Articles tagged with Pain
A recent review of opioid medicines for cancer pain found surprisingly large gaps in evidence regarding their true benefits. Non-steroidal anti-inflammatory drugs (NSAIDs) may be at least as effective as some opioids for background cancer pain, offering potential alternatives to reduce dependence and waning analgesia over time.
A study by the University of Sydney and University of Warwick found large gaps in evidence regarding opioid medicines for cancer pain. Non-opioid medicines, including aspirin, may be as effective as opioids for background cancer pain.
A study published in PLOS ONE reveals that Vikings in Sweden had a high prevalence of tooth decay, with many exhibiting severe caries and other dental pathologies. The findings provide insights into the lives of these ancient Scandinavians and their attempts to treat dental issues.
A study found that saliva biomarkers sTNFR2 and sIgA can effectively detect pain in people with dementia, providing an alternative to invasive methods. The researchers discovered a decrease in sTNFR2 levels and an increase in sIgA in patients with dementia compared to a control group.
A systematic review has identified 29 primary risk factors associated with long-term arm morbidities following breast cancer treatments. The main risk factors include removal of lymph nodes, high body mass index, mastectomy, radiation therapy, chemotherapy, infection, and trauma to the affected arm.
Post-surgery pain relief has shifted away from opioids since 2016, with a 36% drop in prescription rates and 46% decrease in average amount of opioids. However, the rate of decline slowed after 2020, suggesting ongoing efforts are needed to right-size prescribing.
Researchers analyzed leishmaniasis lesions on mouse skin to detect metabolic signaling pathways that differed from uninfected mice. They found pathways with pain-relief properties tied to the brain's endocannabinoid system, which is involved in a host of physiological processes, including the pain response.
A systematic review and meta-analysis of 16 studies involving 875 patients with knee osteoarthritis found significant reductions in patient-reported pain from the third month onwards. Stem cell treatment was most effective when using patient's own fat-derived stem cells, leading to better pain alleviation and recovery of joint function.
Researchers at Michigan State University found that glial cells in the gut can sensitize nearby neurons, causing them to send pain signals more easily during inflammation. This discovery could help develop new therapies to alleviate visceral pain by counteracting the glia's sensitizing efforts.
Nerve damage can lead to severe and long-lasting effects, including depression. Researchers have developed new technology to repair and reconstruct damaged nerves using simple electrical circuitry in implants. This innovation has the potential to benefit people with injuries and neurodegenerative diseases.
A study published in the Journal of Dental Research found that cannabidiol (CBD) reduces dental pain intensity by 70% and improves bite force. While side effects occurred more frequently than placebo, promising results suggest CBD may be an effective alternative to opioid painkillers for managing acute toothache.
A study published in PLOS ONE found that 35% of women with breast cancer used self-discovered or peer-recommended techniques to enhance their sexual function. These techniques fell into four main domains: pain reduction, intimacy and relationship enhancement, desire and arousal enhancement, and emotional coping.
A new study from the University of Pennsylvania School of Medicine found that younger patients and those with no prior experience with opioids are more likely to use few or no opioids after surgery. The researchers used data collected through automated text messages sent to 3,600 patients who underwent common surgical procedures.
Researchers found that acupuncture improved symptoms in patients with chronic spontaneous urticaria (CSU), but the benefits were not significant enough to meet the minimal clinical difference threshold. The study included over 300 participants and suggested that clinicians should consider using acupuncture as an adjunctive treatment.
Jenny Wilkerson receives $1.94 million grant to develop novel models and investigate antinociceptive profiles of basal sex hormone alterations in patients with chronic post-op pain. The study aims to answer questions about the impact of altered sex hormone levels on recovery times, drug effectiveness, and long-term health.
Researchers have identified a small molecule that reverses four types of chronic pain in animal studies without troublesome side effects. The compound, CBD3063, binds to the inner region of a calcium channel, indirectly regulating its activity and reducing neurotransmitter release.
The ORBITA-2 trial found that stenting improves symptoms compared to a placebo procedure, providing evidence-based treatment for stable chest pain. The study suggests updating guidelines for stable coronary artery disease and offers patients and medical teams two treatment strategies with similar benefits.
Two reproductive health conditions, polycystic ovary syndrome and dysmenorrhea, are linked to increased cardiovascular disease risk in women. Studies suggest that girls with polycystic ovary syndrome have a 30% higher risk of high blood pressure, while women with dysmenorrhea are twice as likely to experience ischemic heart disease.
Researchers describe the use of ripretinib and repeated surgical resection in a patient with recurrent GIST harboring a KIT exon 11 mutation. The treatment led to extended clinical benefit, outperforming current reported data from ripretinib clinical trials.
Researchers are conducting a four-year study to investigate the effectiveness of acupuncture in reducing stable angina-related chest pain. The study will enroll 112 participants and compare acupuncture treatment to watching TED Talk videos for symptom relief.
A new study shows a significant decline in dental opioid prescriptions, with 45% fewer opioids dispensed between 2016 and 2022. However, progress slowed significantly during the COVID-19 pandemic, which may be attributed to dentists being more cautious due to limited follow-up appointments.
A Penn State study found that CBD and CBG promoted fracture healing and reduced pain in mice. The cannabinoids accelerated the process of mineral absorption, leading to higher bone volume fraction and density.
Listening to preferred music reduces pain intensity and unpleasantness, while emotional responses play a key role in predicting its effect. The study found that moving or bittersweet emotional themes are associated with lower pain ratings.
A study of 5,435 adolescents and young adults with cancer found that those receiving specialty palliative care experienced a decrease in pain severity. However, the intervention did not affect other symptoms, highlighting the need for new interventions targeting other symptoms during treatment.
A randomized clinical trial found that high-frequency electrical stimulation device reduced opioid use and prescribed opioids after cesarean delivery, suggesting a potential adjunct to decrease opioid use without compromising pain control.
Patients from racial and ethnic minority groups receive inadequate pain treatment in the prehospital setting, according to a study of over 4.7 million encounters across the US. The results suggest a significant disparity in pain management practices based on race and ethnicity.
A new study published in JAMA Health Forum shows that implementing a five-day limit on opioid prescriptions for surgery patients did not lead to increased pain levels or decreased satisfaction. However, the amount of opioid pills patients received dropped significantly after the limit went into effect.
A Monash University study found that methotrexate, a low-cost and effective treatment for inflammatory joint conditions, can reduce pain and stiffness in patients with symptomatic hand OA. The study's results suggest that methotrexate may be a viable treatment option for people with hand osteoarthritis and inflammation.
A study published in Nature Human Behaviour has uncovered a neural pathway preferentially involved in pain perception across species. The researchers identified the central role of the medial-dorsal thalamic nucleus in pain perception, which exhibited a more pronounced activation in response to painful stimuli.
Researchers discovered that people carrying three Neanderthal gene variants in the SCN9A gene are more sensitive to certain types of pain. The study found an association between the variants and a lower pain threshold in response to skin pricking after prior exposure to mustard oil.
Rates of opioid prescribing to US adolescents have decreased in recent years, mainly for non-surgical procedures. Opioid prescribing for surgical indications has remained relatively stable during the same period. This analysis of Medical Expenditure Panel Surveys data from 2015-2020 reveals a significant shift in prescribing patterns.
Researchers surveyed patients undergoing elective surgeries and found that reducing opioid prescriptions led to higher patient satisfaction with pain management. The study's results were used to develop evidence-based guidelines for prescribing opioids after surgery, aiming to balance managing pain and opioid use.
Pediatric patients experience pain that can be detrimental to their brain structure and lead to emotional and behavioral problems. Validated tools such as the Wong-Baker FACES scale and COMFORT scale help healthcare providers assess pain effectively.
A new study found that patients with patellofemoral pain have smaller muscles in their hips and hamstrings, which are not typically targeted in rehabilitation. This suggests that personalized rehabilitation approaches may be necessary to effectively address chronic knee pain.
A study by researchers at the University of Miami Miller School of Medicine found that thoracic surgeons who treat lung cancer are helping to reduce patients' risk of opioid dependence. The ERATS protocol, which includes intercostal nerve blocks and safe pain relievers, enables earlier hospital discharge with nearly opioid-free recovery.
Researchers found that half of patients need only five tablets or fewer of morphine to manage acute pain, varying by condition. The study aims to adapt opioid prescriptions according to patient need and reduce long-term misuse.
The US experienced its highest death rates in over a century, fueled by drug overdose mortality. From 1999 to 2020, drug overdose deaths more than quadrupled, with white and Native Americans experiencing the greatest increase.
Palliative care and addiction experts agree that clinicians should increase monitoring and continue opioids without tapering in patients with advanced cancer who use stimulants. This approach prioritizes pain control and allows for individualized harm-reduction strategies.
A new study finds that targeting the ORAI1 calcium channel may provide a promising approach to treating oral cancer. The study reveals that activating this channel causes an influx of calcium into cancer cells, leading to increased pain sensitivity.
A global analysis of 2.3 million people reveals women are diagnosed and treated late for cardiac issues, with alarming rise in heart attacks among younger women. Non-traditional symptoms like vomiting, jaw pain, and abdominal pain are more common in women.
Researchers found that playing a lullaby reduced pain levels in newborn infants undergoing a heel prick blood test. The study, published in Pediatric Research, suggests that recorded music may be an effective method of pain relief in newborns during minor procedures.
The American Dental Association has released a new clinical practice guideline recommending the use of acetaminophen and/or non-steroidal anti-inflammatory drugs (NSAIDs) as first-line treatments for managing short-term dental pain in children under 12. The guideline has been endorsed by the American Dental Association.
A recent study found that cast immobilization is as effective as surgery in treating older adults with arm fractures. After one year, no statistically significant differences were found between the groups in terms of disability or range of motion. The study included 276 patients aged 70–89 years who suffered a distal radius fracture.
A randomized clinical trial found that a preoperative augmented reality walkthrough decreased preoperative anxiety compared to traditional education and handouts. However, there was no significant impact on postoperative anxiety, pain levels, or narcotic use in patients undergoing surgery.
A new study reveals that Female Genital Mutilation (FGM) is a leading cause of death in African countries, resulting in estimated 44,320 excess deaths per year. The practice remains legal in five countries and requires cultural change to be effective.
A new study published in the Journal of the American Heart Association found that people who experience pain after a heart attack are more likely to die within the next 8.5 years. The study analyzed data from over 18,300 adults who had a heart attack and found that moderate or extreme pain was linked to a higher mortality risk.
Most adults commencing treatment with prescription opioids had relatively low and time-limited opioid exposure over a 5-year period. Individuals with sustained or increasing use were older with more comorbidities, reflecting higher pain needs.
Scientists have identified five distinct subtypes of sensory neurons in the colon that carry signals to the brain, with different subtypes responding to gentle and intense forces. This discovery could lead to a better understanding of gastrointestinal conditions and inform the development of more effective therapies.
Researchers have identified a novel therapeutic target for pelvic pain in endometriosis by focusing on the IL-1β pathway and its regulation via the JNK signaling pathway. This study suggests that JNK inhibitors may be effective in reducing neuroinflammation and alleviating symptoms of endometriosis-associated pain.
A new study found that 81% of women report persistent GI symptoms years after diagnosis, with abdominal bloating and gas being the most common. The analysis also showed that severe GI symptoms are linked to poor quality of life, social activities, and body image satisfaction.
Researchers at University Hospitals Cleveland Medical Center implemented a quality improvement initiative to improve documentation consistency and increase the capture of patient-reported outcomes. The findings show that music therapists' rates of capturing PROs increased significantly, with notable improvements in stress, pain, anxiet...
Researchers at NYU College of Dentistry developed a gene therapy that regulates sodium ion channel activity to alleviate chronic pain. By targeting the specific region where CRMP2 binds to NaV1.7, they were able to reduce sodium influx and quiet down neurons, providing relief from pain in cell and animal studies.
A UTHealth Houston study found that regular cannabis users are more likely to experience complications before, during, and after surgery. Patients with a cannabis use disorder (CUD) were approximately 20% more likely to suffer significant postoperative complications than those without CUD.
A new study published in Human Reproduction found that women with endometriosis are more likely to experience a reduction in live births before receiving a definitive diagnosis. The research, which included over 18,000 women with surgically-confirmed endometriosis, showed that the number of first live births among these women was half ...
Researchers found real breed differences in pain sensitivity thresholds, contradicting veterinarian rankings. The study suggests biological and behavioral factors influence pain tolerance, highlighting the need for individualized treatment approaches.
A national study launched by UNCG's Prevention Strategies aims to prevent opioid misuse among high-risk occupations. The WorkWell mobile app, featuring evidence-based educational strategies, will be tested in the construction and nursing industries.
A University of Essex-led study found that fast-oscillating brain waves linked to brief pain and touch differ widely in scans, with individual patterns stable across time. The research challenges previous findings on the relationship between pain and gamma oscillations.
A new patient-guided intervention using telemedicine has been shown to improve symptoms of fatigue, pain, and depression in dialysis patients. The Technology Assisted Stepped Collaborative Care (TĀCcare) trial found significant improvements in energy levels and pain severity that persisted for six months after treatment.
A novel 'robotic pill' has been found to safely deliver the osteoporosis medication teriparatide orally, with comparable bioavailability to traditional injections. This breakthrough technology could offer a painless and more accessible treatment option for patients suffering from chronic conditions.
Researchers found that morphine interacts with toll-like receptor 4 to contribute to increased bone loss and pain. Blocking TLR4 prevents these effects, suggesting a new target for reducing opioid side effects.