Articles tagged with Pain
Researchers found that playing a lullaby reduced pain levels in newborn infants undergoing a heel prick blood test. The study, published in Pediatric Research, suggests that recorded music may be an effective method of pain relief in newborns during minor procedures.
The American Dental Association has released a new clinical practice guideline recommending the use of acetaminophen and/or non-steroidal anti-inflammatory drugs (NSAIDs) as first-line treatments for managing short-term dental pain in children under 12. The guideline has been endorsed by the American Dental Association.
A recent study found that cast immobilization is as effective as surgery in treating older adults with arm fractures. After one year, no statistically significant differences were found between the groups in terms of disability or range of motion. The study included 276 patients aged 70–89 years who suffered a distal radius fracture.
A new study reveals that Female Genital Mutilation (FGM) is a leading cause of death in African countries, resulting in estimated 44,320 excess deaths per year. The practice remains legal in five countries and requires cultural change to be effective.
A randomized clinical trial found that a preoperative augmented reality walkthrough decreased preoperative anxiety compared to traditional education and handouts. However, there was no significant impact on postoperative anxiety, pain levels, or narcotic use in patients undergoing surgery.
A new study published in the Journal of the American Heart Association found that people who experience pain after a heart attack are more likely to die within the next 8.5 years. The study analyzed data from over 18,300 adults who had a heart attack and found that moderate or extreme pain was linked to a higher mortality risk.
Most adults commencing treatment with prescription opioids had relatively low and time-limited opioid exposure over a 5-year period. Individuals with sustained or increasing use were older with more comorbidities, reflecting higher pain needs.
Scientists have identified five distinct subtypes of sensory neurons in the colon that carry signals to the brain, with different subtypes responding to gentle and intense forces. This discovery could lead to a better understanding of gastrointestinal conditions and inform the development of more effective therapies.
Researchers have identified a novel therapeutic target for pelvic pain in endometriosis by focusing on the IL-1β pathway and its regulation via the JNK signaling pathway. This study suggests that JNK inhibitors may be effective in reducing neuroinflammation and alleviating symptoms of endometriosis-associated pain.
A new study found that 81% of women report persistent GI symptoms years after diagnosis, with abdominal bloating and gas being the most common. The analysis also showed that severe GI symptoms are linked to poor quality of life, social activities, and body image satisfaction.
Researchers at University Hospitals Cleveland Medical Center implemented a quality improvement initiative to improve documentation consistency and increase the capture of patient-reported outcomes. The findings show that music therapists' rates of capturing PROs increased significantly, with notable improvements in stress, pain, anxiet...
Researchers at NYU College of Dentistry developed a gene therapy that regulates sodium ion channel activity to alleviate chronic pain. By targeting the specific region where CRMP2 binds to NaV1.7, they were able to reduce sodium influx and quiet down neurons, providing relief from pain in cell and animal studies.
A UTHealth Houston study found that regular cannabis users are more likely to experience complications before, during, and after surgery. Patients with a cannabis use disorder (CUD) were approximately 20% more likely to suffer significant postoperative complications than those without CUD.
A new study published in Human Reproduction found that women with endometriosis are more likely to experience a reduction in live births before receiving a definitive diagnosis. The research, which included over 18,000 women with surgically-confirmed endometriosis, showed that the number of first live births among these women was half ...
Researchers found real breed differences in pain sensitivity thresholds, contradicting veterinarian rankings. The study suggests biological and behavioral factors influence pain tolerance, highlighting the need for individualized treatment approaches.
A new patient-guided intervention using telemedicine has been shown to improve symptoms of fatigue, pain, and depression in dialysis patients. The Technology Assisted Stepped Collaborative Care (TĀCcare) trial found significant improvements in energy levels and pain severity that persisted for six months after treatment.
A national study launched by UNCG's Prevention Strategies aims to prevent opioid misuse among high-risk occupations. The WorkWell mobile app, featuring evidence-based educational strategies, will be tested in the construction and nursing industries.
A University of Essex-led study found that fast-oscillating brain waves linked to brief pain and touch differ widely in scans, with individual patterns stable across time. The research challenges previous findings on the relationship between pain and gamma oscillations.
A novel 'robotic pill' has been found to safely deliver the osteoporosis medication teriparatide orally, with comparable bioavailability to traditional injections. This breakthrough technology could offer a painless and more accessible treatment option for patients suffering from chronic conditions.
Researchers found that morphine interacts with toll-like receptor 4 to contribute to increased bone loss and pain. Blocking TLR4 prevents these effects, suggesting a new target for reducing opioid side effects.
Researchers at Nagoya University have discovered that targeting Fusobacterium bacteria can reduce the formation of lesions associated with endometriosis. The study suggests an effective non-hormonal antibiotic treatment for this gynecological disorder, which affects one in ten women between 15 and 49 years old.
A study found that even insured patients with diabetes use crowdfunding platforms like GoFundMe to cover excess medical expenses, including uncovered co-pays and life-saving care. Researchers urge policymakers to consider these needs when developing affordable diabetes care policies.
A recent study published in The Journal of Orthopaedics found that patients who underwent partial meniscectomy using a needle arthroscopic technique experienced significantly less pain and improved patient-reported outcomes at two weeks after surgery. However, differences were not sustained at six weeks.
Research found that flat-faced dog enthusiasts tend to be sociable, empathetic, and unaware of the dogs' health signals, considering health problems as normal breed characteristics. This study highlights the need to educate dog owners about the importance of health issues being abnormal and unacceptable.
Researchers at UCSF tested a nitroglycerin patch for treating menopausal women experiencing severe hot flashes. The study found short-term improvements, but benefits did not last past 12 weeks, with some side effects reported.
University of Queensland researchers have identified ant venoms that target nerve cells, leading to a long-lasting pain signal. The discovery provides new insights into the mechanisms of pain and may lead to the development of new pain treatments.
The study found that the immune response to spinal-cord injuries is impaired in older individuals, leading to weaker cell responses and reduced recovery. The researchers identified an essential role for the meninges surrounding the spinal cord in mounting the immune response, paving the way for new therapeutic approaches.
A recent study published in Annals of Internal Medicine found that elderly hospitalized patients treated by physicians with MD or DO degrees had virtually identical mortality rates, readmissions, length of stay, and healthcare spending. The results suggest high-quality care regardless of the physician's educational background.
A combination of intravenous and periarticular corticosteroids improves rehabilitation measures after knee replacement, but not pain relief. The study found that patients who received both IV and PA corticosteroids had better knee movement and walking distances compared to those who received either medication alone.
A study led by Brown University researchers found that qigong practice significantly improved cancer-related fatigue in participants. The program was as effective as a more standard exercise program in reducing fatigue levels.
A new analysis of over 10,000 adults reveals that physically active individuals have higher pain tolerance than sedentary ones. The study suggests that boosting physical activity could be a potential strategy for easing chronic pain.
Researchers at UCL have uncovered the molecular basis of a woman's rare genetic mutation that allows her to live pain-free and heal rapidly. The study found that the mutation in the FAAH-OUT gene turns down FAAH gene expression, affecting other molecular pathways linked to wound healing and mood.
A recent study analyzing US FDA PATH data found a correlation between current tobacco use and symptom burden among adult cancer survivors. However, symptoms were not related to the desire to quit smoking. The findings suggest that better management of cancer symptoms may help survivors quit smoking.
A team of researchers at NYU College of Dentistry has successfully modified an existing anti-nausea drug to target the endosomes within cells, thereby providing a more prolonged analgesic effect. The modified netupitant showed improved pain-relieving properties compared to its original form and other drugs targeting similar receptors.
A cross-sectional analysis of 2,200 individuals with sickle cell disease found associations between employment status, sex, age, and depression with pain frequency. Comprehensive treatment for SCD must consider the full experiences of patients, including mental health impacts on pain reduction.
A global clinical trial found that bioresorbable vascular scaffolds (BVS) are nearly as safe and effective as conventional metal stents in treating coronary artery disease. The study, led by a researcher from the Mount Sinai Hospital, showed improved outcomes for patients when properly implanted.
Researchers have developed a non-invasive magnetic stimulation therapy called ThorS-MagNT that targets hyperactive nerves in the midback, potentially reducing debilitating symptoms of diabetic gastroparesis. In a pilot study, patients experienced significant improvements in nausea and vomiting, allowing them to enjoy meals again.
A new holistic framework evaluates mental and psychological wellbeing in wild animals, including physical and behavioral indicators for positive and negative experiences. This approach has the potential to provide crucial early warning signals about species challenges and population declines.
Researchers at the University of Arizona Health Sciences have discovered a way to enhance pain relief with opioids while reducing side effects. By inhibiting heat shock protein 90, they found that AMPK can block or reduce pain relief by opioids, providing a new pathway for improved therapy.
A new Dartmouth study reveals high rates of childbirth fear in US pregnant people, associated with factors such as racism, low income, and pre-existing conditions. The COVID-19 pandemic further exacerbated these fears, leading to increased stress and anxiety during labor.
A team of researchers is exploring the potential of HDAC inhibitors to treat sickle cell disease by reactivating the fetal hemoglobin gene. Early evidence suggests that panobinostat, a specific inhibitor, can increase fetal hemoglobin levels in red blood cells and mouse models.
A study found that primary arthroscopy significantly improved symptoms and hip function in young adults with borderline hip dysplasia. The procedure showed a low rate of conversion to total hip replacement, with most patients experiencing long-term benefits.
A multicentre registry study found that medicinal cannabis can safely relieve cancer pain while reducing the total number of medications and opioids taken. Products with an equal balance of THC and CBD were particularly effective in reducing pain intensity and symptoms.
A new study found that cannabis use by cancer patients leads to reduced pain levels, improved sleep quality, and enhanced cognitive function. After two weeks of sustained use, patients reported better thinking clarity and objective measures of cognition also showed improvements.
A study found that young women are more likely to experience adverse outcomes and rehospitalization after a heart attack, with non-cardiac hospitalizations showing the most significant disparity. Researchers highlight the need for public awareness and sex-specific post-heart attack care.
A new study found that music therapy significantly reduced pain, stress, and anxiety in patients with moderate-to-severe symptoms at community hospitals. The study, published in Pain Reports, suggests that music therapy can be effective for acute pain management across various adult populations.
A new study from Lund University estimates that regression to the mean can account for up to 1 point improvement in pain scores among osteoarthritis patients. This natural phenomenon can lead to false positives in clinical trials, masking the true efficacy of treatments.
Research finds diclofenac's high variability in metabolism due to UGT2B17, a little-studied enzyme. The study suggests genetic testing and dose adjustments for specific populations can help minimize side effects.
Researchers at UNIGE discovered that natural opioids cannot enter cells, whereas therapeutic opioids can, leading to differences in physiological responses. The study's findings could help develop safer medications with improved efficacy and reduced side effects.
A global study published in Cochrane Reviews found that consuming cranberry products reduces the risk of repeat symptomatic UTIs in women by more than a quarter. The review also showed benefits for children and people susceptible to UTIs following medical interventions, with minimal side effects reported.
Surgery may provide faster relief in pain and disability for people with sciatica, but benefits last only up to 12 months. The certainty of evidence is low to very low, suggesting it might be an early management option for those who value rapid improvement over potential risks.
A recent Mayo Clinic study found that prescription opioid use is associated with declines in cognitive performance, particularly in memory and attention. Older adults who received at least one opioid prescription over 7.5 years had a 20% higher chance of developing mild cognitive impairment.
A comprehensive review reveals that postmenopausal dyspareunia is a common condition with various causes, including lack of estrogen, cancer treatments, and musculoskeletal problems. Effective treatments are available, such as lubricants, vaginal estrogen, and fractional CO2 laser treatments.
A new study published in the American Journal of Psychiatry found a link between opioid prescribing patterns and suicide risk. The researchers analyzed data from 2009-2017 and discovered that regions with the greatest decrease in opioid prescriptions also experienced the greatest decline in suicide deaths. This suggests that policies a...
A Swansea University study reveals the potential of machine learning in identifying Ankylosing Spondylitis (AS) patients, reducing diagnosis delays from eight years to earlier. The research uses a national data repository to develop a predictive model for AS detection, empowering GPs to refer patients more efficiently.
A study published in Radiology found that ultrasound is an effective standalone diagnostic method for patients with focal breast complaints. The analysis showed that ultrasound alone led to accurate diagnosis in 90% of patients, with over 80% of complaints being benign findings.
Researchers found that statin users can engage in moderate-intensity exercise without exacerbating muscle injury or symptoms. The study's findings are reassuring for people experiencing muscle pain or fatigue from statins and provide important guidance for maintaining physical activity and heart health.
A large population study reveals that common cancer symptoms are pervasive across all types of cancer and sociodemographics, with higher symptom burdens among patients with lung, gastrointestinal, and gynecologic cancers. The study highlights the importance of prioritizing symptom management in patients who need or desire treatment.
A new study published in Radiology found that a minimally invasive procedure combining pulsed radiofrequency and epidural steroid injection treatment leads to better pain reduction and disability improvement. The results showed significant benefits at four, 12, and 52 weeks compared to steroid injections alone.
Rates of naloxone prescriptions for high-risk individuals and co-prescribing with opioids rose in emergency departments from 2012 to 2019. Opioid prescribing guidelines made it easier for doctors to prescribe naloxone, which is highly effective at reversing opioid overdose effects.