Articles tagged with Metabolism
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Plant microbiomes have the potential to make agriculture more sustainable, but understanding their complex interactions is crucial. Researchers have developed models that use metabolic capabilities of bacteria to predict how these microbial communities compete or cooperate.
Research shows that wild birds in vineyards are highly susceptible to triazole fungicide contamination, disrupting hormones and metabolism, impacting reproduction and survival. Vineyards use significantly more fungicides than other crops, posing a unique threat to bird populations.
A new study from Aarhus University reveals that female athletes who consume too little energy through their diet in comparison to their training volume experience negatively impacted muscles' ability to respond to training. The study shows that insufficient energy intake can lead to changes in the hormonal system, including a decrease ...
A 12-year study by Pennington Biomedical researchers found that metabolic surgery provides better results, less regression, compared to medical or lifestyle intervention for patients with class 1 obesity. The study showed significant improvements in glycemic control and weight loss, with high rates of diabetes remission.
A new study by University of California, Berkeley biologist Robert Dudley found that hummingbirds happily sip from sugar water with up to 1% alcohol by volume, without being repelled by it. The research suggests that birds are likely consuming ethanol produced by natural fermentation in flowers and nectar-filled feeders.
Scientists at the University of Copenhagen discovered a new type of fat cell called SWAT cells that provide structural integrity to adipose tissue. These flexible cells can differentiate into various types, including fat cells and progenitor cells, suggesting a crucial role in adapting to metabolic conditions.
Researchers have discovered a new record of protosteroids in Earth's Middle Ages, extending the current molecular record of eukaryotes to 1600 million years ago. This finding provides a rare glimpse into the conditions surrounding the evolution of complex life and may shed light on the competitive demise of ancient eukaryote groups.
The study used transcranial photobiomodulation (tPBM) to stimulate the prefrontal cortex, a region involved in cognitive function. The results showed that tPBM modulated hemodynamic and metabolic activities in a wavelength- and site-specific manner.
Defective myelin promotes disease-related changes in Alzheimer's by accelerating amyloid plaque deposition and overwhelming immune cells. Slowing down age-related myelin damage could lead to new therapies and prevent or slow down the disease.
A recent study has found that microbes play a crucial role in storing carbon in the soil, with a four-fold greater importance than other processes. This breakthrough could lead to improved soil health and increased food security through targeted farm management practices.
Researchers at Duke University have identified a climate feedback loop that could accelerate climate change. Monitoring mixotrophs, tiny organisms with dual metabolism modes, may allow us to anticipate the tipping point before it gets there. However, nutrient pollution poses a challenge to detecting early warning signals.
Researchers found that centenarians have a diverse gut virome with high microbial diversity associated with a healthy gut microbiome. The study suggests that intestinal bacteria and bacterial viruses may work together to promote healthy lifespan.
Researchers at UBC Okanagan found that a low-carb breakfast can significantly reduce blood sugar swings and improve glucose control. Participants who followed a low-carb breakfast plan showed lower glycemic variability and some were able to reduce their glucose-lowering medication.
CNIO researchers review the anticancer effects of various diets, including caloric restriction, ketogenic diet, and intermittent fasting. They argue that precision nutrition can be used to treat specific cancers based on tumor metabolism and patient characteristics.
Scientists have rebuilt the complex nanomachine in the laboratory that starts autophagy, revealing its sophisticated cellular mechanism. The study's findings could help develop future drugs to treat diseases based on a faulty autophagy process.
A study by CNIC researchers reveals that gamma-linolenic acid in breast milk binds to the retinoid X receptor protein, activating gene expression and influencing biological functions. This activation initiates genetic programs that equip mitochondria with the necessary enzymes and proteins to start consuming lipids as energy.
A new study suggests that high-sugar diets can exacerbate inflammatory bowel disease (IBD) symptoms by disrupting the colon's lining renewal process. The research found that a high-sugar diet led to impaired cell division and altered metabolic pathways in mice, resulting in faster gut damage.
A new study suggests that cold exposure in the morning may be more effective at boosting metabolism and burning fat than in the evening, especially in men. In women, however, there was no significant difference in response to cold exposure times, but they were more tolerant of cold in the morning.
Research reveals that certain bacteria can replace essential lanthanides with actinides to sustain their metabolism. The findings suggest a possible role for these bacteria in decontaminating areas contaminated with radioactive elements or separating lanthanides and actinides for analytical purposes.
A new paper by Robert K. Naviaux outlines the array of processes that drive healing and whose dysfunction underlies chronic illnesses like diabetes and autism. The cell danger response is triggered by exposure to threats, but persists even after the threat is gone, causing inflammation and cell dysfunction.
Researchers in China have created a simple nomogram using easily accessible and automatable detected routine clinical indicators to reduce missed diagnosis and misdiagnosis of Wilson's disease. The study identified six independent predictors of the disease, including serum copper and direct bilirubin.
Sons of women with PCOS are two times more likely to develop obesity and have high levels of male hormones, leading to insulin resistance and type 2 diabetes. A mouse study confirms these findings, showing fat tissue and metabolism problems in the offspring despite a healthy diet.
Professor Bess Dawson-Hughes has been recognized with the 2023 IOF President’s Award for her significant contributions to advancing osteoporosis research and treatment. Her extensive body of work has led to a greater understanding of nutrition's role in age-related bone loss.
Researchers develop a technique to visualize carnitine distribution in muscle fiber cells, finding higher concentrations in slow-type fibers. The study reveals rapid transport of carnitine into muscle cells during contraction, shedding light on metabolic processes and potential therapeutic applications.
Researchers have engineered yeast Ogataea polymorpha to produce fatty alcohols from sole methanol by coupling peroxisomal metabolism. This approach improves cellular fitness and enables high-level production of up to 3.6 g/L. The study provides a feasible engineering strategy for sustainable production of fatty alcohols.
Researchers at Anglia Ruskin University found that a portable breath test can detect changes in metabolism in response to diet. The study used the Lumen device to monitor metabolic fuel use at home and showed that it could detect acute changes in carbohydrate use, but was not sensitive on a day-to-day basis.
Research finds diclofenac's high variability in metabolism due to UGT2B17, a little-studied enzyme. The study suggests genetic testing and dose adjustments for specific populations can help minimize side effects.
A study from MedUni Vienna found that macrophages in the duodenum control iron absorption by degrading transferrin. This discovery may lead to new treatment options for inflammatory bowel diseases and intestinal infections.
The AChemS meeting brings together scientists to understand the fundamental mechanisms of chemosensory systems and their impact on behavior. Key findings include presentations on learning and memory in the chemical senses and physiology of extraoral taste receptors.
Edward Chouchani, an associate professor at Harvard Medical School, has been awarded the $50,000 Vilcek Prize for Creative Promise in Biomedical Science. His research focuses on understanding metabolic disease using mass spectrometry and biochemical approaches.
Scientists at UMass Amherst found that migrating birds burn high amounts of protein early in their flights, which then taper off as the duration increases. This discovery challenges previous assumptions about bird migration and fuels further research into the evolution of metabolism.
Researchers at the University of Gothenburg discovered that insulin can be stored at room temperature for four weeks, quadrupling its previous storage period. This finding has significant implications for global health, particularly in developing countries where insulin is often in short supply and expensive.
Researchers found that endotherms have well-developed turbinates and larger nasal cavities than ectotherms, helping to cool their brains. This discovery sheds light on the evolution of nasal cooling in warm-blooded animals from their theropod dinosaur ancestors.
Researchers have developed a glycine-based tripeptide that successfully treats nonalcoholic fatty liver disease in non-human primates and mice. The compound, DT-109, reverses fat buildup and prevents scarring by stimulating fatty acid degradation and antioxidant formation.
A study from Indiana University School of Medicine found that people with NAFLD have significantly decreased levels of the liver enzyme CYP2C19, which is important for medication processing. This decrease may lead to slower clearance of certain medications and reduced effectiveness of medicines like antidepressants and clopidogrel.
A new platform has been established to improve the analysis of dynamic metabolic features in cells. The Raman-based flow cytometry tool allows for the profiling of cell populations without labeling or destroying them, providing a non-invasive big-data type for culture-independent phenomes.
Researchers at UMass Amherst have discovered that beneficial microbes in infant gut use nitrogen from human milk to support pediatric nutrition and development. The study provides new insights into the molecular underpinnings of these processes, which could lead to improved infant health around the world.
Researchers found that dieting amplifies neural signals of hunger in the brain, leading to increased food intake and weight gain. This long-term change could be a key target for developing therapies to prevent the yo-yo effect.
Researchers found that eating small amounts of high-fat and sugar foods regularly rewires the brain to prefer these types of foods. The brain's dopaminergic system is activated, leading to a subconscious preference for rewarding food.
A study by Max-Planck-Gesellschaft researchers found that consuming small amounts of high-fat and high-sugar foods regularly rewires the brain, leading to a preference for these types of food.
A new study finds that ocean warming can impact the growth, metabolic rate, and gene activity of newly hatched clownfish larvae. The researchers found that warmer temperatures led to faster growth rates, higher metabolic rates, and changes in gene expression.
Researchers found that hummingbirds can enter into deep or shallow torpor, and their ability to do so is tied to their evolutionary conquest of mountain habitats. Torpor duration varies depending on ambient temperature and physical condition.
Researchers at NTU Singapore have found a way to spur brain immune cells to clear toxic waste linked to Alzheimer’s disease by targeting their metabolism. The study reveals a ‘metabolic switch’ in the brain’s immune cells that can be manipulated to improve their function.
A phase two trial found that exenatide significantly reduced brain pressure and monthly headaches in seven patients with Idiopathic Intercranial Hypertension (IIH). The study showed a rapid action of the drug, with results indicating significant reductions in brain pressure and headache days compared to the placebo arm.
A Keck School of Medicine study found exposure to PFAS, known as 'forever chemicals,' disrupts key biological processes in children and young adults, increasing risk of diseases such as developmental disorders, cardiovascular disease, and cancer. The study highlights the importance of regulating PFAS as a class of chemicals.
Scientists at Ben-Gurion University have discovered a groundbreaking treatment approach targeting the mitochondrial gatekeeper VDAC1 for Alzheimer's disease. The new therapy, VBIT-4, demonstrates significant improvement in mouse models, preventing cell death and neuroinflammation while promoting healthy neuron growth.
A new study from Karolinska Institutet found that exercising in the early active phase increased gene expression involved in fat breakdown and thermogenesis, leading to a higher metabolic rate. This effect was independent of food intake and may prove beneficial for people who are overweight.
Researchers studied cavefish metabolism to understand how humans might adapt over long periods of inactivity, finding genetic changes that enable muscle endurance and efficient energy storage. The study suggests potential implications for understanding and mitigating the negative effects of sedentary lifestyles on human health.
A new study conducted at the University of Turku found that maternal gestational diabetes mellitus may have unfavourable effects on the neurodevelopment of 2-year-old children. A healthy diet during pregnancy supports child's neurodevelopment, while higher maternal body fat percentage is associated with weaker cognitive and motor skills.
Researchers found that blocking mitochondria fusion or fission triggers an inflammatory process, leading to muscular atrophy. This 'sterile inflammation' is not linked to infectious processes and has physiological relevance in mice with mitochondrial fragmentation.
A searchable library of 1,600 chemically-diverse plant extracts has been established, providing valuable insights into plant metabolites' roles in drug development. The library shares both data and methods, making it an exceptional resource for advancing chemodiversity digitization.
Researchers at Salk Institute discover thousands of previously unknown microproteins in brown and white fat tissue, finding that one, Gm8773, increases feeding activity in mice. This discovery could lead to the development of a therapeutic to promote weight gain in certain disease situations.
Researchers genetically engineered mitochondria to convert light energy into chemical energy, increasing ATP production and lifespan by 30-40%. The study provides new insights into mitochondrial function and offers a platform for studying age-related diseases.
Researchers have identified a rare gene mutation that causes severe childhood obesity, leading to a constant feeling of hunger and decreased sensation of satiety. The discovery provides a new understanding of the genetic mechanisms underlying monogenic human obesity.
A recent study by Universitat Oberta de Catalunya reveals that Spanish citizens have lower vitamin D levels compared to Northern European nations. Despite the importance of this hormone for overall health, supplementation is not commonly practiced in Spain.
Researchers at Karolinska Institutet discovered that SARS-CoV-2 infection triggers blood vessel formation in fat tissues, leading to thermogenic metabolism and significant weight loss. Blocking this process with an antiangiogenic drug restored weight loss in mice and hamsters infected with the virus.
Insulin pump use has grown over two decades but disparities persist among racial, ethnic, and socioeconomic groups. Youth from lower-income backgrounds and minority groups are less likely to use insulin pumps.
Researchers identified a genetic variant linked to digestive disturbances in patients with Chagas megaesophagus, a disorder characterized by esophageal dilation and loss of motility. The study suggests that increased interferon-gamma production leads to mitochondrial dysfunction, contributing to the development of the disease.
Researchers at Aarhus University found a link between lipid kinase VPS34 and viral protection in the kidneys. The study used multiomics analysis to show that blocking lipid kinase could reduce viral entry and increase nutrient retention, offering potential new treatments for kidney diseases and infections.
Researchers from the Salk Institute have found that deteriorating neurons from people with Alzheimer's disease undergo a late-life stress process called senescence, leading to brain inflammation and neurodegeneration. By targeting these senescent cells with therapeutics, scientists hope to prevent or treat Alzheimer's disease.