Articles tagged with Cardiovascular Disease
Research published in the journal Heart found that women, Black people, and those from low-income households are less likely to be offered heart surgery than men, White people, and affluent individuals. When they do receive surgery, they are more likely to die within a year. The study highlights the need for prompt action to tackle the...
A randomized, placebo-controlled trial found finerenone improved outcomes in patients with heart failure and mildly reduced or preserved ejection fraction. The drug also showed benefits regardless of the ejection fraction and even in patients on other approved therapies.
Researchers found that measuring two types of fat in the bloodstream along with C-reactive protein can predict a woman's risk for cardiovascular disease decades later. Women with high levels of LDL cholesterol, Lp(a) and CRP had increased associated risks for heart disease, stroke and coronary heart disease.
A novel low-dose 3-in-1 blood pressure pill (GMRx2) significantly reduces blood pressure in patients with uncontrolled hypertension. After six months treatment, the GMRx2 group achieved a 5.8mmHg lower systolic blood pressure compared to standard care.
A blood test that measures three modifiable factors together can better predict cardiovascular risk than any marker used alone. The study found that inflammation is at least as important as cholesterol in predicting cardiovascular events.
The global prevalence of obesity has more than doubled over the past four decades, affecting over a billion individuals. Notably, 67.5% of deaths related to high BMI are attributable to cardiovascular disease.
A recent study led by Brigham and Women's Hospital found that semaglutide reduced deaths from cardiovascular disease and infections, including COVID-19, in obese and overweight patients. The study involved over 17,000 participants and showed a 19% lower overall death rate compared to placebo.
New studies show semaglutide reduces all-cause death, CV death, and non-CV death in people with overweight or obesity and established cardiovascular disease. The medication also improves heart failure symptoms and physical limitations in those with obesity-related HFpEF, regardless of sex.
The new guidelines evaluate PAAD as part of the same cardiovascular system, acknowledging the interconnectedness between aortic and peripheral vascular diseases. The updated recommendations focus on chronic management, screening, and comprehensive treatment strategies to improve treatment outcomes.
A new substudy of the SELECT Trial found that semaglutide reduced rates of all-cause death, CV death, and non-CV death, including death from COVID-19, in patients with overweight or obesity and established cardiovascular disease without diabetes. Semaglutide also showed protective effects against COVID-19-related adverse events.
The new guidelines recommend intensified BP targets, introducing a novel elevated blood pressure category to identify individuals at risk for cardiovascular disease. The updated recommendations also focus on 'frailty' rather than chronological age and introduce a new systolic BP treatment target range of 120-129 mmHg.
High levels of lipoprotein (a) found in 20-34% of Polish patients with heart disease or at risk. Lp(a) measurements may be crucial in preventing cardiovascular diseases and atherosclerosis progression.
Researchers used genetic method Mendelian randomization to show high levels of fasting insulin cause reduction in Lp(a), rather than the other way around. Low Lp(a) is unlikely to be a risk factor for type 2 diabetes, independent of pre-existing hyperinsulinaemia and insulin resistance.
The UofL Green Heart Louisville Project found that residents living in neighborhoods with more trees showed lower levels of general inflammation, a risk indicator for heart disease. The study showed a 13-20% reduction in inflammation, corresponding to a nearly 10-15% reduced risk of heart attacks and certain cancers.
A new study estimates that 1 in 7 Medicare beneficiaries with elevated body mass index (BMI) may qualify for semaglutide, a popular weight loss medication. The study found that maximum annual costs to Medicare could exceed $10 billion if different definitions of cardiovascular risk are considered.
A new study found that semaglutide significantly reduces major adverse cardiac events, including heart attacks and strokes, among overweight individuals with cardiovascular disease. The medication also shows similar benefits for people with pre-existing heart failure, regardless of type or severity.
A 15-minute gamified workplace wellness program increased participants' average daily physical activity levels by 12 minutes per day, with 95% meeting physical activity guidelines. Participants also reported improvements in fitness, energy, overall health, sleep quality, and mood.
A team of researchers from Columbia University and Harvard University report that autoantibodies alone directly affect heart function in lupus patients. The study identified four autoantibodies that may directly affect the heart muscle, potentially leading to new therapeutic strategies.
Researchers have discovered a new site on beta-2 adrenergic receptors that allows healthy signals to pass through, minimizing harmful side effects of beta-blocker medication. The gut microbial pathway is associated with cardiovascular disease risks and can be independently targeted.
Researchers developed a new platelet-centric scoring system to predict platelet hyperreactivity and cardiovascular events. The Platelet Reactivity ExpresSion Score (PRESS) can detect hyperreactive platelets in patients at imminent risk of heart attack and healthy individuals with unknown future risk.
Vascular Adhesion Molecules (VAMs) are linked to inflammation, endothelial dysfunction, and plaque formation. Targeting these molecules could improve CVD prevention and biomarker-guided treatment. The study explores the potential role of VAMs in CVD development.
Elevated PECAM-1 levels found to decrease the risk of coronary artery disease (CAD) and myocardial infarction. The causal relationship between PECAM-1 level and CVDs confirmed through Mendelian randomization study, offering insights into PECAM-1 pathogenesis in CVD.
A new study reveals that chicken, ketchup, and even morning lattes can contribute to overconsumption of saturated fat and added sugar. The analysis of data from 35,000 US adults found that these 'stealth' sources add up to a significant risk for cardiovascular disease, diabetes, and cancer.
The International Space Station National Laboratory is collaborating with NASA to fund up to $4 million in research addressing significant diseases like cancer, cardiovascular disease, and neurodegenerative disease. The joint solicitation aims to leverage microgravity to improve existing or develop new technologies for health problems ...
A nationwide cohort study of 254,670 Chinese adults aged 40-80 years reveals significant interactions between age, gender, and sleep duration on lipid levels. The study highlights the importance of considering age in studies of gender differences in metabolic diseases and advocates for personalized prevention and management strategies.
A new study found that digital health tools can improve health and wellbeing by keeping people active, boosting steps, and improving diet and sleep. The research synthesised data from 206,873 people across 47 studies, indicating that electronic and mobile health interventions can help people achieve positive outcomes.
A recent study published in Cell Metabolism reveals a critical link between defects in the urea cycle and the development of fatty liver disease. The researchers found that these defects lead to secondary impairment in energy metabolism, resulting in excessive fat storage and inflammation in the liver.
A new study found that routine laboratory tests are not reliable for diagnosing Long COVID, with no biomarker among 25 clinical laboratory values providing a clinically useful diagnosis. The researchers suggest treating symptoms rather than relying on lab results to diagnose the condition.
The American College of Cardiology has released a new guidance on managing patients hospitalized for heart failure, recommending tailored therapy based on clinical trajectory. The updated Expert Consensus Decision Pathway aims to improve disease management and reduce mortality.
Researchers will investigate how altered copper metabolism and redox balance contribute to endothelial cell dysfunction, leading to cardiovascular diseases. The five-year project aims to understand the underlying mechanisms of vascular disease and develop effective treatments.
A new study by the Cleveland Clinic found that consuming foods with erythritol increases the risk of cardiovascular events such as heart attack and stroke. The artificial sweetener makes platelets more active, which can raise blood clot risks. This research adds to evidence that erythritol may not be as safe as previously thought.
A UofL cardiologist is leading a Phase II clinical trial of a new stem cell therapy for heart failure, the first in the US to use intravenous delivery. The trial aims to determine whether one or multiple doses of mesenchymal stem cells improve health and quality of life for patients.
A study published in Cardiovascular Diabetology found that higher blood glucose levels at admission significantly increase the risk of a poor functional prognosis or death within three months of an ischemic stroke. The study revealed that even a 10% increase in glucose levels raises the risk by 7%, and mortality risk by 88%.
A five-year randomized control trial found that diets high in fruits and vegetables lower blood pressure, reduce cardiovascular risk, and improve kidney health. The study also suggests that incorporating fruits and vegetables into treatment plans can be more effective than traditional medication approaches.
Researchers analyzed data from 63,700 patients in five clinical trials to understand the impact of clonal hematopoiesis of indeterminate potential (CHIP) on heart disease. They found that patients with CHIP had a 30% higher risk of initial heart attacks but not recurrent events.
Uncontrolled hypertension is a leading cause of premature death and disability worldwide, with 54% of patients aware but only 21% actively controlled. Effective treatment requires lifestyle changes and medication, as well as regular blood pressure monitoring to adjust doses accordingly.
A new study finds that higher levels of six urinary metals are linked to increased cardiovascular disease and mortality in a diverse US population. The findings support the role of urinary metals as novel risk factors for CVD and all-cause mortality.
The paper explores evolving landscape of genetics research into obesity, emphasizing both new discoveries and challenges. Researchers highlight complexity of body weight regulation and advocate for precise phenotyping methods targeting relevant and refined phenotypes related to adiposity.
A new analysis found that people hospitalized for heart disease, stroke, or cardiovascular diseases are 83% more likely to be diagnosed with anxiety, depression, or other psychiatric conditions within the first year after hospitalization. Early mental health screening and intervention are crucial for patients and their loved ones.
Researchers at the University Hospital Bonn have established a highly efficient and cost-effective way to generate functional endothelial cells from human induced pluripotent stem cells (hiPSCs) for tests in cell culture dishes. The new method delivers endothelial cells more quickly, requires fewer additives, and is highly reproducible.
Research at the University of Gothenburg shows that daily activities are insufficient to prevent strokes. Exercise in free time and active transportation significantly reduce stroke risk. The study suggests promoting public health policies encouraging physical activity to improve outcomes.
The AHA PREVENT equations could reduce eligibility for statin and antihypertensive therapy among 15.8 million US adults due to lower atherosclerotic cardiovascular disease risk predictions. This change may impact treatment guidelines and recommendations.
A recent paper surveys advances in diabetes pathogenesis and treatment, highlighting the role of genes, environmental factors, and social determinants. The study suggests that understanding these dynamics is key to developing targeted interventions to reduce diabetes risk and manage its complications.
A new University of Michigan study found that over 82% of Americans aged 50-80 take one or more prescription medications, with 80% open to stopping certain drugs. However, researchers stress the importance of personalized guidance for deprescribing older adults, particularly those taking medication for cardiovascular disease or diabetes.
An exploratory analysis associates current or previous use of antiretroviral drug abacavir with an increased risk of major adverse cardiovascular events (MACE) in people with HIV. The study, funded by the National Institutes of Health, found no elevated MACE risk for other antiretroviral drugs included in the analysis.
A nationwide study from University of Alabama at Birmingham compares two cardiovascular health metrics, Life’s Simple 7 and Life’s Essential 8, with the well-established Pooled Cohort Equation to determine their predictive values for mortality. The researchers found that PCEs outperformed LE8 and LS7 scores in mortality risk prediction.
A study published in Circulation found that adults aged 50-54 with severely narrowed leg arteries had a higher risk of amputation after emergency surgery than those aged 80-84. This contradicts the traditional belief that older people are at increased risk.
A new study has identified CCL27 and TNFRSF14 as genetic markers in inflammation that may contribute to stroke recurrence. These findings could lead to novel drug targets to mitigate disability and mortality after a first stroke.
A UC Riverside-led research team found that obesity causes chronic changes in the brain, leading to reduced connections between neurons and lower testosterone levels. The study suggests that the primary site of obesity's effects on reproductive function is the brain, rather than the testes or pituitary gland.
A new study published in Hypertension journal suggests that both 30-year and 10-year risk predictions should be considered when making high blood pressure treatment decisions. The researchers compared two risk prediction tools and found that long-term, 30-year risk may be more important than short-term, 10-year risk for informing medic...
A systematic review published in Nutrients highlights the positive health outcomes associated with pulse consumption. The study found that eating more pulses reduces the risk of type 2 diabetes and heart disease.
A recent study published in Nature Medicine confirms the health benefits of a diet high in unsaturated plant fats, such as the Mediterranean diet. The research used lipidomics to measure diet-related fat changes in the blood and link them to disease risk.
Research suggests that metabolically healthy obese individuals have a significantly lower risk of cardiovascular disease and death compared to those with metabolic unhealthy obesity. Fat distribution plays a crucial role in defining metabolic health, according to a recent review article.
Researchers found increased liver oxidative stress and impaired antioxidant defenses in a DS murine model. The study suggests potential therapeutic strategies targeting oxidative stress and lipid metabolism to prevent or mitigate liver-related complications.
A study by Michigan Medicine found that older women over 65 who require complex heart surgery are more likely to be treated at low-quality hospitals, where they also die in greater numbers. The sex disparity in mortality doubled from high-quality to low-quality hospitals.
A recent analysis found that nearly half of US counties lack a cardiologist, exacerbating rural-urban health disparities. Counties without cardiologists tend to be more rural, socioeconomically disadvantaged, and experience higher cardiovascular mortality rates.
Researchers at Wake Forest University School of Medicine have been awarded a five-year, $27 million grant from the National Institute on Aging to study the connections between heart health and brain health. The study will examine how cardiovascular disease contributes to Alzheimer's disease and other dementias.
A recent study found that for every same increase of BMI, fat mass and type 2 diabetes risk are increased in taller people. The authors hypothesize that the cardiometabolic risk of a higher BMI may be underestimated in taller grown populations worldwide.
Cutting processed meat intake by 30% reduces the risk of diabetes, cardiovascular disease, and colorectal cancer. The study found that this reduction would lead to over 350,000 fewer diabetes cases and tens of thousands fewer cardiovascular disease and colorectal cancer cases.
A Swedish researchers have created a questionnaire test that quickly identifies individuals at high risk of heart attack. The test has been shown to be as accurate as blood tests and blood pressure measurements, detecting 65% of those at the highest risk of cardiovascular disease.