Research on containing and managing disease. Covers critical-illness theory, zoonotic disease, immunotherapy trials, and historical epidemics.
Researchers developed a faster, more affordable method to analyze serological data and predict COVID-19 wave behavior. The study showed that vaccination boosted immunity, with hybrid immunity producing higher protection levels. Antibody levels rose quickly after the first dose, especially in cities where case numbers were highest.
Research from UVA Cancer Center finds that an unhealthy gut microbiome can trigger changes in normal breast tissue, facilitating cancer's spread to other parts of the body. The study suggests that targeting the gut-mast cell relationship could help prevent breast cancer recurrence and metastasis.
A literature review suggests a significant increase in monkeypox cases globally, with human-to-human transmission now the primary mode of transmission. The study highlights the need for improved surveillance and investigation into potential risk factors and treatments.
A study at the University of Helsinki found that periodontitis has a particular link with diabetes and accelerates its progression. The research highlights the importance of considering general and oral health as a whole in healthcare to achieve better treatment outcomes.
A new study from the University of Maryland cautions that delayed interventions make it harder to eliminate monkeypox. The research suggests that stronger and better-adapted variants may evolve if case numbers are low, making it challenging to control outbreaks.
Women with a history of gestational diabetes are at substantially higher risk of cardiovascular and cerebrovascular diseases, including coronary artery disease, heart attack, and stroke. Continuous monitoring is crucial to mitigate these risks.
Researchers engineered mosquitoes to produce compounds that stunt malaria parasite growth, reducing the risk of disease transmission. The technique could be combined with gene drive technology to drastically cut malaria transmission in real-world settings.
Numerous gaps between dietary intake and recommended guidelines are found, particularly among vulnerable families, with race and ethnicity disparities persisting. A unified plan can improve nutritional outcomes by strengthening federal policies and programs.
A systematic review of children and teens with type 1 diabetes found that girls have poorer metabolic control, are more likely to be hospitalized with serious complications, and require higher insulin doses. The study highlights the need for targeted efforts to improve awareness and care for young females with type 1 diabetes.
Tel Aviv University researchers discovered that skin cancer cells interact with astrocytes in the brain, promoting metastasis. By inhibiting this interaction using existing treatments, they delayed the spread of melanoma to the brain by 60-80%. This breakthrough has implications for treating advanced-stage melanoma.
Cancer cells become resistant to chemotherapies by slowing down DNA replication forks, allowing them to avoid collisions with chemotherapy drugs. A kinase called DNA-PKcs acts as a sensor when a fork is stressed and promotes slowing of the fork and chemo-resistance.
A new study by the University of Maryland found that white-tailed deer in suburban environments often bed down and spend the night within 50 meters of residential properties. This revelation has significant implications for tick management and reducing the risk of human exposure to diseases like Lyme disease and anaplasmosis.
A new study published in PLOS Medicine found that people with hospital-treated infections in early- and mid-life had a higher risk of developing Alzheimer's disease (AD) and Parkinson's disease (PD). The research analyzed data on over 291,000 cases and matched controls to identify the association between infections and neurodegenerativ...
A new study published in the Journal of the American Heart Association found that individuals with autoimmune diseases are at a higher risk of complications after a heart attack. The research emphasizes the importance of controlling cardiovascular disease risk factors and developing personalized treatment plans for this population.
The Society for Healthcare Epidemiology of America highlights the need to strengthen antibiotic stewardship programs to address overuse of antibiotics in early stages of viral epidemics. The guidance provides strategies for hospitals and healthcare personnel to improve antibiotic prescribing and diagnostic testing.
A cercarial dermatitis outbreak occurred in Chana district, South Thailand, affecting rice farmers, due to ruminant parasites like Schistosoma indicum. The study identified two snail species as intermediate hosts for flatworms causing the disease.
A study in the Netherlands found that restricting flights from countries where COVID-19 variants of concern emerge is not enough to halt their spread. The researchers analyzed nearly 40,000 genome sequences and found that all four VOCs had already been introduced into the country by the time flight restrictions were implemented.
The US Preventive Services Task Force (USPSTF) states that screening for type 2 diabetes in asymptomatic children and adolescents under 18 has insufficient evidence to support a recommendation. As of 2018, approximately 23,000 children and adolescents had type 2 diabetes, with incidence rates rising.
A review article suggests that retinol-binding protein-4 (RBP4) may be a potential target for clinical intervention in non-alcoholic fatty liver disease. The study highlights the importance of RBP4 in the pathogenesis of NAFLD, including its role in inducing hepatic de novo lipogenesis and impairing fatty acid oxidation.
A recent study published in Ear, Nose & Throat Journal found that twice-daily nasal irrigation with saline solution significantly reduced hospitalizations and deaths among patients with COVID-19, particularly those aged 55 and older. The technique is safe, effective, and inexpensive, offering a vital public health impact.
Researchers from Johns Hopkins Medicine and Dana Farber Cancer Institute found that irisin reduces levels of a protein linked to Parkinson's disease and halts movement problems in mice. Irisin also speeds up the transport and degradation of alpha synuclein via fluid-filled sacs called lysosomes in brain cells.
A study led by Arizona State University Professor Gabriel Shaibi found that a community-based program combining education and exercise significantly improves the health of Latino children at risk for diabetes. The program, which included 117 families from around the Valley, provided culturally focused lessons on healthy eating and phys...
A study published in JAMA Internal Medicine found that COVID-19-associated hospitalizations among unvaccinated adults were significantly higher than those with booster doses. The study suggests continued vaccination efforts for eligible persons to mitigate hospitalization rates.
The University of California, Davis has received a $10 million grant to continue its work on managing and preventing mosquito- and tick-borne diseases. Researchers will focus on finding effective methods to stop these diseases while training the next generation of public-health scientists.
A new study finds that climate data, particularly UV radiation levels, can help accurately model the spread of COVID-19. The research analyzed data from 196 countries and found that high UV radiation levels are strongly associated with reduced COVID-19 transmission rates.
A new study reviews over 2,000 years of history to shed light on the delay in recognizing airborne transmission of coronavirus. Despite increasing evidence, institutions and governments initially focused on surface disinfection and handwashing, leading to millions of deaths.
Researchers at the University of Gothenburg have identified a protein called HnRNPK that controls tumor growth by binding to messenger RNA, potentially enabling the development of new cancer drugs with fewer side effects.
A study published in Nature Communications suggests that better glucose control can improve brain structure and function in youth with Type 1 diabetes. The findings indicate that participants using a hybrid closed-loop insulin delivery system showed significant improvement in key brain metrics compared to those receiving standard care.
A new clinical decision support system, MPX-CDSS, has been developed to aid frontline clinicians in identifying and treating patients at risk for monkeypox. The tool is embedded in electronic health records and provides structured screening questions and image upload capabilities.
A recent study found three distinct themes in slogans protesting federal COVID-19 vaccine mandates: Support for individual freedom/rights, opposition to government control, and anti-science misinformation/disinformation. The majority of slogans opposing vaccines were about individual rights or resistance to government control.
A Japanese study found that a single ill healthcare worker caused respiratory infections among 17 patients, resulting in $12,324 in medical costs. The findings highlight the importance of addressing presenteeism and its impact on patient safety.
The COVID-19 pandemic had a devastating impact on Mayotte, with over 4,000 laboratory-confirmed cases causing interruptions in work and healthcare services. The island's unique socioeconomic vulnerability and communication challenges affected the surveillance and monitoring of the outbreak.
A recent study published in JAMA found that despite overall improvements in cholesterol levels since 2008, sex, racial, and ethnic disparities persist in lipid control. The research team analyzed data from over 33,000 US adults and discovered significant variations in trends by race and ethnicity.
A recent study by Florida Atlantic University and Nova Southeastern University has linked the use of herbicide Roundup to convulsions in soil-dwelling roundworms, suggesting that glyphosate targets GABA-A receptors. The study found that even low concentrations of glyphosate had concerning effects on the nervous system.
Researchers have developed a new compound, afimetoran, that prevents lupus-like symptoms and reverses organ damage in mice. The compound works by blocking toll-like receptors 7 and 8, which are involved in the immune system's response to viral RNA. Phase 2 clinical trials are underway to test its effectiveness in humans.
Researchers estimated long-term effectiveness of Pfizer-BioNTech COVID-19 vaccine against SARS-CoV-2 infection and critical infections among 3.2 million South Korean adolescents. The study found high vaccine effectiveness in preventing severe illnesses.
A Rutgers scientist has developed a highly sensitive DNA test that can detect Lyme disease in horses, a condition that can cause long-term complications. The test, called genomic hybrid capture assay, was tested on a sick horse and successfully identified the pathogen, allowing for early diagnosis and treatment.
Researchers identified differences in PTK activity between normal and cancer kidney tissue, with Src family kinases and PI3K pathways exhibiting high activity. Ex vivo treatment of clear cell RCC with TKIs revealed that tivozanib and cabozantinib were more potent inhibitors than sunitinib or pazopanib.
A study published in Lancet Regional Health – Americas found that malaria in pregnancy is still a major public health problem in the North of Brazil, with younger women being most at risk. The researchers believe that expansion of healthcare services and inclusion of artemisinin in therapeutic schemes contributed to the decline in cases.
A nationwide survey in El Salvador identified areas with high Chagas disease transmission, highlighting the need for targeted vector control measures. The study suggests that continued efforts are necessary to combat this neglected tropical disease.
A study by CNIC scientists has identified a key role for the MKK3/6–p38γ/δ signaling pathway in cardiac hypertrophy. Inhibition of p38α promotes an unexpected activation of the other branch of the pathway, consisting of the proteins MKK3, p38γ, and p38δ. This activation induces another key pathway in cardiac hypertrophy, the mTOR pathway.
A Texas A&M study sheds light on a major health concern for people with Down syndrome, who may not heal from bone fractures. The researchers found that the glue-like cartilage that helps bones heal doesn't form properly in individuals with DS, leading to devastating health impacts.
A new study published in AJIC suggests that a combination of betadine and silver colloidal gel is more effective than either material alone for inhibiting the growth of common infection-causing bacteria. The findings could help medical professionals better treat and prevent serious infections in large wounds, including burns.
A new study published in The Lancet Regional Health – Europe found that over 55% of respiratory disease hospitalisations during the pandemic's peak were caused by non-SARS-CoV-2 infections. Non-COVID-19 respiratory infections are expected to increase this winter, posing a significant burden on healthcare systems.
A study by researchers at Keck School of Medicine found that flavored oral nicotine products, such as gum and gummies, are increasingly popular among US teens, with 3.4% having used them at least once and 1.7% in the past six months. The use of these products was more common among Hispanic teens, teen girls, and LGBTQ+ teens.
A study by West Virginia University found that over 7% of junior high and high school students in rural Appalachia identified as gender-diverse, including nonbinary or transgender identities. This exceeds previous estimates and highlights the need for support services in these areas.
Researchers used natural language processing and machine learning to analyze nearly 35,500 death records, identifying the most common substances involved in overdose deaths. The system reduced data processing time by months, allowing for more rapid public health responses and interventions.
Researchers found that endothelial cells in blood vessels drive the body's metabolism and produce nitrous oxide to regulate brown fat production. This discovery reverses long-held ideas about the relationship between diabetes, fat and cardiovascular disease.
Researchers at Imperial College London developed a new rapid test called CrisprZyme, which detects biomarkers in the body to diagnose non-infectious diseases like heart attacks and cancers. The test works at room temperature with colorimetric analysis, eliminating the need for amplification and temperature control.
A VA study found nearly identical genetic variations contributing to coronary heart disease risk across major racial and ethnic backgrounds. The findings suggest that other factors like access to healthcare contribute to higher heart disease rates in certain populations.
A research team uncovered the secret of powdery mildew's success by comparing genetic compositions of 172 strains from 13 countries on five continents. The pathogen was introduced to new regions through human migration and trade, undergoing hybridization with local species to form better-adapted hybrids.
Researchers found that microscopic blood vessel disease in the brain's white matter is associated with worse cognitive function and memory deficits in individuals with Alzheimer's. Lifestyle changes such as reducing hypertension, obesity, diabetes, and inactivity may help prevent or slow disease progression.
Middle-aged women are at increased risk of serious health outcomes due to weight gain. New guidelines recommend counseling healthy weight management for all middle-aged women.
A new global dashboard tracks invasive mosquitoes carrying deadly diseases, combining data from three partner apps and utilizing AI-powered image recognition software. The platform has the potential to provide real-time data on disease vectors, enabling early detection and prevention of mosquito-borne diseases worldwide.
Researchers have developed a smartphone clip-on instrument that can rapidly detect Zika virus in whole blood using spatial RT-LAMP technology. The device is sensitive, accurate, and easy to use, making it ideal for point-of-care clinics and controlling the spread of infectious diseases.
A study of 197 confirmed monkeypox cases in London found differences in symptoms between the current outbreak and previous ones. Key findings include rectal pain, penile swelling, and solitary lesions not previously known to be typical features of monkeypox infection.
In India, two out of five eligible children are missing out on preventive vitamin A supplementation, with wide variations in coverage among and within states. The analysis found large 'cold spots' in provision across the country, ranging from just under 13% to 94.5%, and distinct geographical hotspots and coldspots.
A recent study published in Nutrients suggests that regular quinoa consumption can help prevent type 2 diabetes. Researchers replaced carbohydrate-rich foods with quinoa and found a significant reduction in post-meal blood sugar spikes. By mitigating this spike, quinoa may play a crucial role in preventing the progression of type 2 dia...
A recent study from University of East Anglia compared 13 face shield styles in laboratory settings and surveyed over 600 people in Nigeria and Brazil about their views on face shields as PPE. The results showed that all face shields provided some protection, but none gave high levels against external droplets.
Adults with chronic kidney disease are more likely to have a low intake of fruits and vegetables compared to similar individuals without the condition. This study suggests that increasing fruit and vegetable consumption may be beneficial for overall health.