Articles tagged with Pain
A study led by Priscille Brodin and Laurent Marsollier found that the toxin mycolactone from Mycobacterium ulcerans limits the transmission of pain signals to the brain. This mechanism may lead to the development of new analgesics.
Research by Culum Brown suggests that fish are intelligent, social creatures capable of complex behaviors such as learning, cooperation, and tool use. The study concludes that fish should be afforded protection similar to other vertebrates, considering their pain perception and sentience
The American Society of Anesthesiologists (ASA) has identified five tests and procedures commonly performed in anesthesiology that may not be necessary, potentially saving patients time, money, and preventing harm. These recommendations include avoiding baseline laboratory studies, cardiac testing, pulmonary artery catheters, blood tra...
Ultrasound-guided injections of growth factors-containing platelet-rich plasma (PRP) have been shown to be no more effective than saline injections in treating recently developed epicondylitis, also known as tennis elbow. However, pain scores decreased significantly over the course of the trial.
A recent study of over 10,000 patients found that men tend to feel more pain after undergoing major surgery, while women experience higher levels of pain after minor procedures. The research suggests that the type and severity of surgery play a significant role in shaping pain perception.
Research at Euroanaesthesia meeting found that children exposed to indoor coal-burning stoves and/or second-hand tobacco smoke experience higher postoperative complications and excessive pain after tonsillectomies. Elevated carboxyhaemoglobin concentrations were linked to increased pain sensitivity and more frequent use of painkillers.
Researchers found that bicyclists tend to be in the best mood, followed by car passengers and drivers, while bus and train riders experience negative emotions. The study suggests improving transit riders' emotional experience may be as important as traditional service features.
A new tick-borne bacterium, Neoehrlichia, has been linked to six cases of disease in Sweden, posing a significant risk to people with weakened immune systems. Researchers found that those over 50 years old with haematological or rheumatic diseases undergoing immunosuppressive treatment are most vulnerable.
A study published in JAMA found that an endoscopic procedure did not reduce disability due to pain following gallbladder removal. Patients with abdominal pain after cholecystectomy underwent either sphincterotomy or a placebo treatment, and the results showed no significant difference in successful outcomes between the two groups.
A new study found that a home-based walking program significantly improved walking ability in patients with clogged leg arteries, even 12 months after the program started. The program reduced symptoms of peripheral artery disease (PAD) and increased walking distance.
A study published in JAMA Network found that physical therapy did not significantly improve pain or function in adults with hip osteoarthritis. However, the treatment group reported more adverse events, which were relatively mild.
Researchers discovered that squid with increased vigilance after injury outlive their less vigilant counterparts due to enhanced predator avoidance. This finding challenges conventional views on pain and sensitization mechanisms.
A recent Mayo Clinic study found that nerve damage after hip surgery may be caused by inflammation, rather than mechanical factors. The study identified key signs for physicians to look out for, including delayed onset of neuropathy and severe pain.
A phase III clinical trial shows that non-invasive magnetic resonance guided focused ultrasound treatment relieves pain and improves function for most patients with bone metastases. Patients responded well to treatment, with 64 percent experiencing either no pain or a significant reduction in their pain within several days of treatment.
A large-scale study found that patient satisfaction with postoperative pain treatment is linked to perceptions of improvement and the patient-caregiver relationship. Patients who feel involved in their care experience higher levels of satisfaction.
An international team of pain researchers found that male experimenters' scent, caused by pheromones secreted from armpits, can produce a stress response in mice and rats, making them less sensitive to pain. This discovery may contribute to the reliability of rodent research studies.
A study by Fernanda Cristofori and colleagues found that 4.4% of children with irritable bowel syndrome (IBS) had celiac disease, compared to 0.3% in those without IBS. The prevalence was highest among IBS patients, who had four times the risk of developing celiac disease.
Researchers at King's College London have identified new pain relief targets that could help chemotherapy patients who suffer from persistent pain. The discovery was made by investigating how pain occurs in nerves and found that the immune system plays a key role in causing pain.
Researchers develop a prototype of the world's first intelligent prosthetic liner to measure pressure and pulling forces at the interface between a patient's stump and prosthesis. The device aims to provide accurate measurements for optimal socket fit, reducing pain and discomfort for amputees.
Research presented at EuroHeartCare 2014 found that visualizing a safe place reduced operative pain in patients undergoing ablation of atrial fibrillation. Patients who used visualization during the procedure were in pain less often and asked for fewer painkillers, with perceived pain intensity possibly also reduced.
A computer vision system can distinguish between real and faked expressions of pain more accurately than humans, with an 85% accuracy rate. This ability has potential uses in uncovering pain malingering and detecting deceptive actions in various fields.
A study from Rice University found that consumers who shop for leisure travel during business hours tend to select higher quality hotels but are less satisfied with their stay. Consumers who book earlier and pay in advance also tend to be more satisfied.
A new vertebral augmentation implant showed promise in reducing pain and improving function in patients with compression fractures caused by osteoporosis. The study, involving 300 patients, found the implant to be effective in providing similar pain relief as current treatments and improving quality of life.
A computer system has been developed that can detect real or faked expressions of pain more accurately than people, with an 85% accuracy rate. The system uses pattern-recognition abilities to identify subtle differences between involuntary and voluntary facial movements.
A joint study found that a computer system can detect fake facial expressions of pain more accurately than humans. The research team developed a pattern-recognition algorithm that identifies distinctive dynamic features of facial movements, which are often missed by human observers.
The Kessler Foundation has received funding for five research projects focused on spinal cord injury rehabilitation. These projects aim to improve pain management, functional outcomes, and quality of life for individuals with SCI.
A new study suggests that gastric bypass surgery can diminish knee pain in obese patients without osteoarthritis, with improvements comparable to those achieved through knee replacement surgery. Patients who underwent bariatric surgery reported significant reductions in knee pain and physical function at one-year follow-up.
A study published by the American Academy of Orthopaedic Surgeons found that platelet-rich plasma (PRP) treatment is more effective than cortisone injections in treating severe chronic hip bursitis. PRP provided short- and long-term pain relief, with significant improvements in patient function.
A study found that outpatient and inpatient orthopaedic surgeries have comparable outcomes, with patients receiving outpatient care having slightly higher readmission rates. The researchers emphasized the importance of appropriate patient selection for outpatient surgery to minimize complications.
A study of 28 shoulder replacement patients found that their driving skills improved significantly at 12 weeks post-surgery, with a decrease in simulator collisions. Patients who drove less than 1,800 miles per year incurred more collisions, suggesting that long-distance driving may be safe earlier
Researchers found that younger female patients, particularly those with post-traumatic or rheumatoid arthritis, had the highest pain scores. Surgical factors like general anesthesia and longer tourniquet time during knee replacement also contribute to postoperative pain.
A double-blind, placebo-controlled trial found no decrease in knee cartilage damage or improvement in bone marrow lesions with glucosamine supplementation. Glucosamine did not reduce urinary excretion of C-telopeptides of type II collagen, a predictor of cartilage destruction.
Researchers at Chalmers University of Technology developed a new treatment method for phantom limb pain, using muscle signals from the amputated arm stump to drive an augmented reality system. The patient experienced drastically reduced pain and was no longer awakened by intense periods of pain at night.
A new study investigates whether a hangover can delay or hasten subsequent drinking, finding minimal effect on the timing of drinks. Researchers suggest alternative hypotheses linking hangovers and alcoholism, such as increased risk factors for losing control over drinking.
A University of Virginia study reveals that racial bias in pain perception emerges during middle childhood, strengthening by age 10. Parents and teachers should address these biases early, before they develop into adulthood.
A study published in Social Cognitive and Affective Neuroscience found that social exclusion activates the same brain circuits responsible for physical pain. The research used real people in videos to simulate social exclusion and physical pain, revealing activation of the posterior insular cortex in both conditions.
Researchers have developed a new method to treat phantom limb pain, using muscle signals from the arm stump to drive an augmented reality system. The patient's pain was drastically reduced, and he now experiences periods of complete relief.
A neurotensin conjugate has shown effective transportation across the blood brain barrier and dose-dependent pain relief in animal models. In contrast, hematopoietic stem cell transplantation has been found to impact T cell repertoire in multiple sclerosis patients, with diverse repertoires associated with better treatment responses.
Researchers found that non-restorative sleep is a strong predictor of widespread pain onset among adults over 50. Anxiety and poor physical health also increase the risk of developing widespread pain. The study suggests combined interventions for both site-specific and widespread pain are needed for older adults.
Research published in Acupuncture in Medicine found that widely used acupuncture needles have significant surface irregularities and inconsistencies, which could lead to painful reactions, bleeding, or bruising. The study calls for manufacturers to review and improve their quality control procedures for needle fabrication.
Researchers discovered that bacterial LPS components directly activate pain sensors, triggering immediate pain and inflammatory responses. This finding reveals a new target for drugs designed to treat bacterial infections, such as pneumonia and meningitis.
A study published in Neurology found that women who survived a stroke had a lower quality of life compared to men. At three months post-stroke, women were more likely to report problems with mobility, pain/discomfort, and anxiety/depression, with these differences diminishing at one year.
A study found remifentanil patient-controlled analgesia to be less effective in managing pain relief during labor compared to epidural analgesia. The study, which involved 709 women, showed that patients who received remifentanil patient-controlled analgesia had lower pain appreciation scores and overall satisfaction with pain relief.
A novel study found that a single stem cell injection following meniscus knee surgery can provide significant pain relief and aid in meniscus regrowth. The treatment showed no 'clinically important' safety issues, with some patients experiencing strong improvement in pain and meniscal regrowth.
A study published in Nature Chemical Biology found that a molecular switch in the nerves responsible for detecting pain can 'short-circuit', intensifying pain. This alternative pathway activates the pain nerves, increasing the sensation of pain.
A study published in the journal Pain found that individual differences in grey matter in certain brain regions are related to pain sensitivity. People with higher default mode activity and better attention control tend to have reduced sensitivity to pain.
A Mayo Clinic study found that nearly all patients with intact rotator cuffs experience improved function and pain relief after shoulder replacement surgery. The procedure improves range of motion and reduces pain in nearly all cases, especially for those with rheumatoid arthritis.
Researchers at the University of Missouri have developed a comprehensive, nonsurgical treatment that significantly improves symptoms of pelvic floor dysfunction in women. The treatment involves muscle strengthening and relaxation techniques, resulting in an average 80% improvement in urinary incontinence, defecatory dysfunction, and pe...
Researchers at University of Nottingham discovered a potential drug to reduce osteoarthritis pain by targeting cannabinoid receptor2 (CB2), which also reduces joint inflammation. The synthetic compound JWH133 showed promise in animal models and human spinal cord tissue studies.
Researchers analyzed pain response in chickens, discovering that heat stimulation activates TRPA1 receptors similar to cold-blooded animals. Methyl anthranilate, a repellent chemical for birds, also activates chicken TRPA1, highlighting its functional evolution and diversification among vertebrate species.
A study found moderate evidence that mindfulness meditation programs show small improvements in anxiety, depression, and pain. However, there was low evidence of benefits for stress/distress and mental health component of health-related quality of life.
Researchers at Aalto University have discovered that emotional states trigger distinct bodily sensations, with consistent patterns across West European and East Asian cultures. The study found that awareness of these bodily changes can lead to conscious emotional sensations like happiness, highlighting the biological basis of emotions.
The study found that melatonin receptor 1 expression is significantly reduced in the caudal spinal nucleus, leading to an attenuated regulatory effect on pain. This breakthrough discovery has implications for understanding pain transmission and developing new treatments.
Researchers at Children's Hospital of Orange County (CHOC) have identified a new technique that reduces postoperative pain in children following high-risk urology surgeries, resulting in less need for pain medicine. The study evaluates continuous infusion of local anesthesia using the ON-Q pain relief system and shows promising results.
A randomized trial found that exercise reduced worst pain scores by 20% among women taking AIs, with a dose-response effect on pain relief. The study suggests exercise as a potential clinical intervention to improve AI-associated joint pain and adherence.
Researchers have developed a new imaging method to visualize high concentrations of a sodium channel protein associated with pain, potentially leading to improved pain management and treatment monitoring. The technique uses a small molecule attached to saxitoxin, which accumulates at sites of nerve damage in rats.
Researchers at Rhode Island Hospital validated the Critical-Care Pain Observation Tool (CPOT) as an accurate measure of pain level in non-verbal cardiac surgery patients. The study found that CPOT provides a reliable tool for pain assessment, improving patient outcomes such as reduced ventilator use and better pain management.
A study presented at the Radiological Society of North America annual meeting found that ultrasound-guided PRP therapy improves functionality by 80% and pain by 75% in athletes with Achilles and patellar tendinosis. The therapy also normalizes MRI signal intensity in 90% of patients.
A study found that 52.9% of older adults in the US have experienced bothersome pain, with multiple sites common among those with pain. Pain is strongly associated with decreased physical capacity, including weaker muscle strength and slower walking speed.
Researchers analyzed 2,475 patients and found that sex-specific chest pain characteristics were not useful for differentiating between women with heart attacks and those with other causes of chest pain. The study concluded that chest pain characteristics should be used in conjunction with ECG and cardiac markers to diagnose heart attacks.