A comprehensive review of literature reveals a strong relationship between higher testosterone levels and reduced cardiovascular disease and risk factors. Despite four flawed studies sparking concerns, dozens of studies demonstrate benefits of testosterone therapy in reducing mortality, improving cardiovascular health, and alleviating ...
SourceBeth Israel Deaconess Medical Center·JournalMayo Clinic Proceedings·DateJan 27, 2015
A new study found that high-dose testosterone therapy can suppress advanced prostate cancers and reverse resistance to testosterone-blocking drugs. Seven of the 14 men showed a significant decrease in PSA levels, while four stayed on testosterone therapy for up to 24 months with continued low PSA levels.
SourceJohns Hopkins Medicine·JournalScience Translational Medicine·DateJan 7, 2015
A new University of Michigan study found that expectant fathers experience significant hormonal changes, including declines in testosterone and estradiol, even before their babies are born. These changes may be linked to psychological and physical transformations as men prepare to become fathers.
SourceUniversity of Michigan·JournalAmerican Journal of Human Biology·DateDec 18, 2014
Expectant dads experience prenatal hormone changes, with men showing significant declines in testosterone and estradiol levels. The study suggests that impending fatherhood may trigger hormonal shifts in partners, which could impact postpartum behavior and adjustment.
SourceWiley·JournalAmerican Journal of Human Biology·DateDec 15, 2014
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Researchers at the University of Missouri found evidence suggesting testosterone contributes to colon cancer tumor growth. Higher levels of testosterone in post-menopausal women may be associated with increased colon cancer risk.
SourceUniversity of Missouri-Columbia·JournalProceedings of the National Academy of Sciences·DateDec 10, 2014
A new study published in The Journal of Urology analyzed data from three independent registries and found no increase in prostate cancer incidence among men treated with long-term testosterone therapy. The study followed over 1,000 men for up to 17 years, with a median follow-up of approximately 5 years.
SourceElsevier Health Sciences·JournalThe Journal of Urology·DateNov 25, 2014
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism suggests that testosterone has a limited impact on menopausal women's interest in sex and sexual function. Psychosocial factors such as emotional well-being and intimate relationships are found to be stronger contributors to sexual health.
SourceThe Endocrine Society·JournalThe Journal of Clinical Endocrinology & Metabolism·DateNov 20, 2014
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A new study of 5,695 men with low testosterone levels found that testosterone supplementation reduces the risk of major adverse cardiac events such as heart attacks and strokes. Men who received testosterone supplementation had lower rates of death and heart attacks compared to those with persistently low testosterone levels.
A long-term study of wild brown mouse lemurs found they can live at least eight years, twice as long as previously estimated, with no physical signs of aging. The research also revealed no difference in testosterone levels between male and female mouse lemurs, challenging previous assumptions about the role of testosterone in aging.
SourceEmory Health Sciences·JournalPLOS ONE·DateOct 29, 2014
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that diabetic men with low testosterone levels are more likely to develop severe atherosclerotic plaques and other cardiovascular markers. The research suggests a strong association between low testosterone concentration and the severi...
SourceThe Endocrine Society·JournalThe Journal of Clinical Endocrinology & Metabolism·DateOct 16, 2014
A joint FDA advisory panel recommended changes to testosterone product labels and required drug makers to conduct tests on cardiovascular risk related to testosterone therapy. The panel's focus was on male age-related hypogonadism, which affects approximately 20-30% of men ages 40-79 years old.
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A new study published in Endocrinology found that testosterone treatment increased the incidence of prostate carcinomas in rats. The research suggests that testosterone alone is a weak carcinogen in male rats and creates a hospitable environment for tumors to develop when combined with cancer-causing chemicals.
SourceThe Endocrine Society·JournalEndocrinology·DateOct 7, 2014
The Endocrine Society advises against testosterone therapy in healthy women, citing unknown long-term risks and limited benefits. Testosterone therapy may improve sexual function in women with Hypoactive Sexual Desire Disorder, but more research is needed to determine its safety and effectiveness.
SourceThe Endocrine Society·JournalThe Journal of Clinical Endocrinology & Metabolism·DateOct 3, 2014
Researchers found no universal preference for high testosterone faces and nuanced effects of culture on mate choice. Across 12 populations, women preferred slightly less masculine faces, suggesting factors beyond infectious disease rates influence attractiveness.
SourceUniversity of Oregon·JournalProceedings of the National Academy of Sciences·DateSep 23, 2014
A shorter course of androgen deprivation therapy (ADT) has been found to improve the quality of life for high-risk prostate cancer patients, with faster recovery times and better outcomes compared to a longer 36-month ADT regimen. The study analyzed data from 561 patients who received radiation therapy and long-term ADT.
SourceAmerican Society for Radiation Oncology·DateSep 14, 2014
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Researchers found significantly decreased estrogen receptor beta expression in autistic male brains, which may explain the disorder's higher prevalence in boys. Estrogen receptor agonists could potentially reverse autism's behavioral deficits, such as reclusiveness and repetitive behavior.
SourceMedical College of Georgia at Augusta University·JournalMolecular Psychiatry·DateSep 9, 2014
A recent study found that males with more masculine faces tend to have lower semen quality due to increased testosterone levels impairing sperm production. Males often overestimate the attractiveness of other men to females.
SourceWiley·JournalJournal of Evolutionary Biology·DateSep 2, 2014
A new study found lower testosterone levels in men with sudden cardiac arrest and higher estradiol levels in both men and women were associated with increased risk. The research suggests that hormone levels may play a role in predicting patients' likelihood of suffering from the usually fatal condition.
SourceCedars-Sinai Medical Center·JournalHeart Rhythm·DateSep 2, 2014
A study published in Scientific Reports found that methadone treatment significantly suppresses testosterone levels in men with opioid addiction, leading to poor quality of life and erectile dysfunction. In contrast, women using methadone for addiction treatment showed no significant change in testosterone levels.
SourceMcMaster University·JournalScientific Reports·DateAug 26, 2014
A new study found an inverse relationship between phthalate exposure and testosterone levels in various populations, including boys ages 6-12 and men and women ages 40-60. Increased phthalate concentrations were associated with a decline in testosterone levels, potentially impacting reproductive development and sexual function.
SourceThe Endocrine Society·JournalThe Journal of Clinical Endocrinology & Metabolism·DateAug 14, 2014
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A new study published in Biological Psychiatry found that testosterone increases the brain's reactivity to threat cues in healthy men. The study used a novel two-step pharmacological challenge paradigm and found that testosterone increased activity in brain structures involved in threat processing and aggressive behavior.
SourceElsevier·JournalBiological Psychiatry·DateAug 11, 2014
A new study finds that human skulls changed in ways indicating a lowering of testosterone levels during the time culture was blossoming. The research team argues that human society advanced when people started being nicer to each other, leading to more cultural exchange and cooperation.
SourceDuke University·JournalCurrent Anthropology·DateAug 1, 2014
A study found that more left-handed men are born during November, December, and January, with 10.5% of left-handed men born during this period. The researchers suggest a hormonal cause, possibly related to the relative darkness during these months, which delays the maturation of the left brain hemisphere during embryonic development.
SourceUniversity of Vienna·JournalCortex·DateJul 3, 2014
A new US-based study of over 25,000 older men shows that testosterone therapy is not associated with an increased risk of heart attack. In fact, men with cardiovascular problems who used testosterone had a lower rate of heart attacks compared to those who did not.
SourceUniversity of Texas Medical Branch at Galveston·JournalAnnals of Pharmacotherapy·DateJul 2, 2014
A new study found that testosterone replacement therapy can improve aerobic capacity and lessen its decline with age in older men with limited mobility. The therapy showed a significant reduction in the rate of decline of an important marker of physical fitness in these men.
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A new study found that soy protein supplements containing phytoestrogens do not reduce testosterone levels in men with Type 2 diabetes. Instead, they improve diabetes control and cardiovascular risk factors. The supplements also show promise in reducing the risk of heart disease.
A study published by the Endocrine Society found that low testosterone levels are linked to a higher risk of declining physical function in older men. The researchers also discovered that muscle weakness, possibly caused by decreased testosterone levels, may explain most of this relationship.
A recent study published in Menopause found that low doses of testosterone cream for women after menopause can bring their testosterone levels back to normal. The study tested two doses of the AndroFeme product, with the 5-mg dose being sufficient to restore premenopausal levels.
SourceThe Menopause Society·JournalMenopause·DateJun 10, 2014
Research in mice reveals that a previously developed testosterone-based male contraceptive method cannot stop sperm production. Increasing doses of testosterone allowed sexual function to return, but also initiated sperm production, making it impossible to achieve sustained cessation.
SourceFederation of American Societies for Experimental Biology·JournalThe FASEB Journal·DateJun 2, 2014
Men with low-risk prostate cancer who have low testosterone levels may be at increased risk of developing more aggressive disease. Low levels of free testosterone were significantly linked to an increased risk, suggesting a contradictory role for testosterone in prostate cancer progression.
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The prescription of testosterone in older men is associated with unclear cardiovascular risk. Despite the benefits in younger men, ongoing studies are unlikely to provide reliable safety data due to limited sample sizes and power.
SourceThe Lancet·JournalThe Lancet Diabetes & Endocrinology·DateApr 27, 2014
A study by Spanish researchers suggests that women's intuition is related to lower prenatal exposure to testosterone, leading to a more intuitive and less reflective mindset. This effect is stronger among women, who tend to give more intuitive answers in cognitive tests.
SourceUniversity of Granada·JournalPsychoneuroendocrinology·DateApr 23, 2014
A new study suggests that low testosterone exposure in the womb may influence male susceptibility to serious health conditions like obesity and heart disease. Researchers found that reduced testosterone levels in fetal testes can impair Leydig cell function, leading to lifelong health consequences.
SourceUniversity of Edinburgh·JournalProceedings of the National Academy of Sciences·DateApr 22, 2014
A multi-site study will test strategies to improve bone and muscle strength after spinal cord injury, with the goal of minimizing secondary complications. The study aims to develop safe and effective interventions to address rapid wasting of muscles and bones in individuals with SCI.
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A recent study by a University of Chicago professor found that night owls, both males and females, are more likely to be single or in short-term romantic relationships than early risers. Night owls also reported higher numbers of sexual partners compared to early birds.
SourceUniversity of Chicago·JournalEvolutionary Psychology·DateApr 1, 2014
A study published in Psychological Science found that children who participated in the Fast Track program showed reduced aggression later in life. The researchers believe that the program's success may be linked to changes in testosterone reactivity to social threats.
SourceAssociation for Psychological Science·JournalPsychological Science·DateApr 1, 2014
Researchers from the University of Edinburgh found that newborn male deer with high testosterone levels are less likely to survive their first year compared to peers. The study also showed that testosterone levels in offspring are linked to their mother's condition, suggesting a potential survival advantage for younger calves.
SourceUniversity of Edinburgh·JournalFunctional Ecology·DateMar 27, 2014
A new study suggests that male hormones, such as testosterone, play an important role in female fertility and may enhance IVF success rates. The research found that male hormones promote follicle development by preventing cell death and increasing sensitivity to follicle-stimulating hormone.
SourceUniversity of Rochester Medical Center·JournalProceedings of the National Academy of Sciences·DateMar 4, 2014
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A recent study reviews existing research on sports competition and concludes that playing at home can have a significant psychological impact on athletes, with findings including increased testosterone levels and higher cortisol stress hormone levels. However, the exact mechanisms behind this phenomenon are still unclear.
SourceAssociation for Psychological Science·JournalCurrent Directions in Psychological Science·DateFeb 4, 2014
A study found that adding testosterone to hormone therapy did not significantly improve quality of life, self-esteem, or mood in women with primary ovarian insufficiency. Normalizing testosterone levels may not address underlying factors contributing to mood problems.
SourceThe Menopause Society·JournalMenopause·DateJan 29, 2014
A large health care database study has found a twofold increase in the risk of heart attacks among men under 65 using testosterone therapy. The research also confirmed earlier findings that men over 65 experience a similar increased risk.
SourceUniversity of California - Los Angeles·JournalPLOS ONE·DateJan 29, 2014
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A study found that testosterone use has increased sharply among older men in the US and UK, with many having normal testosterone levels and non-specific symptoms. The Endocrine Society's guidelines recommend a clinical diagnosis of low testosterone only for men with consistent symptoms and unequivocally low hormone levels.
SourceThe Endocrine Society·JournalThe Journal of Clinical Endocrinology & Metabolism·DateJan 9, 2014
Researchers at Johns Hopkins University found that testosterone enhances male canary's motivation to sing but not the quality of their songs. The hormone affects different brain areas, increasing song frequency but not altering its attractiveness to females.
SourceJohns Hopkins University·JournalProceedings of the National Academy of Sciences·DateDec 30, 2013
A Stanford University School of Medicine study found that men with high testosterone levels have a weakened immune response to the flu vaccine, whereas women and men with lower testosterone levels have a stronger response. The study also discovered that testosterone interacts with genes in a way that dampens immune response.
SourceStanford Medicine·JournalProceedings of the National Academy of Sciences·DateDec 23, 2013
A new study suggests that testosterone levels may affect the body's response to vaccines, with men often experiencing weaker antibody responses than women. Researchers found that men with high levels of testosterone had suppressed immune responses, which could be linked to their sex-specific differences in infections and vaccinations.
SourceNIH/National Institute of Allergy and Infectious Diseases·JournalProceedings of the National Academy of Sciences·DateDec 23, 2013
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Two new studies published in Menopause journal show that low-dose flibanserin improves sexual function in postmenopausal women, while high-dose testosterone also yields benefits, but with cautionary notes on cardiovascular risks.
SourceThe Menopause Society·JournalMenopause·DateDec 4, 2013
Researchers found that higher doses of testosterone improved sexual function, muscle mass, and physical performance in postmenopausal women who had undergone hysterectomy. However, side effects such as unwanted hair growth and acne were rare in the study.
SourceBrigham and Women's Hospital·JournalMenopause·DateNov 27, 2013
A study published by The Endocrine Society found that older men with optimal testosterone levels lived longer, while those with high or low levels had a higher mortality risk. Higher DHT levels were also associated with reduced ischemic heart disease mortality.
SourceThe Endocrine Society·JournalThe Journal of Clinical Endocrinology & Metabolism·DateNov 20, 2013
A recent study found that men using testosterone therapy have a 29% higher risk of death, heart attack, and stroke compared to those not using the treatment. The study, which analyzed data from over 8,000 patients, highlights the need for caution when prescribing testosterone therapy.
SourceUniversity of Pennsylvania School of Medicine·JournalJAMA·DateNov 5, 2013
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A study found that testosterone therapy was associated with a higher risk of adverse outcomes, including death, heart attack, or ischemic stroke, in men who underwent coronary angiography. The use of testosterone therapy was also linked to an increased risk of these events even among patients without underlying coronary artery disease.
A recent study published in The Endocrine Society's journal refutes the long-held belief that a protein is necessary for producing steroid hormones like testosterone. Researchers found that male mice with a specific protein deficiency produced normal levels of testosterone, challenging the existing scientific understanding.
SourceThe Endocrine Society·JournalEndocrinology·DateOct 30, 2013
An observational study found that testosterone treatment reduced total cholesterol, LDL, triglycerides, and increased HDL in hypogonadal men. Testosterone therapy also lowered systolic and diastolic blood pressure, suggesting a reduction in hypertension.
SourceBoston University School of Medicine·JournalInternational Journal of Clinical Practice·DateOct 23, 2013
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Research suggests that testosterone promotes generosity and reciprocity when there is no threat of competition, helping to maintain social relationships. In the absence of competition, participants with increased testosterone levels chose to give more money back to investors than those with placebo treatment.
SourceAssociation for Psychological Science·JournalPsychological Science·DateSep 30, 2013
A recent study found a modest connection between low testosterone and an increased risk of developing or dying from heart disease. However, treating low testosterone with hormone replacement therapy did not have any beneficial effect on cardiovascular health.
SourceThe Endocrine Society·JournalThe Journal of Clinical Endocrinology & Metabolism·DateSep 24, 2013
A study by Massachusetts General Hospital researchers finds that insufficient estrogen is partly responsible for some age-related symptoms in men. Testosterone levels regulate lean body mass, muscle size and strength, while estrogen regulates fat accumulation.
SourceMassachusetts General Hospital·JournalNew England Journal of Medicine·DateSep 11, 2013
A new study by Emory University researchers found that men with smaller testes tend to be more involved in hands-on childcare, while those with larger testes are less involved. The study suggests that the biology of human males reflects a trade-off between investments in mating and parenting effort.
SourceEmory Health Sciences·JournalProceedings of the National Academy of Sciences·DateSep 9, 2013
UCSB researchers found that tree chopping increases testosterone levels more than soccer, improving muscle energy and performance. The study suggests that Tsimane men maintain high testosterone levels due to their physically demanding lifestyle, contrary to industrialized populations.
SourceUniversity of California - Santa Barbara·JournalEvolution and Human Behavior·DateAug 13, 2013
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A study published in Clinical Science found that a meal plan prioritizing breakfast intake can reduce insulin resistance, lower testosterone levels, and increase ovulation frequency in women with PCOS. This natural therapy may provide new hope for those struggling with fertility issues associated with the disorder.
SourceAmerican Friends of Tel Aviv University·JournalClinical Science·DateAug 13, 2013
Researchers found that keeping a secret can change the way people interact with others, leading to more deceptive behavior among friends and superficial positivity towards acquaintances. Additionally, high neuroticism and low conscientiousness are consistently associated with increased risk of obesity across various samples. Confrontin...
SourceSociety for Personality and Social Psychology·DateJul 31, 2013
A new study by Rush University Medical Center researchers found that a sudden decrease in testosterone levels may cause Parkinson's-like symptoms in male mice. Testosterone supplementation reversed the pathology in the mice. The study suggests that preserving testosterone levels may be important to prevent Parkinson's disease.
SourceRush University Medical Center·JournalJournal of Biological Chemistry·DateJul 26, 2013
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