Research on pain and how to relieve it. Covers chemotherapy nerve injury, music and pain, migraine patterns, and back-pain treatments.
A minimally invasive treatment for carpal tunnel syndrome provides complete and long-term relief to patients. Ultrasound-guided hydrodissection effectively treats nerve entrapments without surgery or corticosteroids.
Two studies found corticosteroid injections associated with osteoarthritis progression, while hyaluronic acid injections may slow down progression. Corticosteroids increase risk of disease progression, highlighting need for cautious use.
A recent study found that cannabis studies are often reported in positive terms in the media regardless of their results. The analysis of 20 studies involving 1,500 individuals showed a moderate to large placebo response, where pain was rated as being significantly less intense after treatment with placebo.
A new study found that taking NSAIDs for osteoarthritis pain and inflammation may worsen joint inflammation and cartilage quality over time. Researchers used MRI-based structural biomarkers to analyze the association between NSAID use and synovitis in patients with knee osteoarthritis.
A pooled data analysis of 10 randomized controlled trials involving 1040 women found that acupuncture significantly relieved pain during pregnancy, improved physical function, and quality of life. The therapy was also found to be safe, with no observable major side effects for newborns.
Researchers found cannabis users had decreased patency and were 1.25 times more likely to require amputation one year after lower extremity bypass surgery. Cannabis use was also associated with a higher risk of opioid use after discharge.
A systematic review found significant effects on anxiety, depression, fatigue, physical activity, quality of life, and social impairment in cancer patients who combined behavioural graded activity with psychological therapies. The effects remained significant after a period of one to three months.
A randomized controlled trial found that both total ankle replacement and ankle fusion improve quality of life and have similar clinical scores in patients with end-stage ankle osteoarthritis. However, TAR is associated with greater wound-healing complications and nerve injuries, while AF is linked to more blood clots and nonunion of t...
A multi-campus research team has created a novel device that can non-invasively measure cervical nerve activity in humans, with potential applications for personalized treatments of sepsis and mental health conditions like PTSD. The device features a flexible array of electrodes that capture electrical activity across different nerves.
A recent clinical trial shows that genicular nerve blocks provide short-term pain relief for patients with knee osteoarthritis. Patients who received the blocks reported significant improvement in pain scores, particularly at weeks 2 and 4.
A new study analyzing often-overlooked racial/ethnic groups provides a new understanding of pain disparities in the US. The research, led by Anna Zajacova, reveals that Native Americans and multiracial Americans have significantly higher pain prevalence than other groups.
Researchers at UVA Cancer Center have identified interleukin-1 as a crucial contributor to the development of myelofibrosis, a potentially deadly bone marrow cancer. Targeting this cytokine could prevent myelofibrosis from progressing and spare bone marrow scarring.
Researchers at Eötvös Loránd University developed two tests to assess age-related memory performance and neophobia differences in dogs. The memory test found that older dogs make more mistakes before finding food, while the novel object test revealed an increased tendency to avoid new objects with age.
Researchers discovered stem cells in mouse dorsal root ganglia (DRG) with the potential to regenerate lost sensory neurons and glia. These cells, known as satellite glia, can become activated and generate new glia and, to a lesser extent, neurons after injury.
The American Roentgen Ray Society (ARRS) named Dr. Sarah Kamel of Thomas Jefferson University Hospital and Dr. Ankur Goyal of the All India Institute of Medical Sciences as Melvin Figley and Lee Rogers Fellows in Radiology Journalism, respectively. They will receive expert instruction in scientific writing and communication through the...
A new study found that a personalized 'precision' testing approach for people with stable chest pain led to more efficient evaluations and improved diagnosis of coronary artery disease. The approach involved assessing cardiovascular risk factors to identify low-risk individuals who may not benefit from further testing.
A recent study found that restoring blood flow to the legs through bypass surgery or stent placement reduced pain and improved quality of life for people with peripheral artery disease (PAD). The Best Endovascular versus Best Surgical Therapy for Patients with Chronic Limb Threatening Ischemia Trial enrolled 1,830 participants and foun...
A new type of pacemaker that uses precise targeting capabilities to bypass pain receptors and reduce patient discomfort is being developed. The device, which uses light and optogenetics, could improve the quality of life for millions of people affected by atrial fibrillation.
Researchers from the University of Connecticut found that both delta-8 and delta-9 THC produce similar effects in mice, including lethargy and catalepsy. The study suggests that delta-8 THC interacts with the same receptors as delta-9 THC and can lead to desensitization and withdrawal-like symptoms.
Researchers developed a wearable soft robot called Reliebo that reduces pain and fear in patients undergoing injections. The robot's effectiveness was proven in a study where participants who wore the robot experienced less pain and reduced stress levels than those without it.
Researchers found that patients awaiting surgery experienced decreased pain and improved relaxation when given a music pillow to listen to during their wait. The study, which included over 30 participants, demonstrated a positive association between music and reduced anxiety in emergency department patients.
A study found that 16.5% of American adults with diabetes ration their insulin, with younger adults and the uninsured being most affected. Insulin rationing is often linked to cost concerns, with many patients delaying purchases or taking less insulin than needed.
Researchers at Weill Cornell Medicine found that gut pain-sensing neurons regulate the microbial community in the intestines, boosting beneficial microbes to protect against inflammation. The study suggests that targeting these neurons could lead to new anti-inflammatory treatments for IBD and other disorders.
A new American Heart Association scientific statement emphasizes the importance of managing PAD based on a person's experience of symptoms, rather than relying solely on clinical measures. This approach aims to improve patient-centered care and outcomes, particularly for individuals with severe limb ischemia or comorbidities.
Research suggests that diets high in omega-6 fatty acids promote inflammation, while foods high in omega-3 fatty acids reduce it. A vegan diet has been found to have the lowest rates of inflammation.
A Washington State University pilot study showed that home sensors can accurately monitor overnight restlessness and sleep problems in people recovering from opioid use disorder. The sensors matched other monitoring methods about 89% of the time, validating patients' concerns about their disturbed sleep.
A major new study found that 24% of farmers reported mobility problems, while 31% experienced anxiety and depression. The research, published in BMC Public Health, highlights the need to tackle physical and mental health issues in the agricultural industry.
A study modeling 1.2 million individuals found 6.2% experienced at least one Long COVID symptom cluster within three months of acute infection. Risk was higher in females and those requiring hospitalization for initial SARS-CoV-2 infection, especially ICU care.
Researchers at UCSF have identified six novel molecules that can alleviate pain in mice without causing sedation. These compounds target the alpha2a adrenergic receptor and are from chemically different families, making them promising candidates for further development.
A recent study published in Acta Oncologica found that young women who have had cancer are at a higher risk of experiencing sexual problems, including loss of libido and intimacy issues. The study, which surveyed nearly 700 women, suggests that the type and intensity of cancer treatment can influence a patient's sex life.
A new study found that medical cannabis users reported significant improvements in pain management, social functioning, and overall health. The majority of participants were able to stop or reduce their opioid use, with some experiencing a five-fold decrease in hydrocodone prescriptions.
A free web-based resource called Menstruation Matters has been developed to provide young people with accurate information about menstrual health. The study found that nearly half of participants reported a change in their understanding of what a normal period is, and 94% could identify symptoms of endometriosis.
A new, dissolvable hydrogel developed by Mass General Hospital promotes wound healing for second-degree burns while minimizing pain and trauma. The biomaterial is highly absorbent, based on green chemistry approaches, and can be dissolved in under five minutes.
Researchers at UVA Health have developed a new magnetic-resonance imaging (MRI) technique to track peripheral artery disease, which affects over 200 million people worldwide. The CEST approach produces comparable results to the current gold standard without requiring specialized equipment.
A new research study by Danielle Abbitt, MD, shows that telehealth follow-up appointments are just as effective as in-clinic visits for detecting and addressing postoperative complications. The study found no significant difference in complication rates or emergency department utilization between telehealth and in-person follow-ups.
A randomized controlled trial found that virtual reality immersion reduced the need for sedatives during hand surgery, leading to lower doses of propofol and shorter post-operative lengths of stay. Patient satisfaction remained unchanged, but discharge times were significantly shorter.
The new SIO-ASCO guideline recommends the use of acupuncture, massage therapy, and other integrative therapies for managing breast cancer-related joint pain, general cancer pain, and chemotherapy-induced peripheral neuropathy. The guidelines also acknowledge areas that need further research to support their recommendations.
Researchers found no significant difference in pain levels between children who received ibuprofen and those who received a placebo before stent removal. Only 7% of pediatric patients reported severe pain following the procedure, compared to 55% of adults.
Researchers found that using 'cracking' technology to break down exhaled nitrous oxide can significantly reduce ambient levels in maternity settings. The study showed a 71-81% reduction in nitrous oxide levels when using specific masks and coaching, suggesting pregnant women should be offered device choice options.
A consultant anaesthetist used a nitrous oxide cracking device to reduce her own exposure to the greenhouse gas during labour. The technology helps collect and break down nitrous oxide breathed out via a facemask, making it easier to use and reducing environmental harm.
For seven years after bariatric surgery, participants showed clinically important improvements in pain levels, physical function, and work productivity, with some backsliding over time. The study found durable effects on walking speed, fitness, and most metrics of pain, even among older adults.
A new poll reveals that nearly half of people over 50 experience joint pain, and many turn to prescription-based treatments despite potential health risks. The poll's authors stress the need for healthcare providers to discuss medication interactions and non-drug options with patients.
Long-term opioid use after lung cancer surgery is associated with a 40% heightened death risk within two years, according to research. The study found that male sex, older age, and chemotherapy treatment are among the factors linked to long-term opioid use.
A study found that resiliency and family support play a crucial role in helping Hispanic breast cancer survivors manage lymphedema. Adaptations such as modifying work tasks and seeking support from family members enable survivors to maintain their quality of life.
A new randomized, controlled trial demonstrates that Medasense's NOL monitoring during major abdominal surgery can reduce postoperative pain by 30% compared to standard care. The study found that personalized fentanyl dosing with NOL guidance leads to lower sympathetic activation and surgical stress, resulting in reduced PACU pain scores.
A small qualitative study found that emergency departments often fail to provide dignified and respectful care to frail older patients, leading to long waits and poor communication. The researchers recommend making healthcare settings more 'frailty friendly' by prioritizing patient comfort and involvement.
The 2022 ACC/AHA guideline updates chest pain definitions and establishes standardized data elements for consistent reporting. The new definitions focus on serious cardiovascular causes of chest pain and acute myocardial infarction, aiming to ensure accurate reporting across clinical trials and registries.
A randomized controlled study found that a flexible e-learning program improved neonate pain management knowledge and skills for nurses. The study compared the e-learning group to a control group with no training.
Researchers report two cases of successful treatment with oral tecovirimat for patients with monkeypox and severe proctitis. The medication rapidly alleviated rectal pain with no serious adverse effects. Early use of tecovirimat may be a promising treatment option until randomized controlled trials can be conducted.
A new University of Rochester study compares two groups of patients with dental extractions, finding that a combination of non-opioid pain medications and gabapentin can minimize or eliminate opioids for dental pain. The results show promise for reducing opioid use during the COVID-19 pandemic.
Researchers studied the impact of withholding nitrous oxide on labor pain and found no adverse outcomes for mothers or children. Opioid use increased significantly but no change in other measures such as epidural use or Caesarean section rates were observed.
Researchers developed nanometric photodiodes that can bind to nerve cell surfaces and activate them with infrared light, allowing for selective stimulation of individual neurons. This technology has the potential to study the nervous system in-depth and develop targeted therapies for neurological diseases.
Researchers found that two new techniques can help reduce needle fear in primary-aged children, including a distraction game and positive memory reframing. The study involved 41 children and showed promising results for broad vaccination programs.
Researchers at Duke University have created a lab-made cartilage substitute that is stronger and more durable than natural cartilage. The hydrogel material can withstand even more stress from pulling and squishing, with improved strength and durability compared to previous methods.
Researchers at Okayama University discovered EPA's molecular target, which blocks purinergic chemical transmission and reduces pain perception. The study suggests EPA can be used as a therapeutic strategy for managing chronic pain with fewer side effects.
A new study published in Current Biology found that humans' ability to interpret babies' cries isn't innate but learned from experience. Parents of young babies are able to identify a baby's pain cries even if they have never heard this baby before, whereas inexperienced individuals are typically unable to do so.
A Michigan Medicine study found that patients who received preoperative education on opioid risks and nonopioid pain management options consumed significantly less oxycodone, with only 16 doses used despite similar pain scores. The results suggest a multimodal approach to managing pain can reduce harm and prevent substance use disorders.
A new study found that people who were given the impression of control over music experienced greater pain relief. Those who actively engage with music in their daily life showed even greater benefits. Music complexity was not linked to pain relief, but feeling in control was key.
A new study at the University of Missouri found that prenatal opioid exposure can trigger long-term neurological or behavioral effects in children. The research suggests that opioids impact the developing fetus' gut microbiome, leading to changes in metabolic pathways and potentially affecting overall health and wellness.
A study of 197 confirmed monkeypox cases in London found differences in symptoms between the current outbreak and previous ones. Key findings include rectal pain, penile swelling, and solitary lesions not previously known to be typical features of monkeypox infection.