Articles tagged with Vaccination
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Researchers have created a high-performance cancer vaccine utilizing self-healing polylactic acid microcapsules, which efficiently activate the immune system and inhibit tumor growth. The vaccine achieves effective T cell response, potent tumor inhibition, and anti-metastatic effects in various tumor models.
New studies in macaques demonstrate protective immunity against SARS-CoV-2 after initial infection or vaccination, with vaccinated animals exhibiting similar immune responses to humans. The findings offer promising results for the development of SARS-CoV-2 vaccines and treatments.
Researchers developed a framework using an epidemiological model of COVID-19 to calculate the optimal statistical threshold for approving a drug during a pandemic. This allows regulators to make a trade-off between false positives and false negatives, prioritizing the need for more timely approvals during outbreaks.
Researchers at Flinders University and US Army Medical Research Institute of Infectious Disease have developed a highly protective Ebola vaccine that appears to be effective against lethal infections in mice. The vaccine, combined with an Advax™ adjuvant, shows promise for preventing future Ebola outbreaks in Africa.
GlycoNet has secured a three-year investment of $16.3 million through the Canadian Glycomics Network to accelerate carbohydrate-based healthcare treatments, vaccines, and technologies. The network aims to improve the quality of life of Canadians by delivering solutions to important health issues.
Researchers at Ludwig-Maximilians-Universität München have identified an earlier indicator of vaccine efficacy: specific white blood cells in the blood. The study shows that these cells can predict the quality of the immune response induced by vaccination, allowing for more rapid assessment of vaccine effectiveness.
A study reviewing 315 articles on Washington Post coverage of autism found a shift from a focus on 'cause and cure' towards acceptance and accommodation, reflecting changing public attitudes and the autistic rights movement.
Researchers found that communities doubting establishment health guidance are more effective than government agencies at engaging undecided individuals on Facebook. Anti-vaccination communities offer diverse narratives that can appeal to a broader audience, while pro-vaccination communities focus on established public health benefits.
Researchers at Baylor College of Medicine are developing coronavirus vaccines using their years of experience in tropical diseases. They highlight experimental evidence showing the challenges and critical points for vaccine development, including the need for a robust antibody response and balanced cellular immunity.
Using convalescent plasma from recovered patients can provide instant, short-term fortification against COVID-19. This approach has shown effectiveness in previous pandemics and outbreaks of viral infections such as Ebola and SARS-CoV.
A diverse range of vaccine approaches is needed to address the global need for COVID-19 protection, with harmonized oversight bodies, shared criteria, and data sharing crucial for success. The ACTIV public-private partnership aims to scale up vaccine manufacturing capacity and distribution chains.
The authors propose a strategic approach to research and development that would generate essential data for multiple vaccine candidates in parallel. They emphasize the need for unprecedented cooperation from governments, academic institutions, industry, and philanthropic partners to develop COVID-19 vaccines.
Researchers are utilizing HPC to understand the virus at a molecular level, identify potential treatments, and accelerate vaccine development. Epidemiologists are also using supercomputers to model disease spread and predict hotspots, guiding policy makers' decisions in containing the pandemic.
A Korean research team developed a new vaccine platform using RNA-based adjuvants for the MERS coronavirus. The platform was successfully tested on nonhuman primates with 100% protective efficacy. The researchers expect the platform to be applicable to COVID-19 vaccine development, which is urgently needed globally.
The development of an effective COVID-19 vaccine is critical to preventing repeated epidemics due to the human population's naivety to the virus. A judicious approach involves evaluating candidate vaccines in healthy adults while also using animal models, with parallel process development for efficient production scale-up.
Researchers at Karolinska Institutet and the universities of Jyväskylä and Tampere have produced a vaccine that protects against all six known strains of Coxsackie B virus, which may play a role in triggering type 1 diabetes. The vaccine was tested in animal models and showed promise, with plans to conduct human clinical trials.
A five-year study has identified the mechanism behind the BCG vaccine's unexpected protection against diseases other than TB in newborns. The researchers found that BCG triggers a rapid increase in neutrophils, white blood cells that fight invading pathogens.
Researchers have developed a vaccine that protects against the Coxsackie B virus, which may play a role in triggering type 1 diabetes. The vaccine was shown to be highly immunogenic and protective in animal models and non-human primates.
The AAVCOVID vaccine program uses adeno-associated viral (AAV) vector to deliver genetic sequences of the SARS-CoV-2 Spike antigen, inducing an immune response. The vaccine is currently in preclinical development with plans for clinical testing later this year.
A McMaster University study found that half of online vaccination information on chiropractors' websites was removed after media coverage. The removal was associated with a large increase in Canadian media attention on anti-vaccination statements by some chiropractors.
A $10 million grant enables the Murdoch Children's Research Institute's clinical trial of the BCG vaccine against COVID-19 to expand to 10,000 healthcare workers across Australia and Europe. The BRACE trial aims to test whether the BCG vaccine can protect those exposed to SARS-CoV-2 from developing severe symptoms.
Researchers mapped the glycan-processing states of the SARS-CoV-2 spike protein using high-resolution mass spectrometry. The study found that SARS-CoV-2 glycans differ from typical host glycan processing, which may impact vaccine effectiveness.
Experts warn that immunity passports pose significant practical, equitable, and legal issues. Vaccination certificates, on the other hand, may be a crucial tool to incentivize vaccination and end the pandemic. The success of public health practices depends on public trust and addressing inequities.
The CUNY SPH Weekly COVID-19 Survey reveals New Yorkers are cautious about resuming normal activities due to the ongoing pandemic. Many believe a safe and effective vaccine is essential for restoring public confidence.
Researchers at Northwestern University developed an AI-powered tool to speed up the search for COVID-19 treatments and vaccines. The model predicts which studies are most likely to be replicable, allowing researchers to prioritize resources on promising research.
Researchers have developed a method of lymphocytic vaccination to counter autoimmune diseases, proving clinically effective in treating multiple sclerosis and rheumatoid arthritis. The technology involves creating an immunology cell bank to enhance immunological protection against infection.
The pneumococcal conjugate and rotavirus vaccines significantly reduce acute respiratory infections and diarrhea among small children, resulting in fewer cases of antibiotic treatment. These vaccines have the potential to prevent millions of episodes of antibiotic-treated illness if universally adopted.
A recent study evaluated Medicaid benefits coverage and reimbursement amounts for recommended adult vaccines across all 50 states and the District of Columbia. The findings suggest that state policies vary widely, with some states providing more comprehensive vaccination services than others.
This study reviews possible clinical strategies for defeating coronavirus, including the use of vaccines, broad-spectrum antivirals like remdesivir, and gene therapy. The authors propose these approaches as promising alternatives to develop effective treatments against SARS-CoV-2 and related coronaviruses.
The University of Saskatchewan's VIDO-InterVac has been awarded $23 million to fast-track COVID-19 vaccine development. The funding will support pre-clinical testing and two phases of clinical trials, with the goal of making a safe and effective vaccine available as early as next spring.
Researchers at UC San Diego are developing a COVID-19 vaccine using a plant virus, which can be easily manufactured and distributed globally. The team plans to create slow-release microneedle patches that patients can self-administer, reducing barriers to vaccination in resource-poor areas.
A Cochrane Review confirms the effectiveness of MMR vaccines in preventing infectious diseases such as measles, mumps, and rubella. The review found that one dose of vaccine was 95% effective in preventing measles and 89% effective in preventing rubella, with no association between the vaccines and autism or other conditions.
Scientists at Cincinnati Children's Hospital Medical Center report development of a potential universal vaccine for Ebola viruses. The new vaccine uses glycoproteins from two Ebola virus species and has shown promise in neutralizing all four pathogenic species, generating cross-reactive responses against multiple viruses.
A new study by URMC aims to investigate how the body's immune system responds to COVID-19, including re-infection risks and vaccine effectiveness. The research will follow 100 COVID-19 patients over 90 days, tracking antibody production and immune cell activation.
New Yorkers face difficulties with schooling at home, particularly for parents with lower education levels; vaccination hopes are mixed, with 53% of respondents willing to get vaccinated. The most trusted source of information is Governor Andrew Cuomo, according to the CUNY SPH weekly COVID-19 survey.
Research finds people with vaccine skepticism tend to overestimate the likelihood of rare negative events, including mortality-related causes. This suggests a possible explanation for their concerns: cognitive or affective variables influencing vaccine skepticism.
Researchers develop vaccine candidate using RNA virus to produce S protein, triggering immune responses against coronaviruses like SARS-CoV-2. The approach effectively blocks MERS virus infections in mice, suggesting potential for COVID-19 prevention.
A study conducted in northwestern São Paulo found that nearly a third of the population under 40 lacked immunity against measles, with only 1% over 50 showing similar results. Vaccination remains essential in preventing transmission and controlling outbreaks.
Phony Russian Twitter accounts contributed to the politicization of vaccine discussions among Americans, leading to increased polarization. Researchers found that pro-Trump personas expressed anti-vaccine sentiments, while anti-Trump personas supported vaccines.
Researchers at the Babraham Institute found that applying genital wart treatment can enhance the immune system of older mice and humans. By boosting T follicular helper cells, they were able to rescue age-dependent defects in immune cell types, offering hope for improving vaccination response in older populations.
Researchers at Texas Biomed launched a comprehensive multi-species study to identify the best animal model for COVID-19. The study includes four additional species and aims to pinpoint the most effective model for diagnostics, vaccines, and therapies.
VIDO-InterVac will receive $12 million in federal funding to construct a pilot-scale vaccine manufacturing facility and $11.3 million for continued operational funding, enabling the development of a human vaccine for COVID-19.
A new oral poliovirus vaccine is urgently needed due to ongoing mutant polio outbreaks. The current OPV2 formulation's continued use contributes to transmission and outbreaks, prompting the need for a novel serotype 2 vaccine.
Combining therapeutic HPV vaccine ISA101 with chemotherapy drugs carboplatin and paclitaxel may extend survival in patients with advanced cervical cancer. The vaccine was well-tolerated, reducing suppressive myeloid cells to better stimulate T cell responses.
Researchers analyzed published scientific data on SARS-CoV-2 and related coronaviruses to identify potential therapeutic agents and vaccines. More than 500 patents have been issued for COVID-19 treatments, including antibodies and nucleic acids.
A Swedish-Finnish study found that HPV vaccination of both boys and girls prevents infections effectively, even if only 80% of girls are vaccinated. Mathematical modelling shows that vaccinating both genders can eliminate the most oncogenic HPV type 16 in a few years after age 30.
Research by University of Otago found significant levels of negative information about vaccines available online, including on Google, Facebook, and YouTube. Health professionals can help inform parents by referring them to credible websites containing well-validated information.
A randomized controlled trial found that tailored messages addressing HPV vaccine concerns improved intent to vaccinate, while a bundled approach was less effective. The study suggests that personalized messaging may be essential for increasing HPV vaccination uptake among hesitant parents.
Researchers at UT Austin found a correlation between higher median incomes, urbanization, and lower vaccination rates among white, educated Texans. The study identified pockets of high-risk communities in Texas where outbreaks of vaccine-preventable diseases are more likely to occur.
A study of 109,908 non-migrant individuals found that routine childhood vaccination was associated with 0.2-0.3 additional schooling grades among adults, a significant link across socioeconomic and demographic factors. The finding supports the long-term benefits of vaccines beyond health outcomes.
A large observational study of nearly 387,000 children found no association between rotavirus vaccination and the development of type 1 diabetes. Researchers noted limitations and potential confounding variables that may have affected results.
A University of Saskatchewan research team has been awarded nearly $1 million to develop animal models and test vaccine candidates for the new coronavirus. The project aims to identify suitable animal models to replicate human disease, with a goal of developing a pan-coronavirus vaccine.
Researchers discovered that pre-immunization with common childhood vaccines can boost anti-tumor efficacy when combined with a hybrid viral platform called PeptiCRAd.
A recent study published in Clinical Infectious Diseases found that adults who completed their childhood vaccination series against tetanus and diphtheria are protected for life. The researchers compared data from millions of people across North America and Europe between 2001 and 2016, concluding that booster shots are not necessary.
The Vaccine For Children (VFC) Program has increased vaccination rates and reduced social disparities among Medicaid-insured children. Pediatricians value the program for its ability to provide free vaccinations regardless of payment status, leading to improved overall vaccination rates.
A breakthrough in coronavirus research has led to the creation of a 3D atomic scale map of the part of the virus that attaches to and infects human cells. This mapping is crucial for developing vaccines and antiviral drugs against the 2019 novel coronavirus.
A study found that people exposed to vaccine content on social media were more likely to be misinformed about vaccines than those exposed to it on traditional media. Up to 20% of respondents were at least somewhat misinformed, with common claims including the link between vaccines and autism.
A recent study published in BMJ Case Reports highlights the serious complications of measles, including hepatitis, appendicitis, and viral meningitis. The authors report on three cases of adults treated for measles, highlighting the need for urgent efforts to ensure global coverage with two-dose measles vaccines.
A study found that HPV vaccination rates dropped significantly after the government's suspension of proactive recommendations, leading to potential 5,000 additional deaths. Restoring high-level political support and proactive recommendations could prevent most of this damage.
A new study found that the Zoster Vaccine Live shingles vaccination may prevent some older adults from having a stroke, reducing the risk by about 16% for ischemic stroke and 12% for hemorrhagic stroke. The vaccine's protection was strongest among people ages 66 to 79 years.