Articles tagged with Sample Size
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A randomized clinical trial suggests that metformin can be an effective treatment for symptomatic knee osteoarthritis in people with overweight or obesity. The study's results support the use of metformin for this condition, but further confirmation is needed in larger clinical trials.
A new study provides a method to estimate sample size required for microbiome studies based on effect sizes and analysis methods. For strong associations, around 500 participants were needed to achieve 80% statistical power, while weaker associations may require thousands of samples.
This randomized clinical trial suggests that transcutaneous auricular vagus nerve stimulation is a safe and effective treatment option for chronic insomnia. Future multicenter trials are needed to validate its effectiveness across different populations.
A Chinese Medical Journal study reveals that patients with prostate cancer can undergo surgical removal without a pre-operative biopsy, using a combination of mpMRI and PSMA PET/CT imaging. This approach reduces costs and complications associated with traditional biopsy methods.
Researchers will examine cognitive and psychomotor functions to compare effects of CBD on driving performance between men and women. The five-year study aims to provide a comprehensive understanding of the substance's influence.
Scientists at the University of Warwick have investigated a range of contributing risk factors for suicide in a large-scale study. The study identified biological and behavioral predictors, including elevated white blood cells, neuroticism, childhood experiences, and reduced grey matter in the brain.
Researchers developed DiFC, a two-color diffuse flow cytometry system that detects rare cancer cells in the bloodstream without invasive methods. The technology provides insights into cancer progression and response to treatments by studying different subpopulations of cancer cells simultaneously.
A large-scale study revealed a profound link between dietary patterns and brain health, with a balanced diet associated with better mental health, superior cognitive functions and higher grey matter in the brain. The researchers suggest that gradual dietary modifications can lead to healthier food choices and improved wellbeing.
A study of 372 veterans found that COVID-19 infection negatively impacted everyday functioning via multiple pathways. The negative effects on functioning persisted even without a documented COVID-19 infection.
A recent study found that cigarette smoking among US adolescents decreased significantly from 1991 to 2021, with decreases in all usage categories. The decline was particularly pronounced among Black and Asian adolescents, while disparities by gender remained but were diminished.
A new AI tool utilizing deep-learning algorithms and volumetric thresholds accurately detected splenomegaly in patients undergoing CT scans. The study analyzed a large sample of 8,901 patients, revealing that splenic volume is strongly associated with weight.
The study found that preferential use of pulmonary MRA for diagnosing PE in the general population helped conserve iodinated contrast media. This substitution reduced iodine usage by approximately 27 liters during the specified time period, which is a noteworthy benefit considering the shortage's impact.
A new paper proposes an itemized checklist to guide researchers in publishing analyses using complex sample survey data. The checklist, PRICSSA, consists of 17 important items to report for any analyses conducted on complex survey data. This reform aims to increase transparency and make analytic mistakes easier to spot.
Researchers have developed a novel autonomous, submersible, 3D holographic microscope and imaging system to study marine particles and plankton in their natural environment. The AUTOHOLO system achieved 90% accuracy in detecting red tide blooms at varying concentrations, enabling near real-time monitoring and tracking of bloom phases.
A team of Brown researchers has developed a new, highly accurate method for detecting antidepressants in patients using liquid chromatography tandem mass spectrometry. The technique requires minimal biological samples and can be fully automated using liquid-handling robots.
A new study published in the Proceedings of the National Academy of Sciences has identified 14 pancreatic islet miRNAs associated with human type 2 diabetes. The study used a large sample size of nearly 65 human pancreatic islets to uncover these miRNAs, revealing potential mechanisms for disease development and novel therapeutic targets.
Researchers found that women are less likely to undergo common heart procedures and more likely to die in the hospital after receiving them. The study analyzed data from over 2 million hospitalizations for heart procedures between 2016 and 2019, revealing significant disparities in treatment and outcomes based on sex and race.
Brainwide association studies need thousands of individuals to yield higher reproducibility, as smaller samples often uncover strong but spurious associations. Larger sample sizes lead to more likely reproductions of correlations, with effect sizes decreasing as the number of participants increases.
Researchers from Harvard University and others have found that large-scale COVID-19 vaccination surveys were off by up to 17 percentage points due to systematic biases in the data. The 'Big Data Paradox' highlights how big data sets can minimize one type of error while magnifying another, leading to misleading results.
Researchers have created tables of responses for gold and platinum to extreme pressure, providing a standard for future researchers to calibrate the responses of other metals. The data generated by these experiments can aid in understanding exoplanets, planetary impacts, and moon formation.
Scientists develop a statistical randomness-based framework to optimally classify extremely large datasets. By analyzing the variance of sample sizes, they can identify the total number of attributes needed, providing a promising solution for high-performance computing and machine learning.
Scientists developed a new model to assess the efficiency of group testing for COVID-19, accounting for dilution effects and detection limits. The model optimizes group size to minimize false negatives and determine contaminated individuals in a population.
A study of secondary body MRI interpretations at tertiary care centers found a high rate of discrepancies, with cognitive errors being the most common type. The researchers suggest that subspecialty interpretations and additional resources are needed to address these errors and their potential impact on patient outcomes.
Research reveals that crossbreeding Holstein cows with Viking Red and Montbéliarde breeds can significantly improve fertility while maintaining milk production. The study, published in the Journal of Dairy Science, found that crossbred cows had better overall well-being, reduced costs of insemination, and longer herd life compared to p...
Twisting 2D materials has uncovered their superpowers, revealing exotic physical behaviors such as high temperature superconductivity and structural super-lubricity. Aalto University's researchers have developed a new method for making twisted layers, allowing precise control of the twist angle on a large scale.
Leipzig researchers have initiated a global primate study project, ManyPrimes, to address fundamental evolutionary questions. The first study focused on short-term memory in primates, with almost 180 animals from 12 species participating across 11 research stations.
A UK government-used VPF valuation undervalues human life due to insufficient sample size and invalid interpretation methods. An alternative method called J-value offers an accurate assessment by balancing safety spend against extended life expectancy, valuing a life at £8.59 million.
Researchers at Baylor College of Medicine found that smaller sample sizes can greatly exaggerate the magnitude of group differences in multisensory integration studies. Studies with sample sizes of 20 or less are more likely to produce inflated results, which can lead to incorrect conclusions and potential failures in therapy development.
Scientists developed a method to characterize the genetic contributions to traits and diseases, revealing that cognitive traits and psychiatric disorders are influenced by tens of thousands of gene variants. The study provides a 'big picture' of genetic influences, useful for designing future genetic studies.
Increasing control and physical activity may be the secret to staying young for older adults. Research suggests that a younger subjective age is associated with better memory performance, health, and longevity. A study found that participants who reported feeling more in control on days with higher step counts felt younger.
A new AI-based framework has been developed to create realistic textures in virtual worlds, addressing the challenge of designing complex and believable textures. The tool uses generative adversarial networks (GANs) to train computers to expand small textures into larger ones, resulting in efficient and realistic designs.
A new analysis reveals that task-based fMRI experiments with typical sample sizes of about 30 participants are only modestly replicable. Larger sample sizes may be needed to improve replicability in neuroscience studies.
Researchers found that graphene's Poisson ratio, which determines material capability to shrink or extend in transverse dimension, varies depending on the applied tensile force. This discovery could help create new materials with required exotic properties and improve existing technologies.
Researchers found that using more diverse study samples can significantly improve the reproducibility of experimental results in pre-clinical animal research. By combining data from multiple studies, they showed that multi-laboratory studies produce more consistent results than single-laboratory studies.
This special issue reports advancements in assay design, microfluidic technologies, and digital assays for improved quantification of rare mutations, molecular analysis, and mechanobiological studies. It also highlights improvements in tissue dissection and sample processing for cancer diagnostics and drug screening.
A new study reveals widespread physician dissatisfaction with electronic health records (EHRs), with hospital-based physicians expressing concerns about reduced patient contact time and office-based physicians worrying about the quality of their interactions. Despite these challenges, some physicians have found ways to minimize disrupt...
A new study published in Frontiers in Behavioral Neuroscience found that hormonal changes during the menstrual cycle have no impact on working memory, cognitive bias, or ability to pay attention. The study followed 68 women across two consecutive menstrual cycles and found no replicable effects of hormones on cognition.
A more flexible approach to study design can significantly improve the efficiency of preclinical research, according to a recent study published in PLOS Biology. By using group sequential designs, researchers can enhance predictive ability and reduce waste in animal studies.
Researchers found anomalies in measurements of 3,200 quantities up to 100,000 times more often than expected, highlighting the limitations of scientific certainty. The study suggests that complex scientific disciplines like medicine and particle physics struggle to eliminate uncertainties.
Researchers create large sample size of ST12-germanium, confirming its semiconductor and optical properties. The material has a tetragonal structure and indirect band gap, making it suitable for infrared detection and imaging technology.
The study finds that women are closing the gap with men in terms of alcohol consumption and related health issues. The trend is most noticeable among young adults, with women's drinking habits approaching parity with those of men, particularly among those born between 1991 and 2000.
A recent study published in the American Journal of Human Biology found that cortisol levels increase with aggressive behavior in 10-year-old boys. Cortisol is not associated with increased aggression in girls during this age range.
Researchers at the University of Bristol examined 40 peer-reviewed articles on the 'hiatus' in global warming and found inconsistent definitions and no consistent pattern. The study concluded that using terms like 'pause' or 'hiatus' creates hazards for the public and scientific community, as they imply global warming has stopped.
A new study from Johns Hopkins University School of Medicine demonstrates the effectiveness of a two-year menopause-focused curriculum for OB/GYN residents. The program improved residents' confidence in managing menopause patients, with 85.7% feeling comfortable or very comfortable after completion.
A new study from NIMBioS suggests that considering a species' selfing rate, seed dispersal distances, and reproductive type can improve seed collection effectiveness. This approach can help conserve genetic diversity and rare species, such as the Trillium tennesseense.
Researchers found amino acids and biologically important molecules in carbon-rich meteorites, suggesting that extraterrestrial material may have played a role in the origin of life. The new technique allows for analysis of tiny samples, enabling future studies on cometary particles and sample-return missions.
Researchers from Brown University recruited frogs from the fair and compared their jumps to those in the lab. Most professional and rental frogs outperformed lab frogs, revealing a non-linear relationship between sample size and jump distance.
Researchers developed a novel microscopy technique that captures precise motion paths in three dimensions, tracking over 24,000 rapidly moving cells. The technique reveals previously unknown statistical pathways for human male gamete cells, showing complex twists and turns in their movements.
Researchers have developed a novel microscopy technique that captures precise motion paths of large numbers of rapidly moving objects under a microscope. The technique recorded the paths of 24,000 human male gamete cells over several seconds, revealing previously unknown statistical pathways.
Research published in Occupational and Environmental Medicine found that certain jobs carried out by fathers may be linked to an increased risk of birth defects in their babies. Jobs such as mathematicians, physicists, and computer scientists, as well as artists and photographers, were associated with a higher risk of birth defects.
New studies find insufficient data to draw conclusions on whether same-sex parenting disadvantages children. A review and new study reveal differences in social and emotional well-being between young adults raised by women with same-sex relationships and those in nuclear families.
The destruction of live smallpox samples is crucial for further research, as the last naturally occurring case occurred in 1977. New vaccines have been developed, but full development is essential for global security and public health.
A population-based study found that parental alcohol use disorders significantly increase the risk of offspring developing an AUD. Female offspring were particularly vulnerable to this increased risk, suggesting a stronger genetic component for female development of AUDs.
A large collaborative study has identified 64 new genetic variants associated with adult height, providing insight into the complex trait. The research suggests that genotyping arrays with rare and uncommon single-nucleotide polymorphisms can capture new signals and disease variants.
Researchers at NIST have created a microminiaturized device that can measure complex viscoelasticity on sample sizes as small as a few nanoliters. This innovation enables biotechnologists to study minute quantities of materials with greater precision and accuracy.
A recent study published in Journal of Archaeological Science suggests that a species of shellfish, the humped conch, has increased in size over the past 3,000 years despite increased human activity. The average length of the conchs increased by approximately 1.5 millimeters, making them about 5% larger than they used to be.
A new study published in the Journal of Forensic Sciences examines the prevalence of 'Suicide by Cop' (SBC) among North American officer-involved shootings. The study found that SBC occurs at an extremely high rate, with 36% of all shootings categorized as SBC, resulting in a 50% chance of death or injury.
Researchers have found a way to increase sensitivity of solid-state nuclear magnetic resonance (SSNMR) by doping samples with paramagnetic copper-acid solution, reducing the waiting period from up to three seconds to 20 times.
A study published in Personnel Psychology reveals that executives' underwater stock option portfolios are more likely to lead to voluntary turnover. Increasing the value of these portfolios can reduce the odds of turnover by substantially, suggesting that firms may need to consider alternative retention strategies.
The study designs a trial to identify differences between groups with high statistical power while minimizing costs. A small number of schools are included in the trial, allowing for more precise analysis and better understanding of how interventions affect pupils within each school.