Articles tagged with Pain
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Researchers aim to understand sex-specific effects of wheelchair use in childhood and adolescence to detect, prevent, and treat shoulder pain more effectively. The study uses state-of-the-art MRI scanners and quantitative morphometrics to quantify anatomical changes related to pain.
Researchers at MIT and MGH developed statistical models based on rigorous physiological data from over 100 surgeries, providing accurate measures of nociception. The new models aim to help anesthesiologists optimize drug doses and minimize post-operative pain and side effects.
A systematic review of risk stratification tools found high-sensitivity troponin tests to have the highest diagnostic accuracy for ruling out acute coronary syndrome. However, these findings require further validation before recommending their use in primary care settings.
A randomized trial of 50 older adults undergoing hip hemiarthroplasty found no difference in pain scores or other outcomes between liposomal bupivacaine and standard bupivacaine. The study suggests that the use of liposomal bupivacaine may not be worth considering for geriatric patients with hip fractures.
A new study from Mass General Brigham researchers found that large language models demonstrated no racial or gender discrimination in opioid treatment recommendations. The results suggest that these AI models have the potential to reduce bias and improve health equity in pain management, which is a critical area where disparities exist.
A new poll shows that 21% of people aged 50 and older used cannabis in the past year, with 12% using it at least monthly. The study highlights potential risks of cannabis use, including risky driving and addiction, as well as the importance of discussing its use with healthcare providers.
A study of 164,170 Medicare beneficiaries reveals racial disparities in opioid prescriptions after hip fracture hospitalization. Black and Asian patients receive significantly lower doses of opioids compared to white patients.
Researchers investigate synthetic oxytocin as a potential pain reducer and addiction curber for susceptible older adults. A two-year study with NIH funding aims to evaluate the effects of oxytocin on acute pain management and opioid use.
A new study found that hospital-admitted patients with sickle cell disease who received Lactated Ringer’s solution had shorter hospital lengths of stay, fewer readmissions, and less pain control medication compared to those who received normal saline. This shift in practice may improve patient outcomes and lower healthcare costs.
A breakthrough technology allows for touchless infrared imaging to monitor changes in pupil size and gaze direction behind closed eyes. This innovation can help identify wakefulness, awareness, and pain in sleep, anesthesia, and intensive care, enabling more accurate clinical decision-making.
Researchers from Medical University of Vienna discovered that TRPV1 is the primary detector of noxious heat in humans, but other molecular mechanisms contribute to protective heat avoidance. The findings have significant implications for research into heat damage prevention and potential new therapies.
Researchers at UF are creating a data biorepository to explore pain pathways and create custom treatments. They're collecting and analyzing human tissue samples and using AI to map and understand the complex relationship between neurons and pain.
Researchers found that sustained neck exertions alter the cervical spine's curvature, leading to muscle fatigue and increased risk of neck pain. The study provides new insights into the mechanical changes that occur in the spine and muscles when performing repetitive tasks.
The World Innovation Summit for Health will explore the need for innovation in healthcare to support vulnerable populations and build resilience. The summit aims to humanize health by addressing pressing global health challenges through evidence-based solutions.
A study by researchers at the University of Helsinki found that high rein tension can cause horses to open their mouths, indicating discomfort. Horse trainers should monitor horse behavior and adjust training to prevent mouth injuries.
A study published in The Lancet found that starting medical abortion at home is as safe as in a hospital, with 71% of participants able to be treated as day patients. The procedure also promotes patient autonomy and can reduce healthcare costs.
A study at Karolinska Institutet reveals that morphine activates a 'morphine ensemble' of neurons in the brain, leading to pain relief. This understanding may help develop new strategies to treat pain without triggering addiction and overdose.
A recent study published in Annals of Internal Medicine found that general exercise programs can reduce urinary incontinence symptoms almost as much as pelvic floor yoga. The LILA study involved 240 women who experienced urinary incontinence at least daily, and randomly assigned them to either a pelvic yoga program or a physical condit...
A study from University of Gothenburg links work-related pain to mental illness among construction workers. Managers' empathetic or neglectful attitudes are highlighted as key factors in mental health.
A recent study by University of Missouri researchers found that giving nurses massages during their shifts can reduce physical aches and pains while improving mental rejuvenation. The study's lead researcher aims to create a healthier work environment where nurses are excited to remain in the profession long-term.
A recent study published in JAMA Surgery found that about one-third of patients experience persisting abdominal pain five years after cholecystectomy. Researchers recommended caution with the procedure in patients with gallstones and abdominal pain, suggesting a restrictive selection strategy may be more effective.
Researchers developed an approach to clearly separate physical and psychosocial components of pain, allowing for more targeted treatment. The new method combines measuring body signals, self-disclosure, and computerized evaluation to create two indices: one for physical component and one for psychosocial component.
A WVU researcher argues that more validation is needed for the increasing number of gallbladder surgeries performed for biliary dyskinesia, a functional gallbladder disorder. The researcher suggests that a combination of factors must come together to diagnose and select patients who would benefit from surgery.
A small comparative study found that 20 minutes of mindful breathing significantly reduced cancer pain intensity and unpleasantness, as well as anxiety. The researchers suggest that this brief intervention holds promise in enhancing pain management for cancer patients.
A study by the University of Gothenburg finds that removing Fallopian tubes during laparoscopic sterilization results in marginally more surgical complications than cutting them. The procedure may help protect against future ovarian cancer, a serious disease with limited early symptoms.
Researchers found the woman was embalmed with costly imported ingredients, contradicting traditional beliefs about mummification. The study also revealed she suffered from arthritis and had a unique facial expression that may be attributed to a cadaveric spasm caused by intense pain.
The review paper examines the scope of people affected by long COVID, ranging from fatigue to cognitive impairment, and current treatment options. Researchers emphasize the need for biomarkers and targeted therapies to address root causes of the disease.
Researchers assessed botulinumtoxin-A treatment to improve walking capacity in children with cerebral palsy. The trial found some evidence of reduced calf pain and delayed improvement in energy cost, but no significant benefit for overall walking ease.
A cross-sectional study in Australia and Canada found that physical exercise is associated with fewer depression symptoms in people with osteoarthritis. The study suggests that exercise may be particularly beneficial for individuals experiencing severe pain, improving mental health outcomes.
Researchers have identified a strategy to design safer opioids that suppress pain with fewer side effects. An experimental opioid, RO76, was found to produce a signal within cells that differs from those initiated by classic opioids, leading to reduced breathing rates and withdrawal symptoms.
The study found that massage therapy has moderate-certainty evidence for some conditions but rare conclusive evidence of its superiority over other treatments. The review highlights the need for more research in this area.
A new technological breakthrough has enabled scientists to visualize opioid signaling in the brain in real-time, providing a deeper understanding of how opioids affect the brain. This breakthrough has opened up new avenues for developing more effective and safer therapeutics for pain management and mental health disorders.
A team of researchers has developed light-activated compounds that can inhibit nerve signals locally and on demand, offering a potential treatment for neuropathic pain. The compounds, which are activated by amber-colored light, show photopharmacological activity in animal models.
The University of Texas at Arlington has awarded seven Interdisciplinary Research Program (IRP) grants totaling $140,000 to foster collaboration between groups. The grant increase represents a 40% boost over the previous year's funding.
A new study by ACS Journal of Proteome Research identifies shifts in tear protein levels as predictors of long-lasting pain after LASIK surgery. The analysis suggests that specific patterns of protein changes could one day be used to evaluate patients' risk of post-surgical eye pain and find new treatments.
A UCLA Health study discovered that suvorexant, an insomnia medication, blocks brain receptors for hypocretin and prevents opioid addiction in mice. The drug maintains behavioral alertness at lower doses than those inducing sleep. Further studies are needed to determine its effectiveness in humans with opioid use disorder.
Researchers have identified a novel compound that can reverse the lethal effects of opioid overdose when paired with naloxone, reducing withdrawal symptoms and extending protection. The discovery builds on new insights into opioid receptors and could combat the devastating fentanyl epidemic.
A randomized controlled trial found that four weeks of outdoor gait training, combined with home exercises, improved running biomechanics and reduced the time feet were in contact with the ground. This technique may help patients improve their stride and reduce pain associated with shin splints.
Researchers characterize thalamic and cortical neurons responding to ocular surface stimulation, showing diverse multimodal response profiles. The study provides insights into how sensory stimulus information is integrated from the peripheral nervous system into the brain's cortical networks.
A new study published in PLOS ONE explores the implementation of a paper-based system for collecting patient-reported outcomes (PROs) in an outpatient integrative health and medicine (IHM) setting. The research found that provider, operational, and clinical-level factors have a greater impact on successful completion than patient factors.
Researchers at the University of Tsukuba found that using VR avatars with muscular bodies reduces pain perception by ~16%. The study also showed that matching the avatar's gender with the user's can further lower pain scores.
Research from the University of South Australia found that people with knee OA unconsciously believe exercise is dangerous, despite medical advice. The study developed a tool to detect and evaluate these implicit beliefs, suggesting they can be a better predictor of actual behavior than reported attitudes.
A study in São Paulo state found that chikungunya virus circulated silently for years before causing major epidemics. The researchers monitored residents for four years and discovered a significant rise in seroprevalence from 0.35% to 2.3%. This finding underscores the need for strengthened disease surveillance.
A recent study published in BRAIN found that males and females differ in their experience of pain due to functional sex differences in nociceptors. The findings support the implementation of a precision medicine-based approach considering patient sex as fundamental to treatment choices.
A breath-holding test assesses cardiorespiratory health and predicts postoperative pain risk in laparoscopic gynecological surgery. The study analyzed 489 patients and found significant correlation between breath-holding time and pain scores.
Researchers at CU Anschutz Medical Campus identified key elements to improve diagnosis and treatment of coronary heart disease (CHD) in women, addressing the common misdiagnosis of heart attacks. The new guidelines provide recommendations to help clinicians better address sex-specific symptoms and treatments.
A new study by University Hospitals Cleveland Medical Center found that patients seeking outpatient integrative health and medicine (IHM) care experience clinically meaningful reductions in symptoms of pain, anxiety, and stress after just one treatment. For all IHM modalities, patients with moderate-to-severe symptoms reported clinical...
A study published in Clinical Oral Investigations found that people with post-traumatic stress disorder (PTSD) often experience bruxism, or teeth grinding. The researchers emphasized the importance of collaboration between dentists and psychiatrists to diagnose and treat these patients effectively.
A recent study published in Anesthesiology found that liposomal bupivacaine is not sufficient to control pain during surgery, with successful blockade achieved in only a third of test subjects. However, the substance did lead to a reduction in pain sensitivity for 3.5 days post-operatively.
A new study from the University of South Australia shows that young children learn about pain through reading, promoting empathy and emotional development. Reading picture books frequently prompts interactions about pain and injury, teaching valuable responses to these concepts.
A new study suggests that premature surgical menopause can lead to increased muscle disorders, including musculoskeletal pain and sarcopenia. Women experiencing premature menopause are more likely to develop these conditions due to significant hormone deficiency, including decreased estrogen and testosterone levels.
Researchers at NeuRA and UniSA found that early detection and comprehensive treatment can lead to significant recovery for most people with Complex Regional Pain Syndrome (CRPS) within 12-18 months. The study reviews the latest advances in CRPS epidemiology, pathophysiology, diagnosis, and treatment.
Researchers discovered a novel brain network condition called 'explosive synchronization' that correlates with pain crises in sickle cell disease. This finding could lead to predicting and preventing severe episodes of pain, improving patient outcomes.
A randomized clinical trial found self-administered acupressure to be efficacious and cost-effective in reducing knee pain and improving mobility in middle-aged and older adults with probable osteoarthritis. The treatment also showed significant benefits in terms of quality of life.
A study published in Cell Reports found that early-life pain experiences can lead to genetic changes in macrophage cells, resulting in more intense pain reactions later in life. The researchers suggest targeting these genetic changes could help prevent long-lasting pain memories.
A study published in The Lancet Gastroenterology & Hepatology found that dietary adjustments, such as a low FODMAP diet and low-carbohydrate diets, resulted in significantly reduced IBS symptoms for over seven out of ten patients. In contrast, medication-based treatment showed fewer symptom improvements.
A new study from the University of South Australia explores female experiences with pelvic pain and identifies key concepts for effective pain management. The study found that women value learning about the biological explanation for persistent pain, which can help change outcomes and reduce stigma.
The study reveals how opioid receptors stabilize a state for effective signal transmission, making superagonists potent and dangerous. It also highlights the importance of understanding molecular interactions for drug development and developing safer medicines.
A study comparing progressive resistance training and neuromuscular exercise found no measurable difference in physical function, pain level, or quality of life between the two groups. The results suggest that patient involvement plays a crucial role in choosing an optimal training type for individual patients.
A 10-minute virtual reality session significantly lessened pain in hospitalized patients with cancer, with sustained benefits even a day later. The study found that VR sessions had a greater impact than guided imagery, improving not only pain severity but also related issues like general distress.