A comprehensive review of over 60 studies confirms that COVID vaccination is around 80% effective in protecting people with cancer against SARS-CoV-2 infection. The mRNA vaccines were found to be the most effective, and multiple vaccinations are recommended for better protection.
SourceLeibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute -·JournalNature Reviews Clinical Oncology·TypeLiterature review·DateMar 14, 2022
Researchers at Texas Biomedical Research Institute have found that adding an antibody to the widely-used TB vaccine significantly improves its long-term effectiveness. The combination of the vaccine and an IL-10 blocker allows for better control of TB infection in mice, with improved lung health and increased memory immune cells.
SourceTexas Biomedical Research Institute·JournalThe Journal of Immunology·DateMar 11, 2022
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SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
The investigational vaccine targets both the spike and nucleocapsid proteins, producing neutralizing antibodies and inducing T cell responses against SARS-CoV-2. COH04S1 is being studied in Phase 2 trials for immunocompromised patients and as a booster for healthy adult volunteers.
SourceCity of Hope·JournalThe Lancet Microbe·TypeRandomized controlled/clinical trial·DateMar 10, 2022
A Moffitt study found that COVID-19 vaccination led to seroconversion in most cancer patients, but with differing antibody response rates among various cancer types and treatments. Patients with blood cancers had lower seroconversion rates compared to those with solid tumors, highlighting the need for personalized immune responses.
SourceH. Lee Moffitt Cancer Center & Research Institute·JournalJAMA Oncology·TypeObservational study·DateMar 10, 2022
Researchers at Johns Hopkins Medicine discovered a critical step in the molecular circuitry of immune cells that mobilizes the immune system to fight off foreign invaders. The findings, published in iScience, shed light on subtle genetic variations among human populations that may explain individual responses to infections.
SourceJohns Hopkins Medicine·JournaliScience·DateMar 8, 2022
Researchers discover unique glycoprotein structure of Nipah and Hendra viruses, which could provide blueprint for vaccine design and antibody treatments. The findings suggest a multi-pronged approach to prevent and treat these deadly illnesses.
SourceUniversity of Washington School of Medicine/UW Medicine·JournalScience·TypeExperimental study·DateMar 3, 2022
Mutations in SARS-CoV-2's spike protein can resist neutralizing antibodies and therapeutics, highlighting the need for improved vaccines and treatments. The study mapped out these 'escape variants' to understand their molecular mechanisms.
SourcePLOS·JournalPLOS Pathogens·TypeSystematic review·DateMar 1, 2022
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Researchers have discovered that bioprosthetic heart valve patients develop an immune response against foreign sugars in the valves, leading to calcification and deterioration. By genetically engineering these sugars out of the valves, durability can be increased, offering a potential solution for patients.
SourceTel-Aviv University·JournalNature Medicine·DateMar 1, 2022
A new study by University of Bonn researchers found that cow's milk protein casein triggers an autoimmune response in mice, damaging neurons and myelin sheath. This cross-reactivity can occur when the immune system mistakes similar molecules for each other.
SourceUniversity of Bonn·JournalProceedings of the National Academy of Sciences·DateMar 1, 2022
Researchers have revealed that during Type 1 Diabetes development, pancreatic duct cells reprogram to suppress autoimmune T cell responses. This discovery advances understanding of the disease by creating a map of pancreatic islet cells over time.
SourceUniversity of Pennsylvania School of Medicine·JournalNature Metabolism·DateFeb 28, 2022
A new study from Oregon Health & Science University found that people infected with SARS-CoV-2 develop durable immunity against variants for at least 11 months. The research suggests that immune protection may endure long-term, potentially reducing the need for vaccine booster shots.
SourceOregon Health & Science University·JournalThe Journal of Infectious Diseases·TypeExperimental study·DateFeb 28, 2022
A new study found that gender-affirming hormone therapy can affect certain regions of DNA, influencing immune function and susceptibility to autoimmune disease. The research has important implications for counseling transgender children and adolescents about the effects of hormone therapies.
SourceMurdoch Childrens Research Institute·JournalClinical Epigenetics·TypeObservational study·DateFeb 28, 2022
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A UC Riverside-led study has identified a potential antiviral therapy for SARS and SARS-like coronaviruses by targeting the papain-like protease enzyme. The research reveals that subgroup 2b PLpros selectively target specific host immune pathways, making them a promising target for future coronavirus therapeutics.
SourceUniversity of California - Riverside·JournalACS Infectious Diseases·TypeExperimental study·DateFeb 24, 2022
A new study from the La Jolla Institute for Immunology reveals that two groups of regulatory CD4+ T cells develop at different times to combat acute inflammation. The early Tregs reduce autoimmune damage, while the second wave shuts down the entire immune response to signal infection clearance.
SourceLa Jolla Institute for Immunology·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateFeb 21, 2022
Researchers at Johns Hopkins Medicine discovered a peptide on the SARS-CoV-2 spike protein that triggers an immune response in humans and is also recognized by cells of the immune system, suggesting potential for protection against future zoonotic outbreaks. The study supports the development of multivalent vaccines against a broad spe...
SourceJohns Hopkins Medicine·JournalJournal of Clinical Investigation·DateFeb 16, 2022
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Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
A recent study found that a subset of immune cells within the alveolar bone marrow were activated by the presence of commensal oral microbes, leading to increased osteoclast-mediated bone resorption and bone loss. Reducing the burden of commensal microbes through oral antiseptic rinses can help protect against alveolar bone loss.
SourceMedical University of South Carolina·JournalJCI Insight·DateFeb 16, 2022
Researchers tracked antibody response to COVID-19 vaccination and found that antibodies improve in quality for months after vaccination. Even low levels of antibodies provide some protection as long as the virus doesn't change.
SourceWashU Medicine·JournalNature·TypeObservational study·DateFeb 15, 2022
Researchers at Tokyo University of Science have developed bionanoparticles derived from corn that selectively target and inhibit the growth of cancer cells, inducing tumor necrosis factor-α release. These findings suggest a novel, economical, and safe anti-cancer therapy approach.
SourceTokyo University of Science·JournalScientific Reports·TypeExperimental study·DateFeb 14, 2022
A new study finds that certain COVID-19 variants can escape the human immune system's cytotoxic T cell response in a significant portion of the population. The researchers identified 1,222 epitopes associated with major HLA subtypes, covering about 90% of the human population.
SourcePLOS·JournalPLOS Computational Biology·TypeComputational simulation/modeling·DateFeb 10, 2022
A novel immune-profiling method can return detailed immune cell type proportions using only DNA from blood, potentially allowing for individualized prediction of outcomes in immunotherapy patients. This approach offers the opportunity to ask and answer questions about the immune system in health and disease.
SourceDartmouth Health·JournalNature Communications·TypeExperimental study·DateFeb 9, 2022
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Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
A study by MedUni Vienna found that many cancer patients can build up sufficient immunity against SARS-CoV-2 after the third vaccination. However, patients with blood cancers may not develop protection due to immunosuppressive treatments.
SourceMedical University of Vienna·JournalEuropean Journal of Cancer·DateFeb 8, 2022
Scientists sequenced the gene expression profiles of more than 170,000 individual cells to shed light on a key mystery: the role of Type I Interferons (IFN) during viral infections. The study reveals interferon plays a crucial role in clearing the virus by alerting immune cells, such as macrophages, to search and destroy infected cells.
SourceTexas Biomedical Research Institute·JournalNature Communications·DateFeb 8, 2022
Researchers found that current COVID-19 vaccines provide robust protection against severe disease caused by the Omicron variant through induced cellular immunity. The study showed that CD8+ T cell responses were over 80% cross-reactive with the original strain, suggesting a key role in vaccine protection.
SourceBeth Israel Deaconess Medical Center·JournalNature·DateJan 31, 2022
A study by UConn Health and Washington University School of Medicine found that eating more meat correlates with worse MS symptoms, altered gut bacteria, and increased immune cells. The research identified key bacteria and metabolites associated with the disease, providing new insights into its causes.
SourceUniversity of Connecticut·JournalEBioMedicine·TypeExperimental study·DateJan 27, 2022
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Researchers found a distinct microbial profile associated with long COVID symptoms, including fatigue, muscle weakness, and insomnia. Patients with long COVID had a less diverse and abundant gut microbiome compared to those without the condition.
SourceBMJ Group·JournalGut·TypeObservational study·DateJan 25, 2022
A new study reveals the Beta variant of SARS-CoV-2 can elicit a wide range of antibodies effective against both Delta and Omicron variants. The findings suggest that vaccination strategies could be improved by leveraging this broad immunity.
SourceDZNE - German Center for Neurodegenerative Diseases·JournalScience·TypeExperimental study·DateJan 25, 2022
Immunosequencing of T cells combined with machine learning techniques reveals that participants with higher numbers of pre-existing memory CD4 T cells develop immunity more quickly and produce more antibodies following vaccination. This study has significant implications for immunity and vaccine development efforts.
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Researchers at UC Riverside have identified a new host protein interaction in chickens that triggers a strong immune response against viral infections. The discovery sheds light on the differences between bird and human immune responses to zoonotic viruses.
SourceUniversity of California - Riverside·JournalFrontiers in Immunology·TypeExperimental study·DateJan 25, 2022
A new study finds that breakthrough infections following vaccination and natural infection followed by vaccination provide roughly equal levels of enhanced immune protection. Researchers at OHSU found that both groups generated greater levels of immunity compared to those who were vaccinated with no infection.
SourceOregon Health & Science University·JournalScience Immunology·TypeExperimental study·DateJan 25, 2022
A recent study found that individuals vaccinated three times or those who were vaccinated after an earlier COVID-19 infection had comparable neutralizing antibody activity to those with a breakthrough case. The study suggests that repeated exposure to SARS-CoV-2 antigens enhances the quality of antibody responses.
SourceUniversity of Washington School of Medicine/UW Medicine·JournalCell·TypeExperimental study·DateJan 21, 2022
The four-year programme will investigate the chemical signatures that trigger immunity in fungal infections, which kill an estimated 1.6 million people worldwide annually. By understanding these signatures and how fungi disguise them, researchers hope to uncover the origins of antifungal immunity.
A study by Mayo Clinic researchers found that cancer patients receiving chemotherapy and targeted therapies may mount inadequate immune responses to COVID-19 vaccination. The authors recommend antibody level testing and booster vaccinations for these patients.
SourceMayo Clinic·JournalMayo Clinic Proceedings Innovations Quality & Outcomes·DateJan 20, 2022
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Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
Researchers at the Josep Carreras Leukaemia Research Institute and the Germans Trias i Pujol Hospital discovered that vitamin D activates the tolerance program of dendritic cells through epigenetic modification. This finding offers new hope for treating autoimmune diseases like multiple sclerosis by optimizing tolerogenic dendritic cells.
SourceJosep Carreras Leukaemia Research Institute·JournalCell Reports·TypeExperimental study·DateJan 19, 2022
Northwestern University scientists have identified a key mechanism used by the Zika virus to evade the antiviral response of host cells. The study reveals how the virus suppresses interferon signaling to gain access to cells, providing a new target for antiviral therapeutics.
SourceNorthwestern University·JournalJournal of Virology·DateJan 18, 2022
Researchers at Lund University discovered that non-neutralising antibodies can also protect against Covid-19 by facilitating phagocytosis. The findings suggest that broader protection from antibodies may be more effective in combating mutations of the virus.
SourceLund University·JournalFrontiers in Immunology·DateJan 17, 2022
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Sky & Telescope Pocket Sky Atlas, 2nd Edition is a durable star atlas for planning sessions, identifying targets, and teaching celestial navigation.
Researchers discovered that pathogens can hijack mitochondrial defense mechanisms by mimicking host proteins, effectively disarming the mitochondria. This allows the pathogen to acquire essential nutrients and evade the host's immune response.
SourceMax Planck Institute for Biology of Ageing·JournalScience·TypeExperimental study·DateJan 14, 2022
Researchers discovered the ZIP-1 gene acts as a cell's first-line response to infection, controlling immune responses to viruses and other threats. The finding could have implications for identifying similar genes that control immune responses in humans.
SourceUniversity of California - San Diego·JournalNature Communications·TypeExperimental study·DateJan 13, 2022
Patients with skin-related side effects from immune checkpoint inhibitors tend to live longer, with a 22-50% decrease in mortality. These findings suggest that skin toxicities can be an indicator of treatment efficacy and may help identify patients who are more likely to benefit from their current immunotherapy regimen.
SourceMassachusetts General Hospital·JournalJAMA Dermatology·TypeObservational study·DateJan 12, 2022
The Sanford Children's Genomic Medicine Consortium has initiated a whole genome sequencing research project to investigate undiagnosed illnesses in children with suspected inborn errors of immunity. The study aims to sequence the genomes of up to 25 patient genomes and learn information that can benefit patients and others.
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Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
A large population study found that living alone for several years and/or experiencing serial relationship break-ups are strongly linked to raised levels of inflammatory markers in the blood of middle-aged men. The researchers suggest that this combination may indicate a heightened risk of age-related ill health and death.
SourceBMJ Group·JournalJournal of Epidemiology and Community Health·TypeObservational study·DateJan 10, 2022
Researchers found that people infected with COVID-19 develop a wide variety of autoantibodies up to six months after recovery, and these autoantibodies persist over time. The study suggests that understanding these autoantibody responses could help identify ways to treat and prevent long-term symptoms.
SourceCedars-Sinai Medical Center·JournalJournal of Translational Medicine·DateDec 29, 2021
A new study found that infection-fighting B cells retain better memory of the coronavirus spike protein in patients who recover from less-severe cases of COVID-19 than those recovering from severe cases. This hints at subtle differences in the quality of immune response based on COVID-19 severity.
SourceUniversity of Texas Health Science Center at San Antonio·JournalPLOS ONE·TypeExperimental study·DateDec 23, 2021
A new study reveals that mRNA vaccines activate a type of helper cell called T follicular helper cells, which assist in creating powerful antibodies and drive the development of immune memory. This strong response helps prevent severe disease and death, even against highly mutated variants like omicron.
SourceWashU Medicine·JournalCell·TypeObservational study·DateDec 23, 2021
Patients with sufficient fiber intake had improved progression-free survival and response to immunotherapy in melanoma. A high-fiber diet was associated with slower tumor growth and increased CD4+ T cells in pre-clinical models, supporting the potential benefits of dietary interventions on cancer treatment outcomes.
SourceUniversity of Texas M. D. Anderson Cancer Center·JournalScience·DateDec 23, 2021
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Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
A global study found that hospitalized COVID-19 patients with metabolic syndrome had a 20% higher risk of developing acute respiratory distress syndrome (ARDS) and dying. The study examined records of over 46,000 patients in 181 hospitals across 26 countries.
SourceTulane University·JournalJAMA Network Open·TypeData/statistical analysis·DateDec 22, 2021
A new study reveals the sophisticated mechanism by which adenoviruses infect human cells and transfer foreign DNA into their nucleus. Protein V plays a crucial role in increasing the virus particle's stability and preventing premature DNA release, which triggers an anti-viral alarm system.
SourceUniversity of Zurich·JournalScience Advances·TypeExperimental study·DateDec 21, 2021
Researchers found that mRNA vaccines were highly effective (86%) in preventing SARS-CoV-2-related deaths among vaccinated individuals, especially in the elderly population. However, vaccine effectiveness against infection was lower (69%) and decreased with increasing age and comorbidity burden.
SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·TypeRandomized controlled/clinical trial·DateDec 20, 2021
A new study suggests that breakthrough infections generate 'super immunity' to COVID-19, providing a robust immune response against the delta variant and potentially other variants. The study found that antibodies generated from breakthrough cases were 1,000% more effective than those from vaccinated individuals.
SourceOregon Health & Science University·JournalJAMA·TypeExperimental study·DateDec 16, 2021
Research from Queen Mary University of London and Cardiff University found that certain MS treatments can reduce Covid-19 vaccine effectiveness in people with MS. The largest peer-reviewed study on the topic provides high-quality evidence to inform clinicians' guidance on treatment options.
SourceQueen Mary University of London·JournalAnnals of Neurology·DateDec 15, 2021
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Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
Researchers have identified a novel immune-like mechanism by which healthy epithelial cells recognize and eliminate precancerous cells through a MHC class I-LILRB3 interaction. This process generates mechanical force to extrude the precancerous cells from the body, offering new hope for cancer prevention and treatment.
SourceWaseda University·JournalNature Immunology·TypeExperimental study·DateDec 15, 2021
A novel vaccine, TOH-Vac1, replicates inside the body's cells and generates a powerful immune response in mice and monkeys. The vaccine is based on a strain of vaccinia virus used to vaccinate against smallpox and can be programmed to protect against multiple variants.
SourceUniversity of Ottawa·JournalMolecular Therapy·DateDec 15, 2021
The KEYNOTE-811 trial demonstrates a significant improvement in objective response rate (74.4%) and tumor size reduction compared to trastuzumab and chemotherapy. The combination of pembrolizumab, trastuzumab, and chemotherapy markedly reduces tumor size and induces complete responses in some patients.
SourceVall d'Hebron Institute of Oncology·JournalNature·TypeRandomized controlled/clinical trial·DateDec 15, 2021
Researchers at Mayo Clinic found that mRNA therapy improves the response of patients who weren't responding to cancer immunotherapy. The study identified a weak spot in T cells, white blood cells crucial for fighting cancer, and developed an mRNA-based strategy to enhance their response.
SourceMayo Clinic·JournalCancer Immunology Research·DateDec 15, 2021
Researchers have discovered a fundamental role of the TBK1 enzyme in deciding B cell fate, crucial for developing effective vaccines for diseases like COVID-19 and malaria. The study reveals that TBK1 is necessary for germinal center formation and high-quality antibody production.
SourceUniversity of Tokyo·JournalJournal of Experimental Medicine·TypeExperimental study·DateDec 15, 2021
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Researchers at La Jolla Institute for Immunology identified Th1* cells as a key marker in the body's immune signature following BCG vaccination. The study found that these cells respond well to the vaccine and can help fight the Mycobacterium tuberculosis bacterium that causes TB.
SourceLa Jolla Institute for Immunology·JournalEBioMedicine·TypeExperimental study·DateDec 13, 2021
A landmark study found that convalescent plasma was safe and effective in treating early COVID-19 patients, particularly those with weakened immune systems. The trial showed improved outcomes in patients given high-titer plasma during the first quarter of the pandemic.
SourceUniversity of Texas Health Science Center at Houston·JournalJAMA Internal Medicine·TypeRandomized controlled/clinical trial·DateDec 13, 2021
Researchers at UCLA have identified rare T cells capable of targeting a protein found in SARS-CoV-2 and other coronaviruses. By adding a fragment of this protein to vaccines, they hope to create a longer-lasting immune response and increase protection against new variants. This breakthrough could lead to more effective COVID-19 vaccines.
SourceUniversity of California - Los Angeles Health Sciences·JournalCell Reports·TypeExperimental study·DateDec 10, 2021
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A new study reveals that infant immune systems are robust and efficient, allowing them to quickly respond to new pathogens. This may explain why infants are less affected by COVID-19 than adults, who take longer to react.
SourceColumbia University Irving Medical Center·JournalScience Immunology·TypeExperimental study·DateDec 10, 2021
Researchers discovered that blood stem cells use high-energy fatty acids from the body's fat stores to power up their response to infection. This finding could lead to new approaches in treating bacterial infections, particularly in vulnerable and older individuals.
SourceUniversity of East Anglia·JournalNature Communications·TypeExperimental study·DateDec 8, 2021
Researchers at Hokkaido University and Texas A¼M University identified a key mechanism used by SARS-CoV-2 to evade host immune systems, targeting the MHC class I pathway. The study found that the virus suppresses the activation of this pathway using the ORF6 protein, allowing it to persist in the body and infect others.
SourceHokkaido University·JournalNature Communications·TypeData/statistical analysis·DateDec 7, 2021