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Preventing HIV infection in newborns

A retrospective review of 6 cases involving HIV-positive infants whose mothers did not know their own HIV status revealed incomplete application of guidelines. The authors recommend universal HIV testing and counselling to prevent perinatal transmission, while a commentary discusses 5 critical steps needed for prevention.

SourceCanadian Medical Association Journal·JournalCanadian Medical Association Journal·DateApr 1, 2002

Oral diabetes drug shows promise in preventing miscarriage in common infertility disorder

A study suggests that metformin, an oral diabetes drug, reduces the risk of miscarriage in women with Polycystic Ovary Syndrome (PCOS). Researchers found that 8.8% of pregnancies treated with metformin ended in miscarriage, compared to 41.9% in those not receiving the medication.

SourceNIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development·JournalThe Journal of Clinical Endocrinology & Metabolism·DateFeb 27, 2002

Study shows no benefit to home uterine monitoring

A multi-center study led by Dr. Jay Iams found that home uterine monitoring has no clinical value in predicting early birth, despite its widespread use for high-risk women. The study's results reinforce previous findings that ambulatory monitors are not more effective than other diagnostic tools or surveillance programs.

SourceOhio State University·JournalNew England Journal of Medicine·DateJan 23, 2002

Thyroid disease raises risk for birth defects

A recent study published in Johns Hopkins Medicine found that women with overactive or underactive thyroid have an increased risk of birth defects in their babies, including cardiac problems and cleft lip or palate. The research suggests routine testing for thyroid disease prior to pregnancy may be warranted.

Educational lag for premature infants persists into adulthood

A study of premature infants born in the late 1970s has found that they continue to face educational challenges into adulthood. The research, which followed 242 infants until age 20, found that fewer premature adults had graduated from high school and had lower I.Q. scores compared to their full-term peers.

Urban air pollution linked to birth defects for first time; UCLA research links two pollutants to increased risk of heart defects

Researchers found a significant link between exposure to high levels of ozone and carbon monoxide during the second month of pregnancy and an increased risk of conotruncal heart defects. The study analyzed data from over 9,000 babies born in Los Angeles and found that women exposed to elevated pollution levels were three times as likel...

SourceUniversity of California - Los Angeles·JournalAmerican Journal of Epidemiology·DateDec 29, 2001

Sharp drop in stress hormones may set stage for arthritis, multiple sclerosis after pregnancy

Researchers found that levels of IL-12 and TNF alpha decreased during pregnancy, while cortisol, norepinephrine, and 1,25 hydroxyvitamin D3 increased. After birth, these stress hormones surged, possibly contributing to the resurgence of immune disorders like rheumatoid arthritis and multiple sclerosis.

SourceNIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development·JournalThe Journal of Clinical Endocrinology & Metabolism·DateOct 30, 2001

How a 'bad' gene may be good for you

Research suggests that the FVL mutation may have advantages for fetal implantation, resulting in higher success rates for fertility treatments. Women with the mutation experience improved receptivity to fertilized eggs, leading to increased pregnancy rates.

SourceThe Lancet_DELETED·JournalThe Lancet·DateOct 11, 2001

American Thoracic Society Journal news tips for September (second issue)

Researchers discovered that fathers' cigarette consumption levels impact children's lung function, with higher levels associated with greater deficits. Non-asthmatic girls showed the greatest declines in pulmonary function tests, suggesting a potential link between paternal smoking and childhood respiratory health.

SourceAmerican Thoracic Society·JournalAmerican Journal of Respiratory and Critical Care Medicine·DateSep 28, 2001

From embryo to placenta, gene transfer in primates a success

Researchers at the University of Wisconsin-Madison have made a breakthrough in gene transfer technology by inserting a jellyfish gene into rhesus monkey embryos, resulting in transgenic placentas that produce the desired protein. The study promises new insights into pathologies of pregnancy and has implications for human gene therapy.

SourceUniversity of Wisconsin-Madison·JournalProceedings of the National Academy of Sciences·DateSep 10, 2001

Study finds lower dose of mifepristone still effective when used with misoprostol in early termination of pregnancy

A recent study published in Obstetrics and Gynecology found that a lower dose of mifepristone is as effective as higher doses when used with misoprostol for early pregnancy termination. The study showed that 72 out of 80 women experienced complete abortions after using the lower dose regimen.

SourceUniversity of Pittsburgh Medical Center·JournalObstetrics and Gynecology·DateAug 31, 2001

Teens' second pregnancy rates lower with long-term contraceptives

A study published in American Journal of Preventive Medicine found that long-term contraceptives, such as Norplant, reduced second pregnancy rates among teens. Among the participants who chose these methods, only 11% became pregnant within a year, compared to 25% of those using oral contraceptives and 38% of those not using birth control.

SourceCenter for Advancing Health·JournalAmerican Journal of Preventive Medicine·DateJul 1, 2001

Cell death during mammary involution

Involuting mammary glands undergo two stages of apoptosis, with the first wave triggered by Fas binding to its ligand FasL. Mutant animals lacking Fas or FasL experience delayed epithelial cell death.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateNov 12, 2000

Psychological well-being of infertile men

A new study published in Fertility and Sterility suggests that most infertile men cope with their situation well, with no significant differences among three groups of men. The researchers found that fertile men reported higher stress levels compared to those with low or no sperm count or unexplained infertility.

SourceUniversity of Alberta·JournalFertility and Sterility·DateOct 2, 2000