Articles tagged with Inflammation
Researchers at Moffitt Cancer Center found that higher c-reactive protein levels were associated with greater depression and less physical activity among patients with gynecologic cancers. However, most inflammatory markers were not linked to treatment-related symptoms.
Researchers have identified two candidate genes, EPHA6 and MUC4, that may play a role in gut chronic inflammation leading to IBD. The study used genetically diverse mice to mirror human populations and found that increased expression of MUC4 in part of the colon may increase IBD risk in humans.
Researchers identified a new drug treatment option for peritonitis in patients on peritoneal dialysis, showing that a low dosage of ceftazidime and avibactam is sufficient to treat the infection. The study's findings could help gain control over peritonitis in patients with difficult-to-treat germs.
A study published in the International Dental Journal demonstrates the use of artificial intelligence to detect signs of gum inflammation, such as redness, swelling, and bleeding, from intraoral photographs with high accuracy. The technology enables population-wide monitoring of gum health and personalized dental care.
A new study has found that an inflammation-targeting antibody may improve preterm birth outcomes by reducing inflammatory signals in the placenta. The same antibody has also shown promise in preventing obesity-linked fatty liver disease, a condition that can progress to cirrhosis and liver cancer.
Researchers identified a rare genetic defect in the DOCK11 gene causing abnormalities in white and red blood cells, leading to inflammation and immune system dysregulation. The defect also affects T cell activation, with potential connections to tumor diseases.
COPD patients treated with dupilumab experienced rapid and sustained improvements in disease, as measured by reduced acute exacerbations, better lung function, and improved quality of life. This is the first biologic to show clinical outcomes improvement in COPD.
Researchers from Tokyo Medical and Dental University found that apple-shaped obesity is associated with cytokine storm and a higher risk of death in COVID-19 patients. The study suggests that obese patients with excess belly fat may benefit from anti-inflammatory therapies, including IL-6 blockers.
A new study reveals that neurons expressing steroidogenic factor 1 (SF1) influence inflammation in white and brown adipose tissue. SF1 neurons help suppress inflammatory responses in inguinal WAT, but not in epididymal WAT, and activate thermogenic activity in BAT.
A case of echovirus 11-induced hepatitis in Italian male twins has been reported, showing a close genetic relation to strains found in France among neonates. The study highlights the importance of rapid recognition and timely treatment to ensure survival, and suggests potential host genetic predisposition in male and twin categories.
A recent study published in Diabetologia has uncovered a crucial gene called RELA that plays a vital role in maintaining normal blood-sugar levels. The researchers found that when the RELA gene is removed, it leads to impaired insulin secretion and pre-diabetic conditions.
Researchers at Nagoya University have discovered that targeting Fusobacterium bacteria can reduce the formation of lesions associated with endometriosis. The study suggests an effective non-hormonal antibiotic treatment for this gynecological disorder, which affects one in ten women between 15 and 49 years old.
Researchers found a peptide from venomous fish Thalassophryne nattereri that controls lung inflammation and airway hyperreactivity. The molecule, TnP, inhibited cytokine production and prevented mucus-producing cell hyperplasia, making it a potential candidate for treating asthma.
Researchers found that blocking histamine-releasing factor (HRF) and immunoglobulin E (IgE) interactions may provide relief for patients with severe asthma. The study, published in The Journal of Allergy and Clinical Immunology, suggests two potential therapies, including HRF-2CA and a therapeutic antibody called SPF7-1.
A new study shows that saracatinib reduces inflammation in patients with atherosclerotic cardiovascular disease by more than 90% and boosts genes that help clean up plaque deposits. The experimental cancer drug may offer an effective therapy for cases where standard treatment fails to help.
Researchers have developed a therapy using nanocarriers engineered from adult skin cells that curb inflammation and tissue injury in damaged mouse lungs. The treatment has shown promise for treating acute respiratory distress syndrome (ARDS), a condition that leads to respiratory failure and puts patients on ventilators.
Researchers found that women with higher-quality cardiovascular fat during midlife had stronger long-term memory and lower inflammation, while those with lower-quality fat had worsening working memory. The study suggests that taking care of heart health during menopause may protect brain health and reduce dementia risk.
Researchers mapped inflammation features in skin cells, revealing their role in spreading to joints and triggering conditions like diabetes and heart disease. The study's findings may help explain how small skin inflammation can affect the entire body.
Researchers at UBC Okanagan found that a low-carb breakfast can significantly reduce blood sugar swings and improve glucose control. Participants who followed a low-carb breakfast plan showed lower glycemic variability and some were able to reduce their glucose-lowering medication.
New research from King's College London suggests that many people with depression have an activated immune response, independent of CRP levels. This finding could pave the way for more personalized approaches to treatment and management of MDD.
Researchers tracked immune cell clusters in the aging mouse prostate using highly multiplexed immune profiling. Early adulthood sees myeloid cells, while between 6-12 months old, there's a profound shift to T and B lymphocyte-dominance. The study reveals new insight into prostatic inflammaging and the window for interventions.
Scientists at Medical College of Georgia are investigating the impact of HIV treatment on bone and muscle aging. They found that common antiretroviral cocktails can accelerate aging by about a decade, leading to increased inflammation and oxidative stress in bone marrow stem cells.
Researchers at USP in Brazil discovered that Leishmania parasites manipulate the protein gasdermin-D to prevent the immune system from killing them. This allows the parasite to continue replicating and causing disease. The findings offer hope for developing novel treatments for leishmaniasis, a disease affecting 30,000 people annually.
Scientists at Temple University have developed a novel gene-editing strategy that disrupts the ability of HIV-1 virus to enter host cells by targeting a rare genetic disorder. This approach may offer another target for developing next-generation CRISPR technology for HIV elimination, while avoiding adverse effects on cell mortality.
Researchers developed human calprotectin ligands based on peptides to detect and quantify the protein in stool samples or serum levels, offering a more accurate and controlled way of detecting biomarkers.
Researchers at MIT have designed new 'smart' sutures that can deliver drugs or sense inflammation after surgery. The bioderived sutures use hydrogel coatings to detect early warning signs of complications, such as Crohn's disease, and can also release therapeutic molecules to promote healing.
A Phase I/II clinical trial combining intratumoral delivery of an engineered oncolytic virus with subsequent immunotherapy improved survival outcomes in a subset of patients with recurrent glioblastoma. The study demonstrated the combination was well-tolerated, with no dose-limiting toxicities.
Scientists have identified a specific gene mutation that triggers an inflammatory cascade, driving the development of treatment-resistant cancers. The study reveals a molecular circuitry by which mutations in the STK11 gene cause inflammation to spiral out of control.
Researchers create a human-brain-like environment to study microglia development and function for the first time in living human-derived tissue. The findings suggest that brain environment influences microglia development and function, particularly in diseases such as autism spectrum disorder and Alzheimer's disease.
Scientists at Duke-NUS Medical School have discovered a protein called ASC2 that inhibits inflammasomes, thereby limiting inflammation in bats. This discovery could lead to the development of new anti-inflammatory drugs for human diseases, including those caused by viral infections and ageing.
Researchers found that high-fat diets increase levels of gut-derived bacterial toxins and systemic inflammation, promoting atherosclerosis. The study suggests targeting interventions for individuals at risk of developing heart disease.
Researchers discovered a link between MCEMP1 protein on mast cells and severe asthma. Inhibiting this protein could provide relief for patients with severe asthma by reducing inflammation in the airway and lungs. The study provides critical information for developing new therapies for long-term lung conditions.
A study published in Cell Reports Medicine found that pro-inflammatory cell types dominate the intestinal mucosa of children with inflammatory bowel disease, while protective cells are underrepresented. The results provide new insights into the immunology of IBD and may lead to the development of more effective treatments.
KNT-127 exhibits anti-stressing and anti-depressant effects in mice, improving social interaction and reducing stress-induced hormone levels. The agent suppresses neuronal inflammation and newborn death without affecting neurogenesis.
Researchers at Mount Sinai have discovered a previously unknown way in which the brain and immune system interact in multiple sclerosis. They found that the inflammatory protein interleukin-3 (IL-3) coordinates this communication, inciting the recruitment of immune cells to the brain and exacerbating brain inflammation.
Researchers have highlighted the importance of stromal vitamin A pathway in regulating IL-6 expression in colorectal cancer-associated fibroblasts. The study found that disrupting retinol-mediated IL-6 expression could be a potential approach to target CAFs during CRC treatment.
A video-based smoking cessation program developed by a University of Massachusetts Amherst researcher has helped nearly 40% of HIV-positive smokers in Nepal quit tobacco. The program, which includes 11 video sessions and is accessible via smartphone app, was found to be highly effective in promoting abstinence among participants.
Researchers found that only four products increased lutein liberation in spinach smoothies, with cow's milk and coconut milk showing the most improvement. Plant-based drinks like soymilk had a negative effect on lutein content.
This study examined the effects of deferoxamine and ferrostatin-1 on salivary gland dysfunction in ovariectomized rats. The researchers found that these compounds reduced inflammation, fibrosis, and improved salivary gland function, suggesting potential treatments for postmenopausal xerostomia.
Researchers at Temple University Health System found that carbonic anhydrase inhibitors reduce inflammation, restore cell function and prevent cognitive impairment in mice with amyloid buildup. CAIs also improved cerebrovascular health and enhanced amyloid-clearing capacity.
Researchers found a genetic variant of TNFAIP3, which regulates inflammation, can paradoxically protect the kidneys from damage in the short term. The study could lead to simple genetic tests for predicting kidney disease risk and personalized treatment approaches.
A cell therapy using myeloid cells bound to drug delivery microparticles reduces disease burden in a preclinical multiple sclerosis model. The therapy partially reverses hind limb paralysis and improves motor functions.
Patients with inflammatory bowel disease (IBD) are at a higher risk of developing lymphoma, particularly those with Crohn's disease. The risk is driven by both the disease activity and treatment, including immunomodulating drugs.
Researchers have developed a glycine-based tripeptide that successfully treats nonalcoholic fatty liver disease in non-human primates and mice. The compound, DT-109, reverses fat buildup and prevents scarring by stimulating fatty acid degradation and antioxidant formation.
A recent study led by Children's Hospital of Philadelphia identifies two different regulatory T cell populations, one related to autoimmunity and the other to protective immunity. The findings could pave the way for new treatments that target the immune system selectively.
A UC Riverside-led study found that reduced PTPN2 activity in intestinal epithelial cells leads to decreased Paneth cell antimicrobial peptide production, disrupting the gut microbiota and increasing E. coli. This loss can serve as a marker of IBD disease.
Human macrophages use Siglec-14 receptors to recognize and engulf carbon nanotubes, leading to inflammation. The discovery could pave the way for developing safer carbon nanotubes and therapies to prevent inflammatory diseases.
The University of Texas at El Paso will study the role of obesity and inflammation in pancreatic cancer development, a disease with high mortality rates. The grant aims to develop targeted treatments and preventives, potentially transforming understanding of pancreatic cancer.
Researchers find that patients with destructive nasal lesions may be suffering from cocaine-induced granulomatosis with polyangiitis, a condition often misdiagnosed. Cocaine use can trigger production of antibodies leading to symptoms similar to idiopathic Granulomatosis With Polyangiitis.
A team at UC San Diego developed a biodegradable polymer system to treat rheumatoid arthritis by working with the immune system. The method uses encapsulated all-trans retinoic acid (ATRA) that transforms disease-causing cells into regulatory T cells.
A recent study by the University of Jyväskylä found that good physical fitness in children does not reduce low-grade inflammation, which is a key factor in childhood obesity. Higher body fat percentage and waist circumference were strongly associated with higher low-grade inflammation levels.
Researchers found that metformin + leucine (MET+LEU) treatment prevents myotube atrophy by reversing cellular senescence and improving proteostasis. The study used C2C12 myoblasts, aged mouse single myofibers, and human primary myotubes to demonstrate MET+LEU's skeletal muscle cell-autonomous properties.
A 3-year-old girl was infected with M. marinum after being bitten by an iguana while on holiday in Costa Rica. The toddler developed a ganglion cyst and eventually responded to treatment with rifampin and clarithromycin.
A new study identifies several cytokine markers associated with poor prognosis in New-Onset Refractory Status Epilepticus (NORSE) patients. The researchers found that the concentration of these inflammatory proteins was higher in NORSE patients than controls, and their increase was correlated with short-term and long-term neurological ...
Researchers found that after 96 weeks, some patients achieved loss of detectable HBsAg and reduced liver inflammation levels, indicating functional cure. The study suggests that discontinuing long-term antiviral therapy may be more effective than continuing it for certain patients.
Studies found that certain T cells in human blood can produce acetylcholine, regulating blood pressure and inflammation. Higher levels of these immune cells were associated with reduced risk of death in seriously ill patients.
A new study published in Radiology found that a minimally invasive procedure combining pulsed radiofrequency and epidural steroid injection treatment leads to better pain reduction and disability improvement. The results showed significant benefits at four, 12, and 52 weeks compared to steroid injections alone.
Researchers at Tokyo Medical and Dental University have developed a polymeric nanoparticle gene delivery system that promotes bone formation after traumatic inflammation. The therapy inhibits excessive inflammation and prevents residual ridge resorption, leading to improved tissue healing after tooth extraction.
Researchers discovered that mechanical loading can exacerbate inflammation in aged muscles, hindering healing. However, combining mechanotherapy with anti-inflammatory treatment significantly improves healing in aged muscles.
A study published in the Journal of Experimental Medicine reveals a unique subset of fibroblastic reticular cells in omental milky spots crucial for immune cell recruitment to prevent sepsis. These cells regulate the display of CXCL12, recruiting lymphocytes to sites of inflammation.