Research on the medical care of infants and children. Covers pediatric emergencies, blood-pressure thresholds, infectious disease, kidney injury, and developmental health.
Researchers at UC San Diego School of Medicine found that COVID-19, MIS-C and Kawasaki disease share similar underlying molecular patterns. The study reveals that MIS-C is a more severe version of the immune response than KD, with potential implications for improved disease diagnosis and treatment.
A study published in the Journal of Surgical Research found that e-cigarette explosions caused 15 traumatic injuries in children between 2016 and 2019. The devices' use of inferior quality batteries prone to explosion puts users at risk of severe injuries, including burn wounds, jaw fractures, and eye damage.
A low-cost ventilator prototype has been developed, making it accessible to all, including adults and children, with a potential price tag of USD $1500. The PVP1 project aims to provide a pressure-controlled ventilator research platform for compatible adult and pediatric uses.
A national study of over 170 pregnant women found rising exposure to potentially harmful chemicals from plastics and pesticides. Latinas had higher levels of parabens, phthalates, and bisphenols, which may be linked to increased risk during fetal development.
A study of 72,000 pediatric encounters found that non-Hispanic Black children were more likely to be readmitted within a year due to diabetic ketoacidosis. Healthcare disparities persist among racial and ethnic groups in pediatric care, emphasizing the need for targeted interventions.
A review of over a decade of data from the HOLBAEK Study reveals wide range of obesity-related complications present at young age, including dyslipidaemia and sleep apnoea. The study also found family-based weight management programmes to have positive effects on overweight and related complications.
A new study found that endurance exercise improves mitochondrial function in some patients with primary mitochondrial diseases, but not others. The research highlights the importance of considering individual genetic status when recommending exercise as therapy.
Canadian and German researchers have identified personalized prescriptions that combine drugs to treat obesity and Type 2 diabetes. The combination therapy shows higher effectiveness in some patients and fewer side effects compared to single drugs. Studies are now needed to understand why individuals respond differently to the treatment.
Researchers used gene therapy to recover the TCF4 gene's function in human brain tissue, rescuing neural structure and function in brain organoids. The study offers promising insights into treating neurological disorders like autism spectrum disorders and schizophrenia.
A study of nearly 9,000 children found that those on a vegetarian diet had similar measures of growth and nutrition compared to those who eat meat. Children with a vegetarian diet also had higher odds of underweight weight status.
Researchers developed a decision support program to reduce blood draws in pediatric intensive care units (PICU), leading to reduced antibiotic prescriptions without increasing sepsis risk. The program resulted in significant reductions in blood culture rates and unnecessary medication use.
A new supplement in Pediatrics suggests that early life interventions can improve later health outcomes and address pressing concerns around youth mental health. The Life Course Intervention Research Network calls for a major focus on supporting children's positive health development and sense of well-being.
Researchers developed a new method using actigraphy to monitor sleep-wake cycles in children with brain injury during inpatient rehabilitation. The study found lower rest-activity ratios, suggesting poorer sleep-wake regulation and lower functional status.
A study found that pediatric transplant patients attend on average less than one appointment per year after transferring to adult care, resulting in longer hospital stays and poorer health outcomes. Maintaining regular appointments is crucial for continued transplant success, according to the researchers.
The Pediatric Academic Societies 2022 meeting will feature over 60 specialties presenting on various topics, with 500 hours of content available. The event will also include keynote speakers and a full scientific program with oral abstract presentations and posters.
A new study from Boston Medical Center found that COVID-19 infection during pregnancy is associated with elevated inflammatory markers in infants, potentially impacting growth and brain development. Researchers emphasize the importance of COVID-19 vaccinations for pregnant women to avoid long-term adverse consequences for their infant.
A team of UTHealth Houston researchers has been awarded a $2.85 million NIH grant to study a new technique assessing cerebrospinal fluid in babies with hydrocephalus, which affects 400,000 newborns globally each year.
Researchers aim to improve pediatric heart transplant outcomes by identifying how certain drugs work and developing new medications to prevent damage to transplanted hearts. The studies will focus on a recently identified population of immune cells, MAIT cells, to adjust medication dosages and minimize side effects.
A study using Ohio license data found that mandatory driver education, including behind-the-wheel training, reduces crash rates among novice drivers under 18. The research suggests reevaluating comprehensive licensing policies to keep young drivers safe.
The COVID-19 pandemic has led to an increase in mental health visits in pediatric primary care, with significant rises in eating disorders and mood disorders. The study highlights the importance of screening and managing youth mental health conditions in primary care during periods of social isolation.
The study compares current recommendations for ventilation and chest compression versus ventilation during neonatal resuscitation using an ovine model. The findings suggest that optimizing ventilation could reduce the need for chest compressions and improve gas exchange in neonates, potentially improving overall outcomes.
A new study examines the effect of rapid infusion of sodium bicarbonate on gas exchange and coronary and cerebral perfusion in the immediate post-resuscitation phase. The study found that rapid administration led to a significant rise in myocardial and cerebral perfusion, as well as higher levels of exhaled carbon dioxide.
A new study examines factors associated with COVID-19 vaccine hesitancy and uptake in the autism community, revealing that early skepticism waned over time. The majority of caregivers eventually received the vaccine following FDA approval. Firmly held vaccine-hesitant beliefs influenced a minority of autism spectrum disorder caregivers.
A study found that fetuses with single-ventricle congenital heart disease are more susceptible to social-emotional problems compared to those with two-ventricle congenital heart disease. Infants with impaired prenatal brain growth also experience worsened language, cognitive, and motor outcomes by 18 months.
Researchers investigated the use of intranasal human milk as a stem cell therapy for preterm infants with intraventricular hemorrhage. The study found that preterm infants could tolerate nasal milk therapy without major safety events, paving the way for further research on long-term outcomes.
A randomized controlled trial found that furosemide increases the risk of electrolyte adverse events but no difference in hearing loss or nephrocalcinosis was observed. The study suggests caution when using furosemide in preterm infants at high risk for bronchopulmonary dysplasia.
A randomized clinical trial found that outreach messages were minimally effective at promoting scheduling of adolescent well care visits, but had limited impact on completing visits. Efforts to address widening disparities are needed.
A study examines adolescent perspectives on TikTok's mental health benefits and risks, including how the algorithm enables unique connections with peers around interests and mental health struggles. Participants also discussed excessive use, peer comparison, and challenges in regulating their TikTok use.
Researchers found no evidence that early selective treatment with ibuprofen reduces death or moderate to severe bronchopulmonary dysplasia in extreme preterm infants. However, treatment reduced the risk of an open patent ductus arteriosus and surgical treatment for a symptomatic PDA.
Firearm-related deaths have surpassed car accidents as the leading cause of death among children under 19, with a widening racial gap. Secure gun storage counseling and hospital-based violence intervention programs show promise for prevention and reduction of all three categories of gun violence.
Scientists have developed novel methods to study human brain cell migration during fetal development by tracking genetic mutations in healthy adult individuals. This allows for the first time to reconstruct brain development and provide key findings on cell type origins and hemisphere separation.
A new study from the University of Georgia found that only about one-third of infants enrolled in WIC meet the daily recommendation for vitamin D by 13 months. Experts recommend increased education and supplementation to address this issue, which can lead to diseases like rickets and Type 1 diabetes.
A new Michigan Medicine study found that for children with a pelvic tilt and lower lumbar spine tilt of fewer than 10 degrees, the pelvis did not need to be included when inserting growing rods. This could help avoid painful complications such as skin breakdown and infection.
A study from the University of Pittsburgh found that methionine restriction can slow down the growth of difficult-to-treat brain tumors in children, known as diffuse midline gliomas. The researchers discovered that these tumors are uniquely dependent on methionine, an amino acid, and that depleting it can repress cancer cell growth.
CHOP researchers have developed a targeted treatment that controls blood sugar in patients with hyperinsulinism, a genetic disease. The study found exendin-(9-39) reduces likelihood of fasting hypoglycemia by 76% and protein-induced hypoglycemia by 82%
A recent study found that COVID-19 spreads extensively in households, with approximately 50% of household members infected from the first-infected individual. Children were less likely to spread the virus but equally likely to become infected as adults, highlighting their potential role in transmission.
A new study found that older children (6–12 years, 13–17 years) and those with high inflammation markers were at highest risk of severe MIS-C. Gastrointestinal symptoms and cardiac involvement were common in affected children.
Pediatric cancer patients from lower- and middle-income countries faced a higher risk of all-cause mortality than those in high-income countries during the COVID-19 pandemic. The study found that patients in LMICs had 35.7 times the risk of all-cause mortality compared to those in HICs.
Scientists have constructed a detailed map of lung development after birth, providing insights into the genetic and epigenetic factors that affect lung health. The study used next-generation single-cell sequencing technologies to analyze over 80,000 human and mouse lung cells, revealing clues on how cell types communicate and develop.
The RACE Act has led to an increase in required studies for cancer drugs targeting molecular targets relevant to pediatric cancer. Since its implementation, 42.9% of approved drugs have been required to conduct pediatric studies, up from 8.3% before the act.
The UCF-developed real-time blood monitor uses an optical fiber to assess blood status and can be inserted directly into heart-lung machines or catheters without withdrawing blood from patients. This device has been shown to save doctors critical time during life-or-death operations, particularly in surgeries on infants.
Disparities in social determinants of health affect people with congenital heart disease, leading to unequal access to care. Strategies to address these issues include increasing specialist availability and improving telehealth capabilities.
A virtual cooking/nutrition program, Flint Families Cook, demonstrates success in reaching youth from low-income families and improving cooking self-efficacy and nutrition knowledge. The program encourages families to cook healthy meals together at home, using local ingredients.
Researchers at MUSC have developed a device to remove toxic chemotherapy drugs, such as doxorubicin, from the blood after cancer treatment. The device uses heat and an activated carbon filter to effectively remove the drug, potentially reducing harmful side effects.
A recent analysis found that hospital admissions for children with lupus showed a decrease in severe kidney problems over time. However, racial disparities persist, with Black and Asian children at higher risk of developing new kidney problems.
A new study reveals that firearm retailers and law enforcement agencies in Colorado and Washington support providing temporary, voluntary firearm storage options. The concept aims to increase safety by limiting access to firearms during times of crisis, such as suicidal thoughts or Alzheimer's disease. However, concerns about civil lia...
The BrainChart platform benchmarks brain development based on MRI data from over 100,000 individuals, creating a standardized chart like those for height and weight. The tool identifies previously unreported neurodevelopmental milestones and provides a common language to understand brain images from different sources.
Dr. Philip D. Greenberg has been elected as the American Association for Cancer Research President-Elect for 2022-2023. He will work to harness advances in cancer research and translate them for patient benefit, with a focus on addressing disparities in minority engagement.
A study by TUM confirms that physically fit primary school pupils perform better in terms of concentration and health-related quality of life. The results show a positive correlation between physical fitness, concentration, and overall well-being.
A study found that opioid prescriptions for children undergoing common outpatient surgeries declined by up to 50% between 2014 and 2019. The trend was most pronounced in adolescents, with a decline from 78.2% to 48% of prescriptions filled within 7 days of surgery.
A new study suggests that children under 5 infected with Omicron have a lower risk of severe health outcomes compared to those infected with the Delta variant. The study found that Omicron is 6-8 times more infectious than Delta, but resulted in fewer hospitalizations and mechanical ventilation cases.
A new study found significant improvement in survival rates of extremely pre-term babies born at 22 and 23 weeks. The study, which examined data from 2013-2018, showed a considerable increase in survival rates compared to previous studies, with survival rates reaching 30.0% at 22 weeks and 55.8% at 23 weeks.
Researchers found increased telehealth use was associated with reduced no-show rates and narrowed access disparities in pediatric care. The study also highlighted the growth of telehealth across various pediatric subspecialties before and during the COVID-19 pandemic.
Researchers at CU Anschutz Medical Campus discovered a reactivated protein, Hand2, in certain cases of mesothelioma, which may lead to new treatments. The study aims to investigate the cause and effect of this reactivation.
A new study found that follow-up care after an asthma-related emergency department (ED) visit can help prevent future ED visits for children. Patients who received follow-up care within two weeks of their ED visit were 12% less likely to return to the ED for asthma within 60 days and 13% less likely to revisit for asthma in the next year.
Research at Universidad Complutense de Madrid found that tumour cells from childhood acute lymphoblastic leukaemia (ALL) can hide in the subventricular neurogenic niche, causing relapses and preventing new neurone generation. This discovery may explain cognitive and sensory alterations in ALL survivors.
A large NIH-funded study found significant disparities in acute asthma care utilization among Black, Latino, and white children. Black children accessed community health centers less frequently than white children, while Latino children were more likely to visit CHCs for comprehensive care.
A new study found that integrating behavioral health into pediatric primary care at federally qualified health centers increases access, timeliness of care, and diagnostic rates of ADHD among diverse children. The model resulted in higher follow-up rates with behavioral health clinicians and reduced polypharmacy.
Researchers from Children's Hospital of Philadelphia found that dysfunction in a key brain cell subtype contributes to chronic symptoms in Dravet syndrome. The study suggests that increasing expression of Nav1.1 in parvalbumin interneuron axon may be a viable therapeutic target for patients.
A new study reveals that Latine children who prefer speaking Spanish are more likely to visit a community health center for their acute asthma symptoms than non-Hispanic white peers. Non-Hispanic Black children are also more likely to receive asthma-related care in emergency departments.