights optics research for human vision improvement. The studies showcase new techniques for earlier disease diagnosis and more accurate guidance for treatment.
A large, multi-site clinical trial will test new patient-centered strategies to prevent fall-related injuries. The trial aims to develop and implement individualized care plans for adults at high risk of falling.
A new study found that African Americans taking metformin saw greater improvements in blood sugar control compared to white individuals. The study suggests that metformin is more effective at controlling blood glucose in African Americans, who are twice as likely to be diagnosed with diabetes.
A UC Davis study found that reducing criminal charges can prevent subsequent violent crimes among those with misdemeanor convictions who purchase handguns. Nearly 25% of handgun purchasers were arrested for a new firearm-related or violent crime within three years.
A NYU Langone expert suggests reforms to improve the VA health system's administration, staffing, and management. Key proposals include changing the culture, creating new scheduling systems, and hiring more primary care physicians to meet the growing demand.
A study of over 2,600 adults with hepatitis B found that antiviral therapy significantly reduced the occurrence of liver cancer (HCC) by 60%. The therapy was more effective than treatment in preventing HCC than untreated patients. Results suggest a potential new approach to preventing a common and deadly form of cancer.
Researchers at Mount Sinai Hospital discovered that a protein called Sirtuin1 (SIRT1) is essential for maintaining healthy aging of blood stem cells. The study found that loss of SIRT1 leads to impaired regeneration and resembles aged, defective stem cells in mouse models.
The VA's decline in safe, effective patient-centered care can be fixed by refocusing on primary mission, ensuring quick screening of veterans on wait lists, and implementing a 'continuous healing relationship' strategy. Strong leadership and greater transparency are key to restoring trust in the system.
A new study found that healthcare providers are reluctant to discuss end-of-life care with heart failure patients, citing discomfort and lack of time. However, experts emphasize the importance of open communication in easing anxiety and improving patient outcomes.
A Penn study reveals how cells remove misfolded proteins, a crucial process for understanding brain diseases caused by toxic protein clumps. The research identified a two-stage recycling system involving proteins PML and RNF4 that tags misfolded proteins for degradation.
A Stanford study found that most physicians choose a do-not-resuscitate status for themselves when terminally ill, yet tend to pursue aggressive treatment for patients facing the same prognosis. The study suggests that the medical system's focus on high-intensity care at end-of-life contradicts Americans' preferences.
The GME system faces transparency and accountability issues, with only 20.9% of residents practicing primary care. Recommendations propose fully funding the National Health Care Workforce Commission and requiring transparent spending of GME funds to support a more efficient physician workforce.
Researchers at University of Southampton have developed a new hybrid energy transfer system that mimics the processes responsible for photosynthesis. The system enables efficient energy transfer over long distances, with potential applications in optoelectronic devices and synthetic systems.
A cost-saving, coordinated brain care model developed by Indiana University researchers is attracting nationwide attention for its ability to improve health outcomes and quality of care while lowering costs. The ABC model, tested in large clinical trials, improves care at a lower cost than standard care.
A Stanford electrical engineer has invented a way to wirelessly transfer power deep inside the body, paving the way for new 'electroceutical' devices to treat illness or alleviate pain. The technology uses roughly the same power as a cell phone and can safely penetrate deep into the body.
A study published in JAMA Surgery found that critical access hospitals have higher transfer rates after surgery compared to non-CAHs. However, the proportion of patients using post-acute care was similar between CAHs and non-CAHs, raising questions about the long-term implications for these facilities.
Researchers at the Mount Sinai Hospital identified subtle changes in inhibitory signaling in the reward pathway, affecting how animals respond to drugs like cocaine. The study highlights sorting nexin 27 as a promising target for treating addiction and may lead to new therapeutic options.
The LEADLESS study found that the leadless pacemaker demonstrated overall device performance comparable to conventional pacemakers, with no infections or failures to sense, pace, or communicate. The device's benefits may allow for less patient discomfort and device complications.
Researchers have identified the RAF1 gene as a cause of childhood-onset dilated cardiomyopathy, a progressive and potentially fatal heart condition. The study found that patients with this genetic variant showed increased activity of the protein mTOR, which can be inhibited with FDA-approved drugs.
The NeuroPace RNS System uses responsive stimulation to suppress seizures before they begin, reducing seizure frequency by up to 50%. The device is surgically placed and coupled with a unique electrode placement planning system that facilitates precise targeting of the seizure focus.
Beaumont researchers will investigate a stem cell-based technique to redirect cells to heal injuries without removing them from the patient's body. The goal is to develop new treatments for osteoarthritis and Achilles tendon ruptures.
The PETA science consortium will present a tiered-testing strategy for assessing nanomaterial hazards at the 7th International Nanotoxicology Congress. The proposed strategy involves multiple in silico and in vitro model systems, data sharing through web-based tools, and is cost-effective while reducing animal use.
A recent study by Allina Health found that sharing clinical information with other health systems can avoid duplicative diagnostic procedures, such as blood work and imaging. By using the Care Everywhere tool, providers were able to eliminate 560 potentially duplicative diagnostic procedures.
Researchers at Brigham and Women's Hospital propose a new Next-Gen Cytogenetic Nomenclature system to standardize chromosomal abnormality descriptions, improving clinical and research reports. The system focuses on nucleotide-level details, reducing errors and saving time in reporting.
Adam Arkin, director of Berkeley Lab's Physical Biosciences Division, has made significant contributions to systems and synthetic biology. He received the 2013 Ernest Orlando Lawrence Award for his work on cellular networks and populations.
A study published in Biological Psychiatry found that intranasal ketamine conferred an unusually rapid antidepressant effect within 24 hours and was well-tolerated in patients with treatment-resistant major depressive disorder. The results show promise for a new treatment class, targeting the NMDA glutamate receptor.
A study at a large academic community hospital system found that an increasing workload for hospitalists was associated with increased length of stay and costs, despite not affecting mortality or patient satisfaction. The results suggest that incentives aimed at increasing workload may lead to inefficient and costly care.
Researchers at Johns Hopkins Medicine have developed a computerized process that enhances image-based guidance in minimally invasive surgery, potentially replacing conventional tracking systems. The new system achieves high accuracy, often exceeding 2 millimeters, while using low-dose radiation, making it suitable for various procedures.
A new team approach has improved safety and reduced rates of major complications by two thirds for complex spinal reconstructive surgery. The standardized protocol before, during, and after the surgery involves two spine surgeons, a live preoperative screening conference, and monitoring bleeding during the operation.
Neurologists investigate the significance of the vestibular system in directing gaze, finding that patients with vestibular or cerebellar dysfunction have difficulty controlling eye movements. The study suggests that rehabilitation training based on active head movements can enhance gaze shift control and learning to find endpoints.
A study examined patient portal enrollment, use, and satisfaction among physicians in a fee-for-service multispecialty system. Despite financial incentives, many physicians struggle to meet meaningful use standards, with primary care physicians often satisfying their expectations without redesigns.
P&G Beauty presents several studies on new ingredient formulations and effective skin care routines, focusing on cellular bioenergetics, anti-aging technologies, and sensitive skin body wash efficacy. The company highlights breakthroughs in microdermabrasion systems, such as the Pro-X Olay Microdermabrasion system, which exfoliates eff...
Researchers at Columbia University Irving Medical Center have devised a new system for classifying periodontal disease based on the genetic signature of affected tissue. The new classification system may allow for earlier detection and more individualized treatment of severe periodontitis.
Researchers discovered that cells respond to rhythmic biological signals by counting the number of cycles, not their strength or duration. This mechanism, found in single-celled organisms, synchronizes changes in cell fate and may explain patterns in developing embryos and snail learning.
Researchers found a significant link between exposure to inhaled particulate matter at Ground Zero and the development of obstructive sleep apnea and post-traumatic stress disorder (PTSD) in first responders. The study also showed that those with PTSD had higher levels of inflammation, increasing their risk for cardiovascular disease.
A new study provides reliable data on antibiotic use in non-EU southern and eastern European countries, highlighting the need for national action plans to enhance judicious use. High rates of self-medication with antibiotics and parenteral administration are reported, emphasizing the urgent need for restriction and education.
A new stool-based screening test, Cologuard, detected 92% of colorectal cancer and 42% of advanced pre-cancerous lesions, outperforming a commercial occult blood fecal immunochemical test. The non-invasive test allows patients to collect samples at home, increasing the potential for higher cancer screening rates.
Researchers at Mount Sinai Hospital have discovered how the Marburg virus interacts with host protein Keap1, allowing it to live longer and replicate better. This knowledge may lead to the development of targeted therapies to arrest the lethal virus.
A recent study found that the ICD-10 transition led to significant information loss, affecting about 8 percent of Medicaid codes. Financial implications also emerged, with 39 codes accounting for 2.9 percent of total Medicaid reimbursements and 5.3 percent of UI Cancer Center billing charges.
A framework for improved geriatric patient care is proposed based on lessons learned from managing complex care transitions. The framework emphasizes the importance of looking at community, system and regional factors in care transitions.