Research on how the immune system defends the body. Covers immune-cell imaging, T-cell responses, longevity genetics, and cancer immunotherapy.
Researchers discuss treatment refractory forms of chronic sinusitis, highlighting the importance of interdisciplinary diagnostics and therapy. Fungal infections are a rare cause, yet crucial to consider when treating this condition.
A novel biomaterials-based approach enhances adoptive T cell therapy with cancer vaccine technology, providing strong and long-lasting effects against solid tumors. In mice carrying melanomas, SIVET enables fast tumor shrinking and long-term protection.
Researchers found that mast cells act as sensors to avoid allergens in mice, protecting against health-threatening inflammatory reactions. The study suggests that both mast cells and IgE are necessary for antigen avoidance.
Researchers at Yale University have discovered that the immune system plays a crucial role in changing behavior in response to allergens and toxins. By manipulating immune system variables, scientists were able to alter the behavior of sensitized mice, demonstrating the importance of immune recognition in controlling defensive behaviors.
New studies show cow colostrum can reduce infant formula use and strengthen mother's milk in premature babies, providing essential nutrients like amino acids. Researchers hope to optimize cow colostrum product for critical first few weeks after birth.
Researchers at Johns Hopkins Medicine have identified a new target for treating HIV infection by blocking the neutral sphingomyelinase-2 (nSMase2) enzyme. Inhibiting this enzyme can prevent HIV replication and kill infected cells, offering a promising therapeutic approach.
A new Boston University study found that COVID vaccines likely do not affect menstrual cycle regularity, bleed length, or pain. Menstrual cycles increased by 1.1 days after a first dose and 1.3 days after a second, but these changes resolved within one to two cycles.
Researchers from the University of Copenhagen have solved the mystery of how the Hepatitis C virus evades the human immune system. The virus uses a molecule called FAD as a 'mask', cloaking itself in a form that is already present in cells, making it invisible to the immune system.
Researchers at Reichman University developed a comprehensive biological model that unifies the processes impacting postpartum depression (PPD) and its symptoms. The model highlights four main factors leading to PPD: immune system activity, continuous stress, hormonal imbalance, and reduced activities involving closeness.
Researchers have developed a method to produce highly active mRNA vaccines at high purity using a unique cap to easily separate the desired capped mRNA. This 'Purecap' technique extracted up to 100% pure Cap2-type mRNA, which showed improved protein production and lower immunostimulatory activity.
A new study from Sanford Burnham Prebys identified a protein called NR2F6 that helps melanoma cells evade the immune system, but also promotes anti-tumor immunity when targeted. The researchers hope to develop new drugs that can block this protein's activity, potentially doubling the effectiveness of immunotherapy for melanoma patients.
A new study from the University of Missouri-Columbia found that supportive communities and education about breastfeeding health benefits can boost breastfeeding rates, particularly in rural areas where it is less common. The study also showed that reduced stigma surrounding breastfeeding occurred with increased community exposure.
A study published in Cellular Immunology reveals that type 1 interferons impair the metabolic response to Mycobacterium tuberculosis, making patients with chronic TB more susceptible to infections. The research identifies these cytokines as a potential target for developing new treatments.
Researchers have isolated and analyzed individual immune cells targeting the hepatitis C virus, providing valuable data for vaccine development. The study found that antiviral treatment reduces cytotoxicity in HCV-specific immune cells, offering a potential pathway to an effective vaccine.
Scientists at the University of Cambridge identified a signature in the blood that could predict how well an individual responds to vaccines. They found that those with higher levels of age-associated B cells are less effective after vaccination.
Researchers at Aarhus University have discovered a new method to activate the complement system using bispecific single-domain antibodies, termed BiCEs. These molecules can specifically target cancer cells and activate the complement system, leading to the killing of targeted cancer cells.
A study found that space travel causes a rapid decrease in the strength of an astronaut's immune system due to changes in gene expression. Most genes returned to normal levels within weeks after returning to Earth, but there is still uncertainty about when full resistance returns.
Researchers identified a rare genetic defect in the DOCK11 gene causing abnormalities in white and red blood cells, leading to inflammation and immune system dysregulation. The defect also affects T cell activation, with potential connections to tumor diseases.
Researchers discuss the potential of glucocorticoid-induced TNFR-related protein (GITR) as a target for cancer immunotherapy. Preclinical studies have shown potent anti-tumor efficacy, but clinical trials have yielded inconsistent results due to complexities in immune responses and antibody structure.
A new study reveals how breast cancer cells suppress anti-cancer immune responses in the lymph nodes to survive and spread. Researchers found that some cancer cells exhibit elevated expression of MHC class II proteins, which are involved in initiating immune responses.
A new study found that food allergy affects all racial and ethnic groups, but is most prevalent among Hispanic, non-Hispanic Black, and Asian individuals. Food allergy rates are also lower in households with higher incomes.
A machine-learning study has found that individual characteristics, including age and weight, determine which drug combinations most effectively reduce COVID-19 recurrence rates. The study used real-world data from a hospital in China and identified unique treatment combinations for different demographic groups.
A new study published in Journal of Leukocyte Biology found that age and sex differences contribute to increased inflammation in older female mice. The research team discovered that immune cells entering areas where they shouldn
Researchers found that blocking histamine-releasing factor (HRF) and immunoglobulin E (IgE) interactions may provide relief for patients with severe asthma. The study, published in The Journal of Allergy and Clinical Immunology, suggests two potential therapies, including HRF-2CA and a therapeutic antibody called SPF7-1.
Researchers have developed a new manufacturing pipeline to simplify and advance high-value manufacturing of tissue-compatible organs, reducing costs and increasing efficiency. This breakthrough aims to address the dire need for artificially engineered organs and tissue grafts, potentially saving thousands of lives in the UK.
A new study reveals a previously unknown way the immune system detects certain viruses, including SARS-Cov-2, using the inflammasome protein CARD8. Researchers found that CARD8 functions differently among various species and even varies between individuals in the human population.
A retrospective study found a 24% response rate to Docetaxel among patients with stage IV non-small cell lung cancer who experienced progression on immunotherapy. The median progression-free survival was 3 months, suggesting chemotherapy may still play an important role in treatment after immunotherapy failure.
Researchers have developed a therapy using nanocarriers engineered from adult skin cells that curb inflammation and tissue injury in damaged mouse lungs. The treatment has shown promise for treating acute respiratory distress syndrome (ARDS), a condition that leads to respiratory failure and puts patients on ventilators.
Researchers at Sanford Burnham Prebys have discovered a new treatment for autoimmune diseases using LY3361237, an antibody that activates BTLA to inhibit the immune system. The study provides insight into the molecular biology of the immune system and could lead to the development of more effective therapies.
Researchers invent time-resolved assessment of single-cell protein secretion with sequencing (TRAPS-seq) to correlate cell functions with secreted proteins. The technique accelerates the development of new therapeutic strategies for disease treatment, including targeting mechanisms selective for cancer cells.
Researchers at Karolinska Institutet have identified how memory killer cells are formed and found a correlation between their presence in cancer tissue and improved survival rates in people with melanoma. The study suggests that harnessing the potential of these cells could lead to more effective immunotherapy.
The study found that the immune response to spinal-cord injuries is impaired in older individuals, leading to weaker cell responses and reduced recovery. The researchers identified an essential role for the meninges surrounding the spinal cord in mounting the immune response, paving the way for new therapeutic approaches.
Researchers developed a method to 'tip the balance' of immune cells from bad to good, reversing MS-like symptoms in 100% of mice and achieving full recovery in 38%. The therapy uses biodegradable microparticles to deliver three key therapeutic agents, including rapamycin and a myelin peptide.
UofL researchers, led by Jun Yan, will investigate the causes of immune system overresponse in COVID-19 patients, leading to severe lung disease and death. They aim to develop methods to predict, prevent or control this response with potential treatments for other conditions.
New research from King's College London suggests that many people with depression have an activated immune response, independent of CRP levels. This finding could pave the way for more personalized approaches to treatment and management of MDD.
Scientists at La Jolla Institute for Immunology found that MAIT cells can be tuned to fight different pathogens via their metabolism, with two distinct subtypes responding to sugar and fat. This discovery may inspire new vaccines and cell therapies to boost the immune response against specific pathogens.
Researchers at UNC School of Medicine discovered that human T cells can independently control RSV replication in lung tissue, suggesting a new approach to developing vaccines. The study's findings support the development of RSV vaccines that elicit effective T cell responses to improve vaccine efficacy.
A recent study published in the Journal of Clinical Immunology suggests that cutaquig infusions at higher infusion rates and volumes are well-tolerated and effective, with reduced infusion time, fewer injection sites, and improved compliance. The study results will be presented at the Clinical Immunology Society 2023 Annual Meeting.
Researchers at UCLA Jonsson Comprehensive Cancer Center have found a potential therapeutic target, IL-21, to reduce endocrine autoimmune side effects from checkpoint immunotherapy. A specific group of immune cells play a central role in this autoimmune attack and blocking IL-21 prevents thyroid autoimmunity.
Researchers from Cima University of Navarra have found that inhaling menthol improves cognitive ability in animal models of Alzheimer's disease by modulating the immune system and reducing interleukin-1-beta levels. This study opens doors to developing therapies based on stimulating and training the olfactory system.
A study published in Cell Reports Medicine found that pro-inflammatory cell types dominate the intestinal mucosa of children with inflammatory bowel disease, while protective cells are underrepresented. The results provide new insights into the immunology of IBD and may lead to the development of more effective treatments.
A new study reveals a shared molecular response to nanoparticles, linking immune activation and particulate matter exposure. The findings propose a solution to the 'one-chemical-one-signature' problem in chemical safety assessment.
Researchers found that IL-6 signaling in allergen-specific T cells was needed to suppress commitment to the harmful Th2 lineage. SOCS3 upregulation by IL-6 inhibits JAK/STAT internal signaling pathway, preventing Th2 cell priming.
Researchers have sequenced the genomes of Leatherback and Green sea turtles, revealing similarities in their immune systems and evolution. The study provides clues for understanding fibropapillomatosis, a cancer affecting these species, and informs conservation efforts.
Researchers discovered that gamma delta T cells can effectively combat triple-negative breast cancer by targeting stress-induced molecules and phosphoantigens. Counteracting metabolic changes with zolendronate makes immunotherapy more efficient.
Researchers at Sanford Burnham Prebys have found a way to revive exhausted T cells, which are crucial for destroying cancerous cells. The new approach targets PSGL-1 protein and slows down T cell exhaustion, significantly reducing tumor growth in mice with immunotherapy-resistant melanoma.
A new study by Cedars-Sinai Medical Center finds that people with long COVID-19 produce higher levels of antibodies against the virus than those without. The elevated antibody levels persist for months longer than expected after receiving a COVID-19 vaccine, sparking further research into the condition.
Heidelberg researchers have identified key proteins that can prevent the formation of fusion pores, allowing viruses like influenza A and Ebola to be trapped in a lipid membrane. This breakthrough could lead to new approaches for preventing infections with these highly infectious viruses.
Researchers found that checkpoint inhibitors are not effective in treating relapsed aggressive lymphomas after CAR T therapy. The study involved 96 patients from 15 centers and showed only 19% response to checkpoint inhibitor therapy.
Researchers discovered a 'cocktail' of human antibodies that show promise in fighting severe SARS-CoV-2 infections, including Omicron variants. The study revealed how the original Moderna vaccine could prompt the body to produce these broad-spectrum antibodies.
Researchers propose a new theory on how cancer cells actively adapt to evade the immune system, losing and gaining tumor-associated antigens. This adaptation makes it difficult for immunotherapies to target cancer cells effectively, but may also create new vulnerabilities that can be therapeutically targeted.
A new liposome-based method aims to kill periodontitis-causing leukotoxin while protecting immune cells, providing an alternative treatment for aggressive gum infections. The approach has potential applications against a range of bacteria and could help combat antibiotic resistance.
A team of researchers has discovered that a naturally produced chemical in the body helps glioblastoma cells go unrecognized by the immune system. The findings could lead to the development of new and more effective treatments for this aggressive brain cancer.
Researchers uncover how HIV enters human bodies via dendritic cells using Siglec-1 membrane protein; formation of nanoclusters enhances capture, leading to virus compartment formation. Understanding this process can aid in developing effective treatments for HIV/AIDS.
Research reveals that immune cells employ tactile sensing and mechanical force to advance their evolution, enhancing antigen recognition and memory diversity. This active process allows the immune system to adapt to new challenges while being plastic and adaptive against future threats.
Researchers found an exceptional number of unknown viruses in the faeces of 647 healthy Danish one-year-olds, representing more than 200 families of yet to be described viruses. These viral species likely have a major impact on whether children develop various diseases later on in life.
Research discovers how cancer cells evade immune system detection and metastasize in the body. Pre-metastatic cells and exhausted CD8+ cells are identified as key players in this process. The study explores ways to target these pathways and activate immune responses to block metastasis.
Researchers found that infected mosquito saliva contains molecules called sfRNAs that can blunt the body's immune response. These molecules are injected during the mosquito bite, making it more likely for people to become infected with dengue virus.
A team at UC San Diego developed a biodegradable polymer system to treat rheumatoid arthritis by working with the immune system. The method uses encapsulated all-trans retinoic acid (ATRA) that transforms disease-causing cells into regulatory T cells.
Researchers found that a combination of IL-22 and IL-1R inhibitors could be a promising treatment for inflammatory bowel diseases like Crohn's disease and ulcerative colitis. The study suggests that targeting both pathways may lead to more effective treatment outcomes.