Articles tagged with Organ Transplantation
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A new study reveals that double-lung transplants significantly improve long-term survival rates compared to single lung transplants. The research found that immune system matching and college education also play crucial roles in extending life after lung transplant surgery.
A recent study by Marcello Tonelli and colleagues found no correlation between remote or rural residence and increased time to kidney transplantation in the US. The likelihood of receiving a transplant from a deceased or living donor was similar among patients dwelling farther away, suggesting disparities may not be solely due to location
A study found that TV networks spend little time discussing organ donation needs and registration processes, resulting in inadequate coverage of the topic. The researchers analyzed over 1,500 stories and found that only 94% of positive health outcomes for living donors were mentioned.
A new Clinical Research Chair in Transplantation has been established at the University of Western Ontario to improve organ transplant outcomes for patients like Pat Davis, who received a kidney transplant after being told it was impossible.
The study found that institutions performing at least 20 lung transplants annually have the best overall patient survival rates and lowest number of deaths from the complex surgery. High-volume centers see over 95% chance of survival for organ recipients within the first month of recovery.
Researchers developed nomograms to predict long-term kidney transplant success and refine patient selection for living donor transplants. The models analyzed over 20,000 cases and identified key donor and recipient characteristics impacting transplant outcomes.
A Johns Hopkins study found that HIV-positive kidney transplant recipients can achieve one-year survival rates comparable to those without HIV, provided key risk factors for transplant failure are recognized and controlled. The study's results reflect the impact of newer antiretroviral therapies on reducing HIV-related deaths.
Research found that patients with hepatitis C who receive livers with high levels of fatty deposits have a more frequent and earlier viral recurrence. Graft survival is inversely proportional to donor liver steatosis, particularly when grafts contain greater than 30% fat and are subject to extended cold ischemic time.
A study found that women over 45 are significantly less likely to be placed on a kidney transplant list than their male counterparts, even though they have an equal chance of survival. The likelihood of being listed decreased incrementally with increasing age, from 3% for women aged 46-55 to 59% for those over 75.
UT Southwestern University Hospital has received awards for its successful efforts to increase organ donation rates, surpassing the 75 percent goal among eligible donors. The hospital achieved this feat through a combination of effective strategies and strong transplant team leadership.
Scientists are investigating methods to selectively suppress the immune response in transplanted organs, inspired by fetal development. Researchers will explore increasing IDO levels to improve transplant survival and look for biomarkers to detect rejection episodes.
The Declaration of Istanbul sets forth recommendations to prevent organ trafficking, including programs to prevent organ failure and maximize deceased donation. Organ trafficking has been linked to increased post-transplant complications and a higher incidence of acute rejection and severe infections.
Kidney transplant wait times vary widely across the US, with some patients waiting just one year and others up to 10 years. Experts will discuss issues and possible solutions for these inequities in organ allocation policies.
A presumed consent system for organ donation could tackle the UK's growing waiting list by encouraging people to talk about their wishes. This approach aims to increase the supply of organs available for transplant, reducing demand on the black market.
Researchers found extensive bidirectional transfer of MHC molecules between donor and recipient cells, making transplanted organs 'invisible' to the immune system. This discovery has major medical implications for organ transplantation, potentially reducing rejection and increasing effectiveness.
China has introduced new regulations for organ transplantation that ban financial rewards for donors and establish safeguards to prevent exploitation. The changes have led to a significant decrease in transplants from dead donors and an increase in living donor transplants.
Kidney transplant specialists at Cedars-Sinai Medical Center have developed innovative laboratory techniques to improve opportunities for highly sensitized patients. The new technology uses solid phase assays to predict patient risk and improve transplant success rates.
The Declaration of Istanbul condemns unethical practices in organ donation and transplantation, urging governments to safeguard patient safety and prevent organ trafficking. The document promotes deceased organ donation and living donor protection.
Researchers have developed a groundbreaking procedure using tailor-made regulatory cells to avoid lifelong drug use for transplant patients. The technique shows promising findings and has been tested in clinical trials on 17 kidney transplant patients, with encouraging results.
The University of Pennsylvania School of Medicine team proposes a new policy requiring transplant programs to disclose all foreseeable risks of the surgery to potential recipients at the waiting list. This change aims to promote greater equity in organ allocation and restrict 'cherry-picking' of organs from suitable but suboptimal donors.
A new arenavirus has been discovered in three transplant recipients who died in Victoria, Australia in April 2007. The virus was identified through rapid sequencing technology and subsequent characterization, revealing a strain sufficiently different from existing screening methods.
The US donor organ allocation system, MELD score, and its impact on liver transplant outcomes are discussed. Early referral for liver transplant evaluation is found to offer advantages unrelated to waiting time, including early detection and treatment of liver cancer.
A new UCLA Medical Center study shows that select patients age 65 and older can safely undergo lung transplantation with acceptable outcomes. The study found similar survival rates between younger and older patients, suggesting that age should not preclude patients from the procedure.
A meta-analysis found that former substance abusers have a low rate of relapse after organ transplantation, with significant associations between relapse and poor social support and family alcohol history. The study included over 3,600 individuals who received transplants and examined the rates of alcohol and drug relapse.
A study published in JAMA found that rural patients are less likely to be wait-listed for heart, liver, and kidney transplants, with disparities of up to 15% in transplantation rates. The researchers suggest that differences in disease burden or access to specialty care services may contribute to these disparities.
New research suggests transplanting kidneys from donors who died after cardiac arrest could increase the donor pool. A study found comparable short-term results between kidneys donated after cardiac death and brain death, with similar survival rates for patients and transplanted organs.
A study of over 300 live kidney donors found that they had good kidney function and tended to suffer a lower incidence of high blood pressure, diabetes, and heart-related deaths compared to the general population. Donors reported high satisfaction rates and would strongly encourage others to become donors if needed.
Using donated kidneys from older donors with health conditions can alleviate organ shortage among older adults, reducing waiting times and improving survival rates. Patient survival rates were similar across age groups, with 91% of patients over 60 receiving ECD kidneys surviving the transplant.
Researchers suggest expanding kidney acceptance criteria and identify key factors improving transplant success. Matching donor and recipient ages and reducing waiting times may optimize results, while understanding risk factors like delayed graft function and acute rejection can aid preventive measures.
A new study found that inhaling nitric oxide during liver transplantation reduces hospital stays and improves blood-clotting and liver-enzyme activity. The treatment also protects transplanted livers from cell death, promising relief for donor-organ shortages.
Researchers from the University of Cincinnati and Louisville found that facial transplant outcomes differ significantly from previous data on kidney and hand transplants. They suggest a more optimistic view of face transplantation, with lower rates of acute and chronic rejection.
Two studies examine the role of sodium levels in predicting mortality for patients with severe liver disease, finding that low sodium levels are associated with increased wait-list mortality and poorer post-transplant outcomes. The results suggest incorporating sodium levels into MELD models could improve prognostic accuracy.
Researchers have developed a groundbreaking new mouse model for lung transplantation, which could lead to breakthroughs in preventing transplant rejection. The study aims to understand the molecular mechanisms controlling lung graft survival and develop therapies to counteract chronic rejection.
A 47-year-old man with congestive heart failure underwent the historic surgery at UPMC, where a beating heart supported by the OCS was successfully transplanted. The patient is doing well after discharge on April 30.
The Immune Tolerance Network, a seven-year-old international consortium, has secured significant NIAID funding to develop new therapies for autoimmune diseases. The network's focus on immune tolerance and biological markers aims to create individually targeted treatments.
Preserving kidneys on a portable pump may improve initial function, reduce viral infections, and promote more organ sharing. The study found similar survival outcomes for patients receiving machine-preserved or cold-stored organs from older deceased donors.
Reducing time interval for transported organs has been shown to increase survivorship and improve outcomes in heart transplant patients. The Organ Care System (OCS) uses warm blood perfusion technology to maintain organs in a living state during transport, allowing for evaluation of organ function and reducing cold ischemic time.
A new virus has been identified as the cause of death in three organ transplant recipients in Australia, who received organs from the same donor. The virus is related to known strains of lymphocytic choreomeningitis virus but has a distinct genetic sequence that could not be detected with existing diagnostic methods.
Xenotransplantation holds promise for replacing diseased organs, but immune rejection and pathogen transmission are major concerns. Genetic modifications in pigs have improved compatibility with humans, offering hope for this technique's success.
Medication errors are common and difficult to detect among outpatient transplant patients, with adverse events associated with 32% of errors. The root causes were identified as patient error (68%), financial issues (5%), and healthcare provider error (27%), highlighting the need for improved processes to prevent such errors.
Researchers at Emory University have developed an algorithm that can predict which sensitized patients on the national waiting list for kidney transplants are compatible with a given donor. This new method, based on innovative technology, has increased transplant rates from 15% to 25% in highly sensitized patients.
Primary graft dysfunction is a significant risk factor for bronchiolitis obliterans syndrome (BOS), a chronic scarring process that affects lung function years after transplantation. The study found that all grades of primary graft dysfunction were associated with an increased risk of BOS.
The Model for End-Stage Liver Disease (MELD) is an accurate predictor of liver disease survival, particularly useful in allocating organs for transplants. However, efforts to refine its accuracy are needed to further improve patient outcomes.
A new Saint Louis University study shows that young transplant patients who lose their federally provided insurance coverage are more likely to stop taking necessary anti-rejection drugs. This can increase the risk of losing the transplanted organ and even death.
A study of over 2,000 kidney transplant patients in the Netherlands found that obese individuals were twice as likely to die within the first year or experience graft failure. This is attributed to a higher incidence of infections and fatal heart conditions among obese patients.
Researchers developed a new model to predict survival after liver transplantation, considering specific characteristics of donors and recipients. The model identified key factors impacting graft survival, including donor age and recipient MELD score.
Researchers found that combined liver-kidney transplants improved patient survival rates compared to separate transplants. Patients who received dialysis for longer than two months before surgery also recovered better after the combined transplant.
A study compares kidney transplant outcomes in the US and Spain, finding similar one-year and five-year graft survival rates for heart-beating and non-heart-beating donors. Living kidney donors also experience higher blood pressure years after donation, highlighting implications for informed consent and follow-up care.
A 'domino' transplant program can effectively double the benefit of altruistically donated kidneys by serving multiple recipients, according to researchers at Johns Hopkins Medicine. The domino-donation model has been shown to increase the likelihood of good outcomes for patients and prioritize those in greatest need.
The SYMPHONY study revealed that a CellCept-based drug combination, including low-dose tacrolimus and corticosteroids, significantly improved kidney function and reduced early rejection rates. This regimen is expected to prolong the life of both patients and their transplanted organs.
A study published in Pediatric Transplantation found that individuals with mental retardation have a 100% one-year survival rate and 90% three-year survivor rate after receiving kidney transplants. The research alleviates concerns about transplant success in this population, showing they are appropriate candidates for organ transplants.
A new study suggests that double transplants using organs from children's kidneys or older adults' kidneys can achieve excellent patient survival and kidney function. The study used kidneys from donors aged 22 months and 65 years, with similar short-term outcomes to single transplants.
Scientists at Queen's University have discovered a new antifreeze protein in fleas that can inhibit ice growth by six Celsius degrees, potentially allowing for longer storage of transplant organs. This could lead to an extended preservation period and improve the viability of transplants.
Researchers found that kidney paired donation (KPD) transplants can be performed with outcomes similar to compatible living donor kidney transplants, offering a cost savings and decrease in waiting time. A national KPD transplant scheme could enable many more transplants for patients with incompatible donors.
Belatacept demonstrates improved kidney function and reduced toxicity in patients undergoing kidney transplantation. The treatment reduces the need for immunosuppressive medications and minimizes chronic allograft nephropathy.
The Phase II clinical trial of belatacept found that it preserved kidney function and reduced the incidence of acute rejection in transplant patients. Belatacept selectively blocks T-cell activation while allowing the body to fight off infections.
A report describes four transplant recipients who contracted rabies from a common donor, demonstrating the risk of transmission through solid organ transplantation. The cases highlight the importance of considering rabies diagnosis in rapidly progressive neurological diseases.
Researchers found that patient and organ survival rates in transplants involving organs from 'extreme' donors were similar to success rates with conventional donors. The studies suggest that pancreas donor criteria can be liberalized without adverse outcomes, potentially increasing the number of available organs for transplant.
A seven-year review of liver transplant recipients who received HBV positive and HCV positive organs found patient and graft survival rates comparable to those receiving livers from negative donors. The use of these organs increases the number available for transplantation while maintaining long-term results.
A new study found that a combination of immunosuppressive therapies significantly reduces non-cellular and humoral rejection in heart transplant recipients. The TAC/MMF group showed the lowest incidence of any treated rejection and improved side effects compared to other groups.