Articles tagged with Gastroenterology
Researchers are working to improve study design and sample collection to better understand the composition and effects of the gut microbiota. The American Gastroenterological Association hosted a World Summit on Gut Microbiota For Health, where experts discussed future research directions.
Fecal microbiota transplantation has been shown to be highly effective in treating recurrent Clostridium difficile infections, with over 90% of patients being cured within a short period. The treatment offers a rapidly acting alternative to standard antibiotic treatments.
Functional bowel disorders affect 50% of patients consulting a gastroenterologist. Recent research suggests that gut microbiota plays a significant role in these conditions. The AGA reports on the latest findings and potential therapeutic avenues.
A recent study published in Clinical Gastroenterology and Hepatology found that injecting botulinum toxin A (Botox) into the stomach does not cause weight loss. The Mayo Clinic researchers used a double-blind, randomized, placebo-controlled trial to compare the effects of BTA to placebo.
Children born prematurely are at increased risk of developing esophageal adenocarcinoma due to gastroesophageal reflux disease (GERD) and chronic exposure to acid reflux. The study found that being small for gestational age or having a short duration of gestation also increases the risk of esophagitis.
A study suggests that Type 2 diabetes increases the risk of Barrett's Esophagus (BE) in diabetic men, with a twofold increase compared to non-diabetic men. The risk is higher in men due to differences in fat distribution, which may contribute to the association between Type 2 diabetes and BE.
Researchers report on cannabinoid hyperemesis syndrome (CH), a little-known but costly effect of marijuana use, characterized by cyclic nausea, vomiting, and abdominal pain. CH can lead to expensive diagnostic tests and ineffective treatments, with some patients requiring multiple hospital visits and costing up to $30,000 in workups.
A new electrical stimulation treatment has shown promising results in resolving gastroesophageal reflux disease (GERD) symptoms. The treatment involves implanting a device that uses low-energy electrical pulses to strengthen the lower esophageal sphincter, which can help prevent acid reflux.
The study found a significant decrease in mortality rate for upper gastrointestinal bleeding, from 4.69% in 1989 to 2.13% in 2009. The proportion of patients undergoing in-hospital endoscopic therapy increased from 2% to 27%, and hospital stays decreased from 4.5 days to 2.8 days.
Advanced endoscopic tools and techniques, such as POEM for achalasia treatment and pCLE for IBS diagnosis, show promising results. These innovations aim to improve diagnosis and treatment options for gastrointestinal disorders.
Researchers highlight two cases of selenium deficiency causing cardiomyopathy in patients who underwent gastric bypass surgery. The studies emphasize the crucial role of long-term follow-up and compliance with vitamin supplements to prevent nutritional deficiencies and related health complications.
The American Gastroenterological Association has launched new iPad apps for its journals, including Gastroenterology and Clinical Gastroenterology and Hepatology. The apps offer full-text and PDF views, note-taking and bookmarking functionality, and are free to download from the Apple App store.
The American Gastroenterological Association and other GI societies have issued updated guidelines for colonoscopy surveillance after screening and polypectomy. These recommendations support previous guidelines, addressing areas such as the need to repeat colonoscopies every 10 years for average-risk patients with a clean exam result.
A new study published in the American Journal of Gastroenterology found that smoking and heavy drinking can lead to an earlier onset of pancreatic cancer. The study analyzed data from 811 patients with pancreatic cancer and found that those who smoked heavily or drank excessively were diagnosed at a younger age than those who did not.
The study found that RRM2 overexpression is positively correlated with invasive properties of CRC cells. Silencing RRM2 inhibited hyperplasia and invasiveness, indicating its role in CRC progression. Additionally, RRM2 depletion increased UV sensitivity, suggesting a facilitating factor in DNA damage repair.
A study found that only 31.1% of moderate-to-severe IBD patients would qualify for biologic trial participation due to strict inclusion criteria. The study highlights the need for more pragmatic approaches to capture real-world treatment effects.
A large double-blind study found that over 80% of children with moderate to severe Crohn's disease responded to adalimumab within a month. Approximately 34% of patients were in clinical remission after six months, and 28.4% remained in remission after one year.
A Mayo Clinic-led analysis found that approximately 1.8 million Americans suffer from undiagnosed celiac disease, while 1.6 million use a gluten-free diet without medical confirmation. The study highlights the need for increased awareness and testing to accurately diagnose and treat this common condition.
A recent study found that most celiac disease patients do not receive adequate medical follow-up, which can lead to non-compliance with a gluten-free diet. The study suggests that gastroenterologists need to improve communication with patients to ensure timely follow-up care and improve outcomes in celiac disease.
A new study published in Clinical Gastroenterology and Hepatology suggests that aspirin use may protect against Barrett's esophagus (BE), the largest known risk factor for esophageal cancer. High-dose aspirin was significantly associated with decreased BE risk, but caution is advised due to potential cardiovascular benefits.
The AGA journals, Gastroenterology and Clinical Gastroenterology and Hepatology, maintained strong standing with high impact factors in 2011. Both journals received a significant number of citations and had outstanding immediacy indices.
The guidelines provide evidence-based information for diagnosing and managing non-alcoholic fatty liver disease, which is rapidly becoming the most common cause of cirrhosis in the US. The condition can lead to liver cancer and failure, emphasizing the need for standardized medical care.
A six-food elimination diet significantly improves symptoms in adult patients with eosinophilic esophagitis, reducing inflammation and improving digestion. The study identified specific food triggers that cause symptoms like heartburn and difficulty swallowing.
A new ethics framework is recommended to manage conflicts of interest in the development of medical guidelines, ensuring expert input without industry influence. The study found that such a framework can help identify and address ethics issues, but further analysis and initiatives are needed.
The Multisociety Sedation Curriculum for Gastrointestinal Endoscopy provides a comprehensive framework for training gastroenterologists in procedure sedation. The curriculum emphasizes the importance of practice and research based on ethical principles, aiming to balance patient comfort with safety.
The American Gastroenterological Association honors outstanding contributions and achievements in gastroenterology through its prestigious recognition awards. The AGA presents several awards, including the Julius Friedenwald Medal, William Beaumont Prize, Distinguished Educator Award, and more.
The American Gastroenterological Association will showcase innovative data and advancements in treating gastrointestinal (GI) disorders during the Digestive Disease Week 2012. The presentation of exciting, cutting-edge information will help physicians diagnose and treat GI disorders more effectively.
This special issue of Gastroenterology focuses on the latest progress made in viral hepatitis research and care, including new diagnostic tools, therapies, and prevention strategies. Classic review articles and expert commentaries address critical unresolved issues and fundamental questions for the future.
A recent study published in Clinical Gastroenterology and Hepatology suggests that GERD-related inflammation may contribute to the development of esophageal cancer. Researchers analyzed data from over 33,000 patients with GERD and found a significant increase in esophageal cancer incidence among those with erosive reflux disease.
A study found that amoxicillin-clavulanate triggers groups of propagated contractions within the small intestine, improving small bowel transit and influencing gut microbiome. The antibiotic may be effective in patients with alterations of duodenal phase III, chronic symptoms of intestinal pseudo-obstruction.
Research published in The Journal of Hepatology found that moderate alcohol consumption can reduce the risk and severity of liver disease in patients with nonalcoholic fatty liver disease (NALFD). Patients with NALFD who consume two drinks or less daily are half as likely to develop hepatitis as non-drinkers, experiencing less severe l...
A study found that patients with inflammatory bowel disease and other gastrointestinal disorders receive significant doses of diagnostic radiation. Alternative, radiation-free imaging options are available, but evidence-based guidelines on reducing radiation exposure are still needed.
A new study found that children who experienced general trauma, physical punishment, and emotional abuse are more likely to develop irritable bowel syndrome (IBS) in adulthood. Emotional abuse was the strongest predictor of IBS, with a significant association observed mainly in women.
The study found a substantial increase in the use of anesthesia services for gastrointestinal endoscopies, with most procedures performed on low-risk patients. Regional variation in anesthesia use was also observed, with higher rates in the Northeast region.
A new study suggests that fecal transplantation is clearly better than any other treatment for recurrent Clostridium difficile infection. The procedure showed an outstanding result in a patient group unresponsive to other treatment methods, with no serious adverse events observed during a one-year period.
A survey of over 1,000 gastroenterologists found that pressure to increase colonoscopy volume negatively affects procedure quality and safety. Gastroenterologists reported reducing time examining the colon wall or aborting difficult procedures due to production pressures.
A new study published in Clinical Gastroenterology and Hepatology found that IBD travelers are not at a higher risk of contracting intestinal infections when visiting developing or tropical countries. Traveling during clinical remission can significantly reduce the risk of illness, according to lead author Shomron Ben-Horin.
The study found significant variability in colonoscopy reporting, but high overall quality. Significant variance between endoscopy departments was also observed. Continuous monitoring and implementation of quality indicators can improve the quality of both reporting and performance.
Researchers found that consuming a high-fiber diet raised, rather than lowered, the risk of developing diverticulosis. Those with lower fiber intake were less likely to develop diverticula.
A global study on inflammatory bowel disease (IBD) reveals increasing incidence and prevalence worldwide, particularly in developing countries. The study found that IBD affects individuals in their most productive years of life, resulting in significant healthcare costs.
Chronic abdominal pain has seen a significant rise in opioid prescriptions, driven by factors such as campaigns to recognize pain as the "fifth vital sign". The use of opioids for non-cancer chronic pain is supported by limited evidence and can lead to gastrointestinal symptoms and worsen abdominal pain.
A new study found that psychological factors, such as pain catastrophisizing and anxiety sensitivity, affect IBS symptoms but not overall severity. GI symptoms like pain, bloating, and defecation explain most of the variance in IBS severity scores.
Certain IBD patients may have an increased risk of nonmelanoma skin cancer, particularly those on thiopurine immunosuppressants. Researchers emphasize the need for dermatologic screening and sun protection in these patients.
A new study reveals that celiac patients may unknowingly expose themselves to gluten through the use of cosmetics, highlighting a significant gap in available information. Researchers found that only two top cosmetic companies provided detailed ingredient information without identifying gluten sources.
Research suggests that childhood and adult traumas contribute to adult irritable bowel syndrome (IBS), with general life traumas being more common than physical or emotional abuse. The study found patients with IBS report higher levels of traumas over a lifetime, which may sensitize the brain and gut.
A combination treatment of telaprevir with pegylated interferon and ribavirin showed substantial improvement in sustained viral response among African Americans, with an SVR rate of 61% compared to 25% with standard care. Screening for Hepatitis C during routine colon cancer screening is also being explored, particularly among Baby Boo...
The Mayo Clinic Facebook group provides a platform for patients to share their experiences and challenges with esophageal cancer. The group, led by Dr. Herbert Wolfsen, has become an invaluable resource for patients, caregivers, and medical professionals.
A study found that moderate alcohol consumption is associated with small intestinal bacterial overgrowth (SIBO), leading to gastrointestinal symptoms. Patients who drank a moderate amount of alcohol, sometimes less than one drink per day, were more likely to have SIBO.
Mayo Clinic researchers have developed a new assessment index for microscopic colitis, allowing physicians to objectively score the condition's severity. The Microscopic Colitis Disease Activity Index provides a consistent way to assess symptoms beyond just diarrhea frequency.
A new study suggests that patients with certain types of abdominal pain may benefit more from gallbladder surgery. Researchers found that episodic pain occurring during the evening or at night, lasting less than 24 hours, and having a specific pattern of symptoms can predict improved relief after surgery.
A new study found that neuroticism is linked to increased brain activity during pain anticipation in individuals with irritable bowel syndrome (IBS). This heightened emotional response may exacerbate chronic pain conditions. Physicians should consider a patient's mental state when determining treatment regimens.
A study published in Clinical Gastroenterology and Hepatology found that low-dose aspirin increases the risk of gastrointestinal bleeding, particularly when combined with other medications. However, proton pump inhibitor use can reduce this risk.
Researchers have discovered a novel cytokine, Interleukin 37 (IL-37), that protects mice from colitis by modulating inflammation. This finding offers a promising approach to treat or control overactive immune systems in humans, particularly for patients with inflammatory bowel disease.
Radiofrequency ablation (RFA) successfully eradicates precancerous cells and intestinal metaplasia in patients with dysplastic Barrett's esophagus, with over 90% of patients showing complete clearance after three years. The procedure offers a minimally invasive alternative to surgery, reducing complication rates and mortality.
A new study found that high folate intake is associated with lower risk of colorectal cancer. The strongest association was with total folate intake, which includes naturally occurring food folate and folic acid from fortified foods and dietary supplements.
A new study found that coffee consumption improved treatment response in advanced patients with chronic liver disease and hepatitis C. Patients who drank three or more cups of coffee per day were two times more likely to respond to treatment, with higher rates of early virologic response and sustained virologic response.
The American Society for Gastrointestinal Endoscopy (ASGE) and the Society for Healthcare Epidemiology of America (SHEA) have updated their 2003 joint guideline to ensure safe reprocessing of flexible gastrointestinal endoscopes. The guidelines emphasize the importance of high-level disinfection and standardized cleaning procedures.
A study found that many gastroenterologists are not knowledgeable about the appropriate immunizations to recommend to IBD patients. In fact, over half of gastroenterologists did not regularly ask their patients about immunization history. This lack of knowledge can lead to IBD patients being vulnerable to vaccine-preventable illnesses.
A Mayo Clinic study found that it takes an average of 275 procedures to reach minimal cognitive and motor competency in gastroenterology fellows performing colonoscopies. The research team used a validated testing method to assess the performance of 41 fellows who performed over 6,600 colonoscopies.
University of North Carolina researchers presented three studies: meditation reduces irritable bowel syndrome symptoms and psychological distress; colonoscopy screening rates decreased among insured Americans during the recession due to high out-of-pocket costs; and diets high in fiber actually increase the risk of diverticulosis, not ...