Research on inflammation and its role in disease. Covers eye inflammation, personalized anti-inflammatory medicine, aging, and chronic pain links.
A Kobe University study establishes a new mouse model to study fetal abdominal inflammation caused by meconium peritonitis. The researchers found that heat-treated proteins in the meconium slurry disrupt digestive enzymes, leading to significant reduction in mortality rates.
Inhalation of live Lactobacilli bacteria attenuates pulmonary inflammation, improves lung function, and structure for COPD and bronchopulmonary dysplasia. The treatment reduces neutrophilic inflammation, MMP-9, and pro-inflammatory markers.
A recent study published in JAMA Psychiatry found that children with persistently raised inflammation are at a higher risk of experiencing serious mental health disorders, including psychosis and depression, in early adulthood. The research also discovered that those who experienced inflammation at a young age were more likely to devel...
Research from the University of Eastern Finland found that obesity-induced inflammation increases the secretion of extracellular vesicles from human adipocytes, which may contribute to the detrimental health effects of obesity. Visceral adipose tissue secretes more extracellular vesicles than subcutaneous adipose tissue.
A new study by Ohio State University Wexner Medical Center found that probiotics can improve the immune system and behavior of both mothers and their offspring during pregnancy. Probiotics may also help counteract negative effects of prenatal stress, such as changes in brain inflammation and amino acid metabolism.
Researchers will investigate how altered copper metabolism and redox balance contribute to endothelial cell dysfunction, leading to cardiovascular diseases. The five-year project aims to understand the underlying mechanisms of vascular disease and develop effective treatments.
Research from the University of Virginia School of Medicine reveals that nearly a quarter of children with recurrent wheezing have undetected lung infections that do not respond to commonly prescribed steroids. The study suggests that antiviral medications such as azithromycin may be a more effective treatment for these cases.
New research published in The FASEB Journal shows that blocking CTLA-4 activates Th17 cells, increasing inflammation and damaging the heart. Inhibiting this activation reverses anti-CTLA-4-mediated heart damage.
Dr. Elks' research focuses on the communication loop between fat cells and immune cells, which promotes inflammation and insulin resistance when disrupted. The grant aims to uncover patterns in cell communication that can be used to treat obesity and other metabolic diseases.
Researchers at the Max Planck Institute discovered that mast cells can trap and recycle neutrophils, which are normally frontline defenders against infections. This unexpected interaction reveals a new layer to our understanding of allergic reactions and inflammation.
Researchers propose a novel hypothesis that exercise reduces depressive symptoms by boosting dopamine function and motivation. Studies found inflammation and disrupted dopamine transmission are linked to depression, while exercise reduces inflammation and enhances motivation.
A new study has identified CCL27 and TNFRSF14 as genetic markers in inflammation that may contribute to stroke recurrence. These findings could lead to novel drug targets to mitigate disability and mortality after a first stroke.
This research perspective reviews the current state of chemoprevention and cancer interception progress in asbestos-induced mesothelioma. The study identifies potential targets for prevention, including inflammatory factors and novel chemoprevention agents.
Inflammation in immune cells, specifically macrophages, may contribute to severe symptoms in children with lysosomal storage diseases. The study suggests that blocking sodium channels or MCP-1 receptors could reduce inflammation and tissue damage.
Researchers at Chiba University have discovered a new mechanism of ILC2 immune cell development, which may exacerbate allergic diseases. The study found that the induction of GATA3 expression by an ILC2-specific super-enhancer is essential for ILC2 differentiation.
Researchers discovered that young adults with higher levels of inflammation were more likely to experience reduced cognitive function in midlife. Higher inflammation was associated with lower performance on skills testing and differences in executive functioning.
A world-first study found that low-dose aspirin can create better blood flow to the placenta during pregnancy, potentially preventing complications caused by flu infections. The research also showed that mice treated with low-dose aspirin had improved fetal development and offspring survival.
Research by a University of Virginia undergraduate may help explain recurrent Crohn’s disease in children and open the door to new ways to treat or even cure the devastating condition. Children with relapsing Crohn’s had persistent disruptions of their microbiomes even after inflammation was successfully controlled.
A study by Ohio State University researchers found that chemotherapy disrupts the gut microbiome in breast cancer patients, leading to cognitive decline and increased inflammation. The research suggests that targeting the gut microbiome may improve behavioral side effects of chemotherapy.
Research by UCLA Health confirms that Tai Chi reduces inflammation and improves anti-viral defenses in breast cancer survivors, while cognitive behavioral therapy shows greater increases in anti-viral gene transcripts. The study found significant reductions in inflammatory biomarkers among Tai Chi participants.
Two studies published in The New England Journal of Medicine show mixed results in treating EoE. Dupilumab is found to be effective in children under 12, while benralizumab fails to provide significant relief for patients. These findings challenge the long-held assumption that eosinophils are the primary cause of the disease.
A new University of Cincinnati study reveals that a signaling pathway in the brain helps maintain health and prevent inflammation and cognitive deficits. Microglia cells produce their own TGF-β ligand to regulate local states of inflammation.
Researchers found that mice lacking the G900 region exhibit reduced inflammatory response and suppressed Th2 differentiation when exposed to allergens. This discovery highlights the importance of the G900 gene enhancer in regulating immune responses and has implications for personalized treatments and asthma care.
Researchers are exploring inflammation caused by COVID-19 as a trigger for Long Covid, a condition characterized by persistent symptoms like fatigue, brain fog, and shortness of breath. The study aims to identify potential causes and treatments for Long Covid, with findings that could lead to enhanced immune function in patients.
Researchers in Brazil have developed bread with probiotic yeast that may help combat asthma by reducing airway inflammation and hyperresponsiveness. The bread's probiotic properties were shown to attenuate asthma symptoms in mice, suggesting potential for a new treatment approach.
Researchers found a link between gut microbiota and Parkinson's disease, revealing reduced B vitamins and intestinal barrier issues. Treatment with B vitamins could alleviate PD symptoms and slow disease progression.
A recent study found that mid-life inflammation is associated with slower late-life mobility, even among healthy adults. The link was strongest for individuals with sustained high inflammation over two decades.
A recent study published in The Open Sports Sciences Journal found that Ascorbic acid supplementation reduced exercise-induced oxidative stress and inflammation in healthy women. The supplement also increased plasma ascorbic acid levels and reduced post-exercise MDA levels, suggesting a potential protective effect against muscle injury.
Scientists at Salk Institute discover a molecular mechanism that helps macrophages mount a coordinated response tailored to a specific immune challenge. The discovery reveals new immune system mechanisms that could be targeted with therapeutics to regulate inflammation.
Researchers have discovered that metabolism plays a crucial role in the balance between T and B cells, leading to autoimmune diseases. The study suggests that targeting the interaction between immune cells and metabolism could lead to more effective treatments for conditions like rheumatoid arthritis and lupus.
A study found that low-dose acetylsalicylic acid (aspirin) can reduce pro-inflammatory responses to sleep restriction. The treatment reduced interleukin-6 expression, COX-1/COX-2 double positive cells in monocytes, and C-reactive protein serum levels.
Researchers at Texas A&M University have discovered a new technique for tissue regeneration using mineral-based nanomaterials inspired by ancient medical practices. The approach aims to induce natural bone formation, reducing the need for invasive procedures and long-term medication, and promoting improved quality of life.
Researchers at the University of Toronto discovered a new RNA virus, Apocryptovirus odysseus, associated with severe inflammation in humans infected with Toxoplasma gondii. The virus is found in two hypervirulent strains of the parasite, exacerbating toxoplasmosis disease and triggering an immune response.
Researchers found a significant association between higher Mediterranean diet intake and lower risk of death from cancer and cardiovascular disease. The study's findings suggest that modest changes in established risk factors can yield substantial long-term benefits from following a Mediterranean diet.
A study finds that prostaglandin E2 elicits mast cells to suppress inflammation by creating soluble ST2, blocking proinflammatory cytokine actions. The findings suggest a promise in targeting PGE2 with therapeutics to treat severe asthma.
Researchers review Silibinin's efficacy in managing inflammation, a key factor in tumour development and aging. The molecule may reduce drug-related toxicity and increase therapeutic potential in integrated cancer therapies.
Researchers at Harvard University have identified a specific cell type in the mouse embryonic brain that responds to an immune response in the mother, altering gene regulation and persisting in juvenile mice. This study provides new insights into how maternal immune responses might influence brain development in embryos, potentially sh...
Researchers at the State University of Campinas found that daily consumption of jaboticaba peel improved glucose metabolism even after meals. The study showed lower post-prandial glycemia and less inflammation in volunteers with obesity and metabolic syndrome.
Researchers report that dupilumab substantially decreases exacerbation frequency and improves lung function as well as symptom burden in COPD patients with type 2 inflammation. The study's findings are promising for these patients, who have a high risk of exacerbations.
A new study from the University of Copenhagen found that long-term exposure to air pollution accelerates cognitive decline and increases risk of dementia. The research, which followed a cohort of nurses for 27 years, also suggests that physical activity may mitigate the adverse effects of air pollution.
A new study analyzed 500,000 individuals and found a strong statistical association between rDNA copy number and well-established markers of systemic inflammation, as well as kidney function. The research suggests that wider genome analysis could bring opportunities for preventative diagnostics and novel therapeutics.
Researchers found that specific combinations of interferon proteins, including I, II, and III, are associated with various lupus symptoms like skin rashes, kidney inflammation, and joint pain. Elevated levels of these interferons can lead to severe disease presentations.
A randomized trial found that aerobic exercise significantly reduced inflammatory markers in adults with obesity, including IL-6 and IFN-γ levels. Exercise combined with liraglutide treatment showed no additional benefits in reducing inflammation compared to placebo or liraglutide alone.
A new study from Washington State University found that just a few days on a night shift schedule can disrupt protein rhythms related to blood glucose regulation and energy metabolism. This dysregulation may lead to chronic metabolic conditions such as diabetes and obesity.
Researchers found that iron is a regulator of energy usage by immune cells in the lungs, which can help treat asthma and other allergic diseases. Blocking or limiting iron uptake may reduce asthma severity.
Researchers found associations between inflammatory and metabolic biomarkers and accelerated aging, with GlycA and GrimAge showing robust correlations. The study provides insight into the relationship between aging and cardiometabolic health, potentially informing vulnerable populations.
Researchers at U of T have identified two compounds, diindolylmethane and diindolylethane, produced by gut bacteria that can regulate the nuclear receptor CAR, potentially treating diseases like diabetes, fatty liver disease, and small intestine ulcerative colitis.
Researchers found that cranberry extracts can stimulate beneficial bacteria in the gut, reducing inflammation and improving the prognosis of chronic diseases. The study suggests that cranberries may be a useful addition to a balanced diet in preventing or managing conditions like diabetes and cardiovascular disease.
A honey-containing nanoemulsion was developed and characterized for stability, maintaining normal pH values corresponding to skin pH throughout a 90-day testing period. The emulsion showed non-Newtonian flow and pseudo-plastic behaviour required for ideal topical formulation.
Studies found a negative relationship between HBV replication and liver inflammation in HBeAg-positive patients with high viral DNA levels, which shifted to positive relationships for those with low DNA levels or HBeAg-negative status. This interaction suggests a complex relationship between viral replication and liver damage progression.
Researchers found that reticulon 3 (RTN3) is downregulated in left ventricular tissue of patients with heart failure after myocardial infarction. RTN3 knockout alleviated cardiac dysfunction after MI, while overexpression decreased systolic function.
A study of 322 participants found racial discrimination to predispose Black young adults to metabolic syndrome through sleep issues and chronic inflammation. This discovery could inform targeted prevention strategies to address existing health disparities in minority populations.
Researchers found that children born to mothers with HIV infection have an increased risk of immune abnormalities, impaired growth, and development. Infants exposed to HIV had a 41% higher mortality rate than those not exposed, with systemic inflammation being strongly associated with infant mortality.
A new analysis has found evidence supporting the use of treatments to enhance mucosal healing and reduce inflammation in the gut, leading to improved outcomes for children with malnutrition. The study identified that a short course of treatment can restore mucosal integrity, reducing intestinal damage and systemic inflammation.
A new study published in the Journal of the American Heart Association suggests that treating gum disease after a heart rhythm ablation procedure can lower oral inflammation and reduce the risk of AFib recurrence. Researchers found that an index measuring the severity of gum inflammation was associated with the return of AFib, highligh...
Researchers found that geraniol reduces oxidative stress and neuroinflammation-mediated cognitive impairment in a mouse aging model. Geraniol treatment improved spatial learning and memory by enhancing anti-oxidant and anti-inflammatory effects.
A newly developed compound called UH15-38 has been shown to safely and efficiently block necroptosis, a key receptor in lung cells causing excessive inflammation and lung damage. The study demonstrates that UH15-38 can prevent influenza deaths even when administered late in the course of an infection.
A routine blood test that measures inflammation levels could improve diagnosis and management of debilitating autoimmune diseases. The Systemic Inflammation Index (SII) has shown high accuracy in diagnosing immunological diseases.
A new study using spatial transcriptomics has generated a unique spatial atlas of intestinal cells in both healthy and inflamed states. The research reveals the evolution of cell populations during inflammation, particularly highlighting the significance of fibroblasts in response to gut inflammation.
Researchers found that synbiotics, a combination of prebiotics and paraprobiotics, improved the gut microbiome of Magellanic penguins, reducing inflammation and enhancing overall health. The study also revealed that parasynbiotics can modulate inflammatory responses in penguins.