Articles tagged with Organ Transplantation
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A recent study by Henry Ford Hospital found that over half of transplant nurses in the US suffer from emotional exhaustion and low personal accomplishment. The researchers suggest that organizations must create environments that nurture both patients and caregivers to prevent burnout.
A large international team of researchers is investigating the genetic factors behind transplant successes and failures. The project, iGeneTRAiN, has generated genomics data for over 32,000 organ donors and recipients, aiming to discover genetic variants that lead to rejection and other complications.
Researchers used ex-vivo lung perfusion (EVLP) to recondition poorly functioning lungs, removing donor white blood cells and reducing the risk of acute rejection. This technique can increase access to transplantation and shorten waiting list times.
A new study of DCD liver transplantations found no significant correlation between donor age and organ survival. The results suggest that stringent donor and recipient selection can help expand the donor pool for life-saving liver transplantation, making aged DCD organs more viable.
Study finds that certain IgG3 and IgG4 donor-specific HLA antibodies correlate with distinct patterns of antibody-mediated injury to transplanted organs. Patients with mostly IgG3 antibodies have a higher likelihood of organ rejection soon after transplantation, while those with mostly IgG4 antibodies experience delayed rejection.
The University of Chicago Medicine has contributed to the Illinois Transplant Fund, providing financial assistance for organ transplants to qualified uninsured residents. The fund, launched by the ITF, offers insurance premium support and financial help to patients in need.
Researchers found that immune tolerance can spontaneously recover after an infection-triggered rejection event, and hosts can accept subsequent transplants as soon as a week after. Regulatory T-cells play a key role in this process, acting as a 'brake' to prevent other immune cells from targeting the second transplant.
A new study found that calcineurin inhibitor-based medications used by organ transplant recipients significantly lower the prevalence of dementia and Alzheimer's disease compared to national data. The research suggests that this treatment strategy may offer a protective effect against the development and progression of Alzheimer's.
Researchers at UCLA successfully tested a portable finger-probe device on 53 potential organ donors, predicting which livers would function properly after transplantation. The device could increase the number of organs used for transplant and save patients waiting for transplants from dying.
New research reveals wide variability in organ donation rates across the US, with Midwest having the highest rates and New York State having the lowest. If consent rates were to increase in low-performing areas, nearly 2,700 lifesaving transplants could be made available.
Medical ethicists propose a solution to the US organ shortage crisis by introducing an 'uncontrolled donation after circulatory determination of death' (UDCDD) approach. This method considers deceased individuals for donation even outside hospitals, allowing families to decide later if they want to preserve organs for potential donation.
Researchers found that transplant outcomes using kidneys from deceased donors with AKI were no different between the AKI and non-AKI groups at both 1 and 3 years post-transplant. The study results suggest that acutely injured kidneys can be considered for transplantation, potentially alleviating the US kidney shortage.
The US transplant organ shortage continues to grow, with thousands on waiting lists for 5 years or more. Medical leaders propose removing financial disincentives and exploring incentives like health insurance post-donation to ensure donor safety. However, there is ongoing debate about the ethics of introducing financial payments.
A Yale-led study found that donated kidneys with acute injury are associated with delayed graft function but not poor long-term transplant outcomes. The research suggests that injured kidneys could be used for transplants, potentially increasing the number of available organs and improving survival rates for patients on dialysis.
Double-lung transplantation was associated with better graft survival in patients with idiopathic pulmonary fibrosis, but not in those with chronic obstructive pulmonary disease. The new lung allocation score system has changed demographics of single- and double-lung transplant recipients.
A national study found nearly half of organ transplant surgeons experience low personal accomplishment and 40% feel emotionally exhausted. Surgeons who reported higher levels of personal accomplishment felt more control in their work life and had more support from co-workers.
A Stanford study found that many donated hearts are being rejected due to varying acceptance criteria across regions. The rejection rate decreased from 44% in 1995 to 32% in 2010, highlighting a pressing need for standardized guidelines.
Researchers at Yale School of Medicine have joined forces with a leading 3D biology company to develop 3D printed tissues for transplant research. The technology could shorten wait times for vital organs and eliminate the need for immunosuppressive drugs.
A US policy giving priority to prior organ donors has been shown to significantly reduce waiting times and improve the quality of organs received. Living donors who later need a transplant experience much shorter waits and receive higher-quality kidneys compared to those on the waiting list without donation history.
Researchers discovered that fondaparinux, an anticoagulant, can protect transplanted kidneys from damage. Improved kidney function was observed both immediately after transplantation and months later, suggesting this strategy could augment the pool of available organs.
A new study found that living liver donor candidates often experience ambivalence regarding donation, which is linked to physical, psychosocial, and financial concerns. Providing social support can help mitigate these concerns and reduce ambivalence among living liver donors.
Using Extracorporeal Membrane Oxygenation (ECMO) has increased the number of organs available for transplant after circulatory death by 20%. This technology improves organ viability, particularly for kidneys, livers, and pancreases, making more life-saving organs available for patients waiting for transplants.
New research reveals that broader organ sharing for liver transplants will not negatively impact Cold Ischemia Time (CIT) but will increase the percentage of organs transported by flying, according to findings published in Liver Transplantation.
Ashley Anh Vo, a transplant pharmacist at Cedars-Sinai, received the 2014 Clinician of Distinction award for her work on anti-rejection drugs. Her research identified IVIG as an effective therapy to reduce HLA antibody levels and prolong patient survival.
Scientists are developing 3D printing technology to create working tissues and organs on-demand, addressing the organ shortage. They discovered that adding more cells in bioinks reduces droplet size and dispensing rate, advancing the technology.
A new study reveals nearly half of transplant surgeons experience burnout, with high emotional exhaustion and low personal accomplishment reported. The findings highlight the need for organizations to develop systems to prevent burnout and support sustainable workforces.
Penn Medicine researchers found that living donor transplant outcomes are superior to those of deceased donors when surgeries are performed at an experienced center. The three-year patient survival rate for living donor recipients was 83% compared to 78% for deceased donors.
A new clinical trial aims to remove the need for immunosuppressive drugs in organ transplant patients by increasing their regulatory T cells. The TRACT study uses a therapeutic approach that isolates and expands T-regs from participants prior to kidney transplantation.
Researchers developed a new supercooling technique to increase liver storage time from 24 hours to 3 days in animal study. The method successfully stored rat livers for up to four days, with 58% survival rate, offering potential for improved organ allocation and reduced costs.
A new kidney allocation policy is expected to improve patient and transplant survival rates, with median organ survival increasing by 2.8%, according to a study published in the Journal of the American Society of Nephrology. The policy prioritizes highly sensitized patients while potentially reducing access for older candidates.
Researchers have found that organs from donors with a history of certain cancers pose little risk to recipients, allowing for improved transplant survival rates. Optimizing donor organ preservation techniques can also improve graft function and reduce energy depletion in livers after circulatory death.
Researchers found that patients with low sodium levels prior to transplantation did not have higher mortality rates after surgery. The study, published in Liver Transplantation, analyzed data from over 19,500 patients who received a liver transplant in the US between 2003 and 2010.
A new study reveals that veterans with liver disease who live over 100 miles from a VA liver transplant center are only half as likely to be placed on the transplant waitlist, increasing their risk of death. The further away they live, the less likely they are to receive a transplant and ultimately die.
A study found that veterans living farther from transplant centers were less likely to be added to a waitlist or receive a transplant, and more likely to die. The researchers suggest that this may be due to reduced access for evaluation and relocation needs.
A recent study published in Liver Transplantation reveals that only 17% of liver transplant centers offer an alibi to potential donors, highlighting the need for standardization. The researchers recommend including written offers of alibis in consent forms to preserve donor autonomy.
A novel approach to long-term tolerance in organ transplantation has been described by REGiMMUNE Corporation. The approach uses activated invariant natural killer T cells with costimulatory blockade to induce mixed chimerism, resulting in donor-specific tolerance.
The study found that traveling to donor hospitals for organ procurement reduced travel time from eight hours to two hours and saved 37% on organ recovery costs. The use of free-standing organ recovery centers significantly improved the efficiency of deceased donor organ transplantation.
Researchers develop a method to predict future clinical events using genomic testing over multiple patient visits. The AlloMap test can assess the risk of dysfunction or rejection of a transplanted heart months before such an event may occur.
A mathematical model simulates and optimizes donor kidney distribution to ease regional inequities and potentially save hundreds of lives. The model identifies areas for policy changes, including sharing within states and transplanting lower-quality kidneys.
Temple researchers have shown that identical or compatible blood types between donor and recipient do not affect rejection rates in double-lung transplants. The study confirms excellent post-transplant lung function and comparable mortality rates for compatible donors.
Researchers at Massachusetts General Hospital have developed a procedure to induce immune tolerance to hand and face transplants, which could free recipients from lifelong immunosuppression. The study successfully tested this approach in miniature swine, paving the way for expanded availability of these complex transplants.
Researchers in the UK found that organs from selected DCD donors with pre-hospital cardiac arrest had no significant impact on graft or transplant recipient survival compared to other deceased donors. The study suggests using these organs could boost the donor pool without adverse outcomes for liver transplant recipients.
A Northwestern Medicine study using stem cells has shown promise in improving organ transplant outcomes by enabling patients to stop taking anti-rejection medicines. The research, which began in 2009, uses specially engineered stem cells to make the recipient's immune system recognize the new kidney as its own.
Kidney transplant recipients who discontinue immunosuppressive drugs before conception have a higher rate of live births and a lower rate of birth defects without an increased risk of kidney problems, according to research published by the American Society of Nephrology.
Researchers have developed a fast and affordable blood test to detect early signs of organ rejection in transplant patients. The new test uses Droplet Digital PCR technology, which can identify graft-derived cell-free DNA released into the bloodstream by dying cells from the transplanted organ.
A team of UCLA researchers is working on a new approach to improve the quality of donor livers, aiming to reduce organ rejection and increase transplant survival rates. They plan to target specific immune activation pathways and enhance local mechanisms that promote liver regeneration.
A fatal case of raccoon rabies virus exposure has been linked to a kidney transplant 18 months earlier, suggesting a long incubation period. The study emphasizes the importance of increased awareness and modified organ donor screening and recipient monitoring for infectious encephalitis.
A new study shows that split liver transplants can last just as long as whole organs in young children, potentially reducing waitlist mortality rates. The data from 2,679 pediatric patients who received liver transplants between 1995-2010 indicates improved safety of partial livers.
Researchers found that partial livers from deceased adult and teen donors have become less risky for infants, saving their lives. The study's findings suggest that the use of partial grafts from deceased donors has increased significantly over time, accounting for up to 32% of liver transplants in children.
The study analyzed patients with prior organ transplants and found that their outcomes after traumatic injury are not worse than those of non-transplanted patients. Transplanted organs were rarely injured in traumatic events, and immunosuppression may have played a role in protecting organs from inflammation.
A new study found that 9% of pediatric and adolescent heart transplant recipients experience non-adherence within two years of receiving their transplant. The risk of mortality among non-adhering patients is significantly higher, with a 26% chance of death within one year and 33% within two years.
Researchers discovered human kidneys discarded for transplant can serve as a natural scaffold material for manufacturing replacement organs in the lab. The study suggests that these organs could potentially be used to help solve the critical shortage of donor organs.
Scientists found that immune cells only need to contact specific antigens on the transplanted organ to be activated and reject it. This discovery could lead to new anti-rejection therapies for organ transplantation.
Two studies published in the Journal of Clinical Investigation found that chemokine stimulation is not required for T cell migration to transplanted organs. Instead, immune-stimulating proteins expressed by the organ direct T cells to migrate. Additionally, researchers identified a protein called TRAIL that causes cell death and can be...
A new Mayo Clinic survey reveals that support for living and deceased organ donation is increasing. Eighty-four percent would consider donating a kidney to a close friend or family member, while 49% would donate to someone they've never met.
A study found a significant shortfall in organ donations at large general hospitals in Ontario compared to those treating transplant recipients. The rate was 1.4 per 100 deaths, significantly lower than the 5.0 per 100 deaths at transplant hospitals.
Pediatric kidney transplant recipients with antibodies are more likely to experience kidney injury and rejection. Steroids do not prevent this antibody-mediated injury, but monitoring recipients for antibodies and customizing immunosuppressive treatments can help.
A team led by Dr. Marie-Josée Hébert discovered a new class of antibodies - anti-LG3 - which can trigger severe rejection episodes and high organ loss rates in kidney transplant patients. This breakthrough holds promise for developing new therapies to prevent or limit organ rejection.
Researchers found that injecting NAC prior to harvesting significantly improves graft survival, with suboptimal organ usage showing higher benefits. The study suggests using NAC during organ procurement to reduce damage and improve transplant outcomes.
A recent UCSF study found that most liver transplant candidates who died or were removed from the transplant list received one or more liver donation offers prior to death/delisting. The study suggests that efforts to reduce wait-list mortality must target multiple factors beyond just organ availability.