Research on therapies used across medicine and how they perform. Covers weight-loss injections, hormone therapy, stem-cell approaches, pain relief, and drug targets.
US public health websites lack accessibility features for people with low literacy or limited English proficiency, making it harder for them to find COVID-19 treatment information. The study suggests the need for national guidelines on accessibility and readability for these websites.
Researchers discovered that administering oxygen during episodes of dystonia significantly reduces symptoms and improves quality of life. The study found that rapid oxygen delivery interrupts cortical spreading depression, a phenomenon linked to hypoxia and triggering the condition.
Researchers found that an immersive virtual reality (IVR) intervention significantly improved pain and anxiety in pediatric patients undergoing a blood draw. The IVR group showed better outcomes compared to the control group.
Research found PIRI to be an independent predictor of infarct growth rate and 90-day outcomes in large-vessel occlusive stroke. The study suggests PIRI may help identify patients who could benefit from late-window endovascular thrombectomy.
Studies elucidate key aspects of traditional Chinese compounds and modern cancer therapeutics, highlighting the efficacy of R. serra in treating colitis and identifying active components of Gan Cao in treating pneumonia. A new radiolabeled antibody-based probe for detecting PD-L1 expression in cancers also provides a novel approach to ...
A nationwide study found that the CAPTURE screening tool identified roughly half of primary care patients with chronic obstructive pulmonary disorder (COPD) who could benefit from available treatments. However, the tool also flagged a large group of patients with breathing symptoms and abnormalities that didn't rise to the level of COPD.
Early follow-up and frequent GP visits are associated with reduced ED presentations, hospital readmissions, and improved asthma outcomes. Gaps in primary care network care highlight the need for better coordination between hospitals and GPs.
A recent study found that about 1 in 5 people who survived an ischemic stroke had irregular heart rhythms, atrial fibrillation, due to atherosclerosis. The study suggests that these patients are at increased risk of recurrent strokes and highlights the need for continuous cardiac monitoring to detect unsuspected atrial fibrillation.
A large international clinical study found that patients with large strokes had significantly better recovery after endovascular thrombectomy plus medical management. The SELECT2 study showed almost 20% of patients who received thrombectomy regained functional independence, compared to 7% on medical treatment only.
A new study of the FDA-cleared Jada System found that it successfully treated postpartum hemorrhage in 92.5% of vaginal births and 83.7% of cesarean births, with a mean indwelling time of 4.6 hours for vaginal births and 6.3 hours for cesarean births.
A study conducted in Colombia found that online storytelling improved cognitive functions and boosted motivation among people with dementia. The program, adapted from the 'TimeSlips' method, increased appreciation for resilient capacities, leading to greater participation and agency.
A new study suggests that intensive blood pressure treatment may slow the accumulation of toxins in the brain's perivascular spaces, a dynamic area involved in brain clearance. This finding is significant for understanding the relationship between high blood pressure and cognitive decline.
Researchers have developed a novel catalytic approach to synthesize monocyclic 3-(pyrrol-1-yl)-azetidin-2-ones, which show potential as therapeutic agents. The method yields all four diastereomers with high selectivity and has been published in Current Organocatalysis.
A large Dutch study found that the BCG vaccine does not protect elderly people with co-morbidities against COVID-19 symptoms. The study analyzed 6,112 participants and showed no difference in disease manifestations or hospitalizations between those who received the vaccine and those who received a placebo.
A recent study found that recurrent stroke risk has declined over the past 20 years, with a greater decrease observed among women compared to men in South Texas. The study analyzed data from nearly 6,000 first-time ischemic stroke survivors and found that lifestyle changes and medication can help prevent recurrent strokes.
A new study published in the Journal of the American Heart Association found that people hospitalized for sepsis are at a higher risk of heart failure and rehospitalization within 12 years. The researchers analyzed data from over 2 million adults who survived non-surgical hospitalizations between 2009 and 2019.
Scientists have discovered compounds that target the circadian clock and collagen synthesis to improve scar healing. These compounds, which include Dwn1 and Dwn2, modulate cell migration and collagen synthesis without damaging fibroblasts, leading to faster healing times and reduced scarring.
Researchers investigated TB screening effectiveness in Germany and globally, finding mandatory programs may increase participation but don't deliver better results. Voluntary programs are considered more effective, ethically and legally justifiable.
A Korean joint research team has developed a new tissue adhesive that restores damaged corneas by filling them and exposing them to light, potentially treating cornea ulcers without surgical interventions. The new sealant integrates well with adjacent tissues and promotes scar-free corneal tissue reconstruction.
Researchers found that spinal cord stimulation improved insomnia severity index and Epworth sleepiness scale scores by at least 30% in 39.1% and 28.1% of participants, respectively. The study also established minimally clinical important difference values to gauge treatment success.
A new study analyzing over 14,000 people found that parents with sleep disorders have a significantly higher risk of experiencing stress. The study also discovered that children with sleep disorders can nearly double the risk of their parents developing insomnia and sleep apnea.
A recent study found that telemedicine use did not compromise the quality of opioid use disorder treatment during the COVID-19 pandemic. Clinical outcomes for patients treated by clinicians with high and low telemedicine use were similar, suggesting telemedicine as a comparable alternative to in-person care.
A new study found that using two insecticides on bed nets can prevent malaria by killing off resistant mosquito variants. The trial showed a significant reduction in malaria cases among people sleeping under dual-ingredient net treated with one pyrethroid and another active ingredient.
A new American Heart Association scientific statement suggests that surgery should be considered for patients with high-risk pulmonary embolism to improve survival rates. The statement also calls for increased research and data quality registries to better understand the disease process and effective treatments.
A new American Heart Association scientific statement emphasizes the importance of rapid evaluation for TIA, which can lead to full-blown stroke. The statement offers a standardized approach to evaluating people with suspected TIA, including guidance for hospitals in rural areas with limited resources.
A new study published in The Lancet Child & Adolescent Health journal suggests that newborn screening for spinal muscular atrophy (SMA) can lead to better movement ability and independence in affected children. At two years post diagnosis, 11/14 children diagnosed by NBS were walking independently or with assistance.
A recent analysis of 56 clinical trials found that many medical treatments are effective for patients with multiple health conditions. The study suggests that treatment effectiveness is not significantly impacted by the presence of comorbidities.
A team of researchers from Chung-Ang University evaluated three different MALDI-TOF MS approaches used in domestic clinical settings for the identification of molds. They compared the performance and diagnostic accuracy of the Bruker Biotyper, ASTA MicroIDSys, and Vitek MS instruments.
A recent study found that transfusion of COVID-19 convalescent plasma is associated with reduced mortality in immunocompromised patients. The research suggests this therapy may be beneficial for these patients, who are at high risk of severe illness and death from COVID-19.
Researchers at Linköping University developed an artificial neuron that closely mimics biological nerve cells, with 15 out of 20 neural features replicated. The 'conductance-based organic electrochemical neuron' uses ions to control electronic current and demonstrates biorealistic behavior.
A randomized clinical trial of 1,288 adults with mild to moderate COVID-19 found that fluvoxamine treatment did not reduce time to sustained recovery compared to placebo. The study suggests that fluvoxamine at a dose and duration tested may not be beneficial in patients with mild to moderate COVID-19.
A new study has identified distinct patterns of circular RNA expression in human ALS muscle tissue, which display disease-specific gradients and could inform about neuromuscular molecular programs in ALS. The research reveals that specific circRNAs are elevated in ALS muscle biopsies but reduced in spinal cord samples from ALS patients.
A third of orthotists in the UK want to leave their profession due to inadequate working conditions and lack of time with patients. This poses a significant threat to the healthcare sector, highlighting the need for urgent action to address staff satisfaction and retention.
A new technique called πNIRS can monitor brain blood flow non-invasively using a fast two-dimensional camera. This method improves upon previous techniques like iNIRS, enabling faster detection of changes in blood flow related to neuronal activity.
A new paper in Nature Reviews Disease Primers provides a global overview of hazardous drinking and alcohol use disorders, highlighting current approaches to diagnosis, screening, prevention, management, and treatment. The study emphasizes the need for further research, particularly on adolescents and effective behavioral interventions.
Researchers from Kyushu University found that evening hot spring bathing is associated with a lower prevalence of hypertension among Japanese older adults. The study analyzed data from over 11,000 residents over 65 and discovered that those who bathed in onsen after 19:00 were 15% less likely to have hypertension.
A virtual reality game called EPELI has been developed to assess ADHD symptoms in children by simulating everyday situations. The game uses eye tracking and machine learning to detect differences in eye movements, which can indicate attention deficits.
A new study reveals that almost a third of long Covid patients suffer from persistent smell loss, with nearly a fifth experiencing loss of taste. The condition can significantly impact daily life, relationships, and overall well-being.
Researchers have developed a new way to time weak electrical pulses that can stop life-threatening arrhythmias like atrial and ventricular fibrillations. The approach, adaptive deceleration pacing, uses a series of weak pulses spaced farther apart over time.
A recent study published in Clinical Gastroenterology and Hepatology found that complete alcohol abstinence significantly reduces complications of liver cirrhosis and increases lifespan in patients with pronounced portal hypertension. Regular medical check-ups are crucial for those affected.
Researchers developed a new method to target diseased neurons using light, changing their long-term behavior. The approach uses light-sensitive enzymes to create insulating or conductive coatings on cell membranes, tuning excitability in neurons.
A study published in the American Journal of Roentgenology found that reconstruction using BI64 kernel and 0.4-mm slice thickness yielded improved bronchial division identification and pulmonary fissure sharpness without loss in pulmonary vessel sharpness or pathology conspicuity.
A new mesoscopic oblique plane microscopy method captures up to three times more resolvable image points than other similar systems, enabling whole-body volumetric recordings of neuronal activity and blood flow dynamics. The technique allows for single-cell tracking within the complete 3D circulation system for the first time.
A study of 510 children with chronic kidney disease found that declining hemoglobin levels were associated with significant growth impairment even when above guideline-targeted levels. Lower hemoglobin values are linked to poorer growth, independent of kidney function and age.
The study of 12,600 adults in Hong Kong found that viral rebound was not associated with increased risk of mortality. Novel oral antivirals like molnupiravir and nirmatrelvir-ritonavir may be effective treatments for more patients with COVID-19 in the early phase of the infection.
Researchers analyzed data from 5,086 children, finding that health issues were more common among those who tested positive for Covid-19. Symptoms experienced by children and young people with long Covid changed over the course of a year, with some symptoms declining while new ones emerged.
A randomized clinical trial found that two anti-inflammatory strategies reduced disease activity and arterial inflammation in patients with moderate to high rheumatoid arthritis. The treatments had no differences in cardiovascular risk reduction, highlighting the importance of specific clinical trials for this population.
The American Psychiatric Association's December journal issues explore new therapeutic approaches involving psychopharmacology, digital technology, and fMRI neurofeedback. The APA also highlights its vision to ensure access to quality psychiatric diagnosis and treatment.
Researchers have identified optimal blood tests to detect Alzheimer's disease at its earliest stages. The study found that phospho-tau217 is a reliable marker for monitoring disease progression and selecting individuals for novel trials.
Researchers studied the strong nuclear force using nickel-64 nuclei, discovering that they change shapes under high-energy conditions. The team used advanced detectors to analyze gamma rays and particle direction, revealing two possible shapes for the nucleus: oblate and prolate.
Two studies found corticosteroid injections associated with osteoarthritis progression, while hyaluronic acid injections may slow down progression. Corticosteroids increase risk of disease progression, highlighting need for cautious use.
A new study using photon-counting CT technology has shown that it can detect more post-COVID-19 lung damage than conventional CT scans, particularly in patients with persistent symptoms. The technology may lead to earlier treatment and better outcomes for those affected by COVID-related lung damage.
A survey of primary care physicians revealed that those with beliefs about BZD potential harm were less likely to prescribe it. Clinicians with low concern about continuing BZDs for long-term treatment were more likely to prescribe the medication.
Researchers at USC's Keck School of Medicine are collaborating with Polaris Dawn to develop a novel method for collecting X-rays in outer space. They aim to harness ambient radiation to create images using analog X-ray film, which could improve medical care on long-duration spaceflights.
Researchers at the University of Gothenburg found that using warmer brain irrigation fluid can halve the number of repeat operations needed to remedy bleeding under the cranium. This method involves replacing room temperature irrigation fluid with body temperature fluid, resulting in a significant reduction in surgical interventions.
Researchers at UNIST developed a subcutaneously implantable electromagnetic biosensor system for continuous glucose monitoring. The new technology eliminates the need for frequent finger pricking, providing more accurate blood glucose level tracking and improved patient care.
A research team at Pohang University of Science & Technology has developed a tailored neutralizer that can adapt to all kinds of mutations in the virus. The hybrid agent mimics the principle of hotspot interaction between the virus and the hACE2 receptor, inhibiting its penetration into cells.
A study of 18,364 children hospitalized with COVID-19 found that pediatricians prescribed medications in accordance with guidelines in only 55-82% of cases. The use of recommended medications quickly increased after national guidelines were released in 2020, but compliance remained lower than expected.
Researchers at the University of Ottawa have discovered that patients with electrolyte abnormalities are twice as likely to be diagnosed with an eating disorder. This study analyzed Ontario health data between 2008 and 2020, identifying a potential preventative treatment for approximately 1 million Canadians.
The DocMapper.ca platform provides an interactive map listing physicians' names, contact info, and language skills in the Ottawa and Renfrew County area. Available in English and French, it lists over 50 languages, addressing a significant language barrier for patients seeking family care.