Articles tagged with Immune System
A new study confirms that COVID-19 deaths among children and young people are rare, with most fatalities occurring in those with severe neurodisability or compromised immune systems. The analysis of detailed data showed that half of COVID-19 deaths occurred within 30 days of infection.
A study by Brigham and Women's Hospital found that specific immune system biomarkers are linked to the acquisition of both HIV and genital herpes. The researchers identified unique predictors for each disease, providing new targets for preventive treatments.
Researchers discovered that a ketogenic diet high in saturated fats can reprogram the mouse immune system, making it better at fighting off infections but more susceptible to systemic inflammatory conditions. The study also found that another type of fat, oleic acid, may be able to counteract the harmful effects of palmitic acid.
Researchers found significant immunological differences mediating sex differences in COVID-19 responses. Infected females had higher rates of symptoms but lower viral loads, with stronger immune response gene expression and molecular signatures.
A study published in Science Immunology clarifies the function of tissue-resident memory T cells (Trm cells) in protecting against infection and cancer. Researchers found that CD103+ Trm cells play a less critical role, while CD103- cells are more effective in attacking bacteria upon reinfection.
Researchers used DNA barcoding to track breast cancer cells over time, finding that some cells can suppress killer T-cells and reduce MHC1 expression to evade the immune system. This study suggests epigenetic mechanisms may play a role in cancer cell adaptation and provides potential targets for therapies.
Researchers have found therapies that can help patients with relapsed multiple myeloma who tried CAR-T therapy, including bispecific antibodies and other types of CAR-T cell therapy. The study analyzed 79 patients and found that stem cell transplants and other drug combinations showed some efficacy in these patients.
A new study by researchers at Dana-Farber Cancer Institute found that patients with cancer and a weakened immune system who receive immunotherapies are more likely to experience severe COVID-19. The study also found that patients treated with other systemic treatments have milder symptoms, but still face increased risk of complications.
A rare genetic variation in the X chromosome's TLR7 gene has been identified as a five times greater risk factor for severe COVID-19. The study, conducted across 12 countries, highlights the importance of host genetics in COVID-19 outcomes.
Researchers at IRB Barcelona found that senescent cells stimulate the immune system to attack tumors more effectively than dead cells. Vaccinating healthy mice with senescent cells reduced tumor growth and improved immune response in animal models of melanoma and pancreatic cancer.
A study published in PLOS Genetics found that genetic variants linked to systemic lupus erythematosus (SLE) may also provide protection against severe COVID-19 infection. The researchers identified TYK2, a gene involved in interferon production, as the key locus behind this protective effect.
A new study led by University of Cincinnati researcher Trisha Wise-Draper found that immunotherapy treatments may worsen COVID-19 disease in patients with baseline immunosuppression. However, patients who received COVID-19 vaccinations had less severe COVID-19 outcomes.
A high-fat diet in pregnant monkeys alters the transcriptional landscape of fetal blood stem cells, leading to a hyperinflammatory response and suppressed B-cell development. The study's findings suggest that maternal obesity may influence fetal bone marrow and immune system development.
Researchers from Johannes Gutenberg University Mainz developed ceria nanoparticles to silence bacteria by modifying signaling molecules, preventing biofilm formation. This approach mimics nature's defense system and has potential for creating antibacterial surfaces without resistance.
A study by the University of Bonn elucidated an important immune mechanism crucial for making hemophilia treatment effective. The researchers found that regulatory T cells can activate a self-destruct button on B cells against factor VIII, leading to its tolerance.
Researchers will investigate immune system differences between men and women to better understand neurodegenerative diseases. The study aims to identify why certain neurological diseases primarily affect males or females, and how this difference impacts disease progression.
A new study reveals that urolithin A from pomegranates can rejuvenate T cells by recycling and renewing mitochondria, enhancing their ability to fight tumors. The researchers plan to investigate the application of urolithin A in clinical trials for colorectal cancer.
A multistate study found that mRNA COVID vaccines were less effective in immunocompromised adults, with protection rates ranging from 34% to 71% after multiple doses. The study emphasizes the importance of non-pharmaceutical interventions, such as masks and antibody treatment, for additional protection against severe COVID-19.
A study found that young women's vaginal immune systems become more active after first-time intercourse, which may increase or decrease the risk of acquiring sexually transmitted infections. The changes were confirmed not to be due to pregnancy or having an STI.
Researchers found a significant association between NTM infection and increased mortality in patients with end-stage renal disease. Early diagnosis and treatment may improve survival. NTM can cause nonspecific symptoms like fever and weight loss, and patients with compromised immune systems are at higher risk.
Researchers analyzed DNA from victims and survivors of the Black Death to identify genetic differences that determined who lived and died. The study found four genes involved in immune defense against pathogens, with versions of these genes linked to increased susceptibility to autoimmune diseases.
Research found that the Black Death drove changes in immune-related genetic variants, affecting disease susceptibility. A specific gene variant, ERAP2, was associated with increased protection against the plague, but also linked to autoimmune diseases like Crohn's disease.
Researchers have designed a potential therapeutic that dampens the activity of regulatory T cells, which can prevent the immune system from unleashing its full potential against tumor cells. The molecule, known as FOX3P, acts as a transcription factor for many Treg genes but isn't vital for other types of T cells.
Researchers identified urolithin A as a compound that improves function of immune cells against cancer. The study found that urolithin A induces mitophagy in T cells, recycling and renewing mitochondria to enhance tumor-fighting capabilities.
Researchers analyzed 408 patients receiving immune checkpoint inhibitor therapy and found no increased risk of side effects from receiving both immunotherapy and the vaccine. The study supports NCCN's recommendations for COVID-19 vaccination in people with cancer, citing strong protection against severe COVID-19 for all variants.
Researchers at the University of Bonn have identified a mechanism that helps dendritic cells migrate more quickly to lymph nodes. The discovery reveals that forming multiple centrosomes enables these immune cells to stay on course longer before continuing their search.
A VUB study has mapped the immune system's response to brain infections, revealing that resident macrophages play a key role in defending against pathogens. The researchers found that blood-derived immune cells can eliminate parasites, but may retain 'memory' of past infections, altering their ability to respond to future insults.
Researchers found that high PERK activity correlates with poorer outcomes and lower anti-tumor immune cells in patients with melanoma. Inhibition of PERK promoted a type of cell death called paraptosis, which involved trafficking of immune cells to tumors and matured dendritic cells triggering anti-tumor T cell immunity.
Experiments in cell cultures and mice showed that blocking the function of NSUN2 triggers a powerful innate immune response, dramatically lowering viral replication and protecting lung tissue. This finding could help change the approach to developing antiviral medications.
Researchers developed an AI model that analyzes immune cells to predict which skin cancer patients will benefit from treatments activating the immune system. The study found that patients with more immune cells recognizing skin cancer had better treatment outcomes.
Researchers at Stanford University have developed a new RNA vaccine tool called RADAR, which can selectively target specific cells and induce protein production. This technology could offer precise treatment options for various diseases, including cancer.
The event will cover various topics including microbiota dysbiosis, oral and vaginal microbiota, and their impact on diseases like depression, cancer, and respiratory infections. The meeting aims to accelerate Microbiota medicine applications through strategic discussions.
Researchers discovered that B cells randomly allocate antibody classes to fight infections and diseases, leading to varying probabilities of developing conditions like asthma. This 'molecular roulette' process can be predicted using a formula, paving the way for understanding individual susceptibility.
Researchers at La Jolla Institute for Immunology have discovered a rare T cell defect tied to the risk of developing MAC disease. People with this defect have fewer specialized Th1* cells, which robs them of an effective immune response to MAC bacteria.
A Rutgers-led study statistically evaluated government data to determine if COVID-19 vaccination increases the incidence of Guillain-Barré syndrome. The results show no significant association between any COVID-19 vaccinations and the disease.
A study published in Science reveals that tumor cells with a specific mutation release a chemical metabolite that weakens nearby immune cells, rendering them less capable of killing cancer cells. The findings highlight the critical role of the tumor microenvironment in cancer growth and provide insights into developing targeted therapi...
Researchers at Karolinska Institutet found that intravenous omega-3 treatment improved immune function and stimulated healing of inflammation without compromising the body's response to COVID-19. The study suggests a potential new, cost-effective low-risk treatment for severe COVID-19.
Researchers from Xi'an Jiaotong-Liverpool University found that brain stimulation combined with a nose spray containing nanoparticles can improve recovery after ischemic stroke. The treatment increased cognitive and motor functions, and weighed more quickly than those treated with TMS alone.
In a new study, researchers found that immune T cells lacking the key transcription factor Satb1 are more susceptible to suppression by regulatory T cells, leading to transplant tolerance. The study provides insight into the mechanism behind transplantation tolerance and may lead to the development of new immunosuppression regimens.
Researchers have identified a complex of proteins in a tiny marine invertebrate that share similarities with the human immune system, suggesting an earlier origin for the building blocks of our immune system. The study could ultimately guide the development of new immunotherapies and improve understanding of transplant rejection.
Researchers explored how differences in skin composition affect susceptibility to diseases like psoriasis and atopic dermatitis. The study found that body site determines skin structure and function, with specific lipids and proteins playing a crucial role in disease diagnosis.
A new study from OHSU reveals that breakthrough infections following vaccination can provide a potent immune response against COVID-19, with increased protection for those 65 and older. The research found an equally strong immune response among people who received a third vaccine booster dose three months prior.
A study published in the European Respiratory Journal found that blood samples from long COVID patients show signs of autoimmune disease a year after infection. Nearly 80% of patients had autoantibodies in their blood, which persisted in around 30% of cases.
A new study finds that consistently losing an hour and a half of sleep per night can negatively impact immune stem cells, leading to increased inflammation and cardiovascular disease. Even after catching up on sleep, the effects of disrupted sleep remain long-lasting.
Researchers at Duke University have identified a previously unknown barrier that separates the bloodstream from smelling cells in the upper airway of mice, which may hinder the effectiveness of vaccines. The BOB barrier also allows antibody-secreting plasma cells to produce neutralizing antibodies locally.
Two studies identify 22 previously unreported NFKB1 variants linked to immune system dysfunction, including reduced expression of the protein and altered gene expression. The findings suggest targeted inhibition of NFkB signaling pathway components as an attractive therapeutic approach for treating these diseases.
Stowers scientists investigate macrophage activation states in zebrafish sensory organ, discovering three distinct anti-inflammatory pathways that may inform human regenerative immunotherapies. The study provides valuable insights into the timing and genetic programs of macrophages, a type of white blood cell, in repair and regeneration.
Researchers have made a breakthrough in treating autoimmune diseases by using genetically modified CAR T cells to target and destroy harmful B cells. This innovative therapy has shown promising results in six young patients with severe forms of systemic lupus erythematosus, curing them completely without returning.
A Cornell undergraduate has found a potential solution to immune dysfunction in space, suggesting that a transcription factor called MRTF could be the missing link. The study identified changes in the cytoskeleton of macrophages as a key factor in immune system dysfunction.
A study by Karolinska Institutet found that children with primary immunodeficiency diseases have a higher mortality rate due to COVID-19. Genetic analysis revealed mutations in genes important for immune defense, and some children lacked antibodies to the coronavirus.
A new biologic drug has been found to be highly effective in reducing the signs and symptoms of moderate-to-severe eczema in infants and young children. The study showed that more than half of treated children experienced a 75% reduction in eczema symptoms, leading to improved sleep and increased ability to lead normal lives.
Researchers at Cleveland Clinic's FRIC found that cytoskeleton disruption is a key signal for the body to respond to viruses. This discovery has potential implications for developing new anti-viral vaccines and treatments.
Researchers discovered a telomere transfer reaction between immune cells that extends their lifespan and confers long-term protection. This 'anti-ageing' mechanism has potential clinical applications for diseases like cancer and dementia, and may enable people to live healthier and longer.
Researchers at the University of Zurich have developed a new immunotherapy strategy to eliminate fibroblasts in targeted manner, reducing lung and liver fibrosis in mice. The treatment triggers an immune response via cytotoxic T-cells, eliminating activated connective tissue cells while leaving resting cells undamaged.
Researchers at University of California - San Francisco have developed a new therapy that overcomes cancer cell barriers and marks them for destruction by the immune system. By pulling mutated KRAS protein to the surface, the drug acts as an “eat me” flag, allowing immunotherapy to eliminate all cells bearing this flag.
Bladder cancer researchers discovered a subset of CD8 T cells that adapts to tumor evasion strategies, offering a strategy to reduce tumor cells' ability to fight them off. The study also identified potential ways to make immunotherapy more effective against this deadly cancer by targeting the HLA-E/NKG2A axis.
Researchers developed a predictive test to assess asthma risk in babies, allowing for preventive treatments and potentially bypassing disease development. The test identifies a network controlled by the IRF1 gene that drives an exaggerated inflammatory response in children who develop asthma.
A study led by University of Pennsylvania scientists reveals how tumor-derived factors stimulate trogocytosis, a process that can help cancer cells evade detection and grow unchecked. Blocking this process improved the effectiveness of CAR T cell therapy in mice.
Researchers have developed a new safety system for CAR-T cells, called VIPER CAR-T cells, that can be turned on or off. This allows doctors to target cancer more aggressively while minimizing side effects. The new system uses an FDA-approved antiviral drug to control the cell's activity.
Threespine stickleback fish evolved resistance to freshwater tapeworms by forming scar tissue around them, which prevents the worms from growing. However, this defense has a significant fitness cost for female sticklebacks, as they are 80% less likely to successfully breed due to the accumulated scarring.