Articles tagged with Metabolites
Researchers used SERS spectroscopy to explore metabolites secreted by cancer cells, discovering a unique paracrine crosstalk that reprograms the tumor environment. This study demonstrates the potential of SERS technology for cancer metabolism research and may lead to new therapeutic strategies.
A study published in Environmental Health Perspectives found that exposure to phthalates can lower the odds of getting pregnant, but not lead to pregnancy loss. The researchers also discovered associations between preconception phthalate exposure and changes in women's reproductive hormones, inflammation, and oxidative stress.
A new study suggests that breastfeeding, even partially alongside formula feeding, positively influences brain development in infants. The research found significant differences in metabolite levels between breastfed and formula-fed infants, with those fed breast milk having better cognitive test scores at age 2.
Scientists in Brazil have developed a method to obtain a substance similar to estrogen from soy isoflavones, which may help alleviate menopause symptoms. The researchers extracted equol from soybean oil production residue and found it to be more bioavailable than glycosylated forms.
A new study identified 60 alcohol-associated circulating metabolites that appear to produce counteractive effects on the risk of heart disease. The findings suggest that moderate alcohol consumption may trigger changes in metabolomic profiles, yielding both beneficial and harmful outcomes.
Researchers at UChicago find that trans-vaccenic acid (TVA), a fatty acid in meat and dairy, enhances CD8+ T cell immunity against tumors. TVA also improves response to immunotherapy treatments for patients with higher levels of the nutrient in their blood.
A new USC study identifies two metabolites that may predict which young Latino people are most likely to develop prediabetes. The research found that allylphenol sulfate and caprylic acid were the most predictive of prediabetes when combined with other risk factors.
A Finnish study found that maternal microbiota affects foetal development by altering gene activity in the intestine, brain, and placenta. The researchers identified previously unknown compounds in the fetus that are likely to be microbial, shedding light on the significance of the microbiota in individual development and pregnancy.
University of Alberta researchers have identified taurine as a key player in predicting poor clinical outcomes and treating long COVID. A predictive test and proposed supplement trial aim to minimize symptoms and improve patient outcomes.
Researchers measured metabolite concentrations of two herbicides in urine samples from Ecuadorian adolescents and found negative associations with attention, memory, and language. Glyphosate was also linked to social perception issues.
A recent study by the University of Vienna and collaborators suggests that microbial metabolites may play a role in inducing Parkinson's-like symptoms. The researchers identified a specific bacterial metabolite that selectively damages dopamine-producing neurons, mirroring the neuronal loss observed in Parkinson's disease.
Scientists have identified a bacterial strain that can break down the toxic tomatine in tomato roots, providing new understanding of how soil microbes interact with plants. This discovery could lead to the development of new bioactive compounds for human applications.
A NUS study found that Blastocystis ST7 produces indole-3-acetyldehyde, which binds to immune cells, reducing gut tolerance and causing inflammation. Probiotic bacteria like lactobacillus may help negate its effects.
A new approach allows researchers to create maps of coral biochemistry, detailing the distribution of compounds integral to reef health. This innovation provides unprecedented insight into coral resilience and potential stressors like warmer ocean temperatures and acidification.
A study published in The Journal of Physiology found that exercise suppresses hunger by acting on hormones and metabolites. Researchers suggest that understanding these mechanisms could lead to new treatments for obesity.
A new electroenzymatic assembly transduction strategy-based biosensor has been developed for simultaneous detection of glucose, lactate, and cholesterol in clinical samples. The sensor exhibits high sensitivity and efficiency, with a detection time of under 30 seconds, and good agreement with laboratory results.
Scientists have developed a new finger sweat test to detect antipsychotic drugs in patients, providing a quicker and more comfortable alternative to blood draws. The test was tested on 60 patients receiving clozapine, quetiapine, or olanzapine, with promising results.
A new study found that antibiotics promote the growth of antibiotic-resistant bacteria in the gut by providing extra nutrients, allowing these 'bad' bacteria to multiply. The research suggests that targeting beneficial bacteria can help restrict the growth of resistant bacteria, paving the way for microbiome therapeutics treatments.
Researchers at George Mason University are developing a new biometric technology that uses sweat analysis to verify identities. The project, led by Emanuela Marasco, aims to characterize a person's extrinsic and intrinsic features for more accurate representation of their identity.
Researchers found that urine levels of adenine are predictive and causative biomarkers of looming progressive kidney failure in patients with diabetes. An oral therapeutic drug showed promise in mice by reducing kidney adenine levels and protecting against diabetic kidney disease.
Glutamine metabolism plays a crucial role in cancer cell growth and survival, with its inhibition shown to block cancer cell growth in vivo and in vitro. A recent editorial paper suggests that glutamine dysregulation may also impact the tumor microenvironment, potentially leading to increased oxidative stress and cancer cell death.
Scientists created a unique data process that provides valuable insights into how drugs are processed in the body and their impact on biochemical responses. The approach reveals detailed maps of drug transformation and allows for simultaneous discovery of fate and effects.
Researchers developed new methods for detecting drug-induced hepatotoxicity using 3D cell cultures and mass spectrometry imaging, identifying biomarkers and effective interventions. A zeolite-based protein corona method was also used to characterize plasma proteins, enabling the identification of low-abundance proteins and their potent...
Mutations in parkin gene break down contacts between lysosomes and mitochondria, disrupting essential metabolite supply to mitochondria. Restoring these contacts may represent a new therapeutic opportunity for Parkinson’s disease.
A new Northwestern Medicine study has furthered the understanding of metabolic pathways underlying organ development, specifically eye development. The research found that aerobic glycolysis and production of lactate regulate critical genes required for early eye development.
Researchers created the Cancer Atlas of Metabolic Profiles (CAMP) to analyze gene activity and metabolite levels in tumor samples. The atlas reveals two broad classes of gene-metabolite connections, pointing to mechanisms at work across cancer types.
The study mapped out metabolite by-products of bacteria processing amino acids linked to cardiovascular disease, comparing patient data to assess disease risk. Researchers developed a method for assessing absolute metabolite levels in the bloodstream, allowing identification of cutoff values for low versus high risk.
Researchers found that vaginal microbiota seeding improved C-section babies' early development by colonizing their guts with maternal bacteria. This approach may reduce the risk of neurodevelopmental disorders like ADHD and intellectual disabilities.
A study by Brigham and Women's Hospital found that higher levels of diglycerides and triglycerides are associated with an increased risk of primary open-angle glaucoma. The research suggests that these lipid metabolites play a role in the disease's pathogenesis, highlighting potential new targets for prevention or treatment.
Researchers found increased levels of TMAO in abdominal aortic aneurysm (AAA) patients, which led to disease progression. Inhibiting TMAO production reduced aneurysm severity, suggesting a potential therapeutic target.
International researchers have identified nutrient-rich black rice varieties with improved agronomic traits, including shorter stem length and early maturity. These findings provide important resources for crop bioengineers to improve pigmented rice for human health and sustainable agriculture.
A new study by North Carolina State University researchers finds that sucralose-6-acetate, a chemical formed when we digest sucralose, is genotoxic and breaks up DNA. The chemical is also present in trace amounts in the sweetener itself, posing potential health risks.
The study found that people younger than age 50 with colorectal cancer had lower levels of citrate and differed in protein and carbohydrate metabolism compared to older patients. Red meat consumption and sugar intake are potential risk factors for young-onset colorectal cancer. Higher levels of 4-hydroxyhippuric acid correlated with im...
Researchers at UC San Diego and Stanford University have developed a roadmap of root chemicals that are critical to plant growth, providing new insights into plant development. The study reveals that key small molecules are clustered in patches across the root, suggesting a purposeful distribution for optimal growth.
Scientists at La Jolla Institute for Immunology found that MAIT cells can be tuned to fight different pathogens via their metabolism, with two distinct subtypes responding to sugar and fat. This discovery may inspire new vaccines and cell therapies to boost the immune response against specific pathogens.
A recent study by researchers at UNICAMP found that low-load with many repetitions and high-load with fewer repetitions both promote similar muscle growth. Muscle activation patterns were different, but metabolic stress was the same in both groups.
Researchers have found a compound that can prevent cisplatin-induced renal toxicity and improve the outcomes of cancer treatment. The aromatic ketone 2',4',6'-trihydroxyacetophenone (THA) inhibits the CCBL1-mediated metabolism of cisplatin, reducing its toxic effects without affecting its potency.
A new study has defined analytical performance specifications for 24,25-dihydroxyvitamin D examinations, which is essential for developing accurate methods to detect this metabolite. The findings show that the variation of 24,25(OH)2D concentration over time was significantly associated with 25(OH)D concentrations and body mass index.
A recent study published in PLOS ONE found that pregnant and lactating dogs share similarities in certain blood metabolites with human pregnancy, including glucose and fatty acid concentrations. The research analyzed 27 dogs from 21 breeds and discovered intriguing correlations between canine metabolism and human physiological processes.
Researchers discovered that fungal antibiotics produced by Penicillium mold in cheese rinds control bacterial community growth and development, leading to a shift in the composition of microbial communities.
A team of researchers used a capsule to collect data on digestion and microorganisms in the upper intestine, revealing nearly 2,000 metabolites and associations between diet and metabolite levels. The study provides new insights into human gut metabolism and microbiome interactions.
A team of researchers has developed an AI tool called CRANK-MS that uses neural networks to analyze biomarkers in patients' bodily fluids and predict Parkinson's disease onset with an accuracy of up to 96%. The tool may help identify early warning signs for the disease, which can be challenging to diagnose.
Researchers at CU Anschutz Medical Campus used metabolomics to study elite cyclists' metabolism during training and racing. The study identified healthy metabolomic signatures that can help detect dysregulations of key areas ahead of time, potentially leading to personalized exercise-as-medicine approaches for preventing chronic diseases.
Researchers reconstructed ancient bacterial genomes from human and Neanderthal remains to discover previously unknown metabolites, including paleofurans. This breakthrough expands the ability to study microbial natural products, offering insights into the nutrition and health of early hominins.
A new machine-learning method analyzes metabolites in blood to predict the time of an individual's internal circadian timing system. This approach has shown accuracy comparable to previous methods, but requires fewer samples.
The study analyzed the growth and productivity of Botryococcus terribilis under different cultivation systems. Stress increased the production of lipids and hydrocarbons by 49% and 29%, respectively, while proteins decreased. The microalgae's metabolites have potential applications in biofuel synthesis, cosmetics, and food.
Researchers found that women with prediabetes after pregnancy had aberrations in their early pregnancy blood serum metabolomic profile, including higher concentrations of small HDL particles. These metabolic changes predicted prediabetes at postpartum and were associated with increased risk of type 2 diabetes.
A study published in Cell Reports found that rodents exposed to microgravity had altered gut microbiomes, which may contribute to bone loss. The researchers also discovered that certain bacterial species in the gut produced molecules that influenced bone remodeling.
Edward Chouchani, an associate professor at Harvard Medical School, has been awarded the $50,000 Vilcek Prize for Creative Promise in Biomedical Science. His research focuses on understanding metabolic disease using mass spectrometry and biochemical approaches.
Researchers have found that fermented sugar-based products and fermented vegetable-based products show promise in improving gut and brain health. Preliminary results suggest these foods contain beneficial metabolites that can positively impact mental health.
Acylceramides and protein-bound ceramides play a vital role in forming the oral barrier, similar to their function in the skin. Researchers found that these molecules protect against pathogens, chemicals, and allergens in mice.
A pilot study at the University of Eastern Finland found metabolites related to oxidative stress and transsulfuration to be associated with a history of sexual or physical abuse in depressed adolescent outpatients. The study's findings suggest that further research into the biological mechanisms underlying trauma is needed.
Researchers developed O-ClickFC technology to analyze lipid metabolic state in cells at high speed. The technology combined with genome editing enabled identification of causative genes of metabolic disorders, including FLVCR1 and its role in choline uptake.
Researchers at Penn Medicine discovered that maintaining nicotinamide adenine dinucleotide (NAD) levels may protect against kidney disease. NAD supplements were shown to be effective in reversing NAD loss and suppressing inflammation in mouse kidneys, suggesting a potential therapeutic target for kidney disease prevention and treatment.
A recent study found that certain microbial metabolites are associated with liver fat content in individuals with fatty liver disease. The researchers identified degradation products of amino acids and differences in testosterone levels as potential biomarkers.
Researchers at Hokkaido University discovered itaconate's modulatory effect on T helper and T regulatory cells, potentially leading to new treatments for autoimmune diseases. The study found that itaconate inhibits Th17 cell differentiation and promotes Treg cell development, reducing disease symptoms in mice models.
Scientists at the University of Utah Health have discovered a complex network of protein-metabolite interactions within cells that enable them to respond to environmental cues and maintain homeostasis. The study, published in Science, highlights the importance of these interactions in regulating metabolic processes and preventing disease.
The study found that Clostridioides difficile uses fermentation to rapidly colonize the gut and identified critical pathways converged on a metabolic integration point to produce amino acid alanine, driving bacterial growth. The findings provide new targets for small molecule drugs to counter C. difficile colonization and infection.
A new study has discovered a connection between a mitochondrial metabolite and the activation of an inflammatory response. Fumarate, produced in the mitochondrion, triggers mitochondrial damage that releases genetic material into small vesicles, leading to inflammation.
A study found that time-restricted feeding improves muscle performance in obese fruit flies by upregulating genes related to glycine production and utilization. This approach may provide a natural alternative therapy for managing obesity-related pathologies.