Articles tagged with Rna Processing
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Scientists have identified the molecular origins of recombination in RNA viruses, a process that can lead to the emergence of new variants. The study reveals a new class of antiviral drugs that target this mechanism, but warns of potential risks when used in large quantities.
Researchers from the University of Birmingham have confirmed a novel COVID-19 testing method called RTF-EXPAR that is highly sensitive and fast, giving results in under 10 minutes even at low viral levels. The test was shown to be equivalent to PCR and LAMP tests but faster.
A new process for making RNA has been developed by researchers at the University of Massachusetts Amherst, yielding purer and more abundant RNA at a fraction of the cost. This breakthrough removes the largest stumbling block on the path to next-generation RNA therapeutic drugs.
Researchers discovered that the protein SPT6 is essential for the arrival of RNA polymerase at the end of a gene, producing functional mRNA. Without it, the polymerase destroys obstacles, making it impossible for functional RNA polymerases to find their way.
Researchers at Heidelberg University developed a novel fluorescence marker called RhoBAST to enable super-resolution RNA imaging in live cells. The method reveals details of subcellular structures and molecular interactions involving RNA, improving image resolution.
The Galej group has discovered the structure and arrangement of the proteins comprising Integrator's catalytic core, revealing a network of multiple subunits interacting with each other. This complex is involved in the transcription attenuation process and plays a crucial role in regulating gene expression.
Researchers have finally determined the atomic structure of the histone mRNA three-prime end-processing machine, a complex assembly of molecules that plays a fundamental role in proper cell activity and DNA duplication. This breakthrough provides valuable insights into how this machine is activated and regulates gene expression.
Scientists at the University of Bonn have developed a new method to study the structure of long ribonucleic acids, which are crucial for cellular regulation. The technique involves marking specific locations on the RNA with artificial flags and measuring their distances using a molecular ruler.
Scientists at the University of Exeter's Living Systems Institute have discovered a fresh understanding of how genes are copied, shedding light on the transcription process. The study suggests that two long-debated models work together to terminate gene expression, providing a more accurate explanation for this complex process.
Scientists have made new discoveries about transcription, a fundamental process in all living cells. Researchers used advanced imaging techniques to study transcription at the scale of individual genes, revealing unexpected drivers of cellular individuality.
Researchers at Barrow Neurological Center discovered aberrant RNA processing in ALS and FTD patients, led by Dr. Rita Sattler's team finding ADAR2 mislocalization affects disease pathways, potentially leading to neuronal loss and neurodegeneration.
A study by a Danish-German research team reveals that modified RNA bases play a crucial role in controlling gene expression from DNA to functional RNA. The researchers used a newly developed technique to label newly made RNA with the m6A modification, demonstrating its impact on RNA maturation and splicing efficiency.
A new study develops an innovative simulation model to predict the three-dimensional conformation of ribonucleic acid molecules, overcoming limitations of existing models. The model shows promising results in predicting RNA structures, with potential implications for basic research and medical therapies.
Researchers at Wits University discover that complex life emerged through the random joining of simple RNA molecules, enabling self-replication and kickstarting life. The process, which occurred billions of years ago, involved the ligation of small molecules to form larger, more complex ones.
Researchers at the University of Illinois have developed a new technique to deliver RNA to soybean aphids using nebulization, which appears to block the function of specific genes. The technique has shown promise in improving the uptake of RNA through tiny breathing tubes and may aid in the development of new pest-control systems.
Researchers at UC Riverside have developed a new method to measure nonsense-mediated RNA decay (NMD) efficiency in real-time, allowing for the identification of molecules that regulate this pathway. This breakthrough has the potential to lead to the development of targeted treatments for diseases such as ALS and muscular dystrophy.
Neurons in the brain store immature RNA copies that are pre-manufactured and only need splicing upon stimulation, significantly reducing production time and enabling rapid adaptation. This discovery reveals a new regulatory mechanism for brain plasticity processes.
Researchers at Northwestern University have developed a technology platform that provides high-resolution representation of RNA folding during synthesis. This breakthrough allows for the study of RNA folding in unprecedented detail, potentially leading to discoveries in basic biology, gene expression, and disease.
Researchers have developed a CRISPR-Cas9 based method to track the movement of RNA in living cells. This approach enables the study of disease-related RNA processes and may support therapeutic approaches to correct disease-causing RNA behaviors.
A team of scientists has uncovered greater intricacy in protein signaling than previously understood, shedding light on the nature of genetic production. The research found that both protein synthesis and mRNA production are highly regulated processes, with different patterns and responses to outside stimuli.
Researchers from Colorado State University have discovered that RNA plays a crucial role in DNA damage, leading to mutations and disease. The study sheds light on the mechanisms behind Aicardi-Goutieres syndrome and has implications for cancer research.
Scientists at IBS Center for RNA Research have elucidated the three-dimensional image of DROSHA, one part of the Microprocessor complex. This discovery confirms previous findings and reveals unique physical characteristics of DROSHA, including a 'bump' that may act as a measuring guide for cleaving pri-miRNA.
Researchers have filled in details on how an enzyme, MOV10L1, protects sperm integrity by producing RNA molecules essential to development. The discovery could lead to a form of reversible male contraception by disrupting piRNA production.
Case Western Reserve University researchers aim to reduce false negative results in Ebola diagnosis by developing a positive control using plant virus nanoparticles. The goal is to create a reliable test for early detection and monitoring of the virus.
Researchers discovered that Ranbp9 controls the correct processing of mRNA molecules after their synthesis from thousands of genes involved in sperm production. This finding places Ranbp9 as a master regulator of sperm production.
Researchers from Brandeis University and UMMS discovered that the spliceosome's major components can attach in any order, eliminating the need for precise communication. This breakthrough sheds light on the process of RNA splicing, a crucial step in protein synthesis, and holds promise for understanding diseases like cystic fibrosis.
Researchers at Emory University have discovered a previously unrecognized type of pathology in Alzheimer's brains that sequesters proteins involved in RNA splicing. This finding could lead to new biomarkers, diagnostic approaches, and therapies by explaining how genes contribute their effects in the disease.
Researchers cracked the 'RNA control code' to understand how it dictates gene expression and movement. The team identified patterns in RNA molecules that can be used to identify new treatments for conditions like autism.
Researchers have discovered that processing bodies can contribute to immune defenses by responding to viral infections. Viruses alter the composition of processing bodies to enhance their replication, but PBs can limit this ability.
Jackson Laboratory researchers discovered a defect in RNA splicing process that contributes to neurological disease. A mutation in one copy of the U2 snRNA gene causes neurodegeneration, leading to movement problems and early neuron death in mice.
Researchers found that temperature affects RNA structure, hiding or showing particular sequences that influence the recognition of intronic endings. This allows for alternative protein isoforms to be generated in response to changing temperatures.
Researchers discovered that Mtr4p, a RNA helicase, controls the number of adenosines appended to RNAs by TRAMP complex. This tagging is critical for cell function and preservation of normal cell process initiation.
Researchers at Brandeis University have developed a method to study the splicing of pre-messenger RNA molecules using lasers and a custom microscope. This technique allows for the visualization of the spliceosome's assembly process in unprecedented detail, providing insights into the fundamental biology of protein synthesis.
UCSF researchers developed a new approach to examine how cells convert DNA into RNA, bridging a gap in understanding gene expression. The technique enables direct observation of the transcription process at unprecedented resolution, providing insights into gene regulation and function.
The spliceosome, a giant complex of RNA and protein subunits, assembles and operates to remove unwanted genetic material and join the remaining pieces. Researchers spied on the process using FRET and observed reversible contortions in the presence of energy.
The Baumann Lab discovered an important step in the maturation pathway of telomerase, an enzyme that replenishes chromosome ends with every cell division. This finding sheds light on human health and demonstrates that interfering with telomerase maturation can inactivate telomerase.
Researchers have identified a previously unknown mechanism that processes non-coding RNA molecules into smaller pieces, including a new class of small RNAs called mascRNA. This discovery suggests that the vast majority of human DNA may not be genetic junk, but instead performs various kinds of work in cells.
Researchers found that a protein called CPSF73 is necessary for producing mRNA needed to create histone proteins, which combine with DNA to form chromosomes. This discovery provides a unified mechanism for synthesizing all messenger RNAs.
Researchers at Yale University have identified a cooperative RNA switch in nature, which responds to various target compounds and regulates metabolic processes. This discovery supports the theory of an RNA World, where RNA molecules served a central role in early life.
Researchers at the University of Southern California have discovered a unique nuclear DNA structure that helps elucidate the process of immunoglobulin class switching. This finding may provide insights into B cell cancer, such as Burkitt's lymphoma.