Articles tagged with Transplantation
The current US kidney allocation system prioritizes wait time over post-transplant survival, leading to higher repeat transplantation rates. Researchers propose ranking kidneys by potential post-transplant survival and matching them with candidates who have the longest expected survival.
A study published in the Clinical Journal of the American Society Nephrology found that kidney transplant recipients who engage in little physical activity face increased risks of dying prematurely. The research suggests that patients need to exercise to fend off an early death and maintain heart health, which is crucial for these indi...
Researchers found a significant association between IL28B genotypes and interferon-based antiviral treatment outcomes, as well as graft inflammation caused by hepatitis C virus (HCV). The presence of G-allele serves as a marker for severe HCV-induced graft inflammation and predictor of unsuccessful treatment.
Researchers tracked corneal transplant success in young patients and found substantial improvement in vision for most children with keratoconus. The study revealed that infants had lower success rates due to related illnesses, while older children fared better.
The AAAS has awarded four researchers with the Joshua E. Neimark Memorial Travel Assistance Award to study stem cell transplantation, sustainable growth, women in academia, and conservation science. The winners will attend the 2011 Annual Meeting of the American Association for the Advancement of Science.
A study published in Hepatology found that HIV-infected patients with liver cancer have a higher risk of dropping off the transplantation wait list compared to HIV-negative patients. Despite this, overall survival and recurrence-free survival rates are not significantly affected following liver transplantation.
A new study found that patients who return to dialysis after a kidney transplant failure can survive just as well on home dialysis as hospital dialysis. However, only 18% of these patients choose the home version due to concerns and limited education about its benefits.
A study published in Liver Transplantation found that over half of liver transplant patients develop metabolic syndrome, a condition associated with obesity, hypertension, and diabetes. This increases their risk for cardiovascular disease and mortality, but not necessarily mortality itself.
Researchers have found that paper mulches can be an effective alternative to traditional polyethylene mulches in commercial vegetable production. Four types of paper mulches were compared with black plastic mulch and found to control weeds as well as or better than polyethylene in some situations.
A randomized controlled trial found that a lung protective strategy increased the number of lungs eligible for donation by nearly doubling it compared to conventional ventilation. This method included lower tidal volumes and higher positive end-expiratory pressure levels.
Research shows that moderate drinking can help prevent diabetes and premature death in kidney transplant recipients, but excessive weight may be detrimental. On the other hand, low dialysis calcium levels have been linked to an increased risk of sudden cardiac arrest among patients on dialysis.
A centralized reference pool could help employers and workers by providing a legal safe harbor for employees and allowing them access to references while also enabling recourse through a neutral third party. This system would promote the flow of accurate information with low transaction costs, making labor markets more efficient.
A study found that a common transmissible strain of Pseudomonas aeruginosa is prevalent among cystic fibrosis patients in Canada, particularly in those infected with strain A, which is associated with a higher risk of death or lung transplantation. The study suggests cross-infection between CF centers in the UK and Canada.
A new study published in Liver Transplantation found that obese children have a higher mortality risk after primary liver transplantation, while severely thin pediatric patients face an early mortality risk within the first year. The study suggests post-metabolic syndrome may contribute to late morbidity and mortality.
Italian researchers found that liver transplant candidates with a strong religious connection had better post-transplant survival rates. The study also revealed that religiosity can prolong life span in individuals undergoing liver transplantation.
A recent study found that South Asian kidney transplant recipients experience a significantly higher risk of heart problems post-transplant. The research identified ethnicity as a key risk factor for cardiovascular events in this population, highlighting the need for tailored care and registry categories.
A recent study led by St. Michael's nephrologist Dr. Ramesh Prasad has found that South Asian patients are more than twice as likely to suffer a heart attack after a kidney transplant compared to Caucasian, black and East Asian men and women.
Researchers have identified a gene likely responsible for Fuchs corneal dystrophy, an inheritable genetic disorder causing corneal transplant operations. The TCF4 gene variation significantly increases the risk of developing the disease.
Researchers successfully reshaped the gut microbiome of rats, inducing long-term changes that could lead to new treatments for intestinal diseases. The study found that transplantation alone was sufficient to introduce new species into the intestinal microbial composition.
A Henry Ford Hospital study found that the Donor Risk Index does not significantly impact liver transplant outcomes on a small scale. Hepatitis C was shown to remain a major contributor to poor graft survival in transplant patients. The study confirms this finding despite large-scale data suggesting otherwise, highlighting the importan...
A new trend in managing benign biliary strictures is emerging with the use of a removable covered SEMS. The stent, made of nitinol wire, imparts an outward radial force on the biliary duct to establish patency and has a radio-opaque string for easy retrieval.
Researchers suggest treatments used on liver cancers beyond Milan criteria be applied to all patients with HCC listed for transplantation. Ablation and waiting can control tumors, allowing time to determine tumor biology and reducing recurrence rates.
A study found significant variability in 5-year patient survival rates for lung transplantation centers in the US, with risks of death ranging from 30% lower to 70% higher. Despite controlling for procedural volume, center performance remained significant, suggesting true differences in quality of care.
Liver transplant patients receiving cyclosporine for immunosuppression are at higher risk of developing de novo cancer, particularly those transplanted in recent years and younger than 50. The study found a significant association between C2 monitoring and increased early de novo cancer risk.
A new study published in Restoration Ecology reveals that coral transplantation is an effective and affordable solution for reef restoration. The research team transplanted elkhorn coral fragments onto a damaged reef in the British Virgin Islands, achieving significant growth and survival rates over four years.
Researchers at UCLA Medical Center found antiviral therapy during compensated cirrhosis to be the most cost-effective approach for treating HCV patients with advanced liver disease. Treatment initiated before progression to more advanced liver disease resulted in improved survival and decreased costs compared to other strategies.
A recent study found that extending hepatitis C treatment for liver transplant patients beyond current standards results in high clearance rates of the virus from the blood. The study also showed a low relapse rate, with only two patients out of 66 eligible for treatment experiencing relapse.
A study investigated transplanting practices during container production of lacebark elm, finding that planting at grade during initial production phase resulted in greater growth. Trees planted below or above grade showed reduced growth in subsequent phases, with those planted at or below grade performing better in the landscape.
Results from two French studies presented at the International Liver CongressTM 2010 show that early liver transplantation can be proposed to non-respondents to steroids, while treatment with combined corticoids plus N-acetyl cysteine (C+NAC) increases survival rates in patients with acute alcoholic hepatitis. The studies add to growin...
A new clinical prediction index can calculate survival for patients with end-stage kidney disease, helping clinicians and patients decide between transplantation or dialysis. The index has been proven to accurately predict mortality among eligible patients.
A study found that sirolimus-based immunosuppression significantly increases survival rates for post-transplant liver cancer patients, while radiofrequency ablation shows promise for very early-stage HCC treatment.
A new study by Henry Ford Hospital finds regadenoson to be a safe alternative to conventional medication used in cardiac nuclear stress tests for heart transplant patients. The drug did not cause adverse side effects such as low blood pressure or heart block, and showed no signs of these conditions.
Scientists have created a bandage that slowly releases nitric oxide, increasing blood flow in laboratory rats. The technology has potential applications for treating diabetic patients and preserving donated organs, suggesting improved outcomes in both conditions.
Researchers at Henry Ford Hospital conducted a study showing that skin transplant surgery is safe and effective in treating vitiligo. The treated area regained an average of 52% of its natural skin color, with some patients experiencing up to 74% regrowth.
Scientists have developed a new bandage that slowly releases nitric oxide, increasing blood flow and regulating body functions. The material is made from zeolites embedded in a water-repellent polymer and has potential applications in therapeutic socks for diabetic patients and organ preservation.
A recent study found that repeated liver stiffness measurements can accurately detect severity of fibrosis in patients with hepatitis C recurrence after a liver transplant. Slow 'fibrosers' progressed at the same rate as non-HCV LT patients, while rapid 'fibrosers' showed significant fibrosis and portal hypertension early on.
Patients with a rare, deadly disease experienced significant reduction in breathlessness using treprostinil, shifting from Class III to Class II NYHA functional class. The treatment improved walking distance and reduced Borg scores, offering substantial improvement in daily capabilities.
A study of 160 kidney transplant patients found that social support was lower in the later transplant period, while medication side effects had a significant impact on quality of life. Researchers highlight the need for more social support and interventions to alleviate medication side effects.
A new study published in the American Journal of Roentgenology found that combining triple-drug TACE with a liver transplant significantly increased long-term survival rates for patients with unresectable liver cancer. The median survival time for patients who underwent the procedure was over 112 months.
A new study reveals that sleep apnea is associated with an increased risk of high blood pressure, heart disease, and stroke in kidney transplant patients. The condition was found to be present in one in four individuals and more than doubled the risk of cardiovascular complications.
A new generation of implanted devices has shown astounding improvements in survival, quality of life, reduced complications, and device durability in patients with heart failure. The newer devices have a higher success rate, allowing patients to walk longer distances and improving their overall well-being.
Research at CHEST 2009 found that patients who have undergone a liver transplant are at an increased risk for developing cardiovascular risk factors, including hypertension, diabetes, and coronary artery disease. Additionally, Asian Indians experience heart attacks at an earlier age than Caucasians, suggesting potential disparities in ...
A new study found that extending hepatitis C treatment after liver transplant results in high rates of virus clearance and a low relapse rate, with only 8 percent of patients experiencing a relapse after 52 weeks of treatment.
A study found that dialysis patients who travel on vacation risk infections, anemia, and other complications. Travelers are advised to take extra precautions to minimize these risks.
A study found that kidney transplant consent forms are written at a 12th-grade reading level, but should be prepared at a 5th-8th grade reading level to ensure all patients can provide informed consent. This disparity may lead to unequal access to treatment and health outcomes among different patient populations.
Recent medical school graduates are more likely to refer CKD patients for preemptive kidney transplantation, which can improve patient outcomes. The study suggests that educating veteran physicians about the benefits of preemptive transplantation may increase early referrals.
Small-for-size graft dysfunction can occur in liver transplant patients with a graft-to-recipient body weight ratio above 0.8%. The study found that patients with a high GV/SLV ratio were more likely to develop early graft dysfunction, highlighting the importance of prompt recognition and timely treatment.
A study has found that coronary angiography does not harm kidney function in advanced chronic kidney disease patients, enabling better transplant decisions. The test detected coronary artery disease in some patients, making them unsuitable for transplantation until their heart complications were addressed.
A study by researchers from the University of Colorado found that hepatologists believe metabolic complications are common in liver transplant patients but poorly controlled. The majority of respondents felt that these complications significantly contributed to morbidity and mortality 10 years after transplantation. Barriers to control...
A cohort study of 120 women who gave birth after receiving a kidney transplant found no differences in kidney function or patient survival compared to those who did not have children. The study's findings provide good news for kidney transplant women who fear getting pregnant due to concerns about their health and lifespan.
A new study found that extending preventive treatment for CMV infection post-kidney transplant reduces the risk of disease by nearly two-thirds. This approach also proves cost-effective, offsetting increased costs with reduced cases of CMV disease.
Researchers found that gut bacteria of transplant patients with an ileostomy opening were dominated by facultative anaerobes, while those without an ileostomy had strictly anaerobic populations. The study suggests the gut can have two stable bacterial ecosystems, one tolerant to oxygen and another not.
A University of Pittsburgh study found that women, blacks, and Medicare recipients are less likely to be evaluated for liver transplantation. The research followed 144,507 patients hospitalized with liver-related conditions, revealing disparities in the evaluation process.
A recent study found similar waitlist and post-transplant outcomes among Asian Americans, African Americans, and Caucasians with HBV. However, Caucasians had a higher rate of HBV recurrence, which needs further validation.
Researchers found that retrieving kidneys from uncontrolled non-heart-beating donors after sudden out-of-hospital cardiac arrests can lead to a 10% increase in transplantation rates. The procedure, which raises ethical concerns, has the potential to alleviate organ shortages.
A recent study led by Keith Lindor found that patients with primary sclerosing cholangitis (PSC) who received high-dose ursodeoxycholic acid experienced poorer clinical results compared to those receiving a placebo. The therapy was associated with an increased risk of death, transplantation, and liver damage.
Contrast-enhanced ultrasound (CEUS) enhances visualization of hepatic arteries, portal veins, and bridging veins, as well as liver graft parenchyma perfusion. CEUS has high sensitivity and specificity for detecting vascular complications after liver transplantation.
A University of Alberta study shows that heart transplant recipients can significantly improve their physical fitness, including cardio-respiratory fitness, muscle mass, and maximal strength. However, exercise training did not improve heart or blood-vessel function.
This study investigated microproteinuria as an indicator for CNI-related nephrotoxicity in liver transplant recipients. Microproteinuria, including β2-microglobulin and α1-microglobulin, was found to be a sensitive marker for detecting CNI-related nephrotoxicity, with correlations between urinary levels and renal function reductions.
Even mild acute kidney injury is associated with reduced patient and graft survival, while the strictest definition linked to poor outcomes including cardiovascular events and end-stage renal disease.