Research on therapies used across medicine and how they perform. Covers weight-loss injections, hormone therapy, stem-cell approaches, pain relief, and drug targets.
Scientists at King's College London and the University of Bath have made a groundbreaking discovery about a molecule that plays a crucial role in nerve cell development. The study found that this molecule, known as SNRNP70, is not only present in the nucleus but also in the cytoplasm of nerve cells, where it shapes messenger RNA strand...
The American Heart Association statement highlights telehealth's benefits in managing cardiovascular disease, including cost-effectiveness and improved rehabilitation. However, challenges like access to broadband internet and privacy security concerns hinder widespread adoption.
A recent study of 4.8 million children with otitis media found that socially disadvantaged kids were less likely to receive treatment, increasing their risk of complications and hearing loss. The findings highlight the need for equitable access to ear infection treatment for all children.
Researchers from the University of Zurich have discovered why a stem cell transplant is effective in treating multiple sclerosis. The study found that memory T cells reappear immediately after the transplant and do not trigger an autoimmune reaction due to pre-damage caused by chemotherapy. This knowledge enables the body to gradually ...
Co-infection with gut parasites increases shedding of respiratory bugs like Bordetella bacterium, leading to higher probability of onward transmission. This study in rabbits has broad implications for human populations and suggests targeting treatment of helminths could be an effective way to reduce disease outbreaks.
A study by the University of Gothenburg found that women with inactive inflammatory bowel disease (IBD) have a higher risk of giving birth prematurely, particularly if they have microscopic inflammation in their intestinal mucosa. This association was not seen for other adverse pregnancy outcomes, such as growth restriction.
A randomized controlled trial found that oral ENT-01 significantly improves constipation and possibly neurological symptoms in persons with Parkinson disease. The treatment is safe for up to 25 days, with a dose-dependent effect that persists beyond the treatment period.
A team of experts recommends adopting the Choosing Wisely campaign's principles to optimize administrative management practices, improving workforce satisfaction and retention. By applying these same principles, healthcare professionals can enhance their well-being and improve the value of clinical care.
The American Journal of Psychiatry focuses on the genetic underpinnings of psychiatric illnesses, while Psychiatric Services reports on community-based treatment programs for people with serious mental illness. The latest Focus journal issue explores borderline and other personality disorders.
A Mayo Clinic study found that clinicians who were high adopters of an AI-enabled clinical decision support tool were twice as likely to diagnose low left ventricular ejection fraction as those who were low adopters. The tool's accuracy was critical in detecting serious health conditions before symptoms appeared.
Researchers discovered a link between reduced protein synthesis and Feingold syndrome type 1, a rare genetic disorder. The study suggests that a nutritional supplement may help reverse this decrease, potentially alleviating intestinal symptoms in patients with the condition.
A new book by Aston University financial regulation expert Dr Daniel Cash proposes a temporary change to the way credit ratings are decided to help poorer countries avoid downgraded ratings and borrow money for vital improvements like healthcare and infrastructure.
Researchers found that structural racism and insurance barriers limit access to advanced epilepsy care for minority groups in New Jersey. Black patients with private insurance and Medicaid had the lowest EMU admission rates relative to emergency room visits.
A new troponin test has been developed to help diagnose heart attacks more accurately. By detecting only large troponin molecules, the test can distinguish between heart attacks and other conditions such as renal insufficiency.
A study of over 2,600 young heart attack survivors found that those who experienced more perceived discrimination had a higher risk of worse health outcomes. The research suggests that perceived discrimination acts as a chronic stressor that adversely impacts cardiovascular disease.
A large stroke trial found that intensive blood pressure lowering after clot removal compromises the return of blood flow to the affected area, leading to more brain tissue deterioration and major disability. The study suggests that this increasingly common treatment strategy should be avoided in clinical practice.
A team of Rutgers physicians successfully treated a 5-year-old girl with anti-NMDAR encephalitis, a rare brain disorder, using blood plasma exchanges. The treatment, which involved nearly a dozen exchanges, led to the child's full recovery, highlighting the potential for late-stage treatment.
Dr. Paul Muntner receives the 2022 Joseph A. Vita Award for his work on identifying cardiovascular disease risk factors and improving hypertension prevention and treatment. He is recognized for his studies on environmental factors, blood pressure measurements, and African American adults.
The NCI-MATCH precision medicine cancer trial found a promising signal for the AKT inhibitor ipatasertib, meeting its primary endpoint with a 22% response rate in patients with rare AKT1 E17K tumor gene mutations. The study demonstrated clinically significant activity in patients, warranting additional studies.
Research from UCLA Health Sciences found that telehealth consultations following an emergency department visit were associated with 28 more repeat ED encounters and nearly 11 more return hospital admissions per 1000 patients. The findings highlight the need for careful consideration of when to use telemedicine for post-ED follow-ups.
Researchers at UCLA have identified an animal model that shares similarities with progressive multiple sclerosis, enabling studies of disability-improving treatments. The model reveals neurodegeneration features and effects on various parts of the brain and spinal cord, holding promise for future treatment discovery.
A global study of over 28,000 people found that lowering blood pressure can significantly reduce the risk of dementia. The researchers analyzed five double-blind placebo-controlled trials and discovered a broad linear relationship between blood pressure reduction and lower dementia risk.
Researchers analyzed S. lugdunensis isolates from pediatric patients and found that skin infections were a common source (68%), while CNS infections linked to VP shunts were also significant. Flucloxacillin was identified as effective against the bacterium.
Researchers at the University of Copenhagen have made a breakthrough in understanding schizophrenia by analyzing individual brain cells. The study identified specific neurons and networks affected by the disease, suggesting that targeting these areas could lead to new treatment options.
A clinical trial of over 1,500 outpatients with mild to moderate COVID-19 found that treatment with ivermectin did not significantly improve time to sustained recovery compared to placebo. Secondary outcomes showed no reduction in hospitalization, death, or acute care visits.
The COVID-19 pandemic saw a significant decrease in hospital admissions for first-time clinical depression and recurrent depression, while outpatient treatment remained stable. This shift implies that many patients did not receive appropriate care for their condition, potentially leading to long-term quality of life loss.
A new study by UCL researchers found that talking therapies on the NHS can improve the mental health of people with dementia, with 63% experiencing a reduction in symptoms. The therapy proved clinically beneficial, even though response rates were lower than those without dementia.
A new platform has been created using 214,000 microbiome samples to track antibiotic-resistant bacteria globally. The data can be used to tailor guidelines on combating resistance in different regions.
A new report from a joint task force recommends improved access to interventional radiologists in small and rural areas. The task force focused on strategies for recruitment and retention, including training opportunities, financial models, and community development.
The study, led by Prof. Wei Hu, demonstrates that endovascular thrombectomy improves functional outcomes and reduces mortality in patients with basilar arterial occlusion compared to standard medical therapy. The trial, ATTENTION, provides high-quality evidence on the efficacy and safety of this treatment for acute basilar artery occlu...
A new study reveals less than half of people over 50 worldwide have received spectacles or contact lenses needed to correct refractive error. The World Health Organisation aims to increase treatment coverage by 40 percentage points by 2030.
Aneurysms occur when blood vessel thins and expands, leading to increased stress on walls and rising rupture probability. The new model uses computed tomography scans to reconstruct geometry and blood flow patterns.
Developing a new technology for preventing catheter obstructions in patients with hydrocephaly has been successfully demonstrated in a European project. Concentrating ultrasound waves can detach materials from the inside of shunts implanted in the brains of patients, enabling preventive cleaning without affecting other areas.
A new CAPSTONE study aims to identify inflammatory biomarkers associated with positive and poor outcomes in patients after intracerebral hemorrhage (ICH) strokes. By analyzing patient blood and plasma samples, researchers hope to develop targeted treatments to prevent long-term brain degeneration.
The Critical Path Institute has launched a pre-consortium collaboration with the FDA's CBER and CDER to accelerate medical product development in alpha-1 antitrypsin deficiency. The collaboration aims to define unmet needs in drug development and lay the groundwork for specific solutions.
A symptom-based screening tool identified children at high risk of pre-school asthma as early as age 3. This finding suggests the potential for routine screening in primary care settings to promote active disease monitoring and timely treatment.
A Swedish cohort study found that direct oral anticoagulants (DOACs) were associated with a lower risk of kidney function decline or kidney failure compared to vitamin K antagonists (VKA). DOACs also showed a lower risk of acute kidney injury.
Scientists have identified long interspersed nuclear element-1 (L1) RNA as a promising new target for treating progeroid syndromes. Increased L1 RNA expression in cells from patients with these disorders led to deactivation of an enzyme, causing cell aging.
A national US kidney disease registry found that 60% of participants were unaware of their kidney function level, hindering clinical trial recruitment. The National Kidney Foundation Patient Network aims to address this issue through real-world data collection and patient-centered research.
Researchers developed a machine learning model to quickly recognize predictive risk factors and their importance for undesirable hospitalization outcomes. The model achieved an accuracy of 95.6% and identified modifiable risk factors that can be mitigated through clinical interventions.
Researchers at Karolinska Institutet found that intravenous omega-3 treatment improved immune function and stimulated healing of inflammation without compromising the body's response to COVID-19. The study suggests a potential new, cost-effective low-risk treatment for severe COVID-19.
Researchers from Xi'an Jiaotong-Liverpool University found that brain stimulation combined with a nose spray containing nanoparticles can improve recovery after ischemic stroke. The treatment increased cognitive and motor functions, and weighed more quickly than those treated with TMS alone.
A recent study published in Science Translational Medicine has found that supporting emotional connections between mothers and their premature infants can significantly improve brain development in these babies. The researchers measured the brain network functions of premature infants at term age after receiving either standard care or...
Anemia is common among adults with advanced kidney disease, associated with adverse outcomes and low eGFR levels. Effective iron supplementation is a low-risk intervention to address this issue, emphasizing the need for increased testing and treatment.
A new study found that medical cannabis users reported significant improvements in pain management, social functioning, and overall health. The majority of participants were able to stop or reduce their opioid use, with some experiencing a five-fold decrease in hydrocodone prescriptions.
A new study found that vulnerable workers react to unfair claims processes with confusion, anger, and disappointment, highlighting the need for improved communication and support. The research aims to inform worker compensation systems and policymakers to address procedural unfairness and promote better outcomes for injured workers.
A cross-sectional study of 60 new therapeutic agents found no association between research and development investments and treatment costs. The study's findings suggest that drug companies should make further data available to justify high prices.
A public consultation is launched to develop best-practice standards for diverse and inclusive healthcare datasets used in Artificial Intelligence. The project aims to reduce biases that affect patients from minoritised racial/ethnic groups, ensuring they receive accurate predictions and treatments.
A study at the University of Helsinki found that people accept human nurses overruling patient autonomy but reject similar decisions made by robots. The researchers suggest that human empathy is required to consider robot-made solutions equally acceptable as those made by humans. The findings imply that machines cannot comprehensively ...
Researchers analyzed changes in substance use disorder treatment admissions during the COVID-19 pandemic, revealing significant disparities by sex and ethnicity. The study highlights the need for tailored treatment approaches to address these inequities and ensure equitable access to care.
A new study found that placing a monthly cap on out-of-pocket costs for commercially insured patients could lower their highest monthly healthcare bills by 50-60%. A $500 monthly limit would affect about 25% of enrollees and reduce in-network OOP costs over a year by 46%, while a $250 limit would show a 51% reduction.
A study at the University of Helsinki found that periodontitis has a particular link with diabetes and accelerates its progression. The research highlights the importance of considering general and oral health as a whole in healthcare to achieve better treatment outcomes.
Researchers at the University of East Anglia have developed a super-fast MRI scan that can diagnose patients with heart failure in record time. The new 4D heart MRI scan takes just eight minutes to produce detailed images of the heart valves and blood flow, helping doctors determine the best course of treatment.
The US Supreme Court's decision to overturn Roe v. Wade may limit medical treatment options for patients with rheumatic diseases, as abortion bans take effect in more states. Providers will need to balance evidence-based clinical recommendations with personal and professional risks of violating reproductive rights.
Researchers at POSTECH have developed a method to engineer organs at scale using bioprinting, overcoming previous limitations of small tissue size and functional complexity. This innovation holds promise for personalized treatment of patients with the potential to create more realistic engineered organs.
A study published in JAMA Health Forum found that out-of-state telemedicine visits among Medicare patients surged during the pandemic, with 422,000 out-of-state visits recorded in 2021. These visits were most common among patients living near state borders and those seeking primary care and mental health treatment.
The NIH is launching a $8 million prize competition to develop technologies improving postpartum healthcare in areas with limited access to maternity care. Diagnostic devices and wearables are prioritized to detect conditions like heart-related conditions, infection, and bleeding during the first year after delivery.
Non-traditional lifestyle interventions, such as physical activity, sleep habits and nutrition, can effectively reduce depressive symptoms in adolescents. These interventions are cost-effective, versatile, and can be implemented by both licensed and non-licensed providers.
A study led by Singapore scientists found that Neisseria, a genus of bacteria once considered harmless, can cause infections in patients with bronchiectasis, asthma, and COPD. The research team identified a specific subgroup of Neisseria called N. subflava as the main culprit behind worsening disease outcomes.
Valentin Fuster, MD, PhD, is honored with the TCT Career Achievement Award for his transformative work in interventional cardiology and patient care. He has made significant global contributions to cardiovascular medicine.