Articles tagged with Chronic Obstructive Pulmonary Disease
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A team of researchers will evaluate whether providing patients with COPD who experience rapid symptom deterioration with a care bundle improves hospital care and reduces readmission. The study aims to shape future health services to deliver better care for patients with chronic obstructive pulmonary disease (COPD) nationwide.
A study by The Miriam Hospital found that women with Chronic Obstructive Pulmonary Disease (COPD) who are also depressed have difficulty sticking to a pulmonary rehabilitation program. Lower depressed mood independently predicted finishing PR for women, but not men.
Research finds that excess belly fat, low physical activity, and underweight status increase COPD risk. People with larger waist circumference have a 72% higher chance of developing COPD.
Researchers developed a new method to predict disease progression by analyzing Denmark's entire population health records. The approach revealed surprising correlations between diseases, such as gout and cardiovascular disease, and showed that certain diagnoses are often followed by others in a causal sequence.
Researchers found that providing in-hospital counseling and post-care support can lead to significant health system savings while increasing the number of quitters. The Ottawa Model for Smoking Cessation (OMSC) was shown to be a cost-effective intervention, generating benefits in terms of reduced hospital readmissions and deaths.
A new study found that eating fish, fruit, and dairy products can improve lung function in patients with chronic obstructive pulmonary disease (COPD). The study analyzed data from over 2,167 participants and showed that those who consumed these foods had better lung function, less emphysema, and improved quality of life.
A new study found that an internet-mediated exercise program supported by online resources improved health-related quality of life and daily step count in COPD patients. The pedometer-based walking program led to a significant improvement in symptoms and impacts, with participants taking 779 more steps per day at 4 months.
A new study from Johns Hopkins University found that warmer indoor temperatures are linked to increased COPD symptoms, rescue medication use, and decreased lung function in patients. The research also suggests that even short periods of outdoor exposure to high temperatures can exacerbate the condition.
A large multicenter clinical trial led by Dr. Gerard J. Criner found that statin drugs do not reduce the number and severity of flare-ups from chronic obstructive pulmonary disease (COPD). The study tested the hypothesis that statins may be beneficial in persons with COPD due to their anti-inflammatory effect.
A study found that COPD patients have a significantly higher risk of heart failure compared to the general population, with African-American patients facing the highest risk. The study also revealed disparities in treatment and outcomes for patients with both conditions.
Research reveals that benzodiazepines can significantly increase the risk of respiratory issues in older adults with chronic obstructive pulmonary disease (COPD). This risk is consistent even after accounting for the severity of the person's illness.
A study of 6,042 patients with COPD found that those who exercised 150 minutes or more per week had a 34% lower risk of readmission within 30 days. Regular physical activity was also associated with improved quality of life and reduced hospitalizations.
A 9-year study found that biogas and improved kitchen ventilation improved lung function and reduced chronic obstructive pulmonary disease (COPD) risk. Participants who adopted these interventions retained more lung function as they aged, suggesting a significant reduction in indoor air pollution's adverse consequences on health.
A study found that older adults with chronic obstructive pulmonary disease (COPD) are at a higher risk for developing mild cognitive impairment (MCI), particularly in skills other than memory. Patients with COPD for over five years had the greatest risk, highlighting the importance of COPD as a risk factor for MCI.
A new study found that Medicare Part D prescription coverage significantly reduced hospital admissions by 8% and annual Medicare expenditures for hospitalization by 7%, resulting in aggregate savings of $1.5 billion per year. This expansion led to a 90% increase in seniors with prescription coverage.
A new decision tool, Ottawa COPD Risk Scale, identifies patients with COPD who are at risk of serious complications or death. The scale provides a quantitative estimate of risk for adverse events in patients with COPD.
Regular walking can significantly reduce the risk of severe COPD attacks and hospitalization. Patients who maintain moderate exercise levels, such as walking at least 3-6 km per day, are less likely to experience severe symptoms.
A recent UK study found that doctors are missing opportunities to diagnose chronic obstructive pulmonary disease (COPD) in up to 85% of cases. The study, published in The Lancet Respiratory Medicine, analyzed data from 38,859 patients and found that missed opportunities for diagnosis were most common in the years preceding diagnosis. T...
A 20-year retrospective study found that 85% of patients with chronic obstructive pulmonary disease (COPD) were overlooked by doctors, highlighting the need for improved early diagnosis and treatment. The study estimates that around 2.2 million people in the UK remain undiagnosed for COPD.
Researchers developed a new antibody that reverses muscle wasting in cancer, COPD, and other diseases by blocking a receptor that puts brakes on muscle development. The compound, BYM338, boosted muscle mass 25-50% and increased strength in animal models, with clinical trials underway.
A new UK review examines gender differences in COPD prevalence, pathophysiology, and clinical presentation. The study finds that women are increasingly affected by COPD due to changing smoking trends and environmental risk factors.
A study by the American College of Chest Physicians found that yoga training improved lung function, breathing, and quality of life in patients with chronic obstructive pulmonary disease (COPD). The 12-week program involved physical postures, breathing techniques, and meditation.
A new study from Brigham and Women's Hospital reveals four novel genetic variants associated with how people living with chronic obstructive pulmonary disease (COPD) respond to inhaled bronchodilators. The findings may reveal genetic pathways associated with the pathogenesis of COPD and identify novel treatment methods.
A genome-wide meta-analysis of COPD patients has identified novel gene variants associated with bronchodilator responsiveness. The study used data from over 6,000 patients and found that genetic determinants likely influence response to inhaled medication.
A new class of drug RPL554 has been developed to treat obstructive airway diseases like asthma and COPD. It works by both reversing the narrowing of the airways and reducing inflammation, producing a 17% increase in respiratory function.
A large international study has found that the drug tiotropium can be delivered safely and effectively to people with COPD using either a mist or traditional dry powder inhaler. The study showed no significant difference in the incidence of major cardiovascular events or risk of death between the two groups.
A new publication by the European Respiratory Society reveals that lung conditions account for 12.5% of EU deaths, with annual costs totaling at least 390 billion Euros. The White Book estimates direct and indirect costs due to lung diseases are around 400 billion Euros annually.
Researchers identified protein biomarkers that predict ovarian cancer recurrence and chronic obstructive pulmonary disease (COPD) development. The findings suggest a potential for using protein analysis to predict patient outcomes and guide treatment decisions in both diseases.
Researchers at WashU Medicine have identified a new therapeutic target for COPD by linking acute viral infections to chronic obstructive pulmonary disease. Viral infection triggers the production of IL-33, a signaling molecule that activates immune cells to produce excess mucus in the lungs.
Researchers found increased expression of interleukin-33 (IL-33) in human airways, linked to mucus production and other genes implicated in COPD. A mouse model also showed IL-33-producing epithelial progenitor cells induced by viral infection, suggesting potential therapeutic strategies.
A new study finds that continuous positive airway pressure (CPAP) therapy significantly reduces the risk of death in patients with chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA). The study, published in the Journal of Clinical Sleep Medicine, analyzed data from 3,396 patients who used CPAP for at least t...
Researchers have discovered that two receptors of leukotriene B4 play opposing roles in inflammation, with BLT1 promoting and BLT2 weakening inflammation during an allergic reaction. This finding suggests new approaches to developing anti-asthma and anti-COPD drugs.
Researchers found that COPD increases the risk of developing cerebral microbleeds in deep or infratentorial brain regions. The study also showed that COPD is associated with both large and small vessel disease, indicating a potential impact on overall vascular health.
A study of 61,650 participants found that elevated levels of C-reactive protein, fibrinogen, and leukocyte count are associated with an increased risk of COPD exacerbations. The risk is even higher in those with milder COPD and no previous exacerbations.
A study of 80 patients found that 42.5% had no obstruction, 23% had reversible obstruction, and only 35% had non-reversible obstruction, suggesting widespread misdiagnosis of COPD. The study highlights the importance of spirometry in confirming diagnosis and reducing unnecessary medical expenses.
A new study published in JAMA Network found that a 5-day glucocorticoid treatment course was non-inferior to a 14-day course in reducing re-exacerbation of chronic obstructive pulmonary disease (COPD) during 6 months of follow-up. The shorter-course regimen also resulted in significantly reduced glucocorticoid exposure.
A study of nearly 9,000 patients found that African-Americans are less likely than whites to have had a prior diagnosis of chronic obstructive pulmonary disease (COPD), regardless of their current disease severity. In contrast, women are more likely than men to have been diagnosed with COPD, even in the absence of airflow obstruction.
A new study suggests that physical activity levels can predict hospitalizations in COPD patients. The study found that those who were able to walk less than 350 meters during the six-minute walk distance and had lower vector magnitude unit scores were significantly more likely to be hospitalized. These findings underscore the importanc...
A study found that patients with COPD experience chronic pain comparable to those with osteoarthritis and rheumatoid arthritis, with higher use of opioids. The researchers also noted a significant impact on quality of life and healthcare costs.
Researchers at the University of Pittsburgh found a strong association between depressive symptoms and levels of interleukin-6, an inflammatory biomarker, in COPD patients. The study suggests that systemic inflammation may play a role in depression associated with COPD.
A post-hoc analysis of a multicenter study found that extended use of azithromycin reduced hospitalization rates among COPD patients, with those treated receiving a significant delay between first and subsequent respiratory-related hospitalizations. The study suggests chronic azithromycin therapy may offer benefits to COPD patients at ...
A new study has identified risk factors for depression among COPD patients, including female patients and those experiencing significant shortness of breath. The study found that physical activity was a protective factor against depression, with patients who had higher levels of physical activity less prone to developing depression.
A study of older patients with chronic obstructive pulmonary disease (COPD) found that new use of long-acting bronchodilators was associated with an increased risk of cardiovascular events. The study suggests that close monitoring of COPD patients taking these medications is necessary to mitigate this risk.
A new device, Lung Volume Reduction Coil (LVRC), has shown significant improvements in lung function, ability to exercise, and quality of life for patients with severe emphysema. The device, implanted through a minimally invasive procedure, gathered and compressed diseased lung tissue, allowing healthy tissue to function more efficiently.
A population-based study found that exposure to both wood smoke and tobacco smoke significantly increases the risk of developing chronic obstructive pulmonary disease (COPD) and experiencing more frequent and severe symptoms. The study also found that those exposed to both types of smoke had poorer lung function scores and more phlegm,...
Research reveals that COPD patients with allergic disease experience worsened respiratory symptoms and increased risk of exacerbations. These findings suggest that addressing allergic disease may help improve respiratory health in COPD patients, according to a new study.
Researchers from BUSM have developed a genetic signature for COPD from airway cells, providing a new way to study the disease and monitor patient response to treatments. This approach has shown consistent gene-expression changes in both airway and lung tissue cells in individuals with COPD.
A new nuclear medicine technique can detect early changes to the lung caused by cigarette smoke exposure, providing a noninvasive method for studying lung dysfunction in preclinical models. This technique has the potential to be applied clinically to study and diagnose the early stages of COPD.
A study published in The BMJ found that long-term use of clarithromycin, a commonly used antibiotic for lower respiratory tract infections, may be associated with an increased risk of heart problems. The research, which analyzed data from over 1,300 patients, suggests that there will be an additional cardiovascular event for every eigh...
Researchers from RIKEN Advanced Science Institute have identified Siglec-14 as a protein involved in the exacerbation of chronic obstructive pulmonary disease (COPD). Patients without this protein are less susceptible to exacerbation, suggesting potential new targets for treatment. The study's findings imply that personalized care base...
Scientists at the University of Pennsylvania School of Medicine have discovered a way to repair lung damage caused by asthma and chronic obstructive pulmonary disease (COPD) by tweaking gene expression. They found that epigenetic regulators, including HDAC2, play a critical role in regulating lung development and regeneration.
A new study investigates the role of protein kinase C (PKC) in airway smooth muscle contraction, revealing its potential as a therapeutic target for treating asthma and chronic obstructive pulmonary disease (COPD). The research suggests that PKC activation could contribute to airway hyperresponsiveness and exacerbate lung diseases.
A new study has found that bronchiectasis is independently associated with an increased mortality risk in patients with moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD). The presence and severity of bronchiectasis were linked to a higher risk of death, independent of other known risk factors.
A study found that more than a third of adults with COPD were prescribed benzodiazepines, despite warnings about their potential harm. The most vulnerable group, those with severe COPD, used the medication at the highest frequency and with the most repeat prescriptions.
A Norwegian study found that emphysema severity is a strong predictor of all-cause and cardiovascular mortality in ever-smokers with or without COPD. The study also showed that airway wall thickness is associated with respiratory mortality in patients with severe emphysema.
A recent study published in the Journal of Thoracic Oncology found that COPD is not an independent risk factor for lung cancer. Researchers associated COPD with lung cancer, but attributed this link to smoking and ascertainment bias, highlighting the need for lung cancer screenings when diagnosing COPD.
Researchers have designed new drugs that inhibit excess mucus production in airway cells, a major cause of death in respiratory conditions like asthma and COPD. The drugs target the MAPK13 protein, which is involved in the mucus pathway and can reduce mucus production by 100 fold.
The study provides the first report of state-level COPD prevalence, revealing significant regional variations. Nationwide, 6% of non-institutionalized adults reported having COPD, with higher prevalence in select states.
The UK BiLEVE study aims to discover the genes affecting lung function and susceptibility to COPD. Researchers will analyze data from 50,000 UK Biobank participants to identify genetic variants associated with COPD, shedding light on why some people are more prone to lung disease.
Dr. Richard Casaburi leads research on COPD, a disease affecting millions, to identify genetic factors and develop new treatments. The study, funded by NIH, aims to understand what genetic deficiencies contribute to COPD development and progression.