Research on the medical care of infants and children. Covers pediatric emergencies, blood-pressure thresholds, infectious disease, kidney injury, and developmental health.
Researchers attribute low vaccination rates in children to misconceptions about vaccine safety and Covid-19 vaccines. Misinformation about vaccine safety predicts reluctance to vaccinate both adults and children.
Acute kidney injury (AKI) affects 25% of hospitalized children and has a high mortality rate. Experts have identified key issues and set a research agenda to improve diagnosis, prevention, and care for AKI in kids. The goal is to develop evidence-based guidelines and quality care for these vulnerable patients.
A new study shows the first-of-its-kind program led to significant declines in anxiety for those with food allergies and improvements in quality of life. The Food Allergy Bravery (FAB) program provides individualized, cognitive behavioral treatment that encourages children to take small steps towards facing allergen-related fears.
Pediatricians and primary care physicians can identify and treat pediatric post-COVID-19 symptoms using new guidelines. The guidelines include best practices from Kennedy Krieger's Pediatric Post-COVID-19 Rehabilitation Clinic.
A novel study in Virginia uses state all-payer claims data to accurately assess and predict future primary care workforce needs. The approach differentiates physicians with primary care training from those who practice true primary care, providing a more accurate estimate of U.S. primary care capacity.
A successful collaboration implemented pediatric early warning systems (PEWS) in 36 Latin American hospitals, training over 11,100 clinicians and improving cancer outcomes. PEWS use was maintained for up to 18 months after implementation, with high-quality results.
A new study found that children infected with COVID-19 have a substantially higher risk of developing type 1 diabetes, with a 72% increase in new diagnoses in the six months following COVID diagnosis. Pediatricians and families should be alert for symptoms of diabetes following COVID.
A recent study has found an association between SARS-CoV-2 infection and new-onset type 1 diabetes among pediatric patients. The study analyzed data from electronic health records and found that children who contracted COVID-19 were more likely to develop new type 1 diabetes compared to those with other respiratory infections.
UC Riverside engineers develop low-cost robotic clothing to help children with cerebral palsy. The soft machine garments contain sealed regions that inflate to provide force for movement, enabling natural limb functioning.
Researchers have discovered that a type of pediatric brain tumour, medulloblastoma, develops in a pre-malignant form during human fetal brain development. This finding suggests that medulloblastomas could be preventable by identifying the genetic variations that cause them and acting before they develop.
Researchers developed a new 3D organoid model that replicates the unique disease process of autosomal recessive polycystic kidney disease (APRKD). The model identified potential therapeutic targets, including FOS and RAC1, and showed therapeutic effects with FDA-approved drugs.
A peer-reviewed study detected PFAS in all 'stain-resistant' school uniforms tested from nine popular brands, with concentrations as high as those in outdoor clothing. The presence of PFAS in school uniforms poses a risk to children's health through skin absorption and inhalation.
A recent study published in Radiology found persistent lung damage on MRI scans in children and teens who recovered from or have long COVID. Lung function and structure show signs of dysfunction, with V/Q matches indicating impaired air and blood flow.
Numerous gaps between dietary intake and recommended guidelines are found, particularly among vulnerable families, with race and ethnicity disparities persisting. A unified plan can improve nutritional outcomes by strengthening federal policies and programs.
A rat study found that excessive blue light exposure is associated with earlier puberty onset, reduced melatonin levels, and increased reproductive hormones. This suggests a potential risk for childhood development and future fertility.
A recent study found that telemedicine is a viable option for many patients, especially those with epilepsy and attention-deficit hyperactivity disorder. However, barriers remain, including limited access for socially vulnerable families and racial/ethnic minorities.
Non-traditional lifestyle interventions, such as physical activity, sleep habits and nutrition, can effectively reduce depressive symptoms in adolescents. These interventions are cost-effective, versatile, and can be implemented by both licensed and non-licensed providers.
Researchers found no significant difference in pain levels between children who received ibuprofen and those who received a placebo before stent removal. Only 7% of pediatric patients reported severe pain following the procedure, compared to 55% of adults.
Researchers developed assistive devices to streamline ear reconstruction surgery, minimizing tissue waste and operating time. The tools use 3D manufacturing to precision-cut rib cartilage, enabling a faster, more accurate process with better outcomes.
A UConn study found that Connecticut's notification system for substance-ex exposed infants has connected over half of identified cases with community supports and services. The system, which uses de-identified data, has shown promise in reducing disparities in testing and reporting, but there is still room for improvement.
A recent study published in Frontiers in Pediatrics suggests that modern immunotherapies, such as CAR-T cell therapy, could replace traditional stem cell transplantation for high-risk ALL patients. The review also discusses the importance of reducing long-term side effects, including organ damage and secondary cancers.
The American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) has selected top research presentations for its 2022 Annual Meeting & OTO Experience. These include groundbreaking studies in otology, laryngology, endocrine surgery, and head and neck surgery.
Researchers at the University of Alabama at Birmingham found that noninvasive ventilation in nano-preterm infants did not show an advantage in reducing bronchopulmonary dysplasia or death. In contrast, infants who received invasive respiratory support had lower rates of severe intraventricular hemorrhage and death.
Researchers from Children's Hospital of Philadelphia used advanced mapping techniques to identify causal genes and target pairings in the pancreas linked to type 2 diabetes. The study revealed alpha and acinar cells play a greater role in disease development than previously thought.
A new study published in Pediatrics has found that children living in neighborhoods with greater hardships are more likely to use emergency departments. The study used the Pediatric Health Information Systems database and found a positive association between neighborhood Child Opportunity Index (COI) scores and ED visits, indicating th...
A machine-learning model developed at Mass Eye and Ear accurately diagnosed pediatric ear infections at a rate 30 percent higher than doctors surveyed. The model achieved 95% accuracy in diagnosing an ear infection from test images, surpassing the average clinical accuracy of 65%.
SAFER Ukraine successfully evacuated over 900 patients and families to reestablish medical care abroad. The effort demonstrates the importance of collaborative networks in global health and provides a model for future international emergency responses.
A study published in Nature Communications suggests that better glucose control can improve brain structure and function in youth with Type 1 diabetes. The findings indicate that participants using a hybrid closed-loop insulin delivery system showed significant improvement in key brain metrics compared to those receiving standard care.
Researchers have made significant breakthroughs in understanding the molecular mechanisms of supratentorial ependymoma, a rare and aggressive form of childhood brain cancer. By targeting the Hedgehog signaling pathway and primary cilia formation, scientists discovered new potential treatments that overcame resistance to existing drugs.
A new study from the National Institutes of Health RECOVER initiative found that post-acute COVID-19 in children is less common than in adults, but more frequent than hospitalization rates for acute COVID-19. Children with medical complexity and those younger than five years old are at higher risk of long COVID-19.
A new study found that school-aged children can successfully use a nasal swab to obtain their own COVID-19 test specimen, providing data for recommendations on self-swabbing in schools and other settings. The study showed that children as young as 4 years old can follow instructions and collect their own samples with high accuracy.
A University of Massachusetts Amherst psychologist is using a $428,000 NIH grant to develop a home-based system that tracks preschoolers' tantrums and predicts mental illness risk. The system uses wearable devices and machine learning algorithms to identify high-risk children and provide critical information to parents.
Researchers found that mothers' higher depressive symptoms did not predict increases in children's behavior problems, including those with autism. The study suggests that maternal depression may have a complex impact on caregiving families.
Researchers identified five new hepatoblastoma tumor signatures that could help predict responses to chemotherapy treatments. The study used single-cell transcriptomic techniques to analyze tumors from infants and children, providing a window into normal development and cancer.
A study found that 47% of parents meeting criteria for post-traumatic stress disorder (PTSD) symptoms, compared to 12% of children with implantable cardioverter-defibrillators. The trauma triggered by a child's heart problems can affect the entire family.
A scalable prototype for newborn screening, including rapid Whole Genome Sequencing and virtual acute management guidance, has been developed to rapidly screen for several hundred genetic diseases. The system demonstrates feasibility in identifying genetic diseases with effective interventions.
A study of 137 children with early-onset psychosis found that over 70% had copy number variants, a common cause of neurodevelopmental disorders. The research suggests that chromosomal microarray testing can bring closure to families and improve treatment outcomes.
A recent study by Johns Hopkins Children's Center researchers found a significant rise in type 2 diabetes cases among children during the COVID-19 pandemic. The increase was largely attributed to reduced physical activity and weight gain due to lockdowns and virtual learning.
A study by Children's Hospital Colorado reveals a 77% surge in newly diagnosed youth-onset type 2 diabetes cases during the COVID-19 pandemic. The increasing prevalence of obesity and unhealthy habits since the pandemic's onset are thought to contribute to this rise.
Researchers at Karolinska Institutet have developed a potential curative treatment for neuroblastoma, using DHODH blockers in combination with chemotherapy to cure mice with the disease. The treatment has shown promising results and could improve survival rates for children with neuroblastoma.
Researchers have found that children with autism show significant differences in their pupillary light reflexes, which can be used as a potential screening biomarker. The study demonstrates the parameters of interest that matter for detecting autism and validates earlier findings using monocular technology.
A new study explores how active parent participation can improve neonatal health and reduce parental stress. The study found that cultural attitudes, collaboration between medical staff and parents, and availability of equipment are key factors in enabling parent-infant closeness.
A new study presents the first data-driven sex-specific model of pediatric cranial bone development, providing a quantitative normative reference for local cranial bone development during the first ten years of life. The model improves current understanding and clinical diagnoses of cranial development disorders.
A national follow-up study found that over a quarter of children and adolescents hospitalized with COVID-19 or multisystem inflammatory syndrome in children had persistent symptoms or activity impairment two to four months later. The study identified risk factors for prolonged recovery, including MIS-C and activity impairment.
A Rutgers study found that early-term births (37–38 weeks) have significantly higher symptoms of hyperactivity, ADHD, and cognitive problems or inattention compared to full-term births. Teachers' reports provided valuable input for the diagnosis of ADHD, highlighting the need for regular screenings.
A recent study published in Pediatrics found that neurologic complications are relatively common among children hospitalized with COVID-19, occurring in about 8% of cases. These complications can lead to life-altering conditions and increased hospital costs, highlighting the importance of vaccination and prevention strategies.
A recent study published in Cancer Research identified a unique vulnerability in certain high-risk cancers that can be exploited for targeted therapy. Researchers found that cancer cells with alternative lengthening of telomeres (ALT) have a common weakness, leading to resistance to DNA-damaging agents and chemotherapy.
A new study by researchers at UTHealth Houston found that children infected with COVID-19, but not hospitalized, can still develop long COVID symptoms up to three months past infection. The study also identified risk factors for long COVID in children, including unvaccination and obesity.
A new study published in Current Biology found that humans' ability to interpret babies' cries isn't innate but learned from experience. Parents of young babies are able to identify a baby's pain cries even if they have never heard this baby before, whereas inexperienced individuals are typically unable to do so.
A study by West Virginia University found that over 7% of junior high and high school students in rural Appalachia identified as gender-diverse, including nonbinary or transgender identities. This exceeds previous estimates and highlights the need for support services in these areas.
A nationwide study is investigating the effects of COVID-19 on patients in the US, with a focus on understanding and preventing lingering symptoms. The four-year study, RECOVER Initiative, will enroll up to 20,000 participants and explore factors that put individuals at risk for long-COVID.
The NCI-backed Molecular Targets Platform streamlines and catalyzes drug development by integrating pediatric cancer targets and pathways. This platform empowers researchers, pharmaceutical companies, and advocacy groups to accelerate the pace of drug development for pediatric cancer.
A study found eight classes of health conditions common among pediatric obese patients, including respiratory and sleep disorders. The researchers used a pattern mining algorithm on electronic health records of 49,694 patients to identify clinically similar subtypes.
A new study published in Clinical & Experimental Allergy reveals a 4-fold increase in allergy clinics for children in the UK, but most are small and vary in services offered. The research highlights the need for standardized care through national networks and simulation training to ensure safe service provision.
A Michigan Medicine study found that patients who received preoperative education on opioid risks and nonopioid pain management options consumed significantly less oxycodone, with only 16 doses used despite similar pain scores. The results suggest a multimodal approach to managing pain can reduce harm and prevent substance use disorders.
Research found that breastfed premature infants have improved gut barrier function and nutrient absorption due to the presence of Bifidobacterium breve. This strain strengthens the intestinal wall, protecting against disease. The discovery could lead to promising clinical interventions to increase survival rates of vulnerable preemies.
A new vaccine formulation has protected newborn mice against respiratory syncytial virus (RSV) and evoked strong responses in human immune cells. The vaccine uses an adjuvant combination that stimulates type 1 T-helper responses, which are hard to stimulate in newborns but are needed for a strong defense against viral pathogens.
Researchers found that ancestral SARS-CoV-2 replicates less efficiently in pediatric nasal epithelial cells, with a heightened antiviral response. This protection is not observed with the Omicron variant, highlighting the need for further study on emerging variants.
Researchers at Columbia University Irving Medical Center developed a novel algorithm that identified nearly 20,000 adverse drug events (ADEs) signals across seven pediatric development stages. The study utilizes predictive modeling on real-world data to overcome limited data within individual stages.
Researchers at VCU Massey Cancer Center have discovered a new target for treating high-risk neuroblastoma, a deadly pediatric cancer. A novel compound called SHP099 has shown promising results in shrinking tumors and killing cancer cells.