Articles tagged with Hormone Therapy
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The American College of Obstetricians and Gynecologists (ACOG) has released new guidelines on using progesterone to prevent preterm birth. Preliminary results show promise in reducing the risk of preterm birth by one-third and half. However, more research is needed to fully understand its effectiveness.
A study of 1,204 men treated with radiation therapy found that hormone therapy significantly increases the risk of moderate to severe genitorurinary and gastrointestinal side effects. Hormone therapy can extend lives but complicates treatment decision-making.
A study tested the ASTRO consensus definition of biochemical failure after combined radiation treatment and hormone therapy, finding it may not accurately predict future disease progression. The study suggests that approximately 20-30% of patients will experience biochemical failure but not continued rises in PSA levels
Two studies found that combining parathyroid hormone (PTH) and alendronate increases bone mineral density (BMD) at least as well as or better than single drug treatment. Further studies are needed to determine the optimal effects of these drugs, particularly through sequential or cyclic therapy.
A study published by the University of Pittsburgh found that hormone therapy has no benefit to postmenopausal women, even those at high risk of fracture. The research suggests that estrogen plus progestin increases bone mineral density but does not outweigh risks associated with breast cancer and heart disease.
Prostate cancer mortality rates are falling fast in the US and Europe due to earlier diagnosis and hormonal treatments. Research shows that prompt surgery and hormonal therapy can improve 10-year survival rates for both prostate and breast cancers.
A major axis within bone cells regulates bone production and loss, providing a potential new target for treating debilitating osteoporosis. Local regulation of bone mass is now believed to occur primarily in the bone, not in the brain as previously thought.
A new study suggests that black cohosh can effectively reduce hot flashes and other menopausal symptoms by binding to serotonin receptors in the brain. The herb is found to have no estrogenic effects, making it a potentially safer alternative to traditional hormone replacement therapies.
A study examined whether limited-field radiation therapy could be an effective alternative to whole-breast radiation therapy for patients at low risk of recurrence. The results showed no significant difference in local recurrence rates or overall survival between the two groups after five years of follow-up.
Researchers at Wake Forest University Baptist Medical Center found that Zemplar, a drug mimicking vitamin D hormone, sensitizes cancer cells to radiation therapy without harming normal cells. The combination reduced radiation dose by 2.4 times while maintaining treatment efficacy.
A substantial increase in breast cancer risk is associated with combination hormone replacement therapy, particularly oestrogen-progestogen therapy. Current users of HRT have a 22% increased risk of death from breast cancer compared to never-users.
A recent study published in NEJM found that hormone replacement therapy does not effectively slow down the progression of atherosclerosis in postmenopausal women who already have cardiovascular disease. The study suggests that estrogen and progestin may not be effective in treating established coronary artery disease.
A large study found that estrogen replacement therapy prolongs the QT interval, increasing risk for arrhythmia and heart problems. Women who used hormone therapy had a 50% higher odds of QT prolongation compared to those who never used hormones.
A new study suggests that psychological factors like anger and anxiety may boost heart risk in postmenopausal women. Hormone replacement therapy provides some artery protection for women with high levels of anger and Type A behavior, but not for those with anxiety or depression.
The study found that rhTSH reduced the mean effective half-life of radioiodine by 26% in patients who received it before therapy. This reduction allowed patients to clear 131I more rapidly, resulting in lower radiation levels in their blood and tissues.
A study analyzing data from pivotal trials of Actonel revealed that bone mineral density explains only a small portion of nonvertebral fracture risk reduction. The analysis found that BMD increases accounted for just 12.2% of the fracture risk reduction at lumbar spine, and 5.5% at femoral neck.
Researchers at U-M examined the effects of aging and menopause on bone health and found that natural estrogen withdrawal after menopause causes more significant bone loss. The study suggests that hormone replacement therapy may not be necessary for all middle-aged women with regular menstrual cycles.
A study of 16,608 postmenopausal women found that estrogen plus progestin therapy was associated with a 31% higher risk of stroke compared to placebo. The risk for ischemic stroke was particularly elevated, with a 44% increase.
A recent study found that combined hormone therapy increases the risk of dementia in women over 65, doubling the risk compared to placebo groups. The research suggests that hormone replacement therapy may be more harmful than helpful for preventing age-associated memory loss.
Researchers found that women taking estrogen and progestin experienced a twice increased risk of dementia compared to those on placebo pills over a 5-year period. The most common type of dementia was probable Alzheimer's disease, accounting for 66% of cases.
A recent study by Wake Forest University Baptist Medical Center found that combination hormone therapy increases the risk of probable dementia in women aged 65 and older, with approximately 23 additional cases per year. The study's results highlight the importance of considering alternative approaches to preventing cognitive decline.
A new study published in JAMA found that a combination therapy of hormone replacement and alendronate was well-tolerated by elderly women with low bone mass. After three years, participants taking the combination therapy showed significantly greater increases in bone mass compared to those taking individual therapies.
A UC Davis study found that a soy extract supplement reduced PSA levels in men with untreated prostate cancer. The study involved 62 men who received genistein concentrated polysaccharide for six months, resulting in an average decrease of 17% in PSA levels.
Researchers discovered that specific p53 mutations facilitate androgen-independent growth in human prostate cells, while another gene, Id-1, promotes tumor aggressiveness. These findings could lead to new therapeutic strategies for hormone-independent prostate cancer.
A recent study published in the Journal of the American College of Cardiology found that oral estrogen therapy increased C-reactive protein (CRP) levels, while transdermal estrogen therapy had no effect. The researchers suggest that the route of administration may be a crucial factor in minimizing cardiovascular risks associated with e...
A new research study suggests that grape seed extract can blunt salt-sensitive hypertension in postmenopausal women, similar to the effects of plant estrogens or 17ß-estradiol. The study found that adding grape seed extract to a high-salt diet reduced blood pressure in estrogen-depleted female rats.
Researchers found that DHEA did not significantly improve cognitive performance or ratings of disease severity in a randomized, double-blind trial. The study's small size and high drop-out rate may limit the findings, with larger studies needed to confirm the results.
Researchers found a significant association between moderate caffeine consumption and reduced risk of Parkinson's disease in postmenopausal women who don't use hormone replacement therapy. However, high caffeine intake increased the risk of PD in women using HRT, suggesting an estrogen-caffeine interaction
High levels of AIB1 expression in breast cancer tumors are associated with poorer tamoxifen treatment outcomes. Patients with both high AIB1 and HER-2 expression have significantly worse disease-free survival compared to other patient groups.
Researchers believe initiating hormone replacement therapy in younger women without advanced vessel disease can prevent heart vessel disease. However, delaying HRT may lead to ineffective or potentially harmful effects on older women with more advanced vessel disease.
A recent study found that combination hormone therapy increased the risk of stroke in postmenopausal women, including those with and without high blood pressure. The therapy was found to be ineffective for primary prevention of cardiovascular disease and heart attack.
The biogerontological community is at war with anti-aging medicine, threatening the status and funding of their own research. Binstock argues that this campaign may inadvertently undermine their own legitimacy and research support by blurring public understanding of the difference between their work and pseudoscientific products.
Researchers found that hormone therapy (HRT) significantly reduced the risk of developing type 2 diabetes among postmenopausal women with coronary heart disease and impaired fasting glucose. The study, published in Annals of Internal Medicine, suggests HRT may have metabolic benefits that outweigh the risks for certain high-risk groups.
A study of 1000 postmenopausal women who survived a first heart attack found no difference in recurrent heart attacks or cardiac death between those given oestrogen therapy and placebo. The study provides insufficient evidence to alter current guidance against HRT for cardiovascular disease prevention.
A study published in Nicotine & Tobacco Research found that postmenopausal women who quit or cut back on smoking experienced a significant drop in SHBG and NTx levels, two proteins linked to bone loss. This discovery may help explain how smoking contributes to osteoporosis in this demographic.
A randomized trial found that a single dose of 1.5 mg levonorgestrel is as effective as traditional regimens for emergency contraception, with no significant differences in pregnancy rates or side-effects. The new regimen simplifies use and reduces side effects, allowing women to begin regular contraception sooner.
A large randomized trial found no improvement in cognitive function among postmenopausal women with coronary disease after four years of hormone replacement therapy. The study provides no evidence regarding the effect of estrogen-only therapy on cognition, contradicting some previous studies that showed an improvement in younger women
A large clinical trial found that hormone replacement therapy did not reduce the progression of coronary disease in postmenopausal women, while high-dose antioxidant vitamins may even increase mortality risk. The study used angiography to assess the effects of hormone therapy and antioxidants on cardiovascular health.
A new study supports routine mammography screening for women over 75, while a separate study finds that postmenopausal hormone use and heavy drinking increase breast cancer risk. The guidelines also recommend against combined estrogen and progestin therapy for preventing cardiovascular disease in postmenopausal women.
A recent study found that a combination of growth hormone and sex steroids showed significant increases in lean body mass and decreases in fat mass, but also reported common side effects such as joint pain and swelling. The study suggests that the treatment is not yet ready for prime time due to its adverse effects.
A study using female rats found that long-term estrogen replacement therapy impaired memory performance, especially when combined with chronic brain inflammation. This effect is analogous to the observed decline in cognitive function in postmenopausal women with Alzheimer's disease who receive continuous estrogen therapy.
Researchers have discovered a promising new treatment that preserves bone mass in both female and male mice without affecting reproductive organs. Estren, a class of compounds called ANGELS, appears to trigger bone-building activities without the side effects associated with sex hormone therapy.
A new study found that synthetic hormone estren can build bone in animals without affecting reproductive organs. The researchers tested estren, estrogen, and testosterone in mice with and without sex organs, showing estren's potential to provide a safe form of hormone replacement therapy.
A new study published in the journal Science suggests that estren, a synthetic compound, can build bone and improve bone density and strength without affecting reproductive organs. The findings may indicate a potential alternative to standard hormone replacement therapy for treating osteoporosis in both men and women.
A study by Professor Lesley Fallowfield found that psychosocial discussions are often overlooked in cancer treatment consultations. Training can help doctors and nurses discuss personal and sexual issues comfortably and sensitively, improving patient outcomes.
The American College of Physicians' Task Force concludes that combined estrogen and progestin therapy has more likely to cause harm than benefit for most women. The evidence is insufficient to recommend hormone therapy alone or together for preventing chronic conditions in postmenopausal women with hysterectomies.
A population-based study of 2,786 diabetic and non-diabetic postmenopausal women found that HRT had a positive effect on blood levels of fats and glucose. Diabetic women on HRT had significantly lower fasting levels of total cholesterol and higher levels of beneficial high-density lipoprotein.
The study found that hormone replacement therapy (HRT) increases the risk of breast cancer, pulmonary embolism, and stroke in women, while reducing the risk of colorectal cancer and hip fractures. HRT may also increase the risk of cardiovascular disease among older women.
A recent study by OHSU suggests that hormone replacement therapy (HRT) can lead to improved breast cancer detection and survival rates. The research found that HRT users had a 100% survival rate after six years, compared to an 87% survival rate for non-users.
The InnoLet system features a dosing dial and reversible dose mechanism, making it easier for patients to administer accurate doses. Clinical studies show that 95% of participants rated the device as 'very easy' or 'easy' to use.
A new study found that flu vaccines can benefit healthy working adults aged 18-50 by avoiding lost work time and treatment costs. Hormone replacement therapy does not prevent or reduce the rate of developing heart disease, contrary to earlier studies.
Researchers are conducting clinical trials to restore sexual desire in menopausal women using an investigational skin patch. Approximately 43% of women experience some form of difficulty in their sexual function, significantly higher than men.
A study of 44,241 women found that postmenopausal estrogen-only therapy increases the risk of ovarian cancer by 60%, with a greater risk for those using therapy for 10 or more years. The relative risk was highest for women who used estrogen for 20 or more years.
Researchers found that adding hormone-suppression therapy to radiotherapy for advanced prostate cancer significantly improved five-year disease-free survival rates. The study involved 415 patients, with those receiving combined therapy showing a substantial increase in overall survival rates.
A new study suggests that growth hormone therapy can significantly enhance human thymic function and increase the production of new T cells in HIV-infected patients. This could potentially help preserve and restore their immune systems. However, more research is needed to confirm these findings and ensure the benefits outweigh the risks.
The Women's Health Initiative has stopped its trial on estrogen-progestin combination Prempro due to significant increased risk of breast cancer and cardiovascular events. Women taking this medication will continue with regular contacts, exams, and mammograms.
A new needle-free device called J-Tip has been successfully used to administer hormones to women undergoing IVF treatment. The device enabled the retrieval of eggs from 16 out of 20 women, resulting in four pregnancies. Patient acceptance was high, with diaries indicating a clear preference for the needle-free approach.
A long-term study of hormone therapy in postmenopausal women with heart disease found no reduction in heart attack risk and increased blood clot risk. The therapy also showed a higher risk of gallbladder disease requiring surgery.
A study of 50 healthy postmenopausal women found that a specific exercise program reduced the risk of vertebral fractures and retained benefits for eight years after completion. The exercise group had lower bone density loss and better back strength than the control group.
Research by Wake Forest University professor suggests that hormone replacement therapy can help prevent heart vessel disease when started at the right time. Studies on postmenopausal monkeys and younger women have found a strong link between estrogen therapy and reduced fatty build-up in the heart's arteries.