Research on containing and managing disease. Covers critical-illness theory, zoonotic disease, immunotherapy trials, and historical epidemics.
Researchers investigate how enzymes regulate metabolism, weight gain, and liver disease, revealing diet's significant role in obesity and altered lipid profiles. The study also shows that age affects metabolic processes, leading to weight gain, increased fat storage, and unhealthy liver changes.
Researchers argue that national strategies ignore pandemic's early lessons on chronic diseases and their disproportionate impact on underserved populations. They recommend incorporating prevention and control of chronic diseases into existing policies.
Researchers successfully reprogrammed non-controllers' CD8+ T cells to acquire properties of natural HIV controllers, enabling them to suppress viral load and survive without exhaustion. This breakthrough could lead to a cell therapy strategy for achieving HIV remission, with potential applications in cancer treatments.
A study found that vaccines induce immune responses beyond neutralizing antibodies, involving T cells and the Fc receptor, to control viral replication and prevent severe disease. The researchers observed dose-dependent effects on these immune mechanisms, providing insights for future vaccine design and boosting.
A study of 4,177 Black women found that higher education levels were associated with lower allostatic loads, indicating reduced chronic stress. Women with college degrees had lower rates of high blood pressure, diabetes, and cardiovascular disease.
Researchers used PCA and fluid dynamics simulation models to show proper fit is crucial for optimal mask protection. Face shape significantly affects mask fit, even with double masking.
A team of scientists found that two beneficial microorganisms (Aureobasidium pullulans and Bacillus amyloliquefaciens) and a copper phosphite fertilizer can reduce Verticillium Wilt in olive trees by up to 70%. The study suggests that these compounds induce resistance in plants through different metabolic pathways, offering a non-speci...
A large-scale study found genetic links between COVID-19 severity and various medical conditions, including venous embolism, type 2 diabetes, and ischemic heart disease. The analysis also revealed shared genetic architecture with idiopathic pulmonary fibrosis and reduced risk of autoimmune conditions.
Researchers found eight major steps in performing CLABSI surveillance, but identified inadequate IT support and lack of a standardized definition as major barriers. The study provides recommendations to improve surveillance, including providing staff with necessary resources and training, and engaging leadership and front-line staff.
Researchers have identified a new strain of the myxoma virus that has enabled it to leap from European rabbits to Iberian hares, causing lethal disease in both species. The study suggests that this viral adaptation may also improve the virus's ability to replicate in human cancer cells.
Researchers developed a model to identify vulnerable geographic areas for Wolbachia-carrying mosquito release, maximizing protection against dengue. The approach prioritizes areas with the greatest vulnerability, allowing targeted interventions.
Five medical societies release recommendations for preventing central line-associated bloodstream infections (CLABSIs) in hospitals. The new guidance highlights the need to strengthen infection prevention programs amid worsening rates of these infections during the COVID-19 pandemic.
Researchers found that low-density neutrophils are associated with chronic inflammation in obesity, which can lead to comorbidities like type 2 diabetes and cancer. Bariatric surgery reduces these cells in circulation, improving metabolic syndrome components.
A CDC study published in AJIC found that healthcare personnel (HCPs) diagnosed with COVID-19 were most likely to be exposed to SARS-CoV-2 in their workplaces as cases increased in their communities. The study suggests improved infection prevention and control measures are needed in occupational settings.
A multistate outbreak in 10 European countries linked to chocolate products has been linked to monophasic Salmonella Typhimurium, primarily affecting young children. The outbreak strain demonstrated a multidrug-resistant profile, highlighting the importance of including uncommon AMR profiles in early international communications.
A five-year, $13 million grant will investigate the molecular and cellular mechanisms of prion transmission in CWD. The researchers aim to understand the inter-species transmission potential of the disease and its ability to spread from animals to humans.
Researchers have made a breakthrough in enhancing the antiviral T cell response triggered by therapeutic vaccines for chronic hepatitis B. By removing natural killer cells and activating them with cytokines, they boosted the control of HBV infection.
CHOP researchers have developed a targeted treatment that controls blood sugar in patients with hyperinsulinism, a genetic disease. The study found exendin-(9-39) reduces likelihood of fasting hypoglycemia by 76% and protein-induced hypoglycemia by 82%
A recent study by the University of Rochester found that mobility patterns can be predicted with surprising accuracy based on data collected from acquaintances, even if individual users turn off their own location tracking. The researchers discovered that up to 95% of an individual's movement pattern can be inferred from people they ar...
Researchers identified rural Georgia counties with high mortality rates from breast, prostate, colorectal, and lung cancer. These hotspots were concentrated in the eastern Piedmont to southern Coastal Plain regions, as well as southwestern and northern rural areas.
The UMass Amherst-based Forecast Hub has generated the most consistently accurate predictions of pandemic deaths at the state and national level. The ensemble model combined individual forecasts, demonstrating improved robustness and ability to overcome individual model biases.
The University of Missouri has received a grant to help nurses discuss COVID-19 vaccination hesitancy with their communities. The project will equip nursing students with knowledge and confidence to promote public health through effective communication strategies.
A recent study suggests that many older adults with rheumatoid arthritis are not prescribed disease-modifying medications, despite guidelines calling for early and aggressive treatment. Only 45% of patients over 65 were prescribed these medications, highlighting the need to improve prescribing practices among primary care physicians.
Researchers discovered newborn neurons and immature astroglia in patients with epilepsy, which could lead to new anti-seizure medications. The study suggests that targeting immature astroglia may be an effective approach to controlling seizures without aggressive brain surgery.
Researchers recruited 300 home cooks to assess the impact of washing poultry on kitchen contamination. Despite interventions aimed at reducing contamination, participants showed similar levels of contamination regardless of whether they washed their chicken or not.
Researchers from North Carolina State University have released a dataset providing detailed information on COVID-19 vaccine shipments and wastage across the US. The data aims to inform modeling and decision-making to optimize vaccine supply chains.
A combination of two biomarkers has been found to identify patients with subcortical small-vessel disease, a common cognitive diagnosis. This discovery improves the potential for treatment and medication development for this patient group.
A new study suggests increasing flu vaccination among US home healthcare workers could significantly reduce flu-related illnesses and hospitalizations among elderly patients. The research highlights the association between HHC staff flu-vaccination rates and patient illness at a national level.
Achieving classical herd immunity against SARS-CoV-2 may be unlikely due to virus mutations and asymptomatic transmission. However, widespread use of current public health interventions can control COVID-19 with minimal disruption.
A novel class of bed net that kills mosquitoes resistant to traditional insecticides by making them unable to move or fly significantly reduces malaria infection in children. The study found a 43% reduction in malaria prevalence and 44% reduction in clinical episodes over two years.
A randomized controlled study found that lack of sufficient sleep increased calorie intake and visceral fat area by 9% and 11%, respectively. The study suggests that inadequate sleep is a previously unrecognized trigger for visceral fat deposition, potentially contributing to obesity and metabolic diseases.
A novel bed net treated with chlorfenapyr has been shown to significantly reduce malaria infection in children, with a 43% decrease in the first year and 37% decrease in the second year. The study found that the bed net reduced clinical episodes of malaria by 44% over two years.
A retrospective study found that cases of metabolic dysfunction-associated fatty liver disease increased since before the COVID-19 pandemic. Late-night meals and higher alcohol intake were identified as independent predictors of developing MAFLD, especially among working-age individuals.
New data published in AJIC suggests aerosolized hydrogen peroxide can significantly reduce Clostridioides difficile (CDI) infections among patients in large, acute-care facilities. A study found a 41% decrease in HA-CDI rates after implementing an aerosolized hydrogen peroxide system.
Scientists at Emory University have identified Heartland virus in lone star ticks in central Georgia, confirming its active transmission within the state. The study reveals that the virus is evolving rapidly and may be confined to isolated areas, highlighting the need for further research on this emerging infectious disease.
A new study by University of Alberta researchers estimates that excessive sugar consumption in Canada results in $5 billion annual healthcare costs due to 16 chronic diseases. Limiting free sugar intake could reduce diabetes prevalence by 27% if Canadians follow the 10% recommendation, and 44.8% if they limit consumption to less than 5...
A study in Nairobi, Kenya, found that bacteria are shared among humans and animals, with households serving as key gateways for transmission. The discovery highlights the importance of understanding the urban environment to prevent emerging diseases.
A new mathematical model reveals high risk of cross-species disease spread on farms with multiple types of livestock. Targeting top 3% of most networked farms can significantly reduce transmission and protect other species.
A team of scientists led by Karine Le Roch has identified two proteins, RAP01 and RAP21, crucial to the malaria parasite's survival. Knocking down these proteins can interrupt protein translation in the mitochondria, leading to the parasite's death.
Researchers discovered that an inorganic polyphosphate released by nerve cells contributes to the death of motor neurons in people with ALS and frontotemporal dementia. The study found that lowering levels of this toxin may be an innovative therapeutic strategy for diverse types of ALS/FTD.
Researchers developed new antimicrobial technology for air filters that can kill bacteria, fungi, and viruses in seconds. The treatment was tested on trains and found to be effective in killing SARS-CoV-2 and other viruses, including E. coli and C. albicans.
Researchers in Brazil developed a computer program that locates swimming pools and rooftop water tanks in aerial photographs, using artificial intelligence to identify socio-economically deprived urban areas at risk for diseases transmitted by Aedes aegypti. The innovation can be used as a public policy tool for dynamic socio-economic ...
A novel diagnostic platform has been developed for rapid, low-cost and decentralized patient testing for infectious diseases like Zika. The platform achieved a diagnostic accuracy of 98.5% with 268 patient samples collected in Recife, Brazil.
CLABSIs contribute significantly to infant morbidity and mortality in the NICU, leading to prolonged hospitalization and increased healthcare costs. The Society for Healthcare Epidemiology of America provides practical guidance on preventing CLABSI through implementation of specific strategies.
The World Congress on Osteoporosis, Osteoarthritis & Musculoskeletal Diseases (WCO-IOF-ESCEO) 2022 will discuss secondary fracture prevention. Global experts will provide clinical guidance and information on post-fracture care through various sessions.
A new study by the University of Surrey and University of Bristol found that FFP2 masks filter out Covid-19 virus particles more effectively than cloth masks. The research suggests that using FFP2 masks can significantly improve protection against transmission and reduce the risk of infection.
A Johns Hopkins Medicine study analyzed over 3,800 patients with prediabetes and found that only 13% received formal diagnosis, nutritionist referral, or metformin prescription. The researchers recommend improved screening and treatment options to prevent disease progression.
Researchers found that verapamil treatment delayed disease progression, lowered insulin requirements, and preserved some beta cell function in patients with Type 1 diabetes. The study used proteomics analysis and RNA sequencing to examine changes in circulating proteins in response to verapamil treatment.
A new study found a strong association between school closures and declines in non-residential trips during COVID-19, leading to reduced risk of dengue transmission. Reduced time spent in public areas was closely associated with reduced dengue risk in countries where COVID-19 restriction measures began at the peak of dengue season.
A study found that a subtype of Newcastle disease virus caused the deaths of dozens of pigeons in São Paulo City. The researchers sequenced the viral genome and identified tissue wounds to determine the cause of death, revealing subgenotype VI.2.1.2 as the responsible pathogen. The risk to humans and poultry is considered low.
A new study by Emory University finds that schistosome transmission can be highest when freshwater snail populations are low. Snails competing for resources may lead to lower infectivity rates, contrary to typical pesticide-based control methods.
A study conducted by Singapore Management University found that perceived effectiveness of government messages outweighs the effect of individuals' belief in a dangerous world. Effective communication with informative, personal, and objective message characteristics is key to driving disease prevention behaviors.
A study by Arizona State University shows that certain proteins can act as efficient electrical conductors, outperforming DNA-based nanowires in conductance. The protein nanowires display better performance over long distances, enabling potential applications for medical sensing and diagnostics.
The study reveals that focusing on occupation and contact network structures can effectively contain pandemic spread while reducing economic costs. The findings suggest simpler methods for mitigating the impact of pandemics without causing significant economic disruption.
A study published in PLOS Medicine found that the COVID-19 pandemic led to an increase in the uptake of childhood immunizations in Scotland. Researchers analyzed data from over 439,000 vaccine invitations and found higher immunization rates during lockdown periods compared to pre-pandemic years.
A new study from the La Jolla Institute for Immunology reveals that two groups of regulatory CD4+ T cells develop at different times to combat acute inflammation. The early Tregs reduce autoimmune damage, while the second wave shuts down the entire immune response to signal infection clearance.
A new study from the University of Copenhagen has made significant breakthroughs in treating Parkinson's disease by targeting specific neurons in the brainstem. By stimulating excitatory neurons in the caudal area of the pedunculopontine nucleus, researchers were able to restore normal walking function in mice with Parkinson's symptoms.
Scientists have devised a method to pinpoint active ingredients from traditional Chinese medicine formulations, revealing 4 analytes with significant anti-inflammatory activity. This breakthrough could improve quality control standards and lead to better herbal remedies.
Researchers found that streptomycin, a widely used antibiotic in U.S. agriculture, impairs bumblebee behavior, including reduced foraging efficiency and slowed cognition. The study aims to understand the potential impacts on pollinators of antibiotic use in agriculture.
The new schedule includes revised guidance on the hepatitis B vaccine for adults aged 60 years and older, as well as simplified recommendations for pneumococcal vaccinations. The updated schedule also recommends co-administration of COVID-19 vaccines with other vaccines.