Articles tagged with Epilepsy
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Researchers identify leiomodin-1 as a key protein in Nodding syndrome, an autoimmune disease linked to Onchocerca volvulus. The study suggests that the immune system mistakenly attacks brain cells containing this protein, leading to symptoms of the disorder.
Older adults with newly diagnosed epilepsy are often prescribed older anti-epileptic drugs, with only half starting treatment within the first 30 days. Despite this, minority groups do not appear to receive different AED treatment compared to whites.
Researchers found a significant excess of mutations in five genes previously implicated only in rare forms of epilepsy in individuals with common forms of the disorder. The study identified these genes as contributing to epilepsy risk in approximately 8 percent of people with familial non-acquired focal epilepsy.
The American Academy of Neurology published a guideline suggesting the use of brain imaging to locate language and memory functions before epilepsy surgery. The guideline found weak evidence for the effectiveness of functional MRI (fMRI) in evaluating language abilities, but moderate evidence for its potential in predicting verbal memo...
Researchers propose that visual stimulation with frequencies close to alpha rhythm can interfere with natural brain activity, leading to increased amplitude and epileptic seizures. This phenomenon is linked to the brain's dynamic properties, such as resonance, which can trigger seizures at specific frequencies.
Researchers have found that inflammation plays a role in the development of epilepsy in TSC patients and that targeting this process could be a potential therapy. Studies using a mouse model of TSC found increased levels of inflammatory molecules in brain tissue before seizure onset, which were reversed by anti-inflammatory compounds.
Researchers at Stanford University School of Medicine used optogenetics to show that inducing synchronized activity in a specific nerve tract within the thalamus is sufficient to cause seizures, while disrupting it can terminate them. This finding may lead to improved ways of reducing or preventing absence seizures in susceptible child...
Scientists have discovered neural stem cells in epileptic brain tissue outside normal regions, suggesting greater plasticity in damaged brain areas. The study provides new knowledge about molecular characteristics of these cells and may lead to improved treatments for epilepsy.
Researchers at Imperial College London have discovered a gene network of 320 genes associated with epilepsy. The M30 network is thought to be involved in how brain cells communicate with each other and its malfunction triggers seizures. Finding medications that restore this network could provide new treatments for the condition.
A team of researchers has identified a network of genes in the brain that contribute to epilepsy, and predicts that a known anti-epileptic drug can restore its function. The study's 'network-biology' approach may provide a faster and cheaper way to discover new treatments.
A $3 million NIH grant will help UTHealth researcher Nitin Tandon decode how the brain processes written words into language. The study, using intracranial electroencephalogram (icEEG), aims to understand the mechanisms of reading and its connection to the broader language system.
A debilitating neurological disease in children has been linked to mutations in the DENND5A gene, which regulates neuronal development through control of protein movement within neuronal cells. The study found that recessive loss-of-function mutations in DENND5A cause severe mental and physical disabilities.
Veterans with Iraq-Afghanistan war-related epilepsy had substantially higher mortality rates than those without the condition. After controlling for comorbid conditions, IAVs with epilepsy were about 2.6 times more likely to die during a 5-year span.
The University of Utah Health has received a five-year contract renewal from the NIH to test drugs for treating refractory epilepsy, with the goal of identifying novel compounds. The program aims to address unmet medical needs in epilepsy patients and develop new therapies for different types of epilepsy.
BMC's Comprehensive Epilepsy Center will lead a program that aims to reach 1,000 children and youth with epilepsy through advanced telemedicine applications. The 'Telehealth Epilepsy Care Collaborative' seeks to identify signs of seizures in infants, children, and adolescents.
A study published in Neurology shows a link between mothers with rheumatoid arthritis and children with epilepsy. Children born to mothers with rheumatoid arthritis were up to 90% more likely to develop epilepsy than those without RA. The study suggests changes in the environment for the fetus may play a role in developing epilepsy.
Researchers discovered huperzine A increases resistance to induced seizures in mouse models of genetic epilepsy. The compound has been shown to protect against febrile seizures, a feature of both Dravet syndrome and GEFS+, with complete protection observed in genetically modified mice.
Researchers analyzed ExAC data to explore normal variation in NMDA receptors and its link to disease-causing mutations. For some patients, this information could guide anticonvulsant treatment with repurposed Alzheimer's medication.
A Canadian study of 421 children with new onset epilepsy found poor families had similar medical courses but less favorable social outcomes as adults. Poor children experienced more failure to graduate, unemployment, and psychiatric diagnoses.
People with epilepsy are seven-fold more likely to experience discrimination due to health problems than the general population. Adverse life events such as discrimination may be an important factor in the development of depression and anxiety disorders among individuals with epilepsy.
A Clemson University scientist is studying how alterations in a complex brain pathway cause neurological disorders like autism and epilepsy. The researcher aims to determine the role of amino acid transporters in brain development.
A study published in Redox Biology found that a decreased cysteine/cystine ratio in plasma may predict the progression of epilepsy. The study used a rat model and found significant changes in the biomarker after seizures were induced, suggesting its potential as a redox biomarker for epilepsy.
Researchers at Duke University discovered a new molecular mechanism by which the brain forms memories, involving the growth of neural connections. The study's findings may lead to better understanding and treatment of diseases such as epilepsy.
Duke University scientists have identified 140 previously unknown proteins at inhibitory synapses, crucial for preventing overexcitement in the brain. The discovery opens new avenues to understanding and treating autism, intellectual disability, and epilepsy.
A new study found that epilepsy surgery significantly improves seizure-free rates for patients, with 69% achieving complete freedom from seizures within a year. The procedure also proves cost-effective, with reduced antiepileptic drug use and lower direct costs over time.
A phase 3 study found that the drug everolimus significantly reduces seizure frequency in patients with treatment-resistant epilepsy and TSC. Nearly half of patients had failed previous antiepileptic drugs before participating in the study.
Researchers found that levetiracetam and topiramate do not reduce IQs or thinking skills in children, unlike valproate which had lower IQ scores, averaging 11 points lower. The study suggests these newer medications are safer alternatives for pregnant women with epilepsy.
A novel inhibitory brain receptor emerges at puberty, reducing seizure-like activity and suggesting a mechanism for epilepsy remission in adolescents. This finding could lead to new treatments for childhood epilepsy.
Neuroene Therapeutics is using the Phase I STTR grant to help further develop a novel class of compounds for treating epilepsy. The company aims to provide a new generation of anti-seizure drugs that can effectively control seizures in patients with limited success from current treatments.
Researchers have developed a small device that can detect the initial signal of an epileptic attack and release a substance to stop it, all in the same area as the signal arises. This technology has the potential to revolutionize the treatment of neurological illnesses such as epilepsy and Parkinson's disease.
Dr. Leonidas Iasemidis leads a multi-institutional team to investigate the origins and impacts of brain seizures associated with epilepsy. The project aims to uncover the causes of seizures and their impact on higher brain functions such as memory.
A new study finds that antiepileptic drugs used to control seizures can trigger psychotic symptoms in certain individuals, particularly women and those with temporal lobe epilepsy. Researchers screened the medical records of over 2,300 patients with epilepsy and identified a link between these medications and psychosis.
Researchers discover that a mutation in the RyR2 gene, which regulates intracellular calcium, can trigger blackouts of the brainstem, increasing the risk of sudden unexpected death in people with epilepsy. This finding may help explain why some individuals with epilepsy are at higher risk for SUDEP.
A recent study published in Epilepsy and Behavior found that individuals with epilepsy have a higher annual suicide mortality rate of 22% compared to the general population. The study also revealed specific risk factors, such as increased likelihood of dying from poisoning or using residential locations for suicides.
A team of researchers developed neuroprotective compounds that prevented seizures and damaged dendritic spines in mice with experimental epilepsy. The study suggests the process of epilepsy development has been arrested up to 100 days post-treatment, offering a potential new approach to disease-modifying treatments.
Researchers created a new approach to scanning brain synapses using PET technology, revealing synaptic loss in patients with epilepsy. The technique may help diagnose and treat various disorders, including Alzheimer's disease and Parkinson's disease.
Epilepsia Open is an international, peer-reviewed journal covering comprehensive epilepsy research, including clinical trials, imaging and pathology research. The journal aims to make original research widely available through open access publication.
A new study by CDC finds that individuals with epilepsy have a 22% higher suicide rate compared to the general population. The study analyzed data from the US National Violent Death Reporting System and found that 17 out of 100,000 people with epilepsy died from suicide each year.
Researchers will investigate how memory systems develop in the human brain using unique neuroimaging methodologies. The project aims to identify spatial and temporal dynamics of memory networks in children with medically uncontrolled epilepsy, with potential clinical applications to improve their quality of life.
Scientists have developed a new method that can accurately identify brain regions triggering seizures in people with epilepsy. The technique, using advanced mathematical modeling procedures, has shown promising results in predicting successful surgery outcomes.
A study found that 22.5% of Malaysian children with epilepsy have vitamin D deficiency, while 19.7% have insufficiency. Children taking multiple medications, having Indian ethnicity or being female are more susceptible to this issue.
Research suggests that anti-inflammatory therapies targeting the CCL2 chemokine may be effective in treating epilepsy. The study highlights the link between inflammation and epileptic seizures, providing a potential new target for anticonvulsant therapy.
Researchers found a unique 'texting rhythm' in approximately 1 in 5 patients using smartphones while having their brain waves monitored. The study suggests that texting can change brain waves and may have significant implications for brain-computer interfacing, gaming, and driving.
Children with epilepsy experience significant long-term socioeconomic consequences, including higher healthcare costs. The study found that people with epilepsy are unable to catch up with their peers in overall health, education, and social status.
A study found that people with a first-degree relative with epilepsy are at higher risk of being diagnosed with autism. Siblings and offspring of those with epilepsy were 63% more likely to develop autism than their peers without a family history.
Researchers at Cardiff University are exploring a potential new treatment for human temporal lobe epilepsy by transplanting immature neuron cells into the brain. The project, funded by Epilepsy Research UK, aims to develop this cell transplantation treatment and potentially lead to clinical trials in the next 3-5 years.
Epilepsy patients experience increased seizures when stressed, but researchers found the disease alters brain signaling; a new potential treatment blocks this stressful effect. New research reveals stress-induced seizures in epilepsy are triggered by changed neurotransmitter signaling.
Microglial cells have been found to be 'blind' and incapable of eliminating dead neurons during epilepsy seizures, leading to inflammation and further brain damage. The study opens up new avenues for exploring therapies to encourage phagocytosis and alleviate the effects of brain diseases.
Researchers found that microglia fail to remove dead neurons during epilepsy, leading to accumulation and inflammatory responses. The study's findings provide a new target for therapies aimed at boosting phagocytosis and alleviating brain diseases.
A crowdsourcing contest analyzing brain data from humans and dogs improved epileptic seizure forecasting. Over half of algorithms performed better than random predictions, accurately predicting more than 70% of seizures.
A third of global burden of disease for mental disorders occurs in India and China, with significant treatment gaps. Community engagement, traditional medicine practitioners, and increased support are key to bridging this gap.
A recent study found that children with cerebral palsy are more likely to suffer from obstructive sleep apnea due to underdiagnosis. Routine screening with a questionnaire can accurately diagnose sleep disorders in this population.
The article reviews national and international guidelines for folic acid supplementation, analyzing its potential risks and benefits on maternal and fetal outcomes. Folic acid is known to prevent neural tube defects, but its effects on other pregnancy outcomes are controversial.
A new research program aims to improve patients' quality of life by monitoring major depressive disorder, epilepsy, and multiple sclerosis using wearable devices and smartphone technology. The RADAR-CNS programme may allow treatment to begin before a patient's health deteriorates, preventing relapses.
A study published in Nature Medicine suggests that brain signals between seizures may be responsible for memory problems in patients with epilepsy. Researchers found that abnormal hippocampal-cortical signaling in both rats and humans with epilepsy tracked closely with the level of memory impairment.
A study published in the American Journal of Human Genetics reveals that PIGG gene mutations are the cause of intellectual disability with seizures and hypotonia. The discovery offers new insights into the development of cerebral nervous systems and provides a potential diagnostic tool for families affected by these disorders.
A traveling spike generator has been found to initiate brain waves in the hippocampus, a part of the brain associated with memory. The generator appears to move across the region while generating brain waves, but produces no electrical signal. This discovery may provide new insights into epilepsy treatment and memory consolidation.
A new study reveals that women with epilepsy have a comparable likelihood of achieving pregnancy and similar time taken to get pregnant as healthy women. The study, which followed over 200 women with epilepsy and healthy controls, found no significant differences in pregnancy outcomes or fertility rates.
A new study suggests that an eslicarbazepine acetate taken once a day may control seizures in people with partial seizures as well as carbamazepine taken twice daily. The six-month study showed that 71% of those taking eslicarbazepine were seizure-free, compared to 76% of those taking carbamazepine.
Research found that subclinical epileptic bursts can prolong reaction times and increase virtual accidents in drivers taking a computer test. Antiepileptic drugs, however, did not significantly impair driving performance.