Articles tagged with Biomarkers
A study funded by the NIH found that children with multisystem inflammatory syndrome (MIS-C) have unique biochemical indicators of cell injury and death. The researchers developed a method to distinguish MIS-C from other conditions, which could lead to improved diagnosis and treatment for these patients.
A new Raman probe, 9CN-JCR, has been developed for detecting multiple enzyme activities in heterogeneous biological tissues. The probe exhibits high sensitivity and multiplexing ability, making it a promising tool for cancer diagnosis and research.
A team of FSU chemists has developed a new test for detecting biological markers related to several types of cancer. The sensing platform uses gold nanoparticles and peptides labeled with a dye, emitting light when the enzyme MMP-14 is present, allowing researchers to generate data on cancer marker levels
A new study published in PLOS ONE found that a heart injury biomarker, cardiac troponin, can identify low-risk COVID-19 patients who have normal troponin levels, potentially helping doctors send them home safely. The study suggests that elevated troponin levels may not accurately predict individual patient risk of death.
Researchers have identified specific biomarker patterns in blood samples that are unique to severe COVID-19 infection and Multisystem Inflammatory Syndrome in Children (MIS-C) in children. These findings may lead to the development of diagnostic tests to predict severe disease and distinguish MIS-C from other conditions.
A new study by Columbia University Mailman School of Public Health finds that water arsenic levels are associated with higher urinary arsenic among the U.S. population, especially in public water supplies in the West and South regions. The researchers found that private well users and those in public water systems have higher urinary a...
A retrospective study found that elevated CA 19-9 and CEA levels were associated with worsened outcomes in duodenal adenocarcinoma patients. The study, which included 68 patients, suggests that these tumor markers may show promise as prognostic tools for this rare malignancy.
Researchers developed an electronic biosensor using DNA aptamers to detect biomarkers in whole blood samples. The biosensor successfully detected clinically relevant levels of a marker protein for cardiovascular disease without further sample preparation.
Acute myeloid leukemia is a cancer that affects blood cells and can lead to infection, anemia, and easy bleeding. The Georgia Cancer Center has received a $2.3 million grant to study how cancer cells resist treatment and propose new options to improve patient survival.
Researchers discovered a misfolded alpha-synuclein protein as a potential biomarker for early detection of Parkinson's disease. The test was accurate in detecting the disease 87% of the time and identifying its absence 96% of the time.
Researchers at Karolinska Institutet have discovered that a type of sugar molecule in blood is associated with the level of tau protein, a critical factor in severe dementia. Measuring blood glycan levels can predict Alzheimer's disease risk to 80% accuracy, almost a decade before symptoms appear.
A new study has identified disrupted levels of molecular compounds in maternal blood and cord blood linked to later diagnosis of autism spectrum disorder. The findings shed light on the biological processes that give rise to ASD and could open the door to early diagnosis and treatment.
Researchers identified a technique to detect abnormal protein deposits linked to Parkinson's disease, confirming its accuracy for early detection and characterisation. The α-synuclein seed amplification assay (αSyn-SAA) can identify people with Parkinson's disease and at-risk individuals prior to diagnosis.
A simple blood test for ALS has been developed using microRNA analysis, which can accurately identify patients with the disease. The test uses a unique protein called L1CAM to concentrate diagnostic particles from extracellular vesicles in the bloodstream.
A study published in Cancer Cell found that prior treatments, such as CTLA-4 blockade, modify the response to anti-PD-1 checkpoint blockade therapy. The research analyzed data from over 500 patients and identified key factors associated with treatment response. This finding may help scientists create more precise future treatments.
Psychiatrists at Indiana University School of Medicine found deaths by suicide increased during the week of a full moon, especially in people over age 55. They also identified 3-4 p.m. and September as peak times for suicides.
A blood draw can provide valuable information on the effectiveness of peptide receptor radionuclide therapy for neuroendocrine cancer patients. Blood-based biomarkers PPQ and NETest were found to predict PRRT response with 96% and 90% accuracy, respectively. The study opens possibilities for tailoring treatment to individual patients.
Researchers have identified a biomarker signature that can predict which patients with kidney cancer will respond well to immunotherapy. The signature is based on the number of immune cells in and around tumors, the amount of dead cancer tissue, and mutations to a tumor suppressor gene called PBRM1.
Researchers have developed a new method called Nano-tRNAseq to measure both the abundance and modification of tRNA molecules in a single step. This technology has significant advantages over conventional techniques, offering rapid, cost-effective, and high-throughput analysis with single-molecule resolution.
Researchers identified potential neurological biomarkers of long COVID-19 in nonhuman primates, which could aid in diagnosis, monitoring, and treatment. The study found elevated proteins associated with neurodegenerative disorders in the brain, cerebrospinal fluid, and blood after SARS-CoV-2 infection.
A new study published in Neurology shows that younger brain age is associated with superior post-stroke outcomes, suggesting a potential biomarker for stroke rehabilitation. The research team used multi-site data sets and 3D brain structural MRIs to analyze the relationship between brain age and stroke recovery.
A recent study identified novel genes that influence PARP inhibitor response in prostate cancer, including MMS22L and RNASEH2B. The research found that loss of CHEK2, a previously approved biomarker, confers resistance to PARP inhibition, highlighting the need for comprehensive genomic analysis to improve treatment decisions.
A study by Johns Hopkins Medicine researchers found that certain biomarkers in urine and blood can predict the risk of developing chronic kidney disease (CKD) in patients with acute kidney injury (AKI). Higher levels of KIM-1, MCP-1, and TNFRI were associated with a increased risk of CKD progression.
A new study identifies several cytokine markers associated with poor prognosis in New-Onset Refractory Status Epilepticus (NORSE) patients. The researchers found that the concentration of these inflammatory proteins was higher in NORSE patients than controls, and their increase was correlated with short-term and long-term neurological ...
Researchers used explainable AI to analyze gut microbiomes for CRC biomarkers, discovering four distinct subgroups with unique bacterial profiles. This approach shows promise for a more personalized microbiome exploration and potential disease subgroup identification.
Seer researchers identified four structurally distinct protein isoforms that were differentially expressed in non-small cell lung cancer patients. These findings suggest that these protein isoforms may play a role in NSCLC disease pathogenesis, potentially leading to the development of new diagnostic markers or therapeutic targets.
A new study found that specific biomarkers in blood can predict PTSD likelihood, diagnose disorder, or monitor treatment response. Researchers discovered four biomarkers with significant differences between those with PTSD or sub-threshold PTSD and those with high resilience.
Breast tumor microbes vary significantly among women of different ethnicities, with potential implications for personalized care and disease progression. Researchers identified distinct microbial biomarkers associated with genes involved in tumor aggressiveness and immune response.
A study of 110,780 participants in the UK Biobank found that individuals with a lifetime history of mental illness had metabolite profiles suggesting they were biologically older than their actual age. This may contribute to shorter lifespans and increased age-related diseases among those with mental health problems.
A new point-of-care testing kit will facilitate early diagnosis and monitoring of Alzheimer's Disease in primary clinics or home settings. The kit detects biomarkers in skin samples, enabling early identification of individuals at greatest risk of dementia.
Researchers analysed wastewater from 10 cities to detect chemical and biological markers of health, including pesticides, pharmaceuticals and disease-causing viruses. The study found that analysing wastewater on a large scale could spot new outbreaks of diseases in communities early on.
New research reveals coffee consumption may help reduce the risk of type 2 diabetes by lowering inflammatory biomarkers in the body. A study published in Clinical Nutrition found that a one cup per day increase in coffee consumption was associated with a 4-6% lower risk of T2D.
Researchers identified high expression of glypican-1 in primary solid tumors, correlating with poor prognosis in various cancer types. Suppression of GPC1 attenuated cancer cell proliferation, suggesting its potential as a novel diagnostic tool and target for therapy.
A recent study found that certain microbial metabolites are associated with liver fat content in individuals with fatty liver disease. The researchers identified degradation products of amino acids and differences in testosterone levels as potential biomarkers.
ISB researchers constructed a biological body mass index that offers a more accurate representation of metabolic health. The team found that even with no weight loss, individuals can be getting healthier biologically through positive lifestyle changes.
A team of researchers from Syracuse University has developed a tiny, nano-sized sensor that can detect protein biomarkers in a sample at single-molecule precision. The sensor is capable of identifying and quantifying specific proteins associated with various hematological malignancies and solid tumors.
A study by Tokyo Medical and Dental University reveals that chronic kidney disease promotes vascular calcification by altering signaling molecules in blood vessel walls. The researchers identified four microRNAs that target a key pathway driving calcification, providing potential biomarkers and therapeutic targets for both diseases.
Researchers collected electrophysiological recordings from prefrontal cortical regions in three human subjects with severe treatment-resistant depression. They found lower depression severity correlated with decreased low-frequency neural activity and increased high-frequency activity.
The European Platform for Neurodegenerative Diseases has launched its Cohort Catalogue, featuring an extensive list of international cohorts across the neurodegeneration disease spectrum. Researchers can search and filter cohorts by metadata characteristics to discover relevant studies and initiate new collaborations.
A study from George Mason University found elevated insulin and hemoglobin A1C levels in early elementary-aged Latino youth with obesity, a risk factor for cardiometabolic diseases. The research aims to identify at-risk children and implement interventions earlier to mitigate the effects of childhood obesity.
Researchers have discovered higher levels of immune proteins in the blood before and after epileptic seizures. The study suggests a potential biomarker for epilepsy, which could be identified using a simple blood test. This finding may help distinguish epilepsy from other conditions, such as psychogenic non-epileptic seizures.
A new urine gene test can detect genetic mutations in urine that predict bladder cancer up to 12 years in advance of clinical symptoms. The test was trialled on over 50,000 participants and showed promising results, suggesting its potential for early detection and reduced unnecessary invasive procedures.
Researchers have identified a biomarker that can select breast cancer patients who may benefit from denosumab treatment. The study found that tumors with high RANK protein expression are associated with poor prognosis and response to chemotherapy, suggesting that denosumab may be effective in hormone-receptor negative tumors.
Researchers at Indiana University School of Medicine have developed a blood test for anxiety that can help identify biomarkers associated with the disorder. The test has been validated by three independent cohorts and shows promise in matching patients to effective treatments, such as medications and nutraceuticals.
Lung cancer patients with moderate to severe depression are 2-3 times more likely to have inflammation levels that predict poor survival rates, according to a new study. The results suggest depression may be as important or even more important than other factors in determining lung cancer outcomes.
A study has identified new microRNA biomarkers for the partial remission phase of type 1 diabetes and linked one of these microRNAs to immunoregulatory processes. The findings suggest a unique microRNA signature expression during this phase, which modulates regulatory T cell expansion and PD-1 expression.
The HALP score, a novel immune-nutritional marker, has been linked to prognostic ability in different cancer types. It integrates indicators of immune status and nutritional status, showing promise as a cost-effective biomarker.
Researchers will use data from New IDEAS study to enroll a representative population of patients with memory impairment and their family members. The goal is to better understand the psychological impact of receiving biomarker-informed diagnoses and inform best practices in diagnostic evaluation.
The NCCN Annual Conference will debut a new hybrid format featuring in-person events at a new venue, allowing for hallway conversations and networking opportunities. The conference will also showcase more than 100 abstract poster presentations on various oncology-related categories.
Researchers discovered that telomere shortening is associated with early subjective depressive symptoms and cognitive complaints among healthy elderly individuals. The study also found a link between telomere shortening and increased interleukin-6 levels.
The CALYPSO study assesses the efficacy of combined MET and PD-L1 inhibition in patients with MET-driven metastatic papillary renal cancer. Response rates were 29% for all patients and 53% for those with MET-driven tumors, with improved progression-free survival observed in MET-driven status.
A new method developed by Flatiron Institute researchers can diagnose COVID-19 with near-perfect accuracy, even in asymptomatic patients. The technique monitors the body's molecular response to a viral attack and measures mRNA molecules to identify an immune response.
The American Roentgen Ray Society (ARRS) has awarded four radiologists with the 2023 Resident/Fellow in Radiology Awards for their exceptional research, education, and administrative work. Drs. Elliot T. Varney, Vincius Alves, Luca Pasquini, and Pallavi Srivastava will present their research findings at the upcoming ARRS Annual Meeting...
Researchers found altered proteins in women's blood during the third trimester, correlating with brain signaling activity and pro-inflammatory pathways. The study aims to develop early diagnosis and treatment protocols for perinatal mood disorders.
A new study has identified a biomarker, placental growth factor (PlGF), which is associated with cognitive impairment and dementia due to vascular brain injury. Higher levels of PlGF in the bloodstream are linked to increased risk of cognitive decline and cerebral small vessel disease.
A new UK Biobank study analyzes data on nearly half a million participants and finds that Asian and Black groups have lower all-cause mortality rates compared to White groups. The study also identifies specific risk factors associated with each ethnic group, such as mental health diagnoses for Asians and parasitic diseases for Blacks.
The study found that nicotinamide riboside (NR) increases NAD+ levels in the blood, which is associated with lower biomarkers of neurodegenerative disease. Researchers measured NAD+ directly in extracellular vesicles and found a correlation between increased NAD+ and changes in disease biomarkers.
The American Gastroenterological Association recommends integrating non-invasive biomarkers for patients with ulcerative colitis in remission or with current symptoms. Biomarkers provide accurate insights into disease activity, offering a cheaper and more convenient option for monitoring.
A recent study suggests that routine evaluation of HER2 expression in ductal carcinoma in situ (DCIS) is crucial to avoid under or overtreatment. The research found a significant association between HER2 overexpression and a higher risk of recurrence, as well as improved radiotherapy outcomes.
Researchers examined three epigenetic age acceleration measurements and found inverse associations with lung cancer risk in men and younger participants. However, these findings did not support a positive association between epigenetic age measures and lung cancer risk in the study.