Articles tagged with Biomarkers
Scientists used AI-driven PandaOmics platform to analyze gene expression datasets from DNA repair diseases, identifying biomarkers associated with treatment response. The study focused on genes that stratify cancer patients by survival outcomes, providing potential targets for personalized therapies.
Researchers discovered three essential amino acids - leucine, valine, and tryptophan - as potential metabolic biomarkers for HCC. The study used metabolomics to analyze the differences in tumor and non-tumor tissue metabolomes, revealing striking differences that could aid in diagnosis.
Researchers have identified optimal blood tests to detect Alzheimer's disease at its earliest stages. The study found that phospho-tau217 is a reliable marker for monitoring disease progression and selecting individuals for novel trials.
Researchers found shared genetic factors that contribute to severe COVID-19 risk and blood analyte levels. High triglyceride levels were strongly linked to increased risk of severe disease, supporting the use of lipid-lowering drugs against severe COVID-19.
A team of scientists has identified three new biomarkers for detecting the consumption of emerging synthetic cannabinoids like OXIZID. These biomarkers will facilitate work by drug enforcement agencies worldwide in monitoring OXIZID abuse, enabling more accurate identification of abusers and potentially preventing overdoses.
Researchers identified formic acid as a sensitive urinary biomarker for early-stage Alzheimer's disease, which could lead to large-scale screening programs. The study found that formic acid levels correlate with cognitive decline and can predict disease stage when combined with blood-based biomarkers.
Researchers at University of Chicago Medical Center have identified biomarker predicting response to combined RT and ICB treatment in mNSCLC. High tumor aneuploidy associated with improved survival when RT is added to ICB, while low aneuploidy shows no survival benefit.
Researchers at ETH Zurich have identified 76 proteins that could serve as biomarkers for Parkinson's disease, with their molecular structures differing between healthy and diseased individuals. The study uses a unique method to analyze protein shapes in cerebrospinal fluid, providing a promising new approach for diagnosis and potential...
A new biomarker has been identified with up to 89% accuracy for corticobasal degeneration, a primary tauopathy. The discovery could accelerate progress toward therapies for this rare brain disease, which is often misdiagnosed due to similar symptoms.
Researchers at VHIO have established a unique collection of metastatic cholangiocarcinoma patient-derived xenografts to help prioritize potential clinical trials and deliver precision patient care. The models have identified mutations in genes such as BRCA2, which could serve as a biomarker for response to PARP inhibitors.
Researchers found that individuals with persistent asthma have higher levels of inflammation and artery plaque, which may increase heart attack or stroke risk. The study also highlights the importance of addressing risk factors for cardiovascular disease in people with persistent asthma.
A new study has identified brain markers of attention-deficit/hyperactivity disorder (ADHD) in children using MRI data. The researchers found changes in almost all regions of the brain, including abnormal connectivity, a thinning of the brain cortex, and significant white matter microstructural changes.
Research findings suggest that skewed X chromosome inactivation may indicate increased risk of developing chronic diseases, including cardiovascular disease and cancer. XCI-skew is a measure of how many cells in a tissue inactivate the same parental X chromosome.
Researchers found reduced levels of D-amino acids in patients with severe COVID-19 and IAV infection, suggesting they could be used as biomarkers. Supplementation with D-alanine improved survival rates and clinical outcomes in mouse models of both infections.
Researchers found that specific immune-related proteins, such as CCL21, FLT3L, and IL-13, can differentiate between neurodegenerative diseases like CTE, AD, PSP, CBD, and AGD. The study's results highlight the importance of the immune system in neurodegenerative diseases and provide novel potential biomarkers for diagnosis.
A new potential biomarker for severe COVID-19 has been identified by researchers at Karolinska Institutet in Sweden. Elevated levels of the cytokine IL-26 are linked to increased inflammation and tissue damage in patients with acute COVID-19.
Researchers at Michigan Medicine found a strong association between lower grip strength and accelerated biological aging in middle-aged and older adults. This study provides evidence that maintaining muscle strength across the lifespan may help protect against age-related diseases.
A Cedars-Sinai study found that a specific protein imbalance can predict the risk of developing severe preeclampsia. The blood test measures the ratio between two proteins involved in blood vessel development, which accurately predicted preterm preeclampsia with severe features over 90% of the time.
A retrospective study found that tumor hyaluronan levels are associated with improved time to progression in non-small cell lung cancer patients. HA-high tumors showed a trend towards improved clinical benefit, suggesting its potential as a prognostic biomarker and therapeutic target.
Researchers have identified a new biomarker, p-tau198, that could help diagnose Alzheimer's disease earlier than current tests. This biomarker shows promise in distinguishing AD from other neurodegenerative diseases and mild cognitive impairment.
Researchers have identified a parasitic protein unique to hypnozoites, which could serve as a potential biomarker of latent malaria vivax infections. The findings lay the groundwork for eliminating the disease by detecting its presence.
A novel insulin-like peptide hormone, INSL3, remains consistent throughout a man's life, making it a reliable predictive biomarker for age-linked disease. High levels of INSL3 in young men correlate with a range of age-related illnesses, while low levels increase the risk of acquiring these diseases.
A study using mRNA and miRNA expression profiles identified molecular signatures that can differentiate muscle invasive bladder cancer patients who respond to neoadjuvant chemotherapy from those who do not. The research found distinct gene pathways and subtypes associated with response, which may lead to more effective treatment delivery.
A study by Brigham and Women's Hospital found that specific immune system biomarkers are linked to the acquisition of both HIV and genital herpes. The researchers identified unique predictors for each disease, providing new targets for preventive treatments.
A higher urine-to-plasma urea ratio is associated with faster decline in eGFR and development of kidney failure in patients with common forms of CKD. This biomarker may improve risk prediction, particularly in low-cost, easily measurable assays.
A recent study found that microRNA-145 can identify breast cancer patients at lower risk of recurrence and those who may need additional therapy. The biomarker was measured in patients' blood samples during chemotherapy and predicted long-term oncological outcomes.
A study published in the Journal of Alzheimer's Disease found that analyzing patients' drawing tests can help diagnose Alzheimer's disease (AD) and distinguish it from dementia with Lewy bodies (DLB). The researchers discovered that DLB patients showed differences in speed-, pressure-, and pause-related features, whereas AD patients sh...
A new metric estimates cumulative exposure to PFAS chemicals, enabling comparisons across studies and applications. The calculator takes into account patterns of exposure to multiple chemicals, providing a robust tool for biomonitoring and disease assessment.
Researchers at the University of Cincinnati are awarded a $3.5 million NIH grant to examine how alcohol use alone or in combination with fentanyl affects HIV medications, including PrEP medication. The study aims to determine metabolite signatures and pharmacological biomarkers of PrEP in HIV-negative populations.
Researchers from Brigham and Women's Hospital found that circulating tumor HPV DNA levels are linked to lymph node presence, making the test less effective for screening. This limits the use of ctHPV DNA testing for early diagnosis and treatment of oropharynx cancer.
Researchers at Penn State aim to create a minimally invasive system using machine learning and multimodal biosensing platforms to detect Alzheimer's disease in its early stages. The system has the potential to improve detection accuracy and reduce false positives.
Two studies found that cigarette smoke and e-cigarette vapor have similar cardiovascular effects due to airway irritation. This irritation can lead to vascular damage and impaired blood vessel function. The research suggests that dual product use may be worse than single product use, highlighting the need for stricter regulations.
Two NIH-funded studies show long-term e-cigarette use can impair blood vessel function, increasing the risk for cardiovascular disease. The findings also suggest combining e-cigs with tobacco may increase health risks compared to using them individually.
A recent study published in BME Frontiers developed an AI-based approach that rapidly transforms autofluorescence images into virtual histological images for accurate HER2 assessment. This computational staining process takes only a few minutes per sample and does not require expensive facilities or toxic chemicals.
Scientists at the Francis Crick Institute developed a new method to study proteins released by cells, which could lead to tracking diseases like cancer. The Bio-Orthogonal Cell line-specific Tagging of Glycoproteins (BOCTAG) method identifies proteins uniquely made by diseased or cancerous cells, even in complex environments.
A new study has identified a specialized and distinctive type of microglia with enhanced antioxidant function in the ischemia/reperfusion injured brain, linked to stroke. The presence of Peroxiredoxin-1 protects against acute I/R injury, reducing microglial cell death and inflammatory responses.
A study from Tokyo Medical and Dental University reveals that the TGF-β signaling molecule can induce EMT in oral cancer cells, leading to high motility and metastatic potential. KRTAP2-3 expression is associated with poorer overall survival, suggesting its role as a prognostic biomarker.
Researchers found that endogenous retrovirus RNA is present in all non-diseased tissue types, including cerebellum and thyroid tissues. This discovery has important clinical implications for the use of HML-2 expression as a cancer biomarker or therapeutic target.
A study found that higher levels of inflammatory markers are associated with lower trabecular bone scores, indicating poorer bone health. Dietary intervention with prunes may counteract inflammation's negative effects on bone health, preserving cortical bone density and strength in postmenopausal women.
A new study found that soluble urokinase plasminogen activator receptor (suPAR) levels are significantly higher in patients with heart failure, predicting both heart failure and death. When combined with traditional measures like BNP, suPAR's predictive ability increases.
A study published in Arthritis & Rheumatology has identified CRTAC1 as a specific biomarker of osteoarthritis, associated with both prevalent and incident knee and hip OA. The protein is also a strong predictor of progression to joint replacements, holding promise for early diagnosis and treatment.
A new study aims to diagnose severe neurodegenerative diseases like ALS and FTD with the help of speech tests. AI can analyze subtle nuances of speech patterns, including pauses, speed, and melodic aspects, to detect early changes.
A Singapore research team has validated a cancer diagnostic assay designed with Asian-centric biomarkers, showing high precision and sensitivity in measuring four major classes of biomarkers. The assay's performance was validated with clinical specimens, indicating its promise for reliable deployment in a clinical setting.
Researchers propose an optical imaging system for real-time hypoxia imaging in cancer treatment. The technique utilizes protoporphyrin IX to enhance contrast between tumors and healthy tissues, allowing for more effective surgical removal.
A UC Riverside-led study found that acute THS exposure initiates mechanisms of inflammatory skin disease and elevates urinary biomarkers of oxidative harm. The researchers discovered elevated molecular biomarkers in blood associated with early-stage activation of contact dermatitis, psoriasis, and other skin conditions.
Researchers analyzing over 3,000 blood samples from Alzheimer's patients and healthy individuals to identify reliable biomarkers. They investigate how well blood tests can diagnose Alzheimer's disease and predict its progression.
Researchers at Hokkaido University have developed a biosensing technology to detect amyloid β build-up in the brain from biomarkers in blood samples. The Digital ICA TM technology can detect Aβ-binding exosomes in mice, increasing with age and disease progression.
A new CAPSTONE study aims to identify inflammatory biomarkers associated with positive and poor outcomes in patients after intracerebral hemorrhage (ICH) strokes. By analyzing patient blood and plasma samples, researchers hope to develop targeted treatments to prevent long-term brain degeneration.
A study found that very light exercise activates brain pathways leading to improved mood and cognitive function. Researchers used pupillometry, a reliable indicator of arousal, to measure pupil dilation during graded exercise.
The Critical Path Institute has launched a pre-consortium collaboration with the FDA's CBER and CDER to accelerate medical product development in alpha-1 antitrypsin deficiency. The collaboration aims to define unmet needs in drug development and lay the groundwork for specific solutions.
Researchers found elevated traumatic brain injury biomarkers in football players in skill positions, including quarterbacks, wide receivers, and defensive backs. The study suggests that head impact magnitude, not frequency, causes the greatest elevations in TBI biomarkers.
Researchers are working on a regulatory science tool based on biomarker data to assess the efficacy of rehabilitative devices for post-stroke motor recovery. The project aims to shed light on how neurological markers can demystify complex neural communication patterns in patients.
Researchers have used single-cell sequencing to uncover novel gene expression patterns in injured kidney cells, providing new avenues for biomarker discovery and treatment. The studies reveal that epithelial cells of all tubule segments are involved in the injury processes, with distinct molecular patterns across patients.
A study by Johns Hopkins Medicine researchers found that changes in extracellular RNA communication are associated with postpartum depression, potentially leading to the development of a blood test for risk prediction. The analysis also suggests that autophagy malfunction may contribute to PPD.
The Keck School of Medicine of USC's Stevens INI has received a $149 million grant to study Alzheimer’s disease among diverse communities. The HABS-HD study aims to develop biomarkers that determine risk for developing the disease, addressing health disparities among Hispanic and African American populations.
Researchers used multi-omics technologies to analyze samples from 350 patients with major depressive disorder, finding distinct blood-based signatures between those with and without a history of attempted suicide. Variations in genes CLOCK and ARNTL were associated with lower antidepressant response rates.
Scientists have identified two new epigenetic biomarkers that can predict the development of aggressive prostate cancer, enabling clinicians to develop more personalized treatment plans. The study used comprehensive molecular analysis of 185 biopsies from men with prostate cancer diagnosed between 1990 and 2000.
Researchers at Universidad de Navarra identified a biomarker that predicts CAR T cell therapeutic capacity, which could improve treatment outcomes for patients. The study found that high CAR density in CAR T cells is associated with a worse clinical response in hematological tumors.
A recent study found that cancer biomarker data is biased towards European populations, potentially misclassifying patients of Asian or African descent. The researchers propose a computational approach to correct this bias, which could have significant implications for treatment selection.
The National Institutes of Health has awarded a $10.7 million grant to Cleveland Clinic to expand a national research consortium focused on improving diagnosis and treatments for Dementia with Lewy Bodies. The consortium, which includes multiple clinical sites, aims to identify biomarkers for disease and develop new therapies.