Research on inflammation and its role in disease. Covers eye inflammation, personalized anti-inflammatory medicine, aging, and chronic pain links.
Researchers found that synbiotics, a combination of prebiotics and paraprobiotics, improved the gut microbiome of Magellanic penguins, reducing inflammation and enhancing overall health. The study also revealed that parasynbiotics can modulate inflammatory responses in penguins.
Researchers found a link between low fiber diets, mucin-degrading bacteria, and increased inflammation in mice with IBD genetics. A high-fiber diet prevented inflammation and even reversed symptoms in some cases.
Researchers discover that certain bacteria can evade the immune system by circumventing antibody coating, leading to severe inflammation. The study identifies IgG2 as a key player in this process, providing potential biomarkers and targets for new treatments.
Researchers developed a curcumin nanoemulsion that effectively improved the bioavailability of curcumin and modulated the gut microbiota of mice with intestinal inflammation. The nanoemulsion increased the presence of beneficial bacteria, reducing symptoms of intestinal damage.
Research found that experiences of racial discrimination and perceived neighborhood racial composition are associated with higher levels of pro-inflammatory cytokines during pregnancy. Higher macrophage migration inhibitory factor (MIF) levels were linked to glucocorticoid resistance, a potential mechanism underlying preterm birth.
Researchers found that viral infections like adenovirus create conditions for arrhythmias by disrupting gap junctions and ion channels in the heart. This discovery opens new directions to diagnose and treat viral infections affecting the heart, particularly for individuals with acute infections.
Researchers at MBL have found a genetic arrangement that confers antibiotic resistance to the bacterium Bacteroides fragilis, which may help it protect itself from tetracycline. The study highlights the role of transposons in horizontal gene transfer and potential mechanisms for controlling gene expression.
Researchers found that faulty mtDNA replication causes mitochondria to leak genetic material, triggering an immune response and leading to disease. By targeting this process, doctors may develop therapies to prevent harmful inflammation.
Researchers identified six blood biomarkers associated with increased cardiovascular risk in patients with rheumatoid arthritis. These biomarkers improved the ability to predict arterial inflammation, an indicator of cardiovascular risk, compared to standard clinical indices.
Researchers at Salk Institute have created a novel organoid model of the human brain that includes mature, functional astrocytes. This allows for the study of inflammation and stress in aging and diseases like Alzheimer's with greater clarity, revealing a relationship between astrocyte dysfunction and inflammation.
Researchers have discovered that certain volatile compounds emitted by microbes and food can alter epigenetic states in neurons and other eukaryotic cells. Exposure to these compounds can slow down neurodegeneration and cancer, while also affecting plant growth and responses to stress.
A national multicenter survey found that up to one-third of children who were hospitalized due to COVID-19 did not fully recover and experienced persistent symptoms. Children who had not recovered were more likely to have neurological symptoms, including headache and weakness.
A new mouse study reveals that the gut microbiome interacts with the loss of female sex hormones to exacerbate metabolic disease. The research suggests that the gut microbiome contributes to weight gain, fat in the liver, and inflammation, particularly in women after menopause.
Rumbaugh's lab aims to understand the effects of dispersing bacteria from a biofilm on their susceptibility to antibiotics and on the host. They will use enzymes as tools to break up biofilms, allowing researchers to better comprehend the relationship between bacterial dispersal and infection outcomes.
A one-year interdisciplinary therapy program reduced inflammation and cardiometabolic risk in obese adolescents, improving insulin resistance and weight management. The semi-intensive model produced better results than previous intensive models, reversing hyperlipidemia and promoting energy balance.
A recent study by Cleveland Clinic researchers discovered a connection between elevated niacin levels and an increased risk of heart disease. The study found that high levels of 4PY, a breakdown product from excess niacin, were strongly linked to the development of heart attacks and strokes.
Researchers at NDORMS identified how cells work to resolve frozen shoulder, opening up potential new targets for treatment. The study found that distinct populations of macrophages in the shoulder capsule promote tissue remodelling and reduce inflammation.
Researchers from Osaka University found that gargling with an antiseptic mouthwash can reduce periodontitis-related bacteria in patients with type 2 diabetes. This simple method may improve the lives of people with periodontitis-linked diseases such as diabetes, dementia, and cardiovascular disease.
A recent study published in Allergy found that climate change has negative effects on atopic dermatitis, including increased inflammation from air pollution and stress from droughts. The researchers called for further research to address the impact of multiple climatic factors on eczema incidence and prevalence.
A new study published in Neurology found that young Black and Hispanic women with multiple sclerosis face greater challenges in pregnancy, have more advanced disease, and experience higher inflammation levels, which may signal MS progression. The researchers also noted disparities in healthcare access and treatment.
A new study found that nicotine-free vape fluid can increase inflammation and oxidative stress in the lungs, causing damage similar to patients with lung injury. The research identified a protein called ARF6 as a key regulator of this damage.
A new study found that stress drives up inflammation in the body, which is linked to metabolic syndrome. Stress management techniques may be a way to improve biological health outcomes. The research suggests that reducing inflammation can help mitigate the connection between stress and metabolic syndrome.
Research suggests that structural changes in upper motor neurons send a signal to immune cells, leading to toxic effects on neurons and reduced synaptic connections. Blocking inflammation with a semi-synthetic drug can restore synaptic connections and improve ALS symptoms.
Researchers have found that a specific pathway, cGAS-STING, is unleashed to prevent cancer formation by detecting DNA damage within cells. The discovery reveals the 'key' to unleashing this pathway, which can potentially reactivate it to treat and prevent breast cancer development.
New Harvard study finds that perceived time influences actual physical healing time, challenging conventional beliefs about psychological influence on health. The study used a standardized procedure to mildly wound volunteer subjects and found that wounds healed faster when participants believed more time had passed.
Researchers from the University of California, San Francisco, discovered that ischaemic cholecystitis is more common in critically ill patients due to poor blood perfusion. The study also found that the gallbladder receives its blood supply from a terminal artery, making it susceptible to ischaemia.
Researchers have gained a deeper understanding of the nuanced roles of JAK inhibitors in inflammation across various cell types and tissues. The study reveals that activating JAK1 signaling has tissue-specific effects, including an unexpected immunoregulatory role in lung sensory neurons, which suppresses lung inflammation.
The AGA releases its first comprehensive evidence-based guideline for managing pouchitis, a complication of ulcerative colitis surgery. The guideline recommends treatment with antibiotics and multi-strain probiotics to prevent recurrent pouchitis.
Researchers at Lunenfeld-Tanenbaum Research Institute have discovered a gut-brain-immune network controlling inflammation across the body. GLP-1 agonists reduce inflammation by interacting with brain receptors, offering new insights into metabolic disease treatment.
A study published in Environmental Health Perspectives found that exposure to phthalates can lower the odds of getting pregnant, but not lead to pregnancy loss. The researchers also discovered associations between preconception phthalate exposure and changes in women's reproductive hormones, inflammation, and oxidative stress.
Researchers from Tokyo Medical and Dental University have identified PD-1+ T cells as the culprit behind harmful inflammation in certain muscular disorders. The study found that these cells, when activated, produce cell-damaging molecules, causing body-wide weakness and pain.
A new study published in The Journal of Nutrition found that daily prune intake can significantly reduce inflammatory cytokines and activated monocytes in postmenopausal women. Prunes contain bioactive compounds that may act synergistically to suppress activated monocytes and their secretion of bone-resorptive inflammatory cytokines.
Researchers have discovered a breakthrough nanobody technology that suppresses pannexin tubes, interrupting inflammatory reactions in the liver. The technology shows promise as a potential treatment for acute liver injury and paracetamol overdose.
A study found increased brain inflammation and structural changes in special operations personnel exposed to blasts, potentially increasing the risk of long-term brain-related disease. The research suggests that repetitive exposure to low-level blasts may cause brain injuries and highlights the need for better protective measures.
Researchers discovered that RvD2, a specialized proresolving lipid mediator, can alleviate established liver scarring or fibrosis. Treatment with RvD2 improved liver histopathology and increased bone marrow and blood monocytes.
Researchers at ADA Forsyth have discovered the regenerative properties of Resolvins, specifically RvE1, which promotes pulp regeneration and reduces bacterial invasion in dental pulp. The technology has far-reaching potential for regenerative medicine beyond oral health, including growing bones in other parts of the body.
Researchers identified a link between neck muscles and primary headaches, including tension-type headaches and migraines. Muscle T2 values were found to be significantly associated with headache frequency and neck pain.
Research reveals that brain inflammation is the primary cause of neuropsychiatric symptoms in Alzheimer's disease, including irritability, agitation, and anxiety. The study found a strong association between microglial activation and neuropsychiatric symptom severity, suggesting new pathways for therapy development.
Extracellular vesicles have been found to transport bacterial products into human cells, alerting the immune system and potentially affecting physiology. This discovery explains a key mechanism by which bacteria impact our health, with implications for both infections and normal bodily functions.
The study analyzed 170 known bacterial languages, grouping them into clusters based on molecular structure. Bacteria can understand related languages, but not those with vastly different languages. This understanding will aid in refining treatment approaches and developing biotechnology applications.
Researchers have found that lowering a form of brain cholesterol known as cholesteryl esters helps prevent brain damage and behavioral changes in mice with Alzheimer's-like tau deposits. The study suggests that reducing cholesteryl ester levels could be a promising candidate to test in neurodegenerative diseases.
Researchers found that immunomodulatory drugs used to treat rheumatoid arthritis can reduce the risk of autoimmune thyroid diseases. Patients treated with these drugs had a 46% lower risk of developing an autoimmune thyroid disease compared to those without rheumatoid arthritis.
The American Gastroenterological Association released a new guideline recommending the use of biomarkers to help manage Crohn’s disease. Biomarkers such as C-reactive protein and fecal calprotectin can measure levels of inflammation, helping doctors assess disease activity and guide treatment decisions.
Researchers at UMass Lowell found that anti-inflammatory bacteria were less abundant in people with Parkinson's disease, suggesting a potential biomarker for early diagnosis. A new study on Latinos may also uncover novel biomarkers for Alzheimer's disease.
Researchers found overactive inflammation and loss of protective mechanisms in the brains of individuals who died by suicide, supporting further exploration of anti-inflammatory medications. The study suggests that targeting these biological changes could reduce suicide risk.
A recent study found that transient inflammatory pain causes persistent mitochondrial and metabolic disturbances in sensory neurons, leading to failure in pain resolution. Targeting the cellular redox balance prevents and treats chronic inflammatory pain in rodents.
A new study found that the gut microbiota plays a significant role in prostate inflammation in aging men, particularly those with metabolic syndrome. The researchers discovered a strong relationship between IL-6 and IL-18 expression and lipid parameters in the prostate tissue of men with BPH + MetS.
Researchers discovered subtle changes in minerals, cells, and inflammation markers in people with inflammatory bowel disease up to 8 years before diagnosis. These findings suggest an opportunity for preventative action or early treatment to improve quality of life.
A study of 144 Covid survivors found that women with elevated inflammatory biomarkers during the acute phase were more likely to experience lingering symptoms like fatigue, breathlessness, and sleep disturbance. This research sheds light on a potential link between inflammation and persistent Long Covid symptoms in women.
Researchers at Texas A&M University have found a correlation between flavonoid compounds and reduced endometriosis symptoms. Flavonoids like Quercetin and Kaempferol show promise in easing inflammation, with studies suggesting they may help suppress the symptoms of inflammatory diseases like endometriosis.
A new study from Tulane University found that frequent salt consumption is associated with a higher risk of developing Type 2 diabetes. The study surveyed over 400,000 adults and found participants who regularly added salt had a 13% to 39% increased risk of developing the disease compared to those who never or rarely used salt.
Research at the University of Gothenburg found that even low-active IBD patients have a higher risk of serious infections due to microscopic intestinal inflammation. Achieving a fully healed intestinal mucosa may reduce this risk, contributing to lower morbidity and mortality in IBD patients.
A recent study published in Nutrients found that daily strawberry consumption can improve cognitive performance and reduce depressive symptoms in middle-aged adults. The research, led by Professor Robert Krikorian, suggests that strawberries contain antioxidants and micronutrients that may help mitigate the risk of dementia.
Researchers developed a low-cost anti-inflammatory hydrogel containing annexin A1 that accelerated complete skin wound healing in mice with induced type 1 diabetes. The hydrogel modulated the wound microenvironment and favored tissue regeneration, reducing inflammation and improving blood vessel formation.
University of Alberta researchers have identified taurine as a key player in predicting poor clinical outcomes and treating long COVID. A predictive test and proposed supplement trial aim to minimize symptoms and improve patient outcomes.
Researchers developed a ceria nanoparticle-immobilized mesenchymal stem cell nanovesicle hybrid system to treat rheumatoid arthritis. This approach provides both immediate pain relief through ROS scavenging and long-term immune tolerance by delivering immunomodulatory cytokines.
A Baylor College of Medicine study analyzed metabolite data from over 4,000 adults and found no direct link between red meat consumption and markers of inflammation. The researchers suggest that body weight may be the driver of increased systemic inflammation instead.
Researchers identified two fungus strains, Cyberlindnera jadinii and Kluyveromyces lactis, with potential probiotic effects on gut inflammation. These strains may offer a new way to develop probiotics and treat inflammatory bowel diseases like Crohn's disease and ulcerative colitis.
A year-long clinical trial found sustained remission of polymyalgia rheumatica in 28% of patients taking sarilumab, compared to 10% of those on placebo. The treatment showed promise in reducing relapse and improving outcomes for patients tapering their steroid medication.
A recent study found a compelling link between vitamin B12 deficiency and chronic inflammation, which can lead to various health problems. The research revealed an inverse relationship between vitamin B12 levels and inflammatory markers in humans and mice, suggesting that higher vitamin B12 levels may lower inflammatory markers.