Articles tagged with Pain
A study by Wake Forest University School of Medicine reveals that a stress response in immune cells contributes to chemotherapy-induced nerve damage. By blocking this pathway, researchers aim to develop new treatments to protect cancer patients from debilitating side effects.
Research found that picture books often show boys experiencing more pain than girls, while girls are more likely to cry when faced with pain. The study also highlights the lack of representation of prosocial behavior, such as helping others in need.
A study published in CMAJ shows a decline in opioid dispensing between 2018 and 2022, but regional variations remain. The authors highlight the need for coordinated national strategies to address differing implementation of prescribing guidelines.
A new study found that patients who continued spinal cord stimulation had similar mortality rates to the control cohort, suggesting successful pain management can avoid excess mortality. Spinal cord stimulation differs from long-term opioid therapy, which is addictive and increases mortality.
Researchers at UC Irvine have identified a molecular mechanism controlling the transition from acute to chronic pain. A newly proposed formula, which includes a modified diet rich in deficient nutrients, showed promise in blocking this transition in mouse models.
A randomized clinical trial found that an unsupervised online Tai Chi intervention improved knee pain and function compared to the control group at 12 weeks. This free web-based intervention offers a safe, accessible, and scalable option for guideline-recommended osteoarthritis exercise.
A new study led by Northwestern Medicine found that botulinum toxin injections provided significant short-term relief for phantom limb pain, with an average reduction of four points on a 10-point scale. The treatment, which targets painful nerve endings around neuromas, showed promise as a potential tool to alleviate post-amputation pain.
A recent study found that cannabis may reduce opioid use among commercially insured patients with cancer diagnoses, indicating potential benefits for pain management. However, further research is needed to confirm the efficacy of cannabis as a treatment for cancer-related pain.
A study by UT Arlington researchers found that state welfare policies affect joint pain trends, with states like Colorado and Hawaii seeing significant increases. In contrast, Texas saw a decrease in the educational gap despite increased pain prevalence, highlighting the need for targeted interventions.
Poor blood sugar control in adolescence increases the risk of painful future complications for people with type 1 diabetes. Children diagnosed with type 1 diabetes at a young age have trouble controlling their blood sugar as teens and are more likely to develop neuropathy in adulthood.
An open-label placebo treatment was associated with improved quality of life and reduced pain-related disability in patients with migraine. However, the treatment did not reduce headache frequency in this study.
Researchers have identified a group of cells called Y1 receptor-expressing neurons in the brainstem's lateral parabrachial nucleus as critical for regulating long-term pain states. These neurons integrate information about hunger, fear and thirst, allowing pain signals to be modulated by other brain circuits signaling more urgent needs.
A new study found that 2/3 people with chronic pain reach for comfort foods to cope, offering pleasure, distraction, and relief from negative emotions. However, this can lead to weight gain, which worsens pain and increases health risks.
Researchers discovered a new enzyme produced by Bacteroides fragilis that activates pain signaling. The enzyme is targeted with nanoparticles to develop treatments for gut pain in inflammatory bowel disease and irritable bowel syndrome. The studies aim to restore balance between good and bad bacteria to reduce symptoms.
A study published in Social Science & Medicine found that people's theoretical willingness to accept money in exchange for enduring pain offers a more reliable way to measure discomfort than conventional measures. The research involved over 300 participants who were exposed to mild painful stimuli and asked to rate the intensity or ind...
Scientists at NYU Pain Research Center identified the EP2 receptor as the main cause of inflammatory pain but not inflammation. Blocking this receptor silenced pain responses without affecting inflammation, offering a new strategy for treating prostaglandin-mediated pain.
Chronic back pain is associated with a higher incidence of cardiovascular disease, arthritis, depression, and other conditions. A study found that people with back pain are more likely to report severe activity limitations due to comorbidities.
Salk scientists pinpoint gracile nucleus as brain area responsible for differentiating between painful and non-painful touch, with dysfunction leading to chronic pain. Altered neuronal activity in the dorsal column nuclei drives mechanical allodynia, causing the brain to misinterpret innocuous light touch as painful.
A recent analysis reveals a modest decline in new and additional opioid prescriptions for patients with cancer from 2016 to 2020. For patients with metastatic cancer, prescribing remained stable for those reporting any pain but declined steeply for those reporting no pain.
Researchers developed a fully automated finite element analysis pipeline to transform spine diagnostics and personalized treatment planning. The new approach enables rapid, patient-specific simulations that support preoperative planning, spinal implant optimization, and early detection of degenerative spine conditions.
A study funded by the NIH found that acupuncture treatment significantly improved physical function and reduced pain in older adults with chronic low back pain, compared to usual medical care. The study showed a modest but positive effect of acupuncture on disability scores, anxiety symptoms, and pain intensity.
A new study published in Psychology and Health journal found that individuals with chronic pain experience higher levels of perfectionism and lower levels of self-compassion. Researchers suggest that increasing self-compassion and addressing perfectionistic tendencies may be beneficial for managing chronic pain.
Researchers found that improving diet quality reduced chronic musculoskeletal pain from 50% to 24%, while also decreasing pain-related quality of life. The study suggests that adopting a healthier diet may lead to meaningful reductions in pain and improve overall wellbeing.
A new study published in the American Cancer Society's journal reveals that nearly 1 in 10 patients undergoing surgery for early-stage cancer will initiate opioid prescriptions long-term. The research found that those with a prior history of chronic pain, comorbidities, and lower socioeconomic status were at higher risk.
A new study from UTS highlights the emotional and mental toll on teachers managing student pain in classrooms, finding educators often feel helpless, emotionally drained, and unsupported. The research identifies three key areas where pain science education can create meaningful change for both teachers and students.
Insomnia patients taking cannabis-based medical products reported significant improvements in sleep quality, anxiety, and pain over 18 months. The study found sustained benefits with minimal side effects, suggesting potential for medical cannabis as an option for conventional treatments.
Research reveals neuroglia play active role in brain function, driving disease progression through atrophy and functional decline. Therapeutic strategies targeting neuroglial signaling may prevent damage following brain injury or protect against neurodegenerative processes.
Despite long-held assumptions, a new study reveals that the brain's somatosensory cortex holds a stable 'body map' even after limb loss. The findings have significant implications for treating phantom limb pain and restoring sensation in prosthetic limbs via brain-computer interfaces.
A new Cochrane review has found no clear evidence of benefit for ketamine in treating chronic pain conditions. The review identified an increased risk of adverse effects such as delusions and vomiting. High-quality trials are needed to determine the role of ketamine in chronic pain care.
Researchers have developed a new approach to relieving arthritic knee pain through gait retraining, which involves adjusting the angle of a person's foot while walking. The study found that participants experienced pain relief equivalent to medication and showed less knee cartilage degradation over a year.
A new study suggests that subtly adjusting the angle of the foot during walking can reduce knee pain caused by osteoarthritis and slow its progression. By tailoring each patient's foot angle to their unique walking pattern, experts believe an easy and fairly inexpensive way to address early-stage osteoarthritis may be found.
Researchers create breakthrough imaging system that shows sensory activity in real time, enabling them to distinguish between different sensations. The technique uses a genetically encoded voltage sensor to observe electrical signals from neurons and has major implications for treating chronic pain and sensory disorders.
Researchers found that injecting botox directly into the TMJ alleviated TMD-related pain, hypersensitivity, and neural activity, while preserving movement abilities. The study suggests avoiding muscle tissue to overcome botox side effects and offers new hope for treating jaw disorders.
A study using anonymized patient records from UC health centers found over 600 correlations between endometriosis and other conditions, including infertility, autoimmune disease, and certain cancers. The research supports the growing understanding of endometriosis as a multi-system disorder.
Researchers found that external cues alleviated pain for all participants but only half reported less pain with placebo treatment. Predictive cues were less impactful when patients received placebo treatment. The study suggests cue-based expectations have more consistent effects than treatment-based expectations.
A study by the University of Exeter found that immersive VR nature scenes can reduce symptoms of long-term pain. Participants who felt more present during the experience experienced the strongest effects. The study suggests that nature scenes delivered using VR can help change how pain signals are transmitted in the brain and spinal cord.
A new genetic study has identified genes involved in neuronal signalling and sensory pathways as key drivers of chronic cough. The findings advance our understanding of cough reflex hypersensitivity as a nervous system-mediated process, opening up opportunities for targeted treatments.
Remote, scalable cognitive behavioral therapy-based treatments improved pain and quality-of-life outcomes for individuals with high-impact chronic pain. These lower-resource treatments could increase availability of evidence-based nonpharmacologic pain treatments.
Studies have shown that emotional or psychological stress enhances pain responses, but the effects of social pain transmission remain elusive. Researchers found that ultrasonic vocalizations emitted by mice in response to pain stimuli can induce emotional transmission and hyperalgesia in other mice.
A study using AI language models analyzed sentiments and emotions expressed by almost 400 pediatric patients on social media, finding that 94% of comments were negative, with sadness and fear prevalent. The study highlights the need for integrated care approaches to support vulnerable young patients managing complex medical conditions.
Researchers at the Salk Institute have identified a brain circuit that gives physical pain its emotional tone, revealing a potential target for treating chronic and affective pain conditions. The study found that a group of neurons in the thalamus can mediate the emotional side of pain in mice.
A new study found that Black emergency department patients are less likely to be treated with opioids, but when their preferences are not met, they are at a higher risk of misusing opioids three months later. Patients who were satisfied with their pain care had lower rates of opioid misuse.
Researchers have discovered that multimodal pain integration in the brain significantly enhances overall pain perception when participants are instructed on how to perceive the pain. The precuneus region of the brain plays a vital role in integrating pain information into a cohesive and intensified pain experience.
Researchers identified a key brain region, the ventrolateral periaqueductal gray matter (vIPAG), that modulates pain and emotional responses in threatening situations. By inhibiting specific cells within this region, scientists discovered a potential pathway for better pain relief.
A new device created by USC biomedical engineers could help sufferers avoid the need for opioids. The UIWI stimulator is designed to provide real-time, personalized pain management through machine learning algorithms and wireless power supply.
A study from The Hebrew University of Jerusalem found that the brain's braking system fails in chronic pain, leading to increased pain signals. This discovery opens the door to targeted therapies and may help prevent pain from becoming chronic.
A machine learning model developed by researchers at Washington University in St. Louis can predict the risk of persistent post-operative pain and provide uncertainty estimates for each prediction. The model achieves better performance than other prediction algorithms and offers a valuable tool for doctors to guide their decisions.
A new study found that babies are born with the ability to sense physical pain but lack the cognitive understanding of it. The research, led by UCL researchers, used brain imaging data from infants and adults to map the development of pain-processing networks in the brain.
A new study reveals that paracetamol blocks pain signals before they reach the brain by acting on nerve endings. This discovery opens the door to developing safer pain treatments. The active metabolite AM404 targets specific sodium channels in pain-sensing neurons, stopping pain signals.
A study published in The Journal of Pain found that nature exposure can help people with chronic lower back pain by providing a sense of escapism, social connection, and physical exercise. Researchers recommend incorporating accessible design features into natural spaces to improve inclusivity.
Researchers at Vrije Universiteit Brussel have developed a method to express and study Nav1.9, a channel protein linked to pain and itch. This breakthrough paves the way for targeted therapies without opioids' downsides, offering new hope for treating unexplained pain symptoms.
A study found that 72.5% of young Brazilian women suffer from symptoms like itching, discharge, and pain during intercourse, negatively affecting quality of life and sexual health. The research suggests that vulvovaginal symptoms are often normalized, leading to undertreatment and emphasizing the need for more intimate health education.
A new study identifies three compounds that suppress the heat of chili peppers, hinting at a potential 'anti-spice' condiment. These compounds, including capsianoside I, roseoside, and gingerglycolipid A, may have pain management implications by desensitizing TRPV1 receptors.
A study by University College London researchers found that depressive symptoms worsen long before pain begins in middle-aged and older adults. Early mental health interventions may help prevent or reduce later aches and pains.
Researchers at University of Arizona Health Sciences identified a potential way to reduce female post-operative pain by inhibiting pituitary prolactin. Stress can increase circulating levels of prolactin, leading to worsened post-operative pain in women.
A cross-sectional study found common experiences of gaslighting and substantial distress among patients with vulvovaginal disorders. The study emphasizes the need for education supporting a biopsychosocial approach to vulvovaginal pain, as well as the development of validated instruments to quantify patient experiences.
Research found that negative expectations have a stronger and longer-lasting impact on pain perception than positive ones. The study showed that nocebo effects, where participants expect a negative outcome, were more powerful and persistent than placebo effects, with implications for patient-practitioner communication.
A global research initiative analyzing data from nearly 2 million people in diverse populations worldwide has uncovered multiple new genes associated with osteoarthritis. The study also identified key genetic pathways and 69 genes whose protein products are targeted by approved drugs, paving the way for repurposed treatments.
A new project identified the top 10 priorities in global burns care research, focusing on psychological effects, cost-effective treatments, and long-term care. The study surveyed over 1,600 people across 88 countries to guide future research and treatment improvements worldwide.
A study published in JAMA found that metformin reduced knee arthritis pain over six months in patients with symptomatic knee osteoarthritis and overweight or obesity. The treatment was shown to have a moderate effect on pain reduction, with the metformin group reporting a 31.3 point decrease compared to the placebo group.