Research on containing and managing disease. Covers critical-illness theory, zoonotic disease, immunotherapy trials, and historical epidemics.
The CDC's four-tiered vaccine prioritization strategy outperformed most approaches in reducing deaths and cases, while some optimizations could improve outcomes. The study found that prioritizing healthcare workers and individuals under 16 was optimal, but strategies focusing on comorbidities were also effective.
Researchers at Hebrew University of Jerusalem discover a 'disrupted' state in bacteria that resists current antibiotics, requiring new pharmacological agents to combat. The breakthrough model predicts bacterial population responses to treatments, offering avenues for better treatments against cancer cells.
Researchers developed EDS-HAT, an AI-powered system combining machine learning and whole genome sequencing to detect clusters of similar infections in real-time. The system identified 99 clusters of infections and prevented potential transmissions in 65.7% of cases, saving the hospital $692,500.
A new study has identified the CCR2 gene as a key player in the progression of type 1 diabetes. The research found that lower blood levels of CCL-2, a ligand for CCR2, were associated with increased immune cell recruitment to the pancreas, leading to islet cell destruction.
Researchers found that CD4+ T lymphocytes — immune system cells — produced by people who received COVID-19 vaccines persisted at high levels six months after vaccination, with a significant response against the delta variant. The study also showed that vaccine-elicited fighters recognize and help attack coronavirus delta variant.
A large study published in Nature Communications has identified a protein in the blood, follistatin, which can predict type 2 diabetes up to 19 years before diagnosis. The study found that higher levels of follistatin circulating in the blood are associated with an increased risk of developing the disease.
Two leading US physicians urge doctors to screen patients for exposure to indoor and outdoor air pollution, recommending interventions to limit exposure and improve cardiovascular health. Governments also have a primary responsibility to adopt technologies and regulations that reduce air pollution.
An updated vaccination strategy is credited with averting an outbreak of urban yellow fever in São Paulo State, according to research published in Scientific Reports. The study found that the virus spread rapidly, reaching cities never affected before, and that a high number of cases were reported in areas with low vaccination coverage.
Researchers identified two distinct clusters of patients with Prurigo nodularis: those with increased inflammation and those with a higher likelihood of spinal disease. This study suggests that personalized treatment approaches can be tailored to specific patient profiles.
Flexible sigmoidoscopy screening significantly reduces colorectal cancer incidence and mortality, with a substantial protective effect maintained up to 19 years. The study's findings confirm the safety and effectiveness of flexible sigmoidoscopy as a preventive measure.
A new study found that UK citizens experienced drastic changes in their daily routines during lockdowns, with parents of young children spending significantly more time on housework and childcare. This led to a reduction in paid work time for most people, with women with young children being particularly affected.
Leaders of high-containment labs argue for a nuanced approach to regulation, drawing from existing practices and considering human and financial costs. They advocate for organizational leaders to take responsibility for lab safety and security, reducing the need for government-level oversight.
Researchers used machine learning and genomics to identify molecular markers of resistance to sugarcane yellow leaf disease in over 97 sugarcane genotypes. The study found that energy cane varieties with higher fiber content are more resistant to the disease, paving the way for commercial launches.
Researchers found that moderate potato consumption among adolescent girls did not increase the risk of overweight or high blood pressure, and may even be associated with improved nutrient intakes. The study suggests that potatoes can be a part of a healthy diet pattern, particularly when consumed in moderation.
Researchers have identified a link between certain gut microbiome molecules and the immune system protein P-gp, which plays a critical role in gut inflammation. The study suggests that supporting a healthy balance of microbes in the gut may help regulate P-gp expression and prevent chronic inflammation.
A large-scale study characterized 585 strains of the Xanthomonas perforans bacterium in Florida commercial tomato fields, finding associations between farms and transplant facilities as key points of pathogen spread. This research provides insights into the diversity of the pathogen population and potential control strategies for farmers.
A study by the University of Georgia's Center for the Ecology of Infectious Diseases identified contaminated water as the most common driver of large-scale zoonotic disease outbreaks. The researchers analyzed over 4,400 outbreaks and found that unusual weather patterns and changes in vector abundance were also significant contributors.
A study published in the Atlantic Journal of Communication analyzed Instagram posts from 20 celebrity influencers about COVID-19 between March and May 2020. The researchers found that celebrities initially modeled guidance from health experts, normalizing suggested behaviors such as staying home and practicing hand hygiene.
Two studies confirm that COVID-19 vaccination significantly reduces both COVID-19 hospitalization rates and severe illnesses among adolescents aged 12-18. A CDC-supported study found two doses of the Pfizer-BioNTech vaccine to be 93% effective in preventing COVID-19 hospitalizations.
Researchers identified a protein leakage related to chronic airway diseases, which restricts breathing. Decreasing this leakage could improve asthma and COPD management by relaxing airways.
A recent study has revealed that Fusarium wilt of cotton is more aggressive and diverse than previously understood, affecting Pima and Upland varieties. The researchers identified a population shift towards FOV4, a fourth race of the fungus, which has overcome some resistance in commercial Pima varieties.
Researchers propose targeted interventions to contain outbreaks in cities like Hong Kong, minimizing economic and social costs. By controlling a small percentage of grids, the virus can be largely contained, offering a balance between risk reduction and human mobility.
A recent UC San Diego study has found that e-cigarette use does not help smokers stay off cigarettes, but rather increases the risk of relapse. Former smokers who switched to e-cigarettes were more likely to relapse compared to those who remained tobacco-free.
Researchers analyzed James Bond's travel history and found he was at greater risk of infections than previously thought. He had contact with raw chicken, ticks, and a Toxoplasmosis-infected cat, increasing his exposure to various pathogens.
A new study reveals the devastating impact of COVID-19 on public health, with the workforce experiencing extreme exhaustion and burnout. The pandemic response has swamped healthcare workers, leaving critical services such as chronic disease prevention, maternal-child health, and environmental health on hold.
A study published in the Journal of Infectious Diseases found that children can carry high levels of live, replicating SARS-CoV-2 virus in their respiratory secretions, with no correlation between age and viral load. The researchers also noted that viral loads are highest early in the illness in both symptomatic and asymptomatic children.
LSU Health has been awarded funding to support community health workers in New Orleans and throughout Louisiana, enabling them to serve as liaisons between healthcare services and under-resourced communities. The grants will promote health equity and provide essential public health response to the COVID-19 pandemic.
A study at Stockholm University has discovered a novel, eco-friendly feeding trap that can be deployed to control mosquito populations. The trap uses a beetroot-based mix with added toxins, which attracts and kills female mosquitoes, while leaving male mosquitoes unaffected.
Scientists at New York University have developed seven new crystal forms of the insecticide imidacloprid, which work up to nine times faster than the original version. The new forms enable the control of disease-carrying mosquitoes in smaller amounts and with reduced environmental impact.
A national review of nocardia infection in kidney transplant patients found that those with compromised immune responses are more vulnerable to the opportunistic agent. Nocardiosis can lead to pneumonia and brain abscess, and screening is crucial, especially in combination with pneumonia symptoms.
A stable regime can be achieved at low case numbers through non-pharmaceutical interventions, but a fast and efficient 'test-trace-and-isolate' system is crucial for maintaining freedom without lockdowns. This approach has been proven effective in containing disease spread during the COVID-19 pandemic.
A new study finds that air pollution is responsible for 1.1 million deaths across Africa in 2019, with household air pollution accounting for 700,000 fatalities. The study also reveals that air pollution is costing African countries billions in gross domestic product and hindering the intellectual development of children.
Chronic P. vivax infections cause significant damage to kidneys, brain, and circulatory system, affecting impoverished communities. The parasite can hide at low levels, making diagnosis difficult and treatment efforts challenging.
Researchers found a chemical inhibitor of PDE9 stimulates cells to burn more fat in mice, reducing obesity and fatty liver. The study's findings suggest the experimental drug may be effective in treating severe obesity and improving heart function.
Researchers discovered that bacteria enter corn plants through natural openings at the leaf's edge, causing Goss's wilt. High concentrations of bacteria lead to freckles and disease symptoms.
A UCLA study found that Black patients with Lyme disease are more likely to have neurological complications, such as meningitis and neuropathy, when diagnosed late. The study analyzed data from 2015-16 and found that approximately 1 in 3 Black patients had these complications, compared to less than 1 in 10 white patients.
The project aims to enhance U.S. surveillance of laboratory-confirmed SARS-CoV-2, influenza, and other respiratory viruses through a network of emergency departments across 21 states and 100 hospitals. Data will be obtained from electronic medical records, providing insights into viral infection trends and patient outcomes.
Researchers comprehensively review T-cell responses to respiratory viral infections and chronic obstructive pulmonary disease (COPD), highlighting key characteristics of peptide-reactive T-cells. The review aims to improve understanding of the underlying mechanisms, leading to more effective immune protection and treatment methods.
Researchers developed a model using data from over 1.1 million volunteers to identify the 7 most informative symptoms for COVID-19 test allocation. The model predicted PCR positivity with high accuracy, resulting in potential 30% to 40% increase in eligible individuals and 70% to 75% detection of positive cases.
Researchers at DTU Health Tech have invented a one-pot assay, NISDA, for rapid detection of SARS-CoV-2 RNA without the need for enzyme-based methods. The assay detects low concentrations of RNA in 30 minutes and has shown high accuracy and sensitivity.
An Australian study found that trust in government approval of safe COVID-19 vaccines is the primary driver of vaccine uptake. Perceived effectiveness in protecting others was also a significant factor. The study revealed lower rates of vaccine uptake among younger, unemployed individuals and those with lower altruistic beliefs.
A new study has shown that a single dose of typhoid conjugate vaccine (TCV) is safe and 84 percent effective in protecting against typhoid in Blantyre, Malawi. The findings are critical as typhoid is an increasing public health threat across sub-Saharan Africa.
Researchers analyzed genome sequences and mobile phone data to track Covid-19 spread in Bangladesh. A three-day window between lockdown announcements and enforcement led to increased infections as citizens traveled to other areas.
The USPSTF advises regular screening for chlamydia and gonorrhea in young women due to their high incidence rates. Screening is also recommended for women at increased risk, with current evidence insufficient to support recommendations for men.
Researchers developed an experimental device to improve blood sugar control in HI patients. The bihormonal bionic pancreas (BHBP) helps maintain stable glucose levels without human error in calculating doses.
A two-dose Ebola vaccine regimen has been found to be safe, well-tolerated, and produce a strong immune response in people over 1 year old. The study also supports the use of this regimen for Ebola virus disease prevention in children and adults.
The UMass Amherst Reich Lab, led by biostatistician Nicholas Reich, will continue to advance real-time forecasting methods during infectious disease outbreaks thanks to a five-year NIH grant renewal. The lab's flu forecasting collaborative has been designated as one of two national Influenza Forecasting Centers of Excellence.
A new poll shows strong support among older Americans for requiring health care workers to get vaccinated against COVID-19. The survey found that 61% of people aged 50 to 80 believe the vaccine should definitely be required, while an additional 19% think it should probably be required.
Researchers at UC San Diego develop precision-guided sterile insect technique (pgSIT) to control mosquito populations. The system uses CRISPR to alter genes linked to male fertility and female flight in Aedes aegypti, reducing disease transmission.
Researchers found a higher incidence of Valley Fever since the last report, with most cases occurring in southwestern Utah. The disease can resemble symptoms of the flu or COVID-19 and is caused by a fungus that becomes airborne when dust is disturbed.
A whole genome analysis of a Staphylococcus aureus collection recovered from Cape Verde reveals high genetic variability among isolates. The study identifies three primary genetic clusters associated with lineages ST152, ST15, and ST5, commonly found in S. aureus infections worldwide.
A comprehensive study of 6.2 million patients found no serious health effects linked to mRNA COVID-19 vaccines, with some early findings previously reported at CDC meetings. The Vaccine Safety Datalink's COVID-19 rapid cycle analysis will continue tracking vaccinated patients for at least 2 years.
Researchers used new approaches to track Lyme disease in Texas, finding an overlap between tick-bite locations and human cases. The study suggests that tick-bite location may serve as an indicator for human disease risk in nonendemic areas.
A CDC analysis of National Healthcare Safety Network data revealed a significant increase in four types of healthcare-associated infections in U.S. hospitals during the COVID-19 pandemic, with central line infections rising by 46-47% compared to pre-pandemic rates.
A single-center retrospective study found that preoperative thoracic CT findings can complement preoperative clinical risk factors to improve risk assessment for the need of postoperative mechanical ventilation. Bronchial wall thickening, pericardial effusion, and anteroposterior chest diameter were identified as independent predictors...
A new analysis suggests that the pace of vaccination should directly dictate the lifting of COVID-19 restrictions to boost freedoms and minimize new waves of infection. The study's findings suggest that further severe waves can be avoided if restrictions are lifted no faster than the pace dictated by vaccination progress.
Research reveals a significant decline in kidney function among COVID-19 long-haulers and even those with mild infections. The study highlights the critical need for paying attention to kidney function and disease in caring for patients who have had COVID-19, as kidney problems can be silent and untreated until it's too late.
Research reveals that genetics determine hypertension more in women than men, with sex-specific genetic risk traits strongly associated with early-onset hypertension. This finding has important implications for patients and physicians, emphasizing the need for closer monitoring of hypertension risks in women.
Researchers at West Virginia University are monitoring wastewater statewide for COVID-19 using an egg-shaped robot that collects samples every 20 minutes. The project aims to develop a testing network throughout the state, providing early indicators of changes in community-level spread of COVID-19.
A study published in Current Rheumatology Reviews found that rehabilitation exercises significantly improved functional strength and reduced weight in knee osteoarthritis patients. The researchers also noted an increase in exercise adherence among the rehabilitation group compared to the control group.