Articles tagged with Pediatrics
The COVID-19 pandemic has led to an increase in mental health visits in pediatric primary care, with significant rises in eating disorders and mood disorders. The study highlights the importance of screening and managing youth mental health conditions in primary care during periods of social isolation.
The study compares current recommendations for ventilation and chest compression versus ventilation during neonatal resuscitation using an ovine model. The findings suggest that optimizing ventilation could reduce the need for chest compressions and improve gas exchange in neonates, potentially improving overall outcomes.
A new study examines the effect of rapid infusion of sodium bicarbonate on gas exchange and coronary and cerebral perfusion in the immediate post-resuscitation phase. The study found that rapid administration led to a significant rise in myocardial and cerebral perfusion, as well as higher levels of exhaled carbon dioxide.
A new study examines factors associated with COVID-19 vaccine hesitancy and uptake in the autism community, revealing that early skepticism waned over time. The majority of caregivers eventually received the vaccine following FDA approval. Firmly held vaccine-hesitant beliefs influenced a minority of autism spectrum disorder caregivers.
A study found that fetuses with single-ventricle congenital heart disease are more susceptible to social-emotional problems compared to those with two-ventricle congenital heart disease. Infants with impaired prenatal brain growth also experience worsened language, cognitive, and motor outcomes by 18 months.
Researchers investigated the use of intranasal human milk as a stem cell therapy for preterm infants with intraventricular hemorrhage. The study found that preterm infants could tolerate nasal milk therapy without major safety events, paving the way for further research on long-term outcomes.
A randomized controlled trial found that furosemide increases the risk of electrolyte adverse events but no difference in hearing loss or nephrocalcinosis was observed. The study suggests caution when using furosemide in preterm infants at high risk for bronchopulmonary dysplasia.
A randomized clinical trial found that outreach messages were minimally effective at promoting scheduling of adolescent well care visits, but had limited impact on completing visits. Efforts to address widening disparities are needed.
A study examines adolescent perspectives on TikTok's mental health benefits and risks, including how the algorithm enables unique connections with peers around interests and mental health struggles. Participants also discussed excessive use, peer comparison, and challenges in regulating their TikTok use.
Researchers found no evidence that early selective treatment with ibuprofen reduces death or moderate to severe bronchopulmonary dysplasia in extreme preterm infants. However, treatment reduced the risk of an open patent ductus arteriosus and surgical treatment for a symptomatic PDA.
Firearm-related deaths have surpassed car accidents as the leading cause of death among children under 19, with a widening racial gap. Secure gun storage counseling and hospital-based violence intervention programs show promise for prevention and reduction of all three categories of gun violence.
Scientists have developed novel methods to study human brain cell migration during fetal development by tracking genetic mutations in healthy adult individuals. This allows for the first time to reconstruct brain development and provide key findings on cell type origins and hemisphere separation.
A new study from the University of Georgia found that only about one-third of infants enrolled in WIC meet the daily recommendation for vitamin D by 13 months. Experts recommend increased education and supplementation to address this issue, which can lead to diseases like rickets and Type 1 diabetes.
A new Michigan Medicine study found that for children with a pelvic tilt and lower lumbar spine tilt of fewer than 10 degrees, the pelvis did not need to be included when inserting growing rods. This could help avoid painful complications such as skin breakdown and infection.
A study from the University of Pittsburgh found that methionine restriction can slow down the growth of difficult-to-treat brain tumors in children, known as diffuse midline gliomas. The researchers discovered that these tumors are uniquely dependent on methionine, an amino acid, and that depleting it can repress cancer cell growth.
CHOP researchers have developed a targeted treatment that controls blood sugar in patients with hyperinsulinism, a genetic disease. The study found exendin-(9-39) reduces likelihood of fasting hypoglycemia by 76% and protein-induced hypoglycemia by 82%
A recent study found that COVID-19 spreads extensively in households, with approximately 50% of household members infected from the first-infected individual. Children were less likely to spread the virus but equally likely to become infected as adults, highlighting their potential role in transmission.
A new study found that older children (6–12 years, 13–17 years) and those with high inflammation markers were at highest risk of severe MIS-C. Gastrointestinal symptoms and cardiac involvement were common in affected children.
Pediatric cancer patients from lower- and middle-income countries faced a higher risk of all-cause mortality than those in high-income countries during the COVID-19 pandemic. The study found that patients in LMICs had 35.7 times the risk of all-cause mortality compared to those in HICs.
Scientists have constructed a detailed map of lung development after birth, providing insights into the genetic and epigenetic factors that affect lung health. The study used next-generation single-cell sequencing technologies to analyze over 80,000 human and mouse lung cells, revealing clues on how cell types communicate and develop.
The RACE Act has led to an increase in required studies for cancer drugs targeting molecular targets relevant to pediatric cancer. Since its implementation, 42.9% of approved drugs have been required to conduct pediatric studies, up from 8.3% before the act.
The UCF-developed real-time blood monitor uses an optical fiber to assess blood status and can be inserted directly into heart-lung machines or catheters without withdrawing blood from patients. This device has been shown to save doctors critical time during life-or-death operations, particularly in surgeries on infants.
Disparities in social determinants of health affect people with congenital heart disease, leading to unequal access to care. Strategies to address these issues include increasing specialist availability and improving telehealth capabilities.
A virtual cooking/nutrition program, Flint Families Cook, demonstrates success in reaching youth from low-income families and improving cooking self-efficacy and nutrition knowledge. The program encourages families to cook healthy meals together at home, using local ingredients.
Researchers at MUSC have developed a device to remove toxic chemotherapy drugs, such as doxorubicin, from the blood after cancer treatment. The device uses heat and an activated carbon filter to effectively remove the drug, potentially reducing harmful side effects.
A recent analysis found that hospital admissions for children with lupus showed a decrease in severe kidney problems over time. However, racial disparities persist, with Black and Asian children at higher risk of developing new kidney problems.
A new study reveals that firearm retailers and law enforcement agencies in Colorado and Washington support providing temporary, voluntary firearm storage options. The concept aims to increase safety by limiting access to firearms during times of crisis, such as suicidal thoughts or Alzheimer's disease. However, concerns about civil lia...
The BrainChart platform benchmarks brain development based on MRI data from over 100,000 individuals, creating a standardized chart like those for height and weight. The tool identifies previously unreported neurodevelopmental milestones and provides a common language to understand brain images from different sources.
Dr. Philip D. Greenberg has been elected as the American Association for Cancer Research President-Elect for 2022-2023. He will work to harness advances in cancer research and translate them for patient benefit, with a focus on addressing disparities in minority engagement.
A study by TUM confirms that physically fit primary school pupils perform better in terms of concentration and health-related quality of life. The results show a positive correlation between physical fitness, concentration, and overall well-being.
A study found that opioid prescriptions for children undergoing common outpatient surgeries declined by up to 50% between 2014 and 2019. The trend was most pronounced in adolescents, with a decline from 78.2% to 48% of prescriptions filled within 7 days of surgery.
A new study suggests that children under 5 infected with Omicron have a lower risk of severe health outcomes compared to those infected with the Delta variant. The study found that Omicron is 6-8 times more infectious than Delta, but resulted in fewer hospitalizations and mechanical ventilation cases.
A new study found significant improvement in survival rates of extremely pre-term babies born at 22 and 23 weeks. The study, which examined data from 2013-2018, showed a considerable increase in survival rates compared to previous studies, with survival rates reaching 30.0% at 22 weeks and 55.8% at 23 weeks.
Researchers found increased telehealth use was associated with reduced no-show rates and narrowed access disparities in pediatric care. The study also highlighted the growth of telehealth across various pediatric subspecialties before and during the COVID-19 pandemic.
Researchers at CU Anschutz Medical Campus discovered a reactivated protein, Hand2, in certain cases of mesothelioma, which may lead to new treatments. The study aims to investigate the cause and effect of this reactivation.
A new study found that follow-up care after an asthma-related emergency department (ED) visit can help prevent future ED visits for children. Patients who received follow-up care within two weeks of their ED visit were 12% less likely to return to the ED for asthma within 60 days and 13% less likely to revisit for asthma in the next year.
Research at Universidad Complutense de Madrid found that tumour cells from childhood acute lymphoblastic leukaemia (ALL) can hide in the subventricular neurogenic niche, causing relapses and preventing new neurone generation. This discovery may explain cognitive and sensory alterations in ALL survivors.
A large NIH-funded study found significant disparities in acute asthma care utilization among Black, Latino, and white children. Black children accessed community health centers less frequently than white children, while Latino children were more likely to visit CHCs for comprehensive care.
A new study found that integrating behavioral health into pediatric primary care at federally qualified health centers increases access, timeliness of care, and diagnostic rates of ADHD among diverse children. The model resulted in higher follow-up rates with behavioral health clinicians and reduced polypharmacy.
Researchers from Children's Hospital of Philadelphia found that dysfunction in a key brain cell subtype contributes to chronic symptoms in Dravet syndrome. The study suggests that increasing expression of Nav1.1 in parvalbumin interneuron axon may be a viable therapeutic target for patients.
A new study reveals that Latine children who prefer speaking Spanish are more likely to visit a community health center for their acute asthma symptoms than non-Hispanic white peers. Non-Hispanic Black children are also more likely to receive asthma-related care in emergency departments.
Researchers collected hundreds of cerebrospinal fluid samples from patients with Diffuse Midline Glioma, tracking changes in cell-free tumor DNA over time. The findings suggest that this method could provide data about tumors sooner than MRIs alone, allowing clinicians to address aggressive brain cancer more effectively.
Researchers found that sulforaphane inhibits replication of SARS-CoV-2 and HCoV-OC43 coronaviruses in cells and mice, reducing viral burden by up to 50%. Sulforaphane also helps control immune response and protects against lung injury.
The ACMG Foundation presented four Next Generation Fellowship Awards to outstanding individuals in medical genetics and genomics. Ibrahim Elsharkawi and Jessica Priestley received the awards for their dedication to biochemical genetics, with support from Bionano Genomics, Spark Therapeutics, Takeda, Sanofi-Genzyme, and Pfizer.
Researchers identified common features of pediatric antiphospholipid syndrome, a rare autoimmune disease causing inflammation and recurring blood clots. Nearly half of children with APS experienced recurrent blood clots despite treatment, highlighting the need for early diagnosis and prevention.
A new study published in Tobacco Control found that cities banning flavored tobacco sales have reduced youth tobacco use, particularly vaping and cigarette smoking. In contrast to a previous study, the new analysis supports a ban on flavored tobacco products as an effective measure to prevent adolescent tobacco use.
A new study found that nearly one in five children with complex medical conditions require out-of-network care for behavioral health treatment, resulting in higher costs and burdens for families. The study highlights the need for improved provider networks and policy solutions to address this issue.
The proportion of US pediatric clinical trials reporting participant race and ethnicity increased from 2011 to 2020, with significant disparities still present according to this analysis. Despite the improvement, underreporting of racial and ethnic diversity remained a concern in published pediatric clinical trials.
The Philadelphia Regional Center for Children's Environmental Health aims to identify and protect vulnerable communities from environmental exposures. The center will focus on four primary research areas: asthma prevention, lead exposure, air pollution, and endocrine disrupting chemicals.
Research led by Adam Green, MD, shows that the youngest patients with brain tumors (ages 0-3 months) have about half the five-year survival rate as children ages 1-19. The study analyzed population-based data for almost 14,500 children and found significantly poorer outcomes among the youngest patients.
A study of over 3,000 mother-child pairs from six European countries found an association between prenatal bisphenol A exposure and increased risk of asthma and wheezing in school-age girls. The study revealed a high prevalence of BPA in maternal urine during pregnancy.
Researchers found that genetic ancestry is associated with differences in biology of acute lymphoblastic leukemia (ALL) and is an independent factor contributing to treatment outcomes. Children from East Asian and South Asian backgrounds had better survival rates than Caucasian children, with Indian children having the best outcomes.
A UC San Diego study found that excessive neuropeptide secretion by neuroendocrine cells in the lungs can lead to fluid buildup and poor oxygenation in both infant lung disease and COVID-19. Blocking these neuropeptides may be an effective treatment for conditions marked by excess lung fluid.
A new manifestation of COVID-19 has been identified in young children, characterized by croup, a common respiratory illness marked by a distinctive barking cough. The omicron strain's preference for the upper airway may account for the sudden appearance of croup during the surge.
A Johns Hopkins study shows that a higher dose of the antibiotic rifampin may be more effective in treating TB meningitis, potentially leading to improved patient outcomes. The research suggests that high doses of rifampin can kill bacteria faster while minimizing brain inflammation.
A study found that an eight-week mindfulness-based program during pregnancy reduced the risk of health problems in offspring, as measured by autonomic nervous system responses. Infants whose mothers underwent the program had a faster cardiovascular recovery from stressful interactions and more self-soothing behavior.
A CHOP-led study found bortezomib significantly improved overall survival in children and young adults with newly diagnosed T-cell lymphoblastic lymphoma. The trial also showed that intensifying the chemotherapy regimen allowed for elimination of radiation in nearly all patients, resulting in excellent outcomes.
A new peer-reviewed study confirms MiSight 1 day contact lenses slow eye growth and halt myopia progression in 90% of children, with no loss of effectiveness over time. The longest-running soft contact lens study among children demonstrates sustained efficacy for nearly all children, regardless of age or initial refractive error.
A multicenter study found relatively high interobserver agreement for chronic pancreatitis findings in children using both CT and MRI. However, subjective findings like atrophy showed moderate agreement, emphasizing the need for standardized criteria.
A new study from Cincinnati Children's Hospital Medical Center found that medical-legal partnerships, which connect pediatric patients with advocates from Legal Aid Society, significantly reduce hospital admissions for children. The program, launched in 2008, has resulted in a 38% reduction in hospitalizations among referred cases.