Changing what heart cells eat could help them regenerate
Researchers found that forcing cardiomyocytes to consume glucose instead of fatty acids extended the window for heart cell regeneration, potentially treating conditions like heart failure.
Cardiac Regeneration
Articles tagged with Cardiac Regeneration
Heart muscle cells change their energy source during heart regeneration
Researchers discovered that zebrafish heart muscle cells switch from fatty acids to sugars for energy, enabling regeneration. This metabolic shift is crucial for heart regeneration and may hold potential for human heart regeneration after a heart attack.
Injecting 'solar cells' into the body to regenerate brain cells
Associate Professor Menglin Chen's team has created a light-controlled neural stimulating scaffold inside the body using nanofibers coated with photovoltaic nanomaterials. This non-genetic method can locally stimulate cells electrically and has shown regenerative effects on neural model cells.
New technique lays foundation for regenerative cardiac therapies
Scientists have devised a method to sort out which heart cells can replicate and which cannot, a critical step toward treatments that may one day help the heart heal itself after injury. This technique combines molecular beacon technology and fluorescence activated cell-sorting to specifically isolate cells that successfully divide.
Special cells contribute to regenerate the heart in Zebrafish
Researchers identify a specific subset of cardiomyocytes with enhanced regenerative capacity in zebrafish, which differ from other myocardial cells in gene expression profile. This discovery could provide new insights into human heart regeneration and potentially stimulate the repair process.
Transcriptional landscape of neonatal heart regeneration
A study identified genes associated with heart regeneration in neonatal mouse hearts. Genes related to immunity and developmental programs were found to promote regeneration. Enhanced post-MI regeneration was observed in mouse hearts overexpressing the RNA-binding protein IGF2BP3.
SourceProceedings of the National Academy of Sciences·JournalProceedings of the National Academy of Sciences·DateAug 26, 2019
Novel dual stem cell therapy improving cardiac regeneration
A new dual stem cell therapy has shown promise in improving cardiac function and vascular regeneration following myocardial infarction. The treatment involves combining two types of stem cells to repair both the muscle cells and vascular systems of the heart, providing a potential alternative to complex heart transplants.
Deciphering the regenerative potential of newborn mammalian hearts
Researchers aim to decipher the mechanisms that govern the regenerative capacity of large neonatal mammalian hearts and manipulate them to remuscularize the heart after muscle death. The study may lead to novel techniques for pediatric and adult heart disease interventions, addressing the fundamental problem of heart failure.
Changes in blood flow tell heart cells to regenerate
A study in eLife reveals that altered blood flow after heart injury triggers a signalling cascade that promotes cell growth and heart tissue regeneration in zebrafish. The findings provide insights into signalling pathways important for heart regeneration in mammals, including the potential to repair the human heart.
Genetic therapy heals damage caused by heart attack
Researchers at King's College London have made a groundbreaking discovery that genetic therapy can heal heart damage caused by a heart attack. The study used microRNA-199 to stimulate cardiac regeneration in pigs, resulting in almost complete recovery of cardiac function.
A Mexican cavefish with a scarred heart
Scientists have discovered that a Mexican cavefish can regenerate its heart tissue, unlike its blind and translucent cousin. Researchers found three DNA segments responsible for the ability to regenerate heart tissue, shedding light on the genetic mechanisms behind this process.
Scientists at MDI Biological Laboratory identify new genetic regulators of regeneration
Researchers discovered long noncoding RNAs play a key role in regulating genetic circuits responsible for regeneration in highly regenerative animals. The discovery may lead to the development of drugs to trigger humans' dormant pathways for regeneration.
Neonatal pig hearts can heal from heart attack
Researchers discovered that neonatal pig hearts can functionally and structurally recover from experimental heart attacks. The ability to regenerate heart muscle is short-lived, disappearing by day three after birth.
'Multiomics' and the newborn mouse heart
Researchers investigated the molecular mechanisms underlying myocardial regenerative ability in newborn mice, identifying fructose-induced glycolysis as a key factor for cardiac muscle cell proliferation. The study provided insights into the loss of regenerative capacity and potential new treatments for heart disease.
Computer-designed customized regenerative heart valves
A team of researchers has successfully designed and produced individualized, computer-modeled regenerative heart valves grown from human cells. These bioengineered replacements can grow and regenerate themselves without causing immune reactions in patients' bodies, addressing a major limitation of current artificial implants.
Exercise could make the heart younger
Researchers found that exercising mice produced over four and a half times more new heart muscle cells than sedentary counterparts. The study suggests exercise can stimulate the heart to regenerate tissue after a heart attack.
New-found stem cell helps regenerate lung tissue after acute injury, finds Penn study
Researchers have identified a lung stem cell that repairs the organ's gas exchange compartment and restores respiratory function after severe influenza and other respiratory ailments. The discovery provides new insights into lung regeneration and identifies novel genetic and epigenetic pathways important for lung regeneration.
UCLA scientists use color-coded tags to discover how heart cells develop
Researchers discovered that most new cardiomyocytes come from cardiac progenitor cells during early embryonic development, but this ability fades as mice mature. The study's findings could lead to methods for regenerating heart tissue after a heart attack.
SourceUniversity of California - Los Angeles Health Sciences·JournalNature Communications·DateFeb 22, 2018
CNIC scientists describe the mechanism of heart regeneration in the zebrafish
A study by CNIC scientists discovered that cardiomyocytes from the innermost heart regions can contribute to the regeneration of the external heart wall in zebrafish. This finding reveals a new way to rebuild a damaged heart and has implications for human heart regeneration.
SourceCentro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.)·JournalNature Communications·DateFeb 8, 2018
Scientists reverse advanced heart failure in an animal model
Researchers at Baylor College of Medicine discovered that silencing the Hippo signaling pathway can reverse severe heart failure in an animal model. The study found that inhibiting this pathway induces heart muscle cell proliferation and reduces fibrosis, leading to improved heart function.
Tension makes the heart grow stronger
Researchers found that mechanical tension plays a crucial role in the regeneration of zebrafish hearts, with supersized cells leading the way and smaller cells multiplying to cover the surface. The study's findings open up new possibilities for developing bioengineering approaches to human heart disease.
MDI Biological Laboratory study finds immune system is critical to regeneration
A new study by James Godwin found that macrophages are essential for heart regeneration in salamanders, suggesting a potential solution to the human disease. The research has significant implications for regenerative medicine and may lead to the development of drug therapies to promote scar-free healing.
Metabolism switch signals end for healing hearts
Scientists have identified a metabolic pathway that governs the loss of the human heart's ability to regenerate tissue. This discovery could potentially lead to the development of drugs to reactivate regeneration in adult hearts, allowing them to repair muscle damage caused by heart attacks and recover full pumping capacity.
SourceUniversity of Queensland·JournalProceedings of the National Academy of Sciences·DateSep 18, 2017
USC Stem Cell discovery refreshes the heart
Researchers identified a genetic variation underlying heart muscle regeneration in adult mammals. The study found that some individuals can naturally recover from a wounded heart due to higher percentages of regenerative cells, and that modulating the activity of a specific gene may enhance regeneration.
Could humans ever regenerate a heart? A new study suggests the answer is 'yes'
Researchers found genes that form heart cells in humans and animals in a sea anemone's gut, which may help explain its regenerative abilities. The study suggests potential for tweaking human gene communication to stimulate regenerative healing and treat heart conditions.
Young at heart: Restoring cardiac function with a matrix molecule
A study by Weizmann Institute researchers reveals that administering 'young matrix' molecules, including Agrin, to damaged mouse hearts can repair and restore heart muscle function. The findings suggest a new direction for research on restoring damaged hearts and may lead to the development of new treatments for heart disease.
Engineering heart valves for the many
A Harvard-Wyss Institute and University of Zurich team developed a nanofiber fabrication technique to create regenerative heart valves with growth potential. The technology enables rapid manufacturing of customizable, scalable, and cost-effective prostheses that can be implanted minimally invasively.
SourceWyss Institute for Biologically Inspired Engineering at Harvard·JournalBiomaterials·DateMay 18, 2017
MDI Biological Laboratory scientists publish groundbreaking study on new heart drug
MDI Biological Laboratory scientists have identified a potential heart drug candidate to restore heart muscle function following a heart attack. In a breakthrough study, MSI-1436 showed significant regeneration in zebrafish and mice, with promising results in adult mice after an artificially induced heart attack.
CHLA researcher awarded $1.7 million to study heart regeneration
Children's Hospital Los Angeles researcher Ching-Ling Lien will investigate the molecular and cellular mechanisms of coronary vessel development and revascularization using zebrafish as a model system. The goal is to determine how the heart regenerates after injury and potentially design therapeutic approaches for humans.
Cancer drug could promote regeneration of heart tissue
Researchers discovered that a cancer drug targeting Wnt signaling molecules improves heart function and reduces scarring in mice, potentially preventing heart failure. The treatment also only needs to be used for a short time, avoiding common side effects.
SourceUT Southwestern Medical Center·JournalProceedings of the National Academy of Sciences·DateFeb 3, 2017
Ovary regeneration in salamanders could provide solutions to human infertility
Researchers have discovered that axolotl salamanders can regenerate their ovaries and produce eggs throughout their lifespan, sparking hopes for regenerative medicine solutions to human infertility. The study found that these salamanders' ability to repair damaged organs could be translated into humans with the help of key signals.
Low-oxygen environment leads to heart regeneration in mice, UTSW research shows
Researchers at UT Southwestern Medical Center have found that a low-oxygen environment can regenerate heart muscle in mice. This discovery builds on previous research that showed the ability of newborn mammals to regenerate their hearts, and demonstrates the potential for this approach to reverse heart disease.
Long term effects of cardiac regenerative therapies in a left ventricle
Researchers develop computational model to simulate long-term effects of cardiac regenerative therapies, overcoming limitations of existing heart models. The results are consistent with some clinical study findings and will aid in optimizing therapy parameters.
No males needed: All-female salamanders regrow tails 36 percent faster
Researchers at Ohio State University found that all-female mole salamanders can regenerate tail tissue at 1.5 times the rate of their heterosexual counterparts, with a 10-week timeline compared to 14 weeks for males. This faster regeneration may be attributed to genetic differences and reproductive strategies.
Duke study uncovers genetic elements that drive regeneration
Researchers have discovered regulatory sequences in zebrafish that can turn on genes involved in regeneration, which also exist in humans. These 'tissue regeneration enhancer elements' or TREEs may hold the key to improving human regenerative capabilities through genome editing technologies.
Scientist at MDI Biological Laboratory identifies mechanism to regenerate heart tissue
Assistant Professor Voot Yin has identified the role of microRNA miR-101a in stimulating heart muscle cell growth and removing scar tissue. This breakthrough research holds promise for developing new drugs to regenerate damaged heart tissue and potentially treating other diseases involving muscle damage.
Delivering missing protein heals damaged hearts in animals, study finds
Researchers develop a bioengineered collagen patch loaded with Fstl1 protein to regenerate heart tissue after damage. The treatment restored function and allowed for progressive recovery in animal models.
Hearts build new muscle with this simple protein patch
A team of researchers has identified a protein that helps heart muscle cells regenerate after a heart attack, improving cardiac function and survival rates in mice and pigs. The protein patch, loaded with Follistatin-like 1, showed remarkable results in animal models, regaining nearly normal function within four to eight weeks.
From heart attacks to cancer: What role do long, non-coding RNAs play?
Stefanie Dimmelers research suggests that long non-coding RNAs play a role in creating heart attacks, strokes, and cancer by regulating endothelial cells. She will use the ERC Advanced Grant to identify new treatments for preventing arteriosclerosis.
Duke study uncovers foundations of heart regeneration
A recent study by Duke University researchers has shed light on the epicardium, a mysterious outer layer of the heart known to regrow cardiac tissue in zebrafish. The findings suggest that this layer is critical for regeneration and may hold key to repairing damaged hearts in humans.
Hemin improves adipocyte morphology and function by enhancing proteins of regeneration
Researchers found that hemin treatment suppresses hypertriglyceridemia and hypercholesterolemia while reducing pericardial adiposity. Hemin also attenuates adipocyte inflammation and oxidative insults, promoting regeneration of proteins such as beta-catenin and Oct3/4.
SourceSociety for Experimental Biology and Medicine·JournalExperimental Biology and Medicine·DateJan 26, 2015
Mammalian heart regenerative capacity depends on severity of injury
Researchers at Children's Hospital Los Angeles found that neonatal mouse hearts can fully recover normal function after mild injury but fail to regenerate after severe injury. The study suggests that cardiac regeneration strategies should be tailored to the type and severity of heart injury.
Long-term use of ventricular assist devices induces heart muscle regeneration, study finds
A study by UT Southwestern Medical Center investigators found that patients with heart failure who used left ventricular assist devices (LVADs) for six months or longer showed significant regeneration of heart muscle. Oxidative damage to a cell-regulator mechanism was prevented, leading to an increase in cardiomyocyte proliferation.
SourceUT Southwestern Medical Center·JournalJournal of the American College of Cardiology·DateJan 21, 2015
Salk scientists discover a key to mending broken hearts
Researchers at Salk Institute have healed injured hearts of living mice by targeting four specific molecules that suppress regenerative programs. This finding provides proof-of-concept for a new type of clinical treatment to fight against heart disease, which kills over 600,000 people annually in the US.
Study urges caution in stem cell clinical trials for heart attack patients
A new study challenges the use of stem cells in heart attack patients, finding that they do not regenerate damaged heart tissue at high enough rates. The study suggests that any potential benefit from injecting c-kit-positive cells into the hearts of patients may come from improving circulation rather than generating new cardiomyocytes.
Stem cells aid heart regeneration in salamanders
Researchers discovered that salamanders can regenerate their hearts within six weeks by activating stem cells from the blood. This finding raises hope for new treatments for people with damaged tissue, potentially paving the way for clinical trials and improved therapies.
Oxygen diminishes the heart's ability to regenerate, researchers discover
New research by UT Southwestern Medical Center discovered that high levels of oxygen in the postnatal environment result in cell cycle arrest of cardiomyocytes, making it impossible for adult hearts to regenerate. The study's findings have significant implications for cardiovascular medicine and may lead to new therapeutic approaches.
New study casts doubt on heart regeneration in mammals
A recent study published in Stem Cell Reports has found no evidence of complete heart regeneration in newborn mice after apex resection. The researchers, led by Ditte Andersen, were unable to replicate the findings of a previous 2011 study that suggested complete regeneration was possible.
JCI early table of contents for Feb. 24, 2014
Researchers found that PPAR-γ agonists can reverse emphysema development despite continuous exposure to cigarette smoke. Additionally, a compound enhancing glutamate uptake improved ALS symptoms and extended lifespan in mice. Increased autophagy also contributed to BRAF inhibitor resistance in melanoma patients.
GW researcher finds gene therapy a promising tool for cardiac regeneration
A GW researcher has discovered that gene therapy can elicit a regenerative response in pig hearts after a heart attack. The treatment utilizes the Cyclin A2 protein to stimulate cellular division and promote cardiac repair.
Transitioning epithelial cells to mesenchymal cells enhances cardiac protectivity
Researchers found that transitioning epithelial cells to mesenchymal cells improved cardiac regeneration by reducing infarct size. The study showed that this process enhanced the cardioprotective effects of human amniotic epithelial cells.
SourceCell Transplantation Center of Excellence for Aging and Brain Repair·JournalCell Transplantation·DateDec 23, 2013
Breakthrough in adult heart repair
Researchers have made a significant discovery in adult heart repair by identifying the Hippo pathway as a key regulator of cardiomyocyte proliferation. This breakthrough has the potential to improve heart function after a heart attack and reduce the severity of heart disease.
Synthetic mRNA can induce self-repair and regeneration of the infarcted heart
A team of scientists has developed a synthetic mRNA that induces self-repair and regeneration of the infarcted heart in mice. The study shows that this approach can lead to long-term therapeutic effects, including improved survival following myocardial infarction.
WPI receives $1.94 million NIH award for research on cardiac regeneration
A biomedical research team at Worcester Polytechnic Institute will use a new microthread technology to deliver adult stem cells into damaged hearts, aiming to promote muscle regeneration and improve heart function. The five-year project aims to advance cell therapies for people suffering from heart disease.
Fondation Leducq awards $6 million grant for global research network for cardiac regeneration
The Fondation Leducq has awarded a $6 million grant to a new global research network focused on cardiac regeneration. The network, which includes researchers from the Cardiovascular Research Center at Mount Sinai, aims to identify cellular and molecular targets for advancing cardiac regenerative therapeutics.
Fate of the heart: Researchers track cellular events leading to cardiac regeneration
Researchers track cellular events leading to cardiac regeneration in zebrafish, revealing a novel potential source of cells for repairing damaged heart muscle. The study's findings provide evidence that various cell lines in the heart are more plastic than previously thought, offering new hope for treating heart failure.
Researchers: Gene regenerates heart tissue, critical finding for heart failure prevention
A specific gene called Meis1 regulates the heart's ability to regenerate after injuries. The study found that deleting this gene extended the proliferation period in newborn mice and re-activated regeneration in adult mouse hearts without harming cardiac functions.
Research pinpoints key gene for regenerating cells after heart attack
UT Southwestern researchers identified microRNA miR-15 as a regulator of the heart's ability to regenerate, with potential therapeutic applications. By understanding this molecular mechanism, scientists may be able to control the heart's regenerative process and develop new treatments for cardiovascular disease.
SourceUT Southwestern Medical Center·JournalProceedings of the National Academy of Sciences·DateDec 20, 2012
Developing effective stem cell therapies for heart disease will hinge on collaboration between multiple specialties
Effective regenerative therapies for heart disease hinge on collaboration between multiple specialties, including cardiovascular medicine and device technology. Recent advances in cardiac stem cell and regenerative biology are yielding potential new targets and treatment strategies.
Mutation in gene that's critical for human development linked to arrhythmia
Researchers found that altered function of Tbx3 gene interferes with cardiac conduction system development, causing lethal arrhythmias. Studies with mice show that Tbx3 levels below a critical threshold lead to arrhythmia and death.
SourceUniversity of Utah Health·JournalProceedings of the National Academy of Sciences·DateDec 27, 2011